{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:49:05Z","timestamp":1785887345922,"version":"3.56.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012957","name":"Friedrich Schiller University Jena","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jtha.2026.04.013","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:07:23Z","timestamp":1776323243000},"page":"2899-2909","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dysregulation of HIF-1\u03b1\u2013regulated and thromboinflammatory genes may contribute to thrombotic risk in patients with BCR::ABL1-negative myeloproliferative neoplasms"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9292-162X","authenticated-orcid":false,"given":"Olga","family":"Morath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese","family":"Wolfrum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Crodel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hochhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Rinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2026.04.013_bib1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the world health organization classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.jtha.2026.04.013_bib2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s12885-019-5387-9","article-title":"A systematic review and meta-analysis of the prevalence of thrombosis and bleeding at diagnosis of Philadelphia-negative myeloproliferative neoplasms","volume":"19","author":"Rungjirajittranon","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jtha.2026.04.013_bib3","first-page":"21","article-title":"Bleeding, thrombosis, and anticoagulation in myeloproliferative neoplasms (MPN): analysis from the German SAL-MPN-Registry","volume":"128","author":"Kaifie","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.013_bib4","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41408-024-01169-6","article-title":"Thrombosis in myeloproliferative neoplasms: a viewpoint on its impact on myelofibrosis, mortality, and solid tumors","volume":"14","author":"Barbui","year":"2024","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.jtha.2026.04.013_bib5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41408-023-00887-7","article-title":"Survival expectation after thrombosis and overt-myelofibrosis in essential thrombocythemia and prefibrotic myelofibrosis: a multistate model approach","volume":"13","author":"Carobbio","year":"2023","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.jtha.2026.04.013_bib6","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1200\/JCO.2014.57.6652","article-title":"Risk and cause of death in patients diagnosed with myeloproliferative neoplasms in Sweden between 1973 and 2005: a population-based study","volume":"33","author":"Hultcrantz","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jtha.2026.04.013_bib7","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00277-023-05217-2","article-title":"Pathological and genomic features of myeloproliferative neoplasms associated with splanchnic vein thrombosis in a single-center cohort","volume":"102","author":"Cattaneo","year":"2023","journal-title":"Ann Hematol"},{"key":"10.1016\/j.jtha.2026.04.013_bib8","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1111\/j.1538-7836.2011.04484.x","article-title":"Long-term follow-up of patients with portal vein thrombosis and myeloproliferative neoplasms","volume":"9","author":"Hoekstra","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.013_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.leukres.2023.107420","article-title":"The molecular landscape of myeloproliferative neoplasms associated with splanchnic vein thrombosis: current perspective","volume":"136","author":"Pescia","year":"2024","journal-title":"Leuk Res"},{"key":"10.1016\/j.jtha.2026.04.013_bib10","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1002\/cam4.2886","article-title":"Thrombosis among 1537 patients with JAK2V617F-mutated myeloproliferative neoplasms: risk factors and development of a predictive model","volume":"9","author":"Zhang","year":"2020","journal-title":"Cancer Med"},{"key":"10.1016\/j.jtha.2026.04.013_bib11","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1182\/blood-2023-179324","article-title":"Cardiovascular risk factors are common in myeloproliferative neoplasms and portend worse survival and thrombotic outcomes","volume":"142","author":"How","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.013_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41408-021-00581-6","article-title":"JAK2V617F variant allele frequency >50% identifies patients with polycythemia vera at high risk for venous thrombosis","volume":"11","author":"Guglielmelli","year":"2021","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.jtha.2026.04.013_bib13","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1007\/s11845-024-03776-5","article-title":"Association between JAK2V617F variable allele frequency and risk of thrombotic events in patients with myeloproliferative neoplasms","volume":"193","author":"Brown","year":"2024","journal-title":"Ir J Med Sci"},{"issue":"Suppl 1","key":"10.1016\/j.jtha.2026.04.013_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1182\/blood-2024-205851","article-title":"Non-driver genomic alterations and venous thromboembolism in myeloproliferative neoplasms","volume":"144","author":"Ajufo","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.013_bib15","article-title":"Molecular and clinical risk factors associated with thrombosis and bleeding in myelofibrosis patients","author":"Morath","year":"2024","journal-title":"Hamostaseologie"},{"key":"10.1016\/j.jtha.2026.04.013_bib16","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1007\/s00277-025-06361-7","article-title":"Molecular