{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:36:31Z","timestamp":1793352991043,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2020T013"],"award-info":[{"award-number":["2020T013"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jtha.2026.08.019","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:00:04Z","timestamp":1788156004000},"page":"4027-4035","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma protein profile in patients with antiphospholipid syndrome and controls without antiphospholipid syndrome"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9185-8974","authenticated-orcid":false,"given":"Dagmar J.M.","family":"van Mourik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3568-8100","authenticated-orcid":false,"given":"Britte F.","family":"van der Vliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorien","family":"Salet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Renee","family":"Ruhaak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasja","family":"Dolezal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Wouter","family":"Drijfhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Cordfunke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"van Hylckama Vlieg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederikus A.","family":"Klok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Coppens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mettine H.A.","family":"Bos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Middeldorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen C.J.","family":"Eikenboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart J.M.","family":"van Vlijmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6520-1597","authenticated-orcid":false,"given":"Thijs E.","family":"van Mens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2026.08.019_bib1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.08.019_bib2","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/art.40901","article-title":"The epidemiology of antiphospholipid syndrome: a population-based study","volume":"71","author":"Duarte-Garcia","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jtha.2026.08.019_bib3","article-title":"Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management","volume":"380","author":"Knight","year":"2023","journal-title":"BMJ"},{"key":"10.1016\/j.jtha.2026.08.019_bib4","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1002\/art.22802","article-title":"Anti-beta2-glycoprotein I antibodies induce monocyte release of tumor necrosis factor alpha and tissue factor by signal transduction pathways involving lipid rafts","volume":"56","author":"Sorice","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jtha.2026.08.019_bib5","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1002\/art.21157","article-title":"Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia","volume":"52","author":"Pierangeli","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jtha.2026.08.019_bib6","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1177\/0961203312458839","article-title":"C6 knock-out mice are protected from thrombophilia mediated by antiphospholipid antibodies","volume":"21","author":"Carrera-Marin","year":"2012","journal-title":"Lupus"},{"key":"10.1016\/j.jtha.2026.08.019_bib7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.molimm.2012.08.012","article-title":"Anti-beta(2)GPI\/beta(2)GPI induced TF and TNF-alpha expression in monocytes involving both TLR4\/MyD88 and TLR4\/TRIF signaling pathways","volume":"53","author":"Xie","year":"2013","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jtha.2026.08.019_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/cei.13248","article-title":"Tissue factor over-expression in platelets of patients with anti-phospholipid syndrome: induction role of anti-beta2-GPI antibodies","volume":"196","author":"Capozzi","year":"2019","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jtha.2026.08.019_bib9","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/ard-2023-224930","article-title":"Single-cell transcriptome analyses reveal disturbed decidual homoeostasis in obstetrical antiphospholipid syndrome","volume":"83","author":"Lu","year":"2024","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jtha.2026.08.019_bib10","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1196\/annals.1422.058","article-title":"C5a receptor-deficient mice are protected from thrombophilia and endothelial cell activation induced by some antiphospholipid antibodies","volume":"1108","author":"Romay-Penabad","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jtha.2026.08.019_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtauto.2023.100202","article-title":"Antiphospholipid antibodies induce proinflammatory and procoagulant pathways in endothelial cells","volume":"6","author":"Patsouras","year":"2023","journal-title":"J Transl Autoimmun"},{"key":"10.1016\/j.jtha.2026.08.019_bib12","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1160\/TH11-08-0554","article-title":"Complement activation in patients with isolated antiphospholipid antibodies or primary antiphospholipid syndrome","volume":"107","author":"Breen","year":"2012","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.08.019_bib13","first-page":"10","article-title":"Serum protein profile in women with pregnancy morbidity associated with antiphospholipid syndrome","volume":"10","author":"Alvarez","year":"2017","journal-title":"J Hum Reprod Sci"},{"key":"10.1016\/j.jtha.2026.08.019_bib14","doi-asserted-by":"crossref","DOI":"10.1177\/1076029620905338","article-title":"Proteins