{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T16:52:46Z","timestamp":1781455966668,"version":"3.54.1"},"reference-count":70,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2023-2027"],"award-info":[{"award-number":["2023-2027"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012352","name":"Universit\u00e0 degli Studi di Milano","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RC2024"],"award-info":[{"award-number":["RC2024"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jtha.2025.11.001","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T04:50:10Z","timestamp":1764391810000},"page":"804-816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune-mediated thrombotic thrombocytopenic purpura as a model of systemic microvascular dysfunction: moving from an acute to a chronic disorder"],"prefix":"10.1016","volume":"24","author":[{"given":"Pasquale","family":"Agosti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio","family":"Ingenito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addolorata","family":"Truma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Artoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7423-9864","authenticated-orcid":false,"given":"Flora","family":"Peyvandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.11.001_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12785","article-title":"Visualizing the microcirculation","volume":"29","author":"Senarathna","year":"2022","journal-title":"Microcirculation"},{"key":"10.1016\/j.jtha.2025.11.001_bib2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000503775","article-title":"Microcirculation: physiology, pathophysiology, and clinical application","volume":"49","author":"Guven","year":"2020","journal-title":"Blood Purif"},{"key":"10.1016\/j.jtha.2025.11.001_bib3","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.3390\/jcm12154892","article-title":"Microcirculation in hypertension: a therapeutic target to prevent cardiovascular disease?","volume":"12","author":"Rizzoni","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtha.2025.11.001_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/cvr\/cvaa085","volume":"117","author":"Alexander","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jtha.2025.11.001_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/apha.14048","article-title":"Glomerular microcirculation: implications for diabetes, preeclampsia, and kidney injury","volume":"239","author":"Goligorsky","year":"2023","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.jtha.2025.11.001_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1144229","article-title":"Endothelial dysfunction and immunothrombosis in sepsis","volume":"14","author":"Maneta","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtha.2025.11.001_bib7","article-title":"Small-vessel disease in the brain","volume":"27","author":"Singh","year":"2023","journal-title":"Am Heart J Plus"},{"key":"10.1016\/j.jtha.2025.11.001_bib8","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.amjmed.2022.04.006","article-title":"Microvascular dysfunction as a systemic disease: a review of the evidence","volume":"135","author":"Feuer","year":"2022","journal-title":"Am J Med"},{"key":"10.1016\/j.jtha.2025.11.001_bib9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s41824-023-00180-7","article-title":"Interrelation between cardiac and brain small-vessel disease: a pilot quantitative PET and MRI study","volume":"7","author":"Mazini","year":"2023","journal-title":"Eur J Hybrid Imaging"},{"key":"10.1016\/j.jtha.2025.11.001_bib10","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.028767","article-title":"Coronary microvascular disease assessed by 82-rubidium positron emission tomography myocardial perfusion imaging is associated with small vessel disease of the kidney and brain","volume":"12","author":"H\u00f8jstrup","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jtha.2025.11.001_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2020.104123","article-title":"Is microvascular dysfunction a systemic disorder with common biomarkers found in the heart, brain, and kidneys? - a scoping review","volume":"134","author":"Nowroozpoor","year":"2021","journal-title":"Microvasc Res"},{"key":"10.1016\/j.jtha.2025.11.001_bib12","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1111\/jth.15006","article-title":"ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura","volume":"18","author":"Zheng","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.11.001_bib13","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1111\/jth.15010","article-title":"ISTH guidelines for treatment of thrombotic thrombocytopenic purpura","volume":"18","author":"Zheng","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.11.001_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2025.103168","article-title":"Caplacizumab use in immune-mediated thrombotic thrombocytopenic purpura: an international multicentre retrospective Cohort study (The Capla 1000+ project)","volume":"82","author":"Coppo","year":"2025","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jtha.2025.11.001_bib15","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/jth.13571","article-title":"Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies","volume":"15","author":"Scully","year":"2017","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.11.001_bib16","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1111\/jth.15009","article-title":"Good practice statements (GPS) for the clinical care of patients with thrombotic thrombocytopenic purpura","volume":"18","author":"Zheng","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.11.001_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.thromres.2024.109151","article-title":"Main