{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:26:12Z","timestamp":1792484772980,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-20-1-0628"],"award-info":[{"award-number":["W81XWH-20-1-0628"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-17-2-0064"],"award-info":[{"award-number":["W81XWH-17-2-0064"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014597","name":"LAM Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014597","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008136","name":"Case Western Reserve University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008136","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jtha.2025.10.030","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T02:47:28Z","timestamp":1762829248000},"page":"877-889","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intraosseous administration of lyophilized synthetic platelets renders hemostatic efficacy in rat model of traumatic hemorrhage"],"prefix":"10.1016","volume":"24","author":[{"given":"Zeyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiha","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary A.","family":"Secunda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman F.","family":"Luc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baylee","family":"Traylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dante","family":"Disharoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Pawlowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riya","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ujjal Didar Singh","family":"Sekhon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Quill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Charles","family":"Spinella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Bruckman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Sen Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8931-6236","authenticated-orcid":false,"given":"Matthew D.","family":"Neal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.10.030_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41572-021-00264-3","article-title":"Trauma-induced coagulopathy","volume":"7","author":"Moore","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jtha.2025.10.030_bib2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/jama.2015.12","article-title":"Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial","volume":"313","author":"Holcomb","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.jtha.2025.10.030_bib3","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/TA.0000000000001017","article-title":"A prospective study of platelet function in trauma patients","volume":"80","author":"Ramsey","year":"2016","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jtha.2025.10.030_bib4","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1097\/TA.0000000000002047","article-title":"Goal-directed platelet transfusions correct platelet dysfunction and may improve survival in patients with severe traumatic brain injury","volume":"85","author":"Furay","year":"2018","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jtha.2025.10.030_bib5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/TA.0000000000003598","article-title":"Do not forget the platelets: the independent impact of red blood cell to platelet ratio on mortality in massively transfused trauma patients","volume":"93","author":"Dorken Gallastegi","year":"2022","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jtha.2025.10.030_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13054-022-03928-y","article-title":"Impact of platelet transfusion on outcomes in trauma patients","volume":"26","author":"Hamada","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/j.jtha.2025.10.030_bib7","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1182\/bloodadvances.2018017699","article-title":"Platelet transfusions improve hemostasis and survival in a substudy of the prospective, randomized PROPPR trial","volume":"2","author":"Cardenas","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2025.10.030_bib8","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1182\/hematology.2022000379","article-title":"Expanding the platelet inventory to mitigate the impact of severe shortages","volume":"2022","author":"Stubbs","year":"2022","journal-title":"Hematology"},{"key":"10.1016\/j.jtha.2025.10.030_bib9","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/SLA.0000000000005393","article-title":"The national blood shortage\u2014an impetus for change","volume":"275","author":"Saillant","year":"2022","journal-title":"Ann Surg"},{"key":"10.1016\/j.jtha.2025.10.030_bib10","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1182\/hematology.2022000402","article-title":"Platelet components and bacterial contamination: hospital perspective 2022","volume":"2022","author":"Szczepiorkowski","year":"2022","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.jtha.2025.10.030_bib11","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1111\/trf.17572","article-title":"How do I manage a blood product shortage?","volume":"63","author":"Gammon","year":"2023","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2025.10.030_bib12","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1200\/JCO.2017.76.1734","article-title":"Platelet transfusion for patients with cancer: American Society of Clinical Oncology clinical practice guideline update","volume":"36","author":"Schiffer","year":"2018","journal-title":"J Clin Oncol"},{"issue":"Suppl 2","key":"10.1016\/j.jtha.2025.10.030_bib13","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1111\/trf.14165","article-title":"Continued decline in blood collection and transfusion in the United States-2015","volume":"57","author":"Ellingson","year":"2017","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2025.10.030_bib14","first-page":"321","article-title":"The effect of platelet storage temperature on haemostatic, immune, and endothelial function: potential for personalised medicine","volume":"17","author":"Shea","year":"2019","journal-title":"Blood Transfus"},{"key":"10.1016\/j.jtha.2025.10.030_bib15","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1111\/trf.16561","article-title":"A survey of US hospitals on platelet inventory management, transfusion practice, and platelet availability","volume":"61","author":"Pandey","year":"2021","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2025.10.030_bib16","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1111\/trf.17565","article-title":"The operational impact of introducing cold stored platelets","volume":"63","author":"Blake","year":"2023","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2025.10.030_bib17","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1097\/TA.0000000000004334","article-title":"A safety and feasibility analysis on the use of cold-stored platelets in combat trauma","volume":"97","author":"Fisher","year":"2024","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jtha.2025.10.030_bib18","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/SLA.0000000000006317","article-title":"Early cold stored platelet transfusion following severe injury: a randomized clinical trial","volume":"280","author":"Sperry","year":"2024","journal-title":"Ann Surg"},{"key":"10.1016\/j.jtha.2025.10.030_bib19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/09537104.2021.1967916","article-title":"Bioinspired artificial platelets: past, present and future","volume":"33","author":"Luc","year":"2022","journal-title":"Platelets"},{"key":"10.1016\/j.jtha.2025.10.030_bib20","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/TA.0000000000001893","article-title":"Intravenous administration of synthetic platelets (SynthoPlate) in a mouse liver injury model of uncontrolled hemorrhage improves hemostasis","volume":"84","author":"Dyer","year":"2018","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jtha.2025.10.030_bib21","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1038\/s41598-018-21384-z","article-title":"Intravenous synthetic platelet (SynthoPlate) nanoconstructs reduce bleeding and improve \u2018golden hour\u2019 survival in a porcine model of traumatic arterial hemorrhage","volume":"8","author":"Hickman","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2025.10.030_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb8975","article-title":"Platelet-mimicking procoagulant nanoparticles augment hemostasis in animal models of bleeding","volume":"14","author":"Sekhon","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jtha.2025.10.030_bib23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/TA.0000000000003938","article-title":"Platelet-inspired synthetic nanoparticles improve hemostasis and hemodynamics in a rabbit model of abdominal hemorrhage","volume":"96","author":"Srinivasan","year":"2024","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jtha.2025.10.030_bib24","doi-asserted-by":"crossref","first-page":"A15","DOI":"10.1186\/1757-7241-23-S2-A15","article-title":"Saving the critically injured trauma patient: a retrospective analysis of 1000 uses of intraosseous access","volume":"23","author":"Lewis","year":"2015","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"10.1016\/j.jtha.2025.10.030_bib25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0378-5173(01)00721-9","article-title":"Filter extrusion of liposomes using different devices: comparison of liposome size, encapsulation efficiency, and process characteristics","volume":"223","author":"Berger","year":"2001","journal-title":"Int J Pharm"},{"key":"10.1016\/j.jtha.2025.10.030_bib26","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/SHK.0000000000000794","article-title":"Platelet transfusion in critical care and surgery: evidence-based review of contemporary practice and future directions","volume":"47","author":"Etchill","year":"2017","journal-title":"Shock"},{"key":"10.1016\/j.jtha.2025.10.030_bib27","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/09537104.2020.1718633","article-title":"Alterations in platelet behavior after major trauma: adaptive or maladaptive?","volume":"32","author":"Vulliamy","year":"2021","journal-title":"Platelets"},{"key":"10.1016\/j.jtha.2025.10.030_bib28","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.drudis.2017.11.006","article-title":"Nanomedicine safety in preclinical and clinical development: focus on idiosyncratic injection\/infusion reactions","volume":"23","author":"Moghimi","year":"2018","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.jtha.2025.10.030_bib29","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1124\/jpet.119.258012","article-title":"The interplay between blood proteins, complement, and macrophages on nanomedicine performance and responses","volume":"370","author":"Moghimi","year":"2019","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jtha.2025.10.030_bib30","series-title":"Intraosseous vascular access","author":"Dornhofer","year":"2024"},{"key":"10.1016\/j.jtha.2025.10.030_bib31","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/aor.14033","article-title":"Liposome-encapsulated hemoglobin (HbV) transfusion rescues rats undergoing progressive lethal 85% hemorrhage as a result of an anti-arrhythmogenic effect on the myocardium","volume":"45","author":"Takase","year":"2021","journal-title":"Artif Organs"},{"key":"10.1016\/j.jtha.2025.10.030_bib32","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/jth.13579","article-title":"In vitro characterization of SynthoPlate\u2122 (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice","volume":"15","author":"Shukla","year":"2017","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.10.030_bib33","first-page":"2891","article-title":"Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in von Willebrand disease murine models","volume":"141","author":"Roullet","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.10.030_bib34","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/jth.14450","article-title":"Trauma-induced coagulopathy: the past, present, and future","volume":"17","author":"Kornblith","year":"2019","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.10.030_bib35","series-title":"Florida","author":"Bounds","year":"2024"},{"key":"10.1016\/j.jtha.2025.10.030_bib36","article-title":"Syndecan-1 as a severity biomarker for patients with trauma","volume":"9","author":"Suzuki","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jtha.2025.10.030_bib37","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1001\/jamasurg.2014.1685","article-title":"Development and validation of 4 different rat models of uncontrolled hemorrhage","volume":"150","author":"Morgan","year":"2015","journal-title":"JAMA Surg"},{"key":"10.1016\/j.jtha.2025.10.030_bib38","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/ajh.26403","article-title":"Freeze-dried platelets are a promising alternative in bleeding thrombocytopenic patients with hematological malignancies","volume":"97","author":"Ohanian","year":"2022","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jtha.2025.10.030_bib39","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1182\/blood.2021014889","article-title":"There and back again: the once and current developments in donor-derived platelet products for hemostatic therapy","volume":"139","author":"Kogler","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.10.030_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2025.101257","article-title":"Application of thrombopoietic agents in cancer therapy-induced thrombocytopenia: a comprehensive review","volume":"70","author":"Mei","year":"2025","journal-title":"Blood Rev"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625008311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625008311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T16:03:04Z","timestamp":1781452984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783625008311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1538783625008311"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.10.030","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intraosseous administration of lyophilized synthetic platelets renders hemostatic efficacy in rat model of traumatic hemorrhage","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.10.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}