{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:12:01Z","timestamp":1778227921180,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100015439","name":"Centres de Recerca de Catalunya","doi-asserted-by":"publisher","award":["CPII22\/00007"],"award-info":[{"award-number":["CPII22\/00007"]}],"id":[{"id":"10.13039\/100015439","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI12\/000612"],"award-info":[{"award-number":["PI12\/000612"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PT17\/0019"],"award-info":[{"award-number":["PT17\/0019"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/00269"],"award-info":[{"award-number":["PI15\/00269"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI 21\/01722"],"award-info":[{"award-number":["PI 21\/01722"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00434"],"award-info":[{"award-number":["PI18\/00434"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001717","name":"Universiteit Leiden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI-11\/0184"],"award-info":[{"award-number":["PI-11\/0184"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI-14\/0582"],"award-info":[{"award-number":["PI-14\/0582"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["RD12\/0042\/0032"],"award-info":[{"award-number":["RD12\/0042\/0032"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005039","name":"Leids Universitair Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2017 SGR 1736"],"award-info":[{"award-number":["2017 SGR 1736"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jtha.2025.10.005","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:35:28Z","timestamp":1761550528000},"page":"545-557","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genome-wide identification of loci associated with plasma coagulation factor IX activity"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0166-2386","authenticated-orcid":false,"given":"Jihee","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"ten Cate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruifang","family":"Li-Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro Pallares","family":"Robles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harsini Raaja","family":"Sulochana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Andrade-Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linjun","family":"Ao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Noordam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Martinez-Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Sabater-Lleal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Soria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Souto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frits R.","family":"Rosendaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp S.","family":"Wild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-1168","authenticated-orcid":false,"given":"Astrid","family":"van Hylckama Vlieg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.10.005_bib1","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1056\/NEJM200106073442307","article-title":"The hemophilias\u2014from royal genes to gene therapy","volume":"344","author":"Mannucci","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtha.2025.10.005_bib2","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1182\/blood.V95.12.3678.012k45_3678_3682","article-title":"High levels of factor IX increase the risk of venous thrombosis","volume":"95","author":"van Hylckama Vlieg","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.10.005_bib3","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1055\/s-0037-1613857","article-title":"Thrombotic variables and risk of idiopathic venous thromboembolism in women aged 45-64 years. Relationships to hormone replacement therapy","volume":"83","author":"Lowe","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.10.005_bib4","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1182\/blood-2009-05-219915","article-title":"Coagulation factors IX through XIII and the risk of future venous thrombosis: the Longitudinal Investigation of Thromboembolism Etiology","volume":"114","author":"Cushman","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.10.005_bib5","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/jth.13698","article-title":"Associations of coagulation factors IX and XI levels with incident coronary heart disease and ischemic stroke: the REGARDS study","volume":"15","author":"Olson","year":"2017","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.10.005_bib6","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1182\/blood-2005-12-023697","article-title":"Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: opposite and synergistic effects of factors XI and XII","volume":"108","author":"Doggen","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.10.005_bib7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-0609.2006.00656.x","article-title":"Procoagulant factors and the risk of myocardial infarction in young women","volume":"77","author":"Tanis","year":"2006","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.jtha.2025.10.005_bib8","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1001\/jama.299.11.1306","article-title":"Gene variants associated with deep vein thrombosis","volume":"299","author":"Bezemer","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.jtha.2025.10.005_bib9","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3324\/haematol.2008.003020","article-title":"F9 Malm\u00f6, factor IX and deep vein thrombosis","volume":"94","author":"Bezemer","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2025.10.005_bib10","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1056\/NEJMoa0904377","article-title":"X-linked thrombophilia with a mutant factor IX (factor IX Padua)","volume":"361","author":"Simioni","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtha.2025.10.005_bib11","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/nprot.2014.071","article-title":"Quality control and conduct of genome-wide association meta-analyses","volume":"9","author":"Winkler","year":"2014","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jtha.2025.10.005_bib12","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/1471-2105-11-288","article-title":"GWAMA: software for genome-wide association meta-analysis","volume":"11","author":"M\u00e4gi","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jtha.2025.10.005_bib13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ng.2213","article-title":"Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits","volume":"44","author":"Yang","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.jtha.2025.10.005_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/652569","article-title":"Methods for analyzing multivariate phenotypes in genetic association studies","volume":"2012","author":"Yang","year":"2012","journal-title":"J Probab Stat"},{"key":"10.1016\/j.jtha.2025.10.005_bib15","doi-asserted-by":"crossref","first-page":"D930","DOI":"10.1093\/nar\/gkr917","article-title":"HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants","volume":"40","author":"Ward","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jtha.2025.10.005_bib16","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.jtha.2025.10.005_bib17","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1038\/s41588-018-0248-z","article-title":"An atlas of genetic associations in UK Biobank","volume":"50","author":"Canela-Xandri","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.jtha.2025.10.005_bib18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/hmg\/ddv454","article-title":"A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration","volume":"25","author":"de Vries","year":"2016","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jtha.2025.10.005_bib19","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1161\/CIRCULATIONAHA.110.009480","article-title":"Genetic predictors of fibrin D-dimer levels in healthy