features of ischemic stroke in patients with acute immune-mediated thrombotic thrombocytopenic purpura","volume":"243","author":"Truma","year":"2024","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.11.001_bib18","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1056\/NEJM199811263392203","article-title":"Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura","volume":"339","author":"Tsai","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtha.2025.11.001_bib19","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1182\/bloodadvances.2024013421","article-title":"Global prevalence of hereditary thrombotic thrombocytopenic purpura determined by genetic analysis","volume":"8","author":"Seidizadeh","year":"2024","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2025.11.001_bib20","article-title":"Immune thrombotic thrombocytopenic purpura: Spotlight on long-term outcomes and survivorship","volume":"10","author":"Selvakumar","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jtha.2025.11.001_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12802","article-title":"Epidemiology, treatment patterns, clinical outcomes, and disease burden among patients with immune-mediated thrombotic thrombocytopenic purpura in the United States","volume":"6","author":"Adeyemi","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.11.001_bib22","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1055\/s-0042-1749589","article-title":"Thrombotic thrombocytopenic purpura: from 1972 to 2022 and beyond","volume":"48","author":"George","year":"2022","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jtha.2025.11.001_bib23","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1182\/blood-2013-04-496752","article-title":"Multiple major morbidities and increased mortality during long-term follow-up after recovery from thrombotic thrombocytopenic purpura","volume":"122","author":"Deford","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.11.001_bib24","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1182\/asheducation-2018.1.548","article-title":"TTP: long-term outcomes following recovery","volume":"2018","author":"George","year":"2018","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.jtha.2025.11.001_bib25","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1182\/bloodadvances.2020004169","article-title":"Cardiovascular disease is a leading cause of mortality among TTP survivors in clinical remission","volume":"6","author":"Sukumar","year":"2022","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2025.11.001_bib26","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1182\/blood.2019001056","article-title":"Reduced ADAMTS13 activity during TTP remission is associated with stroke in TTP survivors","volume":"134","author":"Upreti","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.11.001_bib27","doi-asserted-by":"crossref","first-page":"S216","DOI":"10.1111\/jth.12953","article-title":"Life after acquired thrombotic thrombocytopenic purpura: morbidity, mortality, and risks during pregnancy","volume":"13","author":"Vesely","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.11.001_bib28","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/ajh.26341","article-title":"Major adverse cardiovascular events in survivors of immune-mediated thrombotic thrombocytopenic purpura","volume":"96","author":"Brodsky","year":"2021","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jtha.2025.11.001_bib29","first-page":"325","article-title":"Silent cerebral infarction during immune TTP remission: prevalence, predictors, and impact on cognition","volume":"142","author":"Chaturvedi","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.11.001_bib30","doi-asserted-by":"crossref","first-page":"5945","DOI":"10.1182\/bloodadvances.2025017274","article-title":"Progressive silent cerebral infarction is associated with stroke and persistent cognitive impairment in iTTP survivors","volume":"9","author":"Yu","year":"2025","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2025.11.001_bib31","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1537-2995.2009.02101.x","article-title":"Cognitive deficits after recovery from thrombotic thrombocytopenic purpura","volume":"49","author":"Kennedy","year":"2009","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2025.11.001_bib32","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1537-2995.2008.01938.x","article-title":"Long-term deficits in health-related quality of life after recovery from thrombotic thrombocytopenic purpura","volume":"49","author":"Lewis","year":"2009","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2025.11.001_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/ajh.21881","article-title":"Evidence of persistent neurologic injury following thrombotic thrombocytopenic purpura","volume":"86","author":"Cataland","year":"2011","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jtha.2025.11.001_bib34","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ajh.24060","article-title":"Depression and cognitive impairment following recovery from thrombotic thrombocytopenic purpura","volume":"90","author":"Han","year":"2015","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jtha.2025.11.001_bib35","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/trf.14060","article-title":"Depression and cognitive deficits as long-term consequences of thrombotic thrombocytopenic purpura","volume":"57","author":"Falter","year":"2017","journal-title":"Transfusion"},{"key":"10.1016\/j.jtha.2025.11.001_bib36","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.thromres.2017.01.003","article-title":"Post-traumatic