{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:47:48Z","timestamp":1786121268503,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["CVON 2018-28"],"award-info":[{"award-number":["CVON 2018-28"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2012-06 Heart Brain Connection"],"award-info":[{"award-number":["2012-06 Heart Brain Connection"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001722","name":"Koninklijke Nederlandse Akademie van Wetenschappen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012524","name":"Nederlandse Federatie van Universitair Medische Centra","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jtha.2026.04.022","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T23:32:49Z","timestamp":1778196769000},"page":"3041-3050","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["ADAMTS13 and von Willebrand Factor in relation to vascular cognitive impairment and cerebral small vessel disease: the heart-brain connection study"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3576-9951","authenticated-orcid":false,"given":"Amos C.","family":"Pomp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathijs T.","family":"Rosbergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moniek P.M.","family":"de Maat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Arfan","family":"Ikram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat J.A.P.","family":"Daemen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imo E.","family":"Hoefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiro J.","family":"Niessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"de Bresser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther E.","family":"Bron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert Jan","family":"Biessels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"van Oostenbrugge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2226-4050","authenticated-orcid":false,"given":"Frank J.","family":"Wolters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2026.04.022_bib1","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","volume":"69","author":"Schneider","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.jtha.2026.04.022_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00401-017-1717-7","article-title":"Impact of multiple pathologies on the threshold for clinically overt dementia","volume":"134","author":"Kapasi","year":"2017","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.jtha.2026.04.022_bib3","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.00581.2016","article-title":"Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging","volume":"312","author":"Toth","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jtha.2026.04.022_bib4","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1111\/j.1538-7836.2011.04403.x","article-title":"Association between circulating hemostatic measures and dementia or cognitive impairment: systematic review and meta-analyzes","volume":"9","author":"Quinn","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.022_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.blre.2014.04.003","article-title":"Von Willebrand factor and ADAMTS13 in arterial thrombosis: a systematic review and meta-analysis","volume":"28","author":"Sonneveld","year":"2014","journal-title":"Blood Rev"},{"key":"10.1016\/j.jtha.2026.04.022_bib6","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1182\/blood-2015-05-643338","article-title":"Low ADAMTS13 activity is associated with an increased risk of ischemic stroke","volume":"126","author":"Sonneveld","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.022_bib7","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1038\/s41598-018-23865-7","article-title":"Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia: a population-based study","volume":"8","author":"Wolters","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2026.04.022_bib8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1161\/STROKEAHA.111.628867","article-title":"von Willebrand factor: an emerging target in stroke therapy","volume":"43","author":"De Meyer","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2026.04.022_bib9","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1182\/blood-2016-10-709857","article-title":"Thrombotic thrombocytopenic purpura","volume":"129","author":"Joly","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.022_bib10","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1111\/jth.13479","article-title":"Low ADAMTS-13 activity and the risk of coronary heart disease - a prospective cohort study: the Rotterdam Study","volume":"14","author":"Sonneveld","year":"2016","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.022_bib11","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.3390\/jcm13175152","article-title":"The highs and lows of ADAMTS13 activity","volume":"13","author":"Shaw","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtha.2026.04.022_bib12","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/s12185-016-2091-2","article-title":"ADAMTS13: more than a regulator of thrombosis","volume":"104","author":"Feng","year":"2016","journal-title":"Int J Hematol"},{"key":"10.1016\/j.jtha.2026.04.022_bib13","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1084\/jem.20080130","article-title":"ADAMTS13: a new link between thrombosis and inflammation","volume":"205","author":"Chauhan","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.jtha.2026.04.022_bib14","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1182\/blood.2023021915","article-title":"Novel functions for von Willebrand factor","volume":"144","author":"Atiq","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.04.022_bib15","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S1474-4422(19)30079-1","article-title":"Small vessel disease: mechanisms and clinical implications","volume":"18","author":"Wardlaw","year":"2019","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jtha.2026.04.022_bib16","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.3390\/ijms23073508","article-title":"Small vessel disease: ancient description, novel biomarkers","volume":"23","author":"Moretti","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtha.2026.04.022_bib17","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.jalz.2018.04.007","article-title":"Cerebral small vessel disease and the risk of dementia: a systematic review and meta-analysis of population-based evidence","volume":"14","author":"Bos","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jtha.2026.04.022_bib18","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neubiorev.2018.04.003","article-title":"Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: a systematic review and