{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:59:39Z","timestamp":1791460779256,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jtha.2026.09.024","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:13:13Z","timestamp":1789830793000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis and management of subsegmental pulmonary embolism"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2407-9000","authenticated-orcid":false,"given":"Tzu-Fei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Le Gal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Carrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtha.2026.09.024_bib1","first-page":"831","article-title":"Time trends in pulmonary embolism in the United States: evidence of overdiagnosis","volume":"171","author":"Wiener","year":"2011","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jtha.2026.09.024_bib2","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1111\/j.1538-7836.2010.03938.x","article-title":"Subsegmental pulmonary embolism diagnosed by computed tomography: incidence and clinical implications. A systematic review and meta-analysis of the management outcome studies","volume":"8","author":"Carrier","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.09.024_bib3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0140-6736(17)30885-1","article-title":"Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study","volume":"390","author":"van der Hulle","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jtha.2026.09.024_bib4","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1056\/NEJMoa1909159","article-title":"Diagnosis of pulmonary embolism with D-dimer adjusted to clinical probability","volume":"381","author":"Kearon","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtha.2026.09.024_bib5","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1001\/jama.2021.20750","article-title":"Effect of a diagnostic strategy using an elevated and age-adjusted D-dimer threshold on thromboembolic events in emergency department patients with suspected pulmonary embolism: a randomized clinical trial","volume":"326","author":"Freund","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jtha.2026.09.024_bib6","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1001\/jama.2014.2135","article-title":"Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study","volume":"311","author":"Righini","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jtha.2026.09.024_bib7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/bjh.15556","article-title":"Lower prevalence of subsegmental pulmonary embolism after application of the YEARS diagnostic algorithm","volume":"183","author":"van der Pol","year":"2018","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtha.2026.09.024_bib8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/02841850601100859","article-title":"Multidetector computed tomography (MDCT) in the diagnosis of pulmonary embolism: interobserver agreement among radiologists with varied levels of experience","volume":"48","author":"Ghanima","year":"2007","journal-title":"Acta Radiol"},{"key":"10.1016\/j.jtha.2026.09.024_bib9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2214\/AJR.14.13938","article-title":"Overdiagnosis of pulmonary embolism by pulmonary CT angiography","volume":"205","author":"Hutchinson","year":"2015","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.jtha.2026.09.024_bib10","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/rth2.12422","article-title":"Establishing diagnostic criteria and treatment of subsegmental pulmonary embolism: a Delphi analysis of experts","volume":"4","author":"den Exter","year":"2020","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.09.024_bib11","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/ehjci\/jeaf050","volume":"26","author":"Klok","year":"2025","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jtha.2026.09.024_bib12","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1538-7836.2011.04612.x","article-title":"Difference in interpretation of computed tomography pulmonary angiography diagnosis of subsegmental thrombosis in patients with suspected pulmonary embolism","volume":"10","author":"Pena","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.09.024_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/UGHF6892","article-title":"Stopping anticoagulation for isolated or incidental subsegmental pulmonary embolism: the challenges and lessons from the STOPAPE RCT","volume":"29","author":"Lasserson","year":"2025","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.jtha.2026.09.024_bib14","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.1016\/j.thromres.2010.07.001","article-title":"Clinical outcomes in patients with isolated subsegmental pulmonary emboli diagnosed by multidetector CT pulmonary angiography","volume":"126","author":"Donato","year":"2010","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2026.09.024_bib15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2214\/ajr.184.2.01840623","article-title":"Clinicians' response to radiologists' reports of isolated subsegmental pulmonary embolism or inconclusive interpretation of pulmonary embolism using MDCT","volume":"184","author":"Eyer","year":"2005","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.jtha.2026.09.024_bib16","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1182\/blood-2013-04-497545","article-title":"Risk profile and clinical outcome of symptomatic subsegmental acute pulmonary embolism","volume":"122","author":"den Exter","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jtha.2026.09.024_bib17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.thromres.2019.10.008","article-title":"Clinical presentation and outcomes in elderly patients with symptomatic isolated subsegmental pulmonary embolism","volume":"184","author":"Stoller","year":"2019","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2026.09.024_bib18","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/rth2.12446","article-title":"Symptomatic subsegmental versus more central pulmonary embolism: clinical outcomes during anticoagulation","volume":"5","author":"Fernandez-Capitan","year":"2021","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.09.024_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.7326\/M21-2981","article-title":"Risk for recurrent venous thromboembolism in patients with subsegmental pulmonary embolism managed without anticoagulation: a multicenter prospective cohort study","volume":"175","author":"Le