stress disorder and depression in survivors of thrombotic thrombocytopenic purpura","volume":"151","author":"Chaturvedi","year":"2017","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.11.001_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.136","article-title":"Thrombotic thrombocytopenic purpura patients' attitudes toward depression management: a qualitative study","volume":"2","author":"Terrell","year":"2019","journal-title":"Health Sci Rep"},{"key":"10.1016\/j.jtha.2025.11.001_bib38","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.3324\/haematol.2019.226423","article-title":"Long-term neuropsychological sequelae, emotional wellbeing and quality of life in patients with acquired thrombotic thrombocytopenic purpura","volume":"105","author":"Riva","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2025.11.001_bib39","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/bjh.17126","article-title":"Cerebral MRI findings predict the risk of cognitive impairment in thrombotic thrombocytopenic purpura","volume":"191","author":"Alwan","year":"2020","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.11.001_bib40","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/16078454.2021.1945236","article-title":"Survival after acute episodes of immune-mediated thrombotic thrombocytopenic purpura (iTTP)\u2014cognitive functioning and health-related quality of life impact: a descriptive cross-sectional survey of adults living with iTTP in the United Kingdom","volume":"26","author":"Holmes","year":"2021","journal-title":"Hematology"},{"key":"10.1016\/j.jtha.2025.11.001_bib41","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3390\/jcm10020365","article-title":"Influence of personality, resilience and life conditions on depression and anxiety in 104 patients having survived acute autoimmune thrombotic thrombocytopenic purpura","volume":"10","author":"Falter","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtha.2025.11.001_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.29992","article-title":"Clinical features and neurological outcomes in pediatric immune-mediated thrombotic thrombocytopenic purpura: a report from a large pediatric hematology center","volume":"69","author":"Graciaa","year":"2022","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jtha.2025.11.001_bib43","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1182\/bloodadvances.2022008342","article-title":"Health following recovery from immune thrombotic thrombocytopenic purpura: the patient's perspective","volume":"7","author":"Kelley","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2025.11.001_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrc.2023.154283","article-title":"Post-traumatic stress disorder and quality of life alterations in survivors of immune-mediated thrombotic thrombocytopenic purpura and atypical hemolytic and uremic syndrome","volume":"76","author":"Azoulay","year":"2023","journal-title":"J Crit Care"},{"key":"10.1016\/j.jtha.2025.11.001_bib45","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/bjh.19246","article-title":"Cognitive decline in thrombotic thrombocytopenic purpura survivors: the role of white matter health as assessed by MRI","volume":"204","author":"Hannan","year":"2024","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.11.001_bib46","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1007\/s00277-024-05771-3","article-title":"Long-term health-related quality of life and mental health in patients with immune thrombotic thrombocytopenic purpura","volume":"103","author":"Mulas","year":"2024","journal-title":"Ann Hematol"},{"key":"10.1016\/j.jtha.2025.11.001_bib47","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3390\/jcm14030694","article-title":"Multicenter prospective pilot study identifying thrombomodulin as a potential biomarker for neurocognitive outcomes in immune thrombotic thrombocytopenic purpura","volume":"14","author":"Boothby","year":"2025","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtha.2025.11.001_bib48","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1053\/j.ajkd.2014.03.019","article-title":"Increased urinary albumin excretion following recovery from thrombotic thrombocytopenic purpura due to acquired ADAMTS13 deficiency","volume":"64","author":"Little","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jtha.2025.11.001_bib49","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/bjh.18127","article-title":"Mind and matter: the neurological complications of thrombotic thrombocytopenic purpura","volume":"197","author":"Shaw","year":"2022","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.11.001_bib50","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1111\/jth.13479","article-title":"Low ADAMTS-13 activity and the risk of coronary heart disease\u2014a prospective cohort study: the Rotterdam Study","volume":"14","author":"Sonneveld","year":"2016","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.11.001_bib51","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1182\/blood-2015-05-643338","article-title":"Low ADAMTS13 activity is associated with an increased risk of ischemic stroke","volume":"126","author":"Sonneveld","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.11.001_bib52","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1161\/ATVBAHA.116.308225","article-title":"von Willebrand factor, ADAMTS13, and the risk of mortality: the Rotterdam study","volume":"36","author":"Sonneveld","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2025.11.001_bib53","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1161\/STROKEAHA.110.586289","article-title":"High