predictors of venous and arterial thrombotic events in patients with myelofibrosis","volume":"104","author":"Morath","year":"2025","journal-title":"Ann Hematol"},{"key":"10.1016\/j.jtha.2026.04.013_bib17","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41375-023-02114-5","article-title":"Distinct clinico-molecular arterial and venous thrombosis scores for myeloproliferative neoplasms risk stratification","volume":"38","author":"Pasquer","year":"2024","journal-title":"Leukemia"},{"key":"10.1016\/j.jtha.2026.04.013_bib18","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1182\/blood-2024-207881","article-title":"The role of TET2 mutation in patients with myeloproliferative neoplasms and thrombosis in unusual sites (splanchnic thrombosis and cerebral thrombosis)","volume":"144","author":"Morsia","year":"2024","journal-title":"Blood"},{"issue":"Suppl 1","key":"10.1016\/j.jtha.2026.04.013_bib19","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1182\/blood-2024-194702","article-title":"Increased thromboinflammation is associated with high thrombotic risk in patients with myeloproliferative neoplasms: a multicentric study of 394 cases by the French Intergroup of Myeloproliferative Neoplasms (FIM)","volume":"144","author":"Guy","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.013_bib20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41408-022-00743-0","article-title":"Increased risk of thrombosis in JAK2V617F-positive patients with primary myelofibrosis and interaction of the mutation with the IPSS score","volume":"12","author":"Barbui","year":"2022","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.jtha.2026.04.013_bib21","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1182\/blood.2023020232","article-title":"Association between elevated white blood cell counts and thrombotic events in polycythemia vera: analysis from REVEAL","volume":"143","author":"Gerds","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.013_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2023.100060","article-title":"Platelet function studies in myeloproliferative neoplasms patients with calreticulin or JAK2V617F mutation","volume":"7","author":"Guy","year":"2023","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.013_bib23","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/bjh.14202","article-title":"Impact of white blood cell counts at diagnosis and during follow-up in patients with essential thrombocythaemia and prefibrotic primary myelofibrosis","volume":"179","author":"Buxhofer-Ausch","year":"2017","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2026.04.013_bib24","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1182\/blood-2024-211145","article-title":"Prognostic insights on pre-fibrotic primary myelofibrosis: a clinical-pathological perspective in 762 patients","volume":"144","author":"Cattaneo","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.013_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41408-018-0054-y","article-title":"The 2016 WHO classification and diagnostic criteria for myeloproliferative neoplasms: document summary and in-depth discussion","volume":"8","author":"Barbui","year":"2018","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.jtha.2026.04.013_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12657","article-title":"Thrombosis in myeloproliferative neoplasms during cytoreductive and antithrombotic drug treatment","volume":"6","author":"Barbui","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.013_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179545","article-title":"Hypoxia inducible factor (HIF) transcription factor family expansion, diversification, divergence and selection in eukaryotes","volume":"12","author":"Graham","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2026.04.013_bib28","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jtha.2026.04.013_bib29","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1182\/bloodadvances.2019001379","article-title":"Thrombotic, inflammatory, and HIF-regulated genes and thrombosis risk in polycythemia vera and essential thrombocythemia","volume":"4","author":"Gangaraju","year":"2020","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2026.04.013_bib30","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1182\/blood.V122.21.1604.1604","article-title":"Ph-negative myeloproliferative neoplasms exhibit some features of Warburg effect","volume":"122","author":"Sana","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.013_bib31","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1182\/blood-2018-99-113332","article-title":"Implication of hypoxia-inducible factor-1 (HIF-1) as a new therapeutic target in JAK2V617F positive myeloproliferative neoplasms (MPN)","volume":"132","author":"Baumeister","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.013_bib32","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/s41375-019-0629-z","article-title":"Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms","volume":"34","author":"Baumeister","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.jtha.2026.04.013_bib33","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1182\/bloodadvances.2025016344","article-title":"Hypoxia-inducible factors contribute to venous thrombosis in a mouse model of myeloproliferative neoplasms","volume":"10","author":"Ghosh","year":"2026","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2026.04.013_bib34","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.jtha.2023.01.027","article-title":"JAK-STAT inhibition reduces endothelial prothrombotic activation and leukocyte-endothelial