{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:59:11Z","timestamp":1790949551932,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR47172\/MED\/32\/824\/2022"],"award-info":[{"award-number":["BT\/PR47172\/MED\/32\/824\/2022"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jtha.2026.04.014","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T15:05:17Z","timestamp":1776697517000},"page":"2766-2778","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["A rapid point-of-care test for the diagnosis of factor VIII inhibitors in hemophilia A patients"],"prefix":"10.1016","volume":"24","author":[{"given":"Shruti","family":"Kharat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiza","family":"Jivani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kranti","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpreet Kaur","family":"Saini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anam","family":"Dhawlarker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juili","family":"Bharankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1473-4948","authenticated-orcid":false,"given":"Shrimati","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2026.04.014_bib1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1046\/j.1365-2516.2003.00780.x","article-title":"The epidemiology of inhibitors in haemophilia A: a systematic review","volume":"9","author":"Wight","year":"2003","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2026.04.014_bib2","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1182\/blood-2012-09-457036","article-title":"Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study","volume":"121","author":"Gouw","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.014_bib3","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1046\/j.1365-2516.1998.440558.x","article-title":"Factor VIII inhibitors in mild and moderate-severity haemophilia A","volume":"4","author":"Hay","year":"1998","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2026.04.014_bib4","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1182\/blood-2012-07-444877","article-title":"Distinct characteristics of antibody responses against factor VIII in healthy individuals and in different cohorts of hemophilia A patients","volume":"121","author":"Whelan","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.014_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/jth.12768","article-title":"Characterization of the anti-factor VIII immunoglobulin profile in patients with hemophilia A by use of a fluorescence-based immunoassay","volume":"13","author":"Boylan","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.014_bib6","doi-asserted-by":"crossref","first-page":"e406","DOI":"10.1111\/hae.12508","article-title":"Are low-density lipoprotein receptor-related protein 1 or non-neutralizing antibodies predictors of 999FVIII in vivo recovery in haemophilia A patients?","volume":"20","author":"Clere","year":"2014","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2026.04.014_bib7","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1182\/blood-2016-06-720086","article-title":"Nonneutralizing antibodies against factor VIII and risk of inhibitor development in severe hemophilia A","volume":"129","author":"Cannav\u00f2","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.014_bib8","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1182\/blood-2008-08-174987","article-title":"Quantitation of anti-factor VIII antibodies in human plasma","volume":"113","author":"Krudysz-Amblo","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.014_bib9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/MBC.0000000000000843","article-title":"Evaluation of nonneutralizing antibodies against factor VIII in severe haemophilia A patients from India","volume":"30","author":"David","year":"2019","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.jtha.2026.04.014_bib10","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1016\/j.jtha.2024.07.001","article-title":"Development of a rapid and fully automated factor VIII inhibitor assay, insensitive to emicizumab, and a lowest level of quantification of 0.2 BU\/mL","volume":"22","author":"Verbruggen","year":"2024","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.014_bib11","first-page":"612","article-title":"Proceedings: a more uniform measurement of factor VIII inhibitors","volume":"34","author":"Kasper","year":"1975","journal-title":"Thromb Diath Haemorrh"},{"key":"10.1016\/j.jtha.2026.04.014_bib12","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1055\/s-0037-1615080","volume":"79","author":"Giles","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.014_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/hae.14046","article-title":"WFH guidelines for the management of hemophilia, 3rd edition","volume":"26","author":"Srivastava","year":"2020","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2026.04.014_bib14","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1111\/ijlh.13384","article-title":"Validation of the chromogenic Bethesda assay for factor VIII inhibitors in hemophilia A patient receiving emicizumab","volume":"43","author":"Miller","year":"2021","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.jtha.2026.04.014_bib15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/hae.13435","article-title":"Effects of pre-analytical heat treatment in factor VIII (FVIII) inhibitor assays on FVIII antibody levels","volume":"24","author":"Boylan","year":"2018","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2026.04.014_bib16","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1111\/jth.12672","article-title":"Definitions in hemophilia: communication from the SSC of the ISTH","volume":"12","author":"Blanchette","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.014_bib17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000067272","article-title":"An ELISA assay for the detection of factor VIII antibodies - comparison with the conventional Bethesda assay in a large cohort of haemophilia