adults","volume":"123","author":"Smith","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2025.10.005_bib20","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1182\/blood-2018-05-849240","article-title":"A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology","volume":"133","author":"de Vries","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.10.005_bib21","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCULATIONAHA.118.034532","article-title":"Genome-wide association transethnic meta-analyses identifies novel associations regulating coagulation factor VIII and von Willebrand factor plasma levels","volume":"139","author":"Sabater-Lleal","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2025.10.005_bib22","first-page":"637","article-title":"Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels","volume":"26","author":"Sennblad","year":"2017","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jtha.2025.10.005_bib23","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1161\/ATVBAHA.113.302088","article-title":"Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2","volume":"34","author":"Huang","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2025.10.005_bib24","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1182\/blood-2012-06-436188","article-title":"Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation","volume":"120","author":"Huang","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.10.005_bib25","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ajhg.2012.05.009","article-title":"Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease","volume":"91","author":"Tang","year":"2012","journal-title":"Am J Hum Genet"},{"issue":"W1","key":"10.1016\/j.jtha.2025.10.005_bib26","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jtha.2025.10.005_bib27","first-page":"82","article-title":"PyMOL: an open-source molecular graphics tool","volume":"40","author":"DeLano","year":"2002","journal-title":"CCP4 Newsl Protein Crystallogr"},{"key":"10.1016\/j.jtha.2025.10.005_bib28","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jtha.2025.10.005_bib29","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s10654-013-9801-3","article-title":"The Netherlands Epidemiology of Obesity (NEO) study: study design and data collection","volume":"28","author":"de Mutsert","year":"2013","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jtha.2025.10.005_bib30","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1007\/s00103-012-1502-7","article-title":"Die Gutenberg Gesundheitsstudie [The Gutenberg Health Study]","volume":"55","author":"Wild","year":"2012","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"key":"10.1016\/j.jtha.2025.10.005_bib31","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.jtha.2025.10.005_bib32","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.3390\/biom12101486","article-title":"Functional tuning of intrinsically disordered regions in human proteins by composition bias","volume":"12","author":"Kastano","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.jtha.2025.10.005_bib33","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/CIRCULATIONAHA.122.059675","article-title":"Cross-ancestry investigation of venous thromboembolism genomic predictors","volume":"146","author":"Thibord","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2025.10.005_bib34","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.thromres.2017.10.008","article-title":"An update on factor XI structure and function","volume":"161","author":"Mohammed","year":"2018","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.10.005_bib35","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1182\/blood-2009-09-199182","article-title":"Structure and function of factor XI","volume":"115","author":"Emsley","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.10.005_bib36","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.thromres.2014.03.020","article-title":"The mechanism underlying activation of factor IX by factor XIa","volume":"133","author":"Gailani","year":"2014","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.10.005_bib37","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10719-020-09922-2","article-title":"Identification of novel glycosylation events on human serum-derived factor IX","volume":"37","author":"Pegg","year":"2020","journal-title":"Glycoconj J"},{"key":"10.1016\/j.jtha.2025.10.005_bib38","doi-asserted-by":"crossref","first-page":"6580","DOI":"10.2741\/3175","article-title":"Understanding eukaryotic linear motifs and their role in cell signaling and regulation","volume":"13","author":"Diella","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.jtha.2025.10.005_bib39","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","article-title":"A cross-population atlas of genetic associations for 220 human phenotypes","volume":"53","author":"Sakaue","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.jtha.2025.10.005_bib40","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.cell.2020.06.045","article-title":"Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jtha.2025.10.005_bib41","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1161\/ATVBAHA.116.308109","article-title":"Identification of genetic variants linking protein c and lipoprotein metabolism: the ARIC Study (Atherosclerosis Risk in Communities)","volume":"37","author":"Pankow","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2025.10.005_bib42","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","article-title":"Large-scale integration of the plasma proteome with genetics and disease","volume":"53","author":"Ferkingstad","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.jtha.2025.10.005_bib43","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ng.291","article-title":"Common variants at 30 loci contribute to polygenic dyslipidemia","volume":"41","author":"Kathiresan","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jtha.2025.10.005_bib44","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.2337\/db07-1807","article-title":"The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population","volume":"57","author":"Vaxillaire","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.jtha.2025.10.005_bib45","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1182\/blood.2020005843","article-title":"The relationship between ABO blood group, von Willebrand factor, and primary hemostasis","volume":"136","author":"Ward","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.10.005_bib46","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1111\/jth.14573","article-title":"Glucose metabolism affects coagulation factors: the NEO study","volume":"17","author":"van der Toorn","year":"2019","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.10.005_bib47","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1161\/ATVBAHA.120.315365","article-title":"Association between hepatic triglyceride content and coagulation factors: the Netherlands Epidemiology of Obesity Study","volume":"40","author":"Morelli","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2025.10.005_bib48","doi-asserted-by":"crossref","first-page":"9018","DOI":"10.1039\/D3FO02579A","article-title":"Associations between the inflammatory potential of diets with adherence to plant-based dietary patterns and the risk of new-onset cardiometabolic diseases in Chinese adults: findings from a nation-wide prospective cohort study","volume":"14","author":"Wu","year":"2023","journal-title":"Food Funct"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625006683?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625006683?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:23:11Z","timestamp":1778224991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783625006683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1538783625006683"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.10.005","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide identification of loci associated with plasma coagulation factor IX activity","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}