meta-analysis","volume":"90","author":"Rensma","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jtha.2026.04.022_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.c3666","article-title":"The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis","volume":"341","author":"Debette","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.jtha.2026.04.022_bib20","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S1474-4422(17)30196-5","article-title":"Detection, risk factors, and functional consequences of cerebral microinfarcts","volume":"16","author":"van Veluw","year":"2017","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jtha.2026.04.022_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.738359","article-title":"The relationship between ADAMTS13 activity and overall cerebral small vessel disease burden: a cross-sectional study based on CSVD","volume":"13","author":"Sun","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jtha.2026.04.022_bib22","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000480738","article-title":"The missing link in the pathophysiology of vascular cognitive impairment: design of the heart-brain study","volume":"7","author":"Hooghiemstra","year":"2017","journal-title":"cerebrovasc Dis Extra"},{"key":"10.1016\/j.jtha.2026.04.022_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability","volume":"9","author":"Assarsson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jtha.2026.04.022_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2141.2005.05420.x","article-title":"FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay","volume":"129","author":"Kokame","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2026.04.022_bib26","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.neuroimage.2009.01.011","article-title":"White matter lesion extension to automatic brain tissue segmentation on MRI","volume":"45","author":"de Boer","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.jtha.2026.04.022_bib27","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","article-title":"Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jtha.2026.04.022_bib28","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S1474-4422(23)00131-X","article-title":"Neuroimaging standards for research into small vessel disease-advances since 2013","volume":"22","author":"Duering","year":"2023","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jtha.2026.04.022_bib29","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jcmg.2020.06.040","article-title":"Hypertensive exposure markers by MRI in relation to cerebral small vessel disease and cognitive impairment","volume":"14","author":"Amier","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jtha.2026.04.022_bib30","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1161\/ATVBAHA.116.308225","article-title":"Von Willebrand factor, ADAMTS13, and the risk of mortality: the Rotterdam study","volume":"36","author":"Sonneveld","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2026.04.022_bib31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/jth.12456","article-title":"ADAMTS13 modulates atherosclerotic plaque progression in mice via a VWF-dependent mechanism","volume":"12","author":"Gandhi","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.022_bib32","doi-asserted-by":"crossref","first-page":"7184","DOI":"10.1038\/s41598-017-07340-3","article-title":"ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis","volume":"7","author":"Alflen","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtha.2026.04.022_bib33","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1111\/jth.15873","article-title":"Mechanisms of ADAMTS13 regulation","volume":"20","author":"DeYoung","year":"2022","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.022_bib34","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.1073\/pnas.0608422104","article-title":"Shear-induced unfolding triggers adhesion of von Willebrand factor fibers","volume":"104","author":"Schneider","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jtha.2026.04.022_bib35","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s00125-016-4139-5","article-title":"ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study","volume":"60","author":"de Vries","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.jtha.2026.04.022_bib36","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1161\/01.STR.0000189721.31432.26","article-title":"Fibrinogen is associated with an increased risk of Alzheimer disease and vascular dementia","volume":"36","author":"van Oijen","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.jtha.2026.04.022_bib37","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/jth.15649","article-title":"Constitutively active ADAMTS13: an emerging thrombolytic agent for acute ischemic stroke","volume":"20","author":"Nayak","year":"2022","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.022_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100916","article-title":"Inflammation and cerebral small vessel disease: a systematic review","volume":"53","author":"Low","year":"2019","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jtha.2026.04.022_bib39","doi-asserted-by":"crossref","DOI":"10.1111\/ene.70063","article-title":"Coagulation factors and white matter hyperintensities in middle-aged women with and without migraine and ischemic stroke","volume":"32","author":"Ali","year":"2025","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.jtha.2026.04.022_bib40","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1111\/j.1538-7836.2009.03603.x","article-title":"Elevated plasma fibrin D-dimer as a risk factor for vascular dementia: the Three-City cohort study","volume":"7","author":"Carcaillon","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.04.022_bib41","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1161\/ATVBAHA.109.197368","article-title":"Is sticky blood bad for the brain?: Hemostatic and inflammatory systems and dementia in the Caerphilly Prospective Study","volume":"30","author":"Gallacher","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtha.2026.04.022_bib42","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1474-4422(09)70013-4","article-title":"Cerebral microbleeds: a guide to detection and interpretation","volume":"8","author":"Greenberg","year":"2009","journal-title":"Lancet Neurol"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783626002722?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783626002722?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T04:13:59Z","timestamp":1786076039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783626002722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1538783626002722"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2026.04.022","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ADAMTS13 and von Willebrand Factor in relation to vascular cognitive impairment and cerebral small vessel disease: the heart-brain connection study","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2026.04.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}