{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:26:21Z","timestamp":1791584781434,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD106326"],"award-info":[{"award-number":["R01HD106326"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1K23HL177270"],"award-info":[{"award-number":["1K23HL177270"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015438","name":"International Society on Thrombosis and Haemostasis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jtha.2025.12.007","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:11:13Z","timestamp":1766189473000},"page":"1548-1558","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Perceived relative clinical significance of the risks of venous thromboembolism and bleeding from pharmacologic thromboprophylaxis in children: an international survey of pediatric providers: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2652-9731","authenticated-orcid":false,"given":"Robert Marcel T.","family":"Huibonhoa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Raffini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony A.","family":"Sochet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Chiusolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Nossair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Vincent S.","family":"Faustino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.12.007_bib1","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2021-054649","article-title":"The continued rise of venous thromboembolism across US children\u2019s hospitals","volume":"149","author":"O\u2019Brien","year":"2022","journal-title":"Pediatrics"},{"key":"10.1016\/j.jtha.2025.12.007_bib2","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1542\/peds.2009-0768","article-title":"Dramatic increase in venous thromboembolism in children\u2019s hospitals in the United States from 2001 to 2007","volume":"124","author":"Raffini","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jtha.2025.12.007_bib3","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fped.2017.00198","article-title":"Pediatric hospital acquired venous thromboembolism","volume":"5","author":"Witmer","year":"2017","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jtha.2025.12.007_bib4","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.jtha.2023.02.018","article-title":"Decision-analysis modeling of effectiveness and cost-effectiveness of pharmacologic thromboprophylaxis for surgical inpatients using variable risk assessment models or other strategies","volume":"21","author":"Davis","year":"2023","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.12.007_bib5","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1111\/jth.15729","article-title":"Venous thrombosis risk during and after medical and surgical hospitalizations: the medical inpatient thrombosis and hemostasis (MITH) study","volume":"20","author":"Jordan Bruno","year":"2022","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.12.007_bib6","doi-asserted-by":"crossref","first-page":"278","DOI":"10.7326\/0003-4819-146-4-200702200-00007","article-title":"Meta-analysis: anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients","volume":"146","author":"Dentali","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtha.2025.12.007_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.021765","article-title":"Thromboprophylaxis for children post-Fontan procedure: insights from the UNIVERSE study","volume":"10","author":"McCrindle","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jtha.2025.12.007_bib8","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2022-056726","article-title":"Enoxaparin thromboprophylaxis in children hospitalized for COVID-19: a phase 2 trial","volume":"150","author":"Sochet","year":"2022","journal-title":"Pediatrics"},{"key":"10.1016\/j.jtha.2025.12.007_bib9","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.jacc.2023.10.010","article-title":"Apixaban for prevention of thromboembolism in pediatric heart disease","volume":"82","author":"Payne","year":"2023","journal-title":"Am Coll Cardiol"},{"key":"10.1016\/j.jtha.2025.12.007_bib10","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3324\/haematol.2018.194175","article-title":"THROMBOTECT - a randomized study comparing low molecular weight heparin, antithrombin and unfractionated heparin for thromboprophylaxis during induction therapy of acute lymphoblastic leukemia in children and adolescents","volume":"104","author":"Greiner","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2025.12.007_bib11","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1016\/j.jacc.2022.09.031","article-title":"Edoxaban for thromboembolism prevention in pediatric patients with cardiac disease","volume":"80","author":"Portman","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtha.2025.12.007_bib12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12887-017-0877-x","article-title":"TropicALL study: thromboprophylaxis in children treated for acute lymphoblastic leukemia with low-molecular-weight heparin: a multicenter randomized controlled trial","volume":"17","author":"Klaassen","year":"2017","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.jtha.2025.12.007_bib13","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1111\/jth.12372","article-title":"Developmental hemostasis: age-specific differences in the levels of hemostatic proteins","volume":"11","author":"Attard","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.12.007_bib14","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.thromres.2021.10.024","article-title":"Validation of risk assessment models for venous thromboembolism and bleeding in critically ill adolescents","volume":"208","author":"Gupta","year":"2021","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2025.12.007_bib15","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2020-042325","article-title":"A real-time risk-prediction model for pediatric venous thromboembolic events","volume":"147","author":"Walker","year":"2021","journal-title":"Pediatrics"},{"key":"10.1016\/j.jtha.2025.12.007_bib16","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.37789","article-title":"Model-guided decision-making for thromboprophylaxis and hospital-acquired thromboembolic events among hospitalized children and adolescents: the CLOT randomized clinical trial","volume":"6","author":"Walker","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jtha.2025.12.007_bib17","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1055\/s-0031-1297173","article-title":"Safety and efficacy of low molecular weight heparins in children: a systematic review of the literature and meta-analysis of single-arm studies","volume":"37","author":"Bidlingmaier","year":"2011","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jtha.2025.12.007_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.blre.2018.06.003","article-title":"Are low-molecular-weight heparins safe and effective in children? A systematic review","volume":"33","author":"Klaassen","year":"2019","journal-title":"Blood Rev"},{"key":"10.1016\/j.jtha.2025.12.007_bib19","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1007\/s11606-021-06737-1","article-title":"A consensus-based Checklist for Reporting of Survey Studies (CROSS)","volume":"36","author":"Sharma","year":"2021","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.jtha.2025.12.007_bib20","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.jtha.2023.03.004","article-title":"Updated