{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T07:51:01Z","timestamp":1781941861673,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["171002214"],"award-info":[{"award-number":["171002214"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jtha.2026.01.005","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:34:16Z","timestamp":1770078856000},"page":"1438-1447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thrombin generation and thrombin dynamics are associated with recurrent venous thromboembolism after anticoagulation withdrawal"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4520-9732","authenticated-orcid":false,"given":"Geke C.","family":"Poolen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romy M.W.","family":"de Laat-Kremers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Roest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert-Jan","family":"Geersing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1601-9393","authenticated-orcid":false,"given":"Rolf T.","family":"Urbanus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas","family":"de Laat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger E.G.","family":"Schutgens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2026.01.005_bib1","article-title":"Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis","volume":"366","author":"Khan","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.jtha.2026.01.005_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.749342","article-title":"Long-term survival after venous thromboembolism: a prospective cohort study","volume":"8","author":"Nilius","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jtha.2026.01.005_bib3","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ijcard.2019.06.032","article-title":"The association of recurrence and bleeding events with mortality after venous thromboembolism: from the COMMAND VTE Registry","volume":"292","author":"Yamashita","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jtha.2026.01.005_bib4","doi-asserted-by":"crossref","first-page":"7559","DOI":"10.2147\/IJGM.S359893","article-title":"Incidence and predictors of recurrence and mortality following first venous thromboembolism among the saudi population: single-center cohort study","volume":"15","author":"AlEidan","year":"2022","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.jtha.2026.01.005_bib5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1161\/ATVBAHA.108.182188","article-title":"Biomarkers and venous thromboembolism","volume":"29","author":"Pabinger","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2026.01.005_bib6","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3390\/jcm9051582","article-title":"Predicting the risk of recurrent venous thromboembolism: current challenges and future opportunities","volume":"9","author":"Stevens","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtha.2026.01.005_bib7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/ATVBAHA.116.308253","article-title":"Prothrombotic fibrin clot phenotype is associated with recurrent pulmonary embolism after discontinuation of anticoagulant therapy","volume":"37","author":"Zabczyk","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2026.01.005_bib8","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/bjh.13911","article-title":"Prolonged clot lysis time increases the risk of a first but not recurrent venous thrombosis","volume":"172","author":"Karasu","year":"2016","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2026.01.005_bib9","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1111\/j.1538-7836.2008.03117.x","article-title":"High rate of unprovoked recurrent venous thrombosis is associated with high thrombin-generating potential in a prospective cohort study","volume":"6","author":"Besser","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.01.005_bib10","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1373\/clinchem.2008.112243","article-title":"Prediction of recurrent venous thromboembolism by endogenous thrombin potential and D-dimer","volume":"54","author":"Eichinger","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.jtha.2026.01.005_bib11","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/j.1538-7836.2008.03018.x","article-title":"High thrombin generation measured in the presence of thrombomodulin is associated with an increased risk of recurrent venous thromboembolism","volume":"6","author":"Tripodi","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.01.005_bib12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/jama.296.4.397","article-title":"Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation","volume":"296","author":"Hron","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.jtha.2026.01.005_bib13","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1365-2141.2007.06738.x","article-title":"Elevated endogenous thrombin potential is associated with an increased risk of a first deep venous thrombosis but not with the risk of recurrence","volume":"138","author":"van Hylckama Vlieg","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2026.01.005_bib14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.thromres.2012.11.015","article-title":"Is thrombin generation at the time of an acute thromboembolic episode a predictor of recurrence? The LInk\u00f6ping Study on Thrombosis (LIST)\u2014a 7-year follow-up","volume":"131","author":"Chaireti","year":"2013","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2026.01.005_bib15","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1111\/jth.13043","article-title":"The risk of a first and a recurrent venous thrombosis associated with an elevated D-dimer level and an elevated thrombin potential: results of the THE-VTE study","volume":"13","author":"van Hylckama Vlieg","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.01.005_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69415-y","article-title":"Deciphering the coagulation profile through the dynamics of thrombin activity","volume":"10","author":"de Laat-Kremers","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2026.01.005_bib17","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/jth.12798","article-title":"The balance of pro- and anticoagulant processes underlying thrombin generation","volume":"13","author":"Kremers","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.01.005_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003142","article-title":"Effect of tailoring anticoagulant treatment duration by applying a recurrence risk prediction model in patients with venous thromboembolism compared to usual care: a randomized controlled trial","volume":"17","author":"Geersing","year":"2020","journal-title":"PLoS Med"},{"key":"10.1016\/j.jtha.2026.01.005_bib19","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1161\/CIRCULATIONAHA.109.925214","article-title":"Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model","volume":"121","author":"Eichinger","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2026.01.005_bib20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000071636","article-title":"Calibrated