proadhesive interactions","volume":"21","author":"Beckman","year":"2023","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.013_bib35","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41375-025-02843-9","article-title":"JAK2V617F reprograms hypoxia inducible factor-1 to induce a non-canonical hypoxia regulon in myeloproliferative neoplasms","volume":"40","author":"Kealy","year":"2026","journal-title":"Leukemia"},{"key":"10.1016\/j.jtha.2026.04.013_bib36","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.1073\/pnas.1620458114","article-title":"Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia","volume":"114","author":"Gupta","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jtha.2026.04.013_bib37","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1161\/STROKEAHA.111.622217","article-title":"Plasminogen activator inhibitor-1 and thrombotic cerebrovascular diseases","volume":"43","author":"Tjarnlund-Wolf","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2026.04.013_bib38","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1182\/blood-2018-04-841585","article-title":"Hypoxia downregulates protein S expression","volume":"132","author":"Pilli","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.013_bib39","doi-asserted-by":"crossref","first-page":"E37","DOI":"10.1002\/ajh.26402","article-title":"Tissue factor activity is increased in neutrophils from JAK2 V617F-mutated essential thrombocythemia and polycythemia vera patients","volume":"97","author":"Reeves","year":"2022","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jtha.2026.04.013_bib40","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1038\/s41375-018-0119-8","article-title":"Molecular patterns in cytopenia patients with or without evidence of myeloid neoplasm: a comparison of 756 cases","volume":"32","author":"Baer","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.jtha.2026.04.013_bib41","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/bjh.18834","article-title":"Molecular-defined clonal evolution in patients with classical myeloproliferative neoplasms","volume":"202","author":"Hinze","year":"2023","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2026.04.013_bib42","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1093\/nar\/29.17.e88","article-title":"An efficient procedure for genotyping single nucleotide polymorphisms","volume":"29","author":"Ye","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jtha.2026.04.013_bib43","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jtha.2026.04.013_bib44","doi-asserted-by":"crossref","first-page":"D792","DOI":"10.1093\/nar\/gkp1005","article-title":"PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification","volume":"38","author":"Spandidos","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jtha.2026.04.013_bib45","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/1756-0500-4-427","article-title":"Selection of reliable reference genes for quantitative real-time PCR in human T cells and neutrophils","volume":"4","author":"Ledderose","year":"2021","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.jtha.2026.04.013_bib46","doi-asserted-by":"crossref","first-page":"6790","DOI":"10.3390\/ijms26146790","article-title":"Selection of stable reference genes for gene expression studies in activated and non-activated PBMCs under normoxic and hypoxic conditions","volume":"26","author":"Wardaszka","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2026.04.013_bib47","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.3726","article-title":"Identification of reference genes in blood before and after entering the plateau for SYBR green RT-qPCR studies","volume":"5","author":"Xiao","year":"2017","journal-title":"PeerJ"},{"key":"10.1016\/j.jtha.2026.04.013_bib48","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1182\/blood-2003-07-2535","article-title":"Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors","volume":"103","author":"Gordeuk","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.013_bib49","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.3324\/haematol.2016.158170","article-title":"Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia","volume":"102","author":"Sergueeva","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2026.04.013_bib50","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.3324\/haematol.2019.216267","article-title":"Thrombotic risk in congenital erythrocytosis due to up-regulated hypoxia sensing is not associated with elevated hematocrit","volume":"105","author":"Gordeuk","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.jtha.2026.04.013_bib51","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/ng1019","article-title":"Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia","volume":"32","author":"Ang","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.jtha.2026.04.013_bib52","doi-asserted-by":"crossref","DOI":"10.1093\/function\/zqae008","article-title":"The Warburg effect reinterpreted 100 yr on: a first-principles stoichiometric analysis and interpretation from the perspective of ATP metabolism in cancer cells","volume":"5","author":"Nath","year":"2024","journal-title":"Function"},{"key":"10.1016\/j.jtha.2026.04.013_bib53","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The Warburg effect: how does it benefit cancer cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jtha.2026.04.013_bib54","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6130806","article-title":"HIF-1\u03b1 regulated WTAP overexpression promoting the Warburg effect of ovarian cancer by m6A-dependent