samples","volume":"109","author":"Shetty","year":"2003","journal-title":"Acta Haematol"},{"key":"10.1016\/j.jtha.2026.04.014_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1039\/df9511100055","article-title":"A study of the nucleation and growth processes in the synthesis of colloidal gold","volume":"11","author":"Turkevich","year":"1951","journal-title":"Discuss Faraday Soc"},{"key":"10.1016\/j.jtha.2026.04.014_bib20","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.3390\/s25175414","article-title":"Advancements and applications of lateral flow assays (LFAs): a comprehensive review","volume":"25","author":"Kinyua","year":"2025","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.jtha.2026.04.014_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.virol.2025.110686","article-title":"Colloidal gold technology in viral diagnostics: recent innovations, clinical applications, and future perspectives","volume":"612","author":"He","year":"2025","journal-title":"Virology"},{"key":"10.1016\/j.jtha.2026.04.014_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1355813","article-title":"The spectrum of neutralizing and non-neutralizing anti-FVIII antibodies in a nationwide cohort of 788 persons with hemophilia A","volume":"15","author":"Oomen","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtha.2026.04.014_bib23","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.jtha.2024.02.016","article-title":"Comprehensive domain-specific analysis and immunoglobulin G profiling of anti-factor VIII antibodies using a bead-based multiplex immunoassay","volume":"22","author":"Pezeshkpoor","year":"2024","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.014_bib24","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/jth.12259","article-title":"Comparison of clot-based, chromogenic and fluorescence assays for measurement of factor VIII inhibitors in the US Hemophilia Inhibitor Research Study","volume":"11","author":"Miller","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.014_bib25","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1055\/s-0033-1334464","article-title":"External quality assessment of factor VIII inhibitor assays","volume":"39","author":"Bonar","year":"2013","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jtha.2026.04.014_bib26","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1055\/s-0029-1245111","article-title":"The between-laboratory variation of factor VIII inhibitor testing: the experience of the external quality assessment program of the ECAT foundation","volume":"35","author":"Meijer","year":"2009","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jtha.2026.04.014_bib27","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1365-2516.2009.02173.x","article-title":"Laboratory identification of factor VIII inhibitors in the real world: the experience from Australasia","volume":"16","author":"Favaloro","year":"2010","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2026.04.014_bib28","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1055\/s-0033-1356573","article-title":"Problems and solutions in laboratory testing for hemophilia","volume":"39","author":"Favaloro","year":"2013","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jtha.2026.04.014_bib29","doi-asserted-by":"crossref","first-page":"7398","DOI":"10.3390\/s22197398","article-title":"Lateral flow immunoassay reader technologies for quantitative point-of-care testing","volume":"22","author":"Park","year":"2022","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.jtha.2026.04.014_bib30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.snb.2018.03.110","article-title":"A simple and compact smartphone-based device for the quantitative readout of colloidal gold lateral flow immunoassay strips","volume":"266","author":"Xiao","year":"2018","journal-title":"Sens Actuators B Chem"},{"key":"10.1016\/j.jtha.2026.04.014_bib31","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1055\/s-0037-1614875","article-title":"Evidence for antiphospholipid antibodies in hemophilic children with factor VIII inhibitors. Recombinate PUP Study Group","volume":"82","author":"Nuss","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.014_bib32","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/j.1365-2516.2009.02034.x","article-title":"Antiphospholipid antibodies in haemophilia patients with severe bleeding tendency: cause, consequence or a consequential cause?","volume":"15","author":"Shetty","year":"2009","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2026.04.014_bib33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1067\/mlc.2000.107299","article-title":"Heparin neutralization is essential for accurate measurement of factor VIII activity and inhibitor assays in blood samples drawn from implanted venous access devices","volume":"136","author":"Johnson","year":"2000","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.jtha.2026.04.014_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/hae.12467","article-title":"New predictive approaches for ITI treatment","volume":"20","author":"Minno","year":"2014","journal-title":"Haemophilia"},{"key":"10.1016\/j.jtha.2026.04.014_bib35","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/hae.14885","article-title":"Two-center validation of assays for the detection of binding and neutralizing anti-factor VIII antibodies","volume":"30","author":"M\u00fcller","year":"2024","journal-title":"Haemophilia"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783626002618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783626002618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T03:30:04Z","timestamp":1786073404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783626002618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1538783626002618"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2026.04.014","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A rapid point-of-care test for the diagnosis of factor VIII inhibitors in hemophilia A patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2026.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}