guidance for efficacy and safety outcomes for clinical trials in venous thromboembolism in children: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis","volume":"21","author":"Whitworth","year":"2023","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.12.007_bib21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3233\/NPM-210848","article-title":"Effective questionnaire design: how to use cognitive interviews to refine questionnaire items","volume":"15","author":"Balza","year":"2022","journal-title":"J Neonatal Perinatal Med"},{"key":"10.1016\/j.jtha.2025.12.007_bib22","doi-asserted-by":"crossref","first-page":"53S","DOI":"10.1378\/chest.11-2288","article-title":"Methodology for the development of antithrombotic therapy and prevention of thrombosis guidelines: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"141","author":"Guyatt","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.jtha.2025.12.007_bib23","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/MOP.0000000000000084","article-title":"Venous thromboembolism in critically ill children","volume":"26","author":"Polikoff","year":"2014","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.jtha.2025.12.007_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fped.2017.00047","article-title":"Venous thromboembolism in critical illness and trauma: pediatric perspectives","volume":"5","author":"Chima","year":"2017","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jtha.2025.12.007_bib25","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.4187\/respcare.11698","article-title":"Invasive mechanical ventilation and risk of hospital-acquired venous thromboembolism","volume":"69","author":"Havlicek","year":"2024","journal-title":"Respir Care"},{"key":"10.1016\/j.jtha.2025.12.007_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/795645","article-title":"The perception of evidence for venous thromboembolism prophylaxis current practices after cardiac surgery: a Canadian cross-sectional survey","volume":"2015","author":"Mufti","year":"2015","journal-title":"Thrombosis"},{"key":"10.1016\/j.jtha.2025.12.007_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.vhri.2015.03.016","article-title":"Comparing patient and physician risk tolerance for bleeding events associated with anticoagulants in atrial fibrillation\u2014evidence from the United States and Japan","volume":"6","author":"Okumura","year":"2015","journal-title":"Value Health Reg Issues"},{"key":"10.1016\/j.jtha.2025.12.007_bib28","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1111\/jth.12324","article-title":"Antithrombotic Trials Leadership and Steering (ATLAS) Group. Balancing risk and benefit in venous thromboembolism trials: concept for a bivariate endpoint trial design and analytic approach","volume":"11","author":"Kittelson","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.12.007_bib29","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1160\/TH15-12-1000","article-title":"Bivariate evaluation of thromboembolism and bleeding in clinical trials of anticoagulants in patients with atrial fibrillation","volume":"116","author":"Kittelson","year":"2016","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.12.007_bib30","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/jth.13687","article-title":"A decision model to estimate a risk threshold for venous thromboembolism prophylaxis in hospitalized medical patients","volume":"15","author":"Le","year":"2017","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.12.007_bib31","doi-asserted-by":"crossref","first-page":"e737S","DOI":"10.1378\/chest.11-2308","article-title":"Antithrombotic therapy in neonates and children: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"141","author":"Monagle","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.jtha.2025.12.007_bib32","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fped.2017.00136","article-title":"Neonatal venous thromboembolism","volume":"5","author":"Haley","year":"2017","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jtha.2025.12.007_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12793","article-title":"Current practices in pediatric hospital-acquired thromboembolism: survey of the Children's Hospital Acquired Thrombosis (CHAT) Consortium","volume":"6","author":"Abrams","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.jtha.2025.12.007_bib34","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/jamaneurol.2022.1991","article-title":"One-Year outcome trajectories and factors associated with functional recovery among survivors of intracerebral and intraventricular hemorrhage with initial severe disability","volume":"79","author":"Shah","year":"2022","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jtha.2025.12.007_bib35","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/archdischild-2021-322634","article-title":"Global incidence proportion of intraventricular haemorrhage of prematurity: a meta-analysis of studies published 2010\u20132020","volume":"107","author":"Lai","year":"2022","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jtha.2025.12.007_bib36","doi-asserted-by":"crossref","first-page":"e235","DOI":"10.1097\/CCM.0000000000004784","volume":"49","author":"Faustino","year":"2021","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jtha.2025.12.007_bib37","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1161\/CIRCULATIONAHA.124.070251","article-title":"Hierarchical composite outcomes and win ratio methods in cardiovascular trials: a review and consequent guidance","volume":"151","author":"Gregson","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2025.12.007_bib38","volume":"160","author":"Sochet","year":"2025","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.jtha.2025.12.007_bib39","series-title":"Encyclopedia of survey research methods","article-title":"Replication","author":"Ben-Nun","year":"2008"},{"key":"10.1016\/j.jtha.2025.12.007_bib40","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1182\/bloodadvances.2019000462","article-title":"Patient values and preferences regarding VTE disease: a systematic review to inform American Society of Hematology guidelines","volume":"4","author":"Etxeandia-Ikobaltzeta","year":"2020","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2025.12.007_bib41","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s12891-015-0777-x","article-title":"Patients' perception about risks and benefits of antithrombotic treatment for the prevention of venous thromboembolism (VTE) after orthopedic surgery: a qualitative study","volume":"16","author":"Najafzadeh","year":"2015","journal-title":"BMC Musculoskelet Disord"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625009055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783625009055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T07:19:23Z","timestamp":1781939963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783625009055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1538783625009055"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.12.007","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perceived relative clinical significance of the risks of venous thromboembolism and bleeding from pharmacologic thromboprophylaxis in children: an international survey of pediatric providers: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}