Gal","year":"2022","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtha.2026.09.024_bib20","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/jth.12803","article-title":"Sub-segmental pulmonary embolism in three academic teaching hospitals: a review of management and outcomes","volume":"13","author":"Goy","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.09.024_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.thromres.2026.109669","article-title":"Anticoagulation therapy vs clinical surveillance in isolated subsegmental pulmonary embolism: a systematic review and meta\u2013analysis","volume":"261","author":"Nicoletto","year":"2026","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2026.09.024_bib22","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/jth.12485","article-title":"Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: a systematic review and meta-analysis","volume":"12","author":"van der Hulle","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.09.024_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.thromres.2014.10.033","article-title":"Case-fatality of recurrent venous thromboembolism and major bleeding associated with aspirin, warfarin, and direct oral anticoagulants for secondary prevention","volume":"135","author":"Wu","year":"2015","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2026.09.024_bib24","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","article-title":"2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)","volume":"41","author":"Konstantinides","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jtha.2026.09.024_bib25","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1016\/j.chest.2021.07.056","article-title":"Executive summary: antithrombotic therapy for VTE Disease: second update of the CHEST guideline and expert panel report","volume":"160","author":"Stevens","year":"2021","journal-title":"Chest"},{"key":"10.1016\/j.jtha.2026.09.024_bib26","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1182\/bloodadvances.2020003442","article-title":"American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer","volume":"5","author":"Lyman","year":"2021","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2026.09.024_bib27","first-page":"e977","article-title":"2026 AHA\/ACC\/ACCP\/ACEP\/CHEST\/SCAI\/SHM\/SIR\/SVM\/SVN Guideline for the evaluation and management of acute pulmonary embolism in adults: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"153","author":"Writing Committee","year":"2026","journal-title":"Circulation"},{"key":"10.1016\/j.jtha.2026.09.024_bib28","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-040151","article-title":"Clinical surveillance vs. anticoagulation for low-risk patients with isolated subsegmental pulmonary embolism: protocol for a multicentre randomised placebo-controlled non-inferiority trial (SAFE\u2013SSPE)","volume":"10","author":"Baumgartner","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.jtha.2026.09.024_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.thromres.2024.109037","article-title":"Risk of recurrent venous thromboembolism and bleeding in patients with acute isolated subsegmental pulmonary embolism","volume":"239","author":"Girardi","year":"2024","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2026.09.024_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.thromres.2025.109386","article-title":"Long-term recurrence, bleeding, and mortality after first-time subsegmental pulmonary embolism compared to more proximal pulmonary embolism: findings from the TROLL registry","volume":"252","author":"Jorgensen","year":"2025","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2026.09.024_bib31","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.3390\/jcm12041640","article-title":"Clinical Significance and outcome in patients with asymptomatic versus symptomatic subsegmental pulmonary embolism","volume":"12","author":"Rodriguez-Cobo","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtha.2026.09.024_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.thromres.2025.109335","article-title":"Letter-To-The-Editor: long-term outcomes of patients with isolated subsegmental pulmonary embolism managed without anticoagulant therapy","volume":"250","author":"Brown","year":"2025","journal-title":"Thromb Res"},{"key":"10.1016\/j.jtha.2026.09.024_bib33","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1111\/j.1538-7836.2010.03991.x","article-title":"Risk of recurrent venous thromboembolism after stopping treatment in cohort studies: recommendation for acceptable rates and standardized reporting","volume":"8","author":"Kearon","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.09.024_bib34","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1182\/bloodadvances.2020003136","article-title":"Clinical factors and outcomes of subsegmental pulmonary embolism in cancer patients","volume":"5","author":"Yan","year":"2021","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtha.2026.09.024_bib35","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1055\/a-2661-2326","article-title":"Risk factors and outcomes of subsegmental versus more central pulmonary embolism in patients with lung cancer","volume":"126","author":"Yang","year":"2026","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.09.024_bib36","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.jtha.2026.02.006","article-title":"Anticoagulation management and outcomes in patients with cancer\u2013associated small venous thromboembolism: a retrospective cohort study","volume":"24","author":"Kou","year":"2026","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jtha.2026.09.024_bib37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13045-022-01289-1","article-title":"Direct oral anticoagulant versus low molecular weight heparin for the treatment of cancer-associated venous thromboembolism: 2022 updated systematic review and meta-analysis of randomized controlled trials","volume":"15","author":"Frere","year":"2022","journal-title":"J Hematol Oncol"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783626006124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783626006124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:35:39Z","timestamp":1791459339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783626006124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":37,"alternative-id":["S1538783626006124"],"URL":"https:\/\/doi.org\/10.1016\/j.jtha.2026.09.024","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnosis and management of subsegmental pulmonary embolism","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtha.2026.09.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}]}}