automated thrombin generation measurement in clotting plasma","volume":"33","author":"Hemker","year":"2003","journal-title":"Pathophysiol Haemost Thromb"},{"key":"10.1016\/j.jtha.2026.01.005_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000073575","article-title":"The calibrated automated thrombogram (CAT): a universal routine test for hyper- and hypocoagulability","volume":"32","author":"Hemker","year":"2002","journal-title":"Pathophysiol Haemost Thromb"},{"key":"10.1016\/j.jtha.2026.01.005_bib22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12959-018-0164-6","article-title":"Thrombin generation in low plasma volumes","volume":"16","author":"Bloemen","year":"2018","journal-title":"Thromb J"},{"key":"10.1016\/j.jtha.2026.01.005_bib23","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1182\/bloodadvances.2018018036","article-title":"Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin","volume":"2","author":"Kremers","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2026.01.005_bib24","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s10654-021-00794-w","article-title":"Prediction or causality? A scoping review of their conflation within current observational research","volume":"36","author":"Ramspek","year":"2021","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jtha.2026.01.005_bib25","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1177\/1076029618764847","article-title":"Markers of thrombin generation are associated with long-term clinical outcome in patients with ST-segment elevation myocardial infarction","volume":"24","author":"Hansen","year":"2018","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.jtha.2026.01.005_bib26","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.jtha.2024.12.002","article-title":"Low thrombin inactivation capacity is associated with an increased risk of recurrent ischemic events after ischemic stroke at a young age","volume":"23","author":"Spiegelenberg","year":"2025","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.01.005_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12959-015-0061-1","article-title":"Markers of thrombin generation are associated with myocardial necrosis and left ventricular impairment in patients with ST-elevation myocardial infarction","volume":"13","author":"Hansen","year":"2015","journal-title":"Thromb J"},{"key":"10.1016\/j.jtha.2026.01.005_bib28","doi-asserted-by":"crossref","DOI":"10.1177\/10760296231152897","article-title":"Increased in vivo thrombin generation in patients with localized non-small cell lung cancer unfit for surgery","volume":"29","author":"Hojbjerg","year":"2023","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.jtha.2026.01.005_bib29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.thromres.2015.06.003","article-title":"Coagulation activation after discontinuation of VTE treatment with different oral anticoagulants and impact on 12-month clinical outcomes","volume":"136","author":"Beyer-Westendorf","year":"2015","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2026.01.005_bib30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12959-022-00392-0","article-title":"Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background","volume":"20","author":"van Paridon","year":"2022","journal-title":"Thromb J"},{"key":"10.1016\/j.jtha.2026.01.005_bib31","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1160\/TH11-04-0254","article-title":"Thrombin generation and activated protein C resistance in the absence of factor V Leiden correlates with the risk of recurrent venous thromboembolism in women aged 18-65 years","volume":"106","author":"Sonnevi","year":"2011","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.01.005_bib32","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1111\/jth.14863","article-title":"Towards standardization of thrombin generation assays: inventory of thrombin generation methods based on results of an International Society of Thrombosis and Haemostasis Scientific Standardization Committee survey","volume":"18","author":"de Laat-Kremers","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.01.005_bib33","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1111\/jth.15287","article-title":"Recommendations for the measurement of thrombin generation: Communication from the ISTH SSC Subcommittee on Lupus Anticoagulant\/Antiphospholipid Antibodies","volume":"19","author":"Ninivaggi","year":"2021","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.01.005_bib34","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2165\/00003088-199630040-00003","article-title":"Warfarin withdrawal. Pharmacokinetic-pharmacodynamic considerations","volume":"30","author":"Palareti","year":"1996","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.jtha.2026.01.005_bib35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.thromres.2010.01.017","article-title":"Influence of anticoagulant therapy with vitamin K antagonists on plasma levels of coagulation factor VIII","volume":"126","author":"Passamonti","year":"2010","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2026.01.005_bib36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.thromres.2019.03.022","article-title":"Correlation of thromboelastography and thrombin generation assays in warfarin-treated patients","volume":"178","author":"Schmidt","year":"2019","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2026.01.005_bib37","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1016\/j.jtha.2025.04.030","article-title":"Elevated levels of (active) von Willebrand Factor during anticoagulation are associated with early recurrence of venous thromboembolism","volume":"23","author":"Poolen","year":"2025","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.01.005_bib38","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/bjh.14134","article-title":"Adherence to long-term anticoagulation treatment, what is known and what the future might hold","volume":"174","author":"Abdou","year":"2016","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2026.01.005_bib39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3324\/haematol.10516","article-title":"The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients","volume":"92","author":"Prandoni","year":"2007","journal-title":"Haematologica"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783626000541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783626000541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T07:16:27Z","timestamp":1781939787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783626000541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1538783626000541"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2026.01.005","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombin generation and thrombin dynamics are associated with recurrent venous thromboembolism after anticoagulation withdrawal","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2026.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}