von Willebrand factor levels increase the risk of stroke: the Rotterdam study","volume":"41","author":"Wieberdink","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2025.11.001_bib54","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/01.STR.0000244767.39962.f7","article-title":"High von Willebrand factor levels increase the risk of first ischemic stroke: influence of ADAMTS13, inflammation, and genetic variability","volume":"37","author":"Bongers","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2025.11.001_bib55","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.atherosclerosis.2009.04.013","article-title":"Lower levels of ADAMTS13 are associated with cardiovascular disease in young patients","volume":"207","author":"Bongers","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jtha.2025.11.001_bib56","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1182\/blood-2009-03-213264","article-title":"von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke","volume":"114","author":"Zhao","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.11.001_bib57","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1182\/blood-2009-06-230110","article-title":"ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion","volume":"115","author":"Fujioka","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.11.001_bib58","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1111\/j.1538-7836.2012.04822.x","article-title":"ADAMTS13 reduces VWF-mediated acute inflammation following focal cerebral ischemia in mice","volume":"10","author":"Khan","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.11.001_bib59","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.brainres.2015.07.027","article-title":"Delayed treatment with ADAMTS13 ameliorates cerebral ischemic injury without hemorrhagic complication","volume":"1624","author":"Nakano","year":"2015","journal-title":"Brain Res"},{"key":"10.1016\/j.jtha.2025.11.001_bib60","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1182\/blood-2016-10-747089","article-title":"ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery","volume":"130","author":"Xu","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.11.001_bib61","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/jth.12456","article-title":"ADAMTS13 modulates atherosclerotic plaque progression in mice via a VWF-dependent mechanism","volume":"12","author":"Gandhi","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.11.001_bib62","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1161\/ATVBAHA.112.247262","article-title":"Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model","volume":"32","author":"Jin","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2025.11.001_bib63","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1038\/s41598-018-23865-7","article-title":"Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia: a population-based study","volume":"8","author":"Wolters","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2025.11.001_bib64","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3390\/brainsci11050583","article-title":"Distinguishing Alzheimer\u2019s disease patients and biochemical phenotype analysis using a novel serum profiling platform: potential involvement of the VWF\/ADAMTS13 axis","volume":"11","author":"Hanas","year":"2021","journal-title":"Brain Sci"},{"key":"10.1016\/j.jtha.2025.11.001_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000313","article-title":"ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology","volume":"17","author":"Cao","year":"2019","journal-title":"PLoS Biol"},{"key":"10.1016\/j.jtha.2025.11.001_bib66","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1182\/blood.2021012896","article-title":"Deletion of platelet CLEC-2 decreases GPIb\u03b1-mediated integrin \u03b1IIb\u03b23 activation and decreases thrombosis in TTP","volume":"139","author":"Shao","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.11.001_bib67","doi-asserted-by":"crossref","first-page":"E304","DOI":"10.1002\/ajh.26603","article-title":"Aspirin prophylaxis for hereditary and acquired thrombotic thrombocytopenic purpura?","volume":"97","author":"Shao","year":"2022","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jtha.2025.11.001_bib68","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1182\/blood-2018-04-840090","article-title":"Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura","volume":"132","author":"Jestin","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.11.001_bib69","doi-asserted-by":"crossref","first-page":"e407","DOI":"10.1055\/s-0038-1676357","article-title":"Rituximab prevents stroke recurrences in atypical chronic immune-mediated thrombotic thrombocytopenic purpura","volume":"2","author":"Dupuy","year":"2018","journal-title":"TH Open"},{"key":"10.1016\/j.jtha.2025.11.001_bib70","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.recesp.2021.10.016","volume":"75","author":"Visseren","year":"2022","journal-title":"Rev Esp Cardiol (Engl Ed)"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625008372?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625008372?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T16:03:15Z","timestamp":1781452995000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783625008372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1538783625008372"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.11.001","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune-mediated thrombotic thrombocytopenic purpura as a model of systemic microvascular dysfunction: moving from an acute to a chronic disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}