{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:09:29Z","timestamp":1783973369133,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000241","name":"PSI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004381","name":"University of Western Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jtha.2025.12.021","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T16:43:36Z","timestamp":1768841016000},"page":"1700-1712","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endothelial injury to cognitive decline: a 12-month follow-up using computed tomography perfusion and diffusion magnetic resonance imaging in immune-mediated thrombotic thrombocytopenic purpura"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8321-683X","authenticated-orcid":false,"given":"Fahad","family":"Hannan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Thiessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Patriquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Pavenski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Tristao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yim","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Poirier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Th\u00e9berge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Mandzia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Al-Jaishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Han Susan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2025.12.021_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/antib14010024","article-title":"Anti-ADAMTS13 autoantibodies in immune-mediated thrombotic thrombocytopenic purpura","volume":"14","author":"Snyder","year":"2025","journal-title":"Antibodies"},{"key":"10.1016\/j.jtha.2025.12.021_bib2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/CCM.0b013e31822e9d66","article-title":"Efficacy and safety of first-line rituximab in severe, acquired thrombotic thrombocytopenic purpura with a suboptimal response to plasma exchange. Experience of the French Thrombotic Microangiopathies Reference Center","volume":"40","author":"Froissart","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jtha.2025.12.021_bib3","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1182\/blood.2019001056","article-title":"Reduced ADAMTS13 activity during TTP remission is associated with stroke in TTP survivors","volume":"134","author":"Upreti","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.12.021_bib4","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/ajh.26341","article-title":"Major adverse cardiovascular events in survivors of immune-mediated thrombotic thrombocytopenic purpura","volume":"96","author":"Brodsky","year":"2021","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jtha.2025.12.021_bib5","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ajh.24060","article-title":"Depression and cognitive impairment following recovery from thrombotic thrombocytopenic purpura","volume":"90","author":"Han","year":"2015","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jtha.2025.12.021_bib6","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/bjh.19246","article-title":"Cognitive decline in thrombotic thrombocytopenic purpura survivors: the role of white matter health as assessed by MRI","volume":"204","author":"Hannan","year":"2024","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2025.12.021_bib7","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1152\/jn.00221.2016","article-title":"White matter and cognition: making the connection","volume":"116","author":"Filley","year":"2016","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jtha.2025.12.021_bib8","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1182\/bloodadvances.2021005317","article-title":"Blood\u2013brain barrier permeability in survivors of immune-mediated thrombotic thrombocytopenic purpura: a pilot study","volume":"5","author":"Huang","year":"2021","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2025.12.021_bib9","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3390\/jcm10030536","article-title":"Thrombotic thrombocytopenic purpura: pathophysiology, diagnosis, and management","volume":"10","author":"Sukumar","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtha.2025.12.021_bib10","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1046\/j.1471-0528.2003.02074.x","article-title":"A case of thrombotic thrombocytopenic purpura and neonatal alloimmune thrombocytopenia in the same pregnancy","volume":"110","author":"Richmond","year":"2003","journal-title":"BJOG Int J Obstet Gynaecol"},{"key":"10.1016\/j.jtha.2025.12.021_bib11","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1471-4159.2006.04393.x","article-title":"Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction","volume":"101","author":"Haorah","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.jtha.2025.12.021_bib12","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1590\/S1980-57642012DN06030008","article-title":"Diffusion tensor imaging studies in vascular disease: a review of the literature","volume":"6","author":"Alves","year":"2012","journal-title":"Dement Neuropsychol"},{"key":"10.1016\/j.jtha.2025.12.021_bib13","series-title":"Computed tomography","first-page":"347","article-title":"CT perfusion techniques and applications in stroke and cancer","author":"Lee","year":"2020"},{"key":"10.1016\/j.jtha.2025.12.021_bib14","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1056\/NEJMcp053024","article-title":"Thrombotic thrombocytopenic purpura","volume":"354","author":"George","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtha.2025.12.021_bib15","first-page":"1855","volume":"137","author":"Cuker","year":"2021","journal-title":"Redefining outcomes in immune TTP: an international working group consensus report"},{"key":"10.1016\/j.jtha.2025.12.021_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.acra.2012.08.013","article-title":"The effect of scan duration on the measurement of perfusion parameters in CT perfusion studies of brain tumors","volume":"20","author":"Yeung","year":"2013","journal-title":"Acad Radiol"},{"key":"10.1016\/j.jtha.2025.12.021_bib17","doi-asserted-by":"crossref","first-page":"giae049","DOI":"10.1093\/gigascience\/giae049","article-title":"the Alzheimer\u2019s Disease Neuroimaging Initiative. CAT: a computational anatomy toolbox for the analysis of structural MRI data","volume":"13","author":"Gaser","year":"2024","journal-title":"Gigascience"},{"key":"10.1016\/j.jtha.2025.12.021_bib18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s41824-020-00079-7","article-title":"18F-FDG PET-guided diffusion tractography reveals white matter abnormalities around the epileptic focus in medically refractory epilepsy: implications for epilepsy surgical evaluation","volume":"4","author":"Poirier","year":"2020","journal-title":"Eur J Hybrid Imaging"},{"key":"10.1016\/j.jtha.2025.12.021_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuroimage.2018.07.070","article-title":"TractSeg\u2014fast and accurate white matter tract segmentation","volume":"183","author":"Wasserthal","year":"2018","journal-title":"Neuroimage"},{"key":"10.1016\/j.jtha.2025.12.021_bib20","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/schbul\/sbv171","article-title":"Tractography analysis of 5 white matter bundles and their clinical and cognitive correlates in early-course schizophrenia","volume":"42","author":"Seitz","year":"2016","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.jtha.2025.12.021_bib21","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/brain\/awad308","article-title":"White matter tracts and executive functions: a review of causal and correlation evidence","volume":"147","author":"Ribeiro","year":"2024","journal-title":"Brain J Neurol"},{"key":"10.1016\/j.jtha.2025.12.021_bib22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.biopsych.2013.05.020","article-title":"Age-related