manner","volume":"2022","author":"Lyu","year":"2022","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jtha.2026.04.013_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.849040","article-title":"Therapeutic targeting hypoxia-inducible factor (HIF-1) in cancer: cutting Gordian knot of cancer cell metabolism","volume":"13","author":"Sharma","year":"2022","journal-title":"Front Genet"},{"key":"10.1016\/j.jtha.2026.04.013_bib56","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s11658-021-00263-y","article-title":"Worenine reverses the Warburg effect and inhibits colon cancer cell growth by negatively regulating HIF-1\u03b1","volume":"26","author":"Ji","year":"2021","journal-title":"Cell Mol Biol Lett"},{"issue":"10","key":"10.1016\/j.jtha.2026.04.013_bib57","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1182\/blood-2015-09-671982","article-title":"Diverse roles of cell-specific hypoxia-inducible factor 1 in cancer-associated hypercoagulation","volume":"127","author":"Evans","year":"2016","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jtha.2026.04.013_bib58","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3324\/haematol.2018.195321","article-title":"Vascular endothelial cell expression of JAK2V617F is sufficient to promote a pro-thrombotic state due to increased P-selectin expression","volume":"104","author":"Guy","year":"2019","journal-title":"Haematologica"},{"issue":"9","key":"10.1016\/j.jtha.2026.04.013_bib59","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1055\/s-0038-1667015","article-title":"Endothelial cells harbouring the JAK2V617F mutation display pro-adherent and pro-thrombotic features","volume":"118","author":"Guadall","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.013_bib60","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/01.CIR.103.4.491","article-title":"Soluble P-selectin and the risk of future cardiovascular events","volume":"103","author":"Ridker","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2026.04.013_bib61","first-page":"340","article-title":"Prognostic impact of soluble P-selectin on long-term adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention","volume":"119","author":"Tscharre","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.013_bib62","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.ehj.2003.08.021","article-title":"The adhesion molecule P-selectin and cardiovascular disease","volume":"24","author":"Blann","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jtha.2026.04.013_bib63","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1182\/bloodadvances.2025015860","article-title":"ADORE: an open platform study of ruxolitinib in combination with other novel therapies in patients with myelofibrosis","volume":"9","author":"Ross","year":"2025","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2026.04.013_bib64","first-page":"669","article-title":"The effect of ruxolitinib on the expression of VEGF and HIF-1 alpha in leukemia HEL cells","volume":"47","author":"Xu","year":"2016","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.jtha.2026.04.013_bib65","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/ajh.21974","article-title":"Platelet-induced thrombin generation by the calibrated automated thrombogram assay is increased in patients with essential thrombocythemia and polycythemia vera","volume":"86","author":"Panova-Noeva","year":"2011","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jtha.2026.04.013_bib66","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1182\/blood-2021-153736","article-title":"Characterizing the metabolic determinants of thromboinflammation in myeloproliferative neoplasms","volume":"138","author":"Esparza","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.013_bib67","doi-asserted-by":"crossref","first-page":"5332","DOI":"10.1074\/jbc.M806653200","article-title":"The Akt\/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors","volume":"284","author":"Harada","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtha.2026.04.013_bib68","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1182\/bloodadvances.2024013170","article-title":"Combination therapy with ruxolitinib and pegylated interferon alfa-2a in newly diagnosed patients with polycythemia vera","volume":"8","author":"S\u00f8rensen","year":"2024","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2026.04.013_bib69","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1200\/JCO.22.01935","article-title":"Ruxolitinib versus best available therapy for polycythemia vera intolerant or resistant to hydroxycarbamide in a randomized trial","volume":"41","author":"Harrison","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jtha.2026.04.013_bib70","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1038\/s41467-025-56848-0","article-title":"Alternatively spliced NFKB1 transcripts enriched in Andean Aymara modulate inflammation, HIF and hemoglobin","volume":"16","author":"Song","year":"2025","journal-title":"Nat Commun"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153878362600259X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153878362600259X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:22:21Z","timestamp":1785885741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153878362600259X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":70,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S153878362600259X"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2026.04.013","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulation of HIF-1\u03b1\u2013regulated and thromboinflammatory genes may contribute to thrombotic risk in patients with BCR::ABL1-negative myeloproliferative neoplasms","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2026.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}