involved in the induction of procoagulant activity and autoimmune response in patients with primary antiphospholipid syndrome","volume":"26","author":"Araujo","year":"2020","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.jtha.2026.08.019_bib15","doi-asserted-by":"crossref","first-page":"e308","DOI":"10.1055\/s-0044-1788653","article-title":"An intestinal microbiome intervention affects biochemical disease activity in patients with antiphospholipid syndrome","volume":"8","author":"Jansen","year":"2024","journal-title":"TH Open"},{"key":"10.1016\/j.jtha.2026.08.019_bib16","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/jth.15623","article-title":"Targeted proteomics for evaluating risk of venous thrombosis following traumatic lower-leg injury or knee arthroscopy","volume":"20","author":"Mohammed","year":"2022","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.08.019_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2025.103018","article-title":"Quantitative targeted proteomics for occult cancer screening in patients with unprovoked venous thromboembolism: results from the prospective PLATO-VTE study","volume":"9","author":"Guman","year":"2025","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.08.019_bib18","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/bjh.70278","article-title":"Plasma proteomic profiles of patients during oral anti-coagulant treatment with vitamin K antagonists","volume":"208","author":"Camilleri","year":"2026","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2026.08.019_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaz0274","article-title":"The human secretome","volume":"12","author":"Uhlen","year":"2019","journal-title":"Sci Signal"},{"key":"10.1016\/j.jtha.2026.08.019_bib20","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgag120","article-title":"Distinct plasma protein profiles after long-term remission of Cushing\u2019s disease","author":"van der Vliet","year":"2026","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jtha.2026.08.019_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"2018","journal-title":"J R Stat Soc Ser B Stat Methodol"},{"key":"10.1016\/j.jtha.2026.08.019_bib22","article-title":"Proteomics analysis of plasm exosomes in early pregnancy among normal pregnant women and those with antiphospholipid syndrome","volume":"10","author":"Sun","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jtha.2026.08.019_bib23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1081\/DMR-100104402","article-title":"Human alpha-1-glycoprotein and its interactions with drugs","volume":"33","author":"Israili","year":"2001","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.jtha.2026.08.019_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.686251","article-title":"Into the labyrinth of the lipocalin alpha1-acid glycoprotein","volume":"12","author":"Ruiz","year":"2021","journal-title":"Front Physiol"},{"key":"10.1016\/j.jtha.2026.08.019_bib25","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41574-024-00970-4","article-title":"Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit","volume":"20","author":"Baxter","year":"2024","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jtha.2026.08.019_bib26","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/bbrc.1998.8089","article-title":"Interleukin-1 beta suppresses growth hormone-induced acid-labile subunit mRNA levels and secretion in primary hepatocytes","volume":"243","author":"Delhanty","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jtha.2026.08.019_bib27","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.34067\/KID.0004922020","article-title":"Beta-2 microglobulin amyloidosis: past, present, and future","volume":"1","author":"Portales-Castillo","year":"2020","journal-title":"Kidney360"},{"key":"10.1016\/j.jtha.2026.08.019_bib28","article-title":"Research progress on leucine-rich alpha-2 glycoprotein 1: a review","volume":"12","author":"Zou","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jtha.2026.08.019_bib29","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12882-020-01782-0","article-title":"Leucine-rich alpha2-glycoprotein-1 upregulation in plasma and kidney of patients with lupus nephritis","volume":"21","author":"Yang","year":"2020","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.jtha.2026.08.019_bib30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1182\/blood.2019003863","article-title":"Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS","volume":"135","author":"Chaturvedi","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.08.019_bib31","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/1744666X.2020.1745063","article-title":"Revisiting the complement system in systemic lupus erythematosus","volume":"16","author":"Sharma","year":"2020","journal-title":"Expert Rev Clin Immunol"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783626005441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783626005441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:03:18Z","timestamp":1793350998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783626005441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S1538783626005441"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2026.08.019","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma protein profile in patients with antiphospholipid syndrome and controls without antiphospholipid syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2026.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}