differences in white matter tract microstructure are associated with cognitive performance from childhood to adulthood","volume":"75","author":"Peters","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jtha.2025.12.021_bib23","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neurobiolaging.2015.11.021","article-title":"Altered tract-specific white matter microstructure is related to poorer cognitive performance: the Rotterdam Study","volume":"39","author":"Cremers","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jtha.2025.12.021_bib24","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br J Psychiatry J Ment Sci"},{"key":"10.1016\/j.jtha.2025.12.021_bib25","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.neuron.2012.06.022","article-title":"Fractionating human intelligence","volume":"76","author":"Hampshire","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.jtha.2025.12.021_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049790","article-title":"Tract profiles of white matter properties: automating fiber-tract quantification","volume":"7","author":"Yeatman","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2025.12.021_bib27","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00259-003-1430-8","volume":"31","author":"Ito","year":"2004","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.jtha.2025.12.021_bib28","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1182\/blood-2013-04-496752","article-title":"Multiple major morbidities and increased mortality during long-term follow-up after recovery from thrombotic thrombocytopenic purpura","volume":"122","author":"Deford","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.12.021_bib29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF02282981","article-title":"Brain MRI and SPET in thrombotic thrombocytopenic purpura","volume":"16","author":"Fiorani","year":"1995","journal-title":"Ital J Neurol Sci"},{"key":"10.1016\/j.jtha.2025.12.021_bib30","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1537-2995.2009.02101.x","article-title":"Cognitive deficits after recovery from thrombotic thrombocytopenic purpura","volume":"49","author":"Kennedy","year":"2009","journal-title":"Transfusion (Paris)"},{"key":"10.1016\/j.jtha.2025.12.021_bib31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10571-015-0308-1","article-title":"Microvascular dysfunction and cognitive impairment","volume":"36","author":"De Silva","year":"2016","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.jtha.2025.12.021_bib32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/JNN.0b013e3182527690","article-title":"The impact of inflammation on cognitive function in older adults: implications for health care practice and research","volume":"44","author":"Sartori","year":"2012","journal-title":"J Neurosci Nurs"},{"key":"10.1016\/j.jtha.2025.12.021_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0041-008X(03)00251-5","article-title":"Brain barrier systems: a new frontier in metal neurotoxicological research","volume":"192","author":"Zheng","year":"2003","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jtha.2025.12.021_bib34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/jamaneurol.2015.2960","article-title":"Blood-brain barrier permeability and gadolinium: benefits and potential pitfalls in research","volume":"73","author":"Montagne","year":"2016","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jtha.2025.12.021_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101450","article-title":"Cerebral blood flow in mild cognitive impairment and Alzheimer\u2019s disease: a systematic review and meta-analysis","volume":"71","author":"Zhang","year":"2021","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jtha.2025.12.021_bib36","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1177\/0271678X20948614","article-title":"Reduced parenchymal cerebral blood flow is associated with greater progression of brain atrophy: The SMART-MR study","volume":"41","author":"Ghaznawi","year":"2021","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jtha.2025.12.021_bib37","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1161\/STROKEAHA.112.680223","article-title":"Changes in normal-appearing white matter precede development of white matter lesions","volume":"44","author":"de Groot","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2025.12.021_bib38","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1161\/STROKEAHA.118.020980","article-title":"Progression of white matter hyperintensities preceded by heterogeneous decline of microstructural integrity","volume":"49","author":"van Leijsen","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2025.12.021_bib39","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bbi.2023.07.010","article-title":"Mapping acute neuroinflammation in vivo with diffusion-MRI in rats given a systemic lipopolysaccharide challenge","volume":"113","author":"Kim","year":"2023","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jtha.2025.12.021_bib40","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/RLI.0000000000000394","article-title":"Diffusion tensor imaging in chronic inflammatory demyelinating polyneuropathy: diagnostic accuracy and correlation with electrophysiology","volume":"52","author":"Kronlage","year":"2017","journal-title":"Invest Radiol"},{"key":"10.1016\/j.jtha.2025.12.021_bib41","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13195-024-01633-2","article-title":"Neuropathological contributions to grey matter atrophy and white matter hyperintensities in amnestic dementia","volume":"17","author":"Ortega-Cruz","year":"2025","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.jtha.2025.12.021_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2021.106552","article-title":"White matter hyperintensities and patterns of atrophy in early onset Alzheimer\u2019s disease with causative gene mutations","volume":"203","author":"Mao","year":"2021","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.jtha.2025.12.021_bib43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000226774","article-title":"White matter lesions and brain atrophy: more than shared risk factors? A systematic review","volume":"28","author":"Appelman","year":"2009","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jtha.2025.12.021_bib44","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1056\/NEJMoa1806311","article-title":"Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura","volume":"380","author":"Scully","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtha.2025.12.021_bib45","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1182\/blood-2017-06-788026","article-title":"Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura","volume":"130","author":"Scully","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2025.12.021_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.transci.2024.104065","article-title":"How rare is rare? The first multi-centre epidemiological study of thrombotic thrombocytopenic purpura in a large Canadian city","volume":"64","author":"Tse","year":"2025","journal-title":"Transfus Apher Sci"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783626000085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783626000085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:56:51Z","timestamp":1783972611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783626000085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S1538783626000085"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2025.12.021","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial injury to cognitive decline: a 12-month follow-up using computed tomography perfusion and diffusion magnetic resonance imaging in immune-mediated thrombotic thrombocytopenic purpura","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2025.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}