{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:13:48Z","timestamp":1778634828320,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31472006"],"award-info":[{"award-number":["31472006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31470474"],"award-info":[{"award-number":["31470474"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["020103"],"award-info":[{"award-number":["020103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thermal Biology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.jtherbio.2019.102452","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T02:11:16Z","timestamp":1572833476000},"page":"102452","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["HSP70 plays a role in the defense of acute and chronic heat stress in Mongolian gerbils (Meriones unguiculatus)"],"prefix":"10.1016","volume":"86","author":[{"given":"Shu-Lei","family":"Lou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtherbio.2019.102452_bib1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cbpa.2013.04.013","article-title":"Effect of Light at Night on oxidative stress markers in Golden spiny mice (Acomys russatus) liver","volume":"165","author":"Ashkenazi","year":"2013","journal-title":"Comp. Biochem. Physiol. A"},{"key":"10.1016\/j.jtherbio.2019.102452_bib2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.cbpa.2010.07.011","article-title":"Time course of ROS production in skeletal muscle mitochondria from chronic heat-exposed broiler chicken","volume":"157","author":"Azad","year":"2010","journal-title":"Comp. Biochem. Physiol. A"},{"key":"10.1016\/j.jtherbio.2019.102452_bib3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jtherbio.2019.102452_bib4","first-page":"608","article-title":"Depressed expression of the inducible form of HSP 70 (HSP 72) in brain and heart after in vivo heat shock","volume":"269","author":"Beck","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jtherbio.2008.01.001","article-title":"Transcriptional profiling of mouse liver in response to chronic heat stress","volume":"33","author":"Bhusari","year":"2008","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev-ecolsys-102710-145055","article-title":"Physiological correlates of geographic range in animals","volume":"42","author":"Bozinovic","year":"2011","journal-title":"Annu. Rev. Ecol. Evol. Systemat."},{"key":"10.1016\/j.jtherbio.2019.102452_bib7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nclimate1452","article-title":"A decade of weather extremes","volume":"2","author":"Coumou","year":"2012","journal-title":"Nat. Clim. Chang."},{"key":"10.1016\/j.jtherbio.2019.102452_bib8","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/1749-4877.12272","article-title":"Inter-group associations in Mongolian gerbils: quantitative evidence from social network analysis","volume":"12","author":"Deng","year":"2017","journal-title":"Integr. Zool."},{"key":"10.1016\/j.jtherbio.2019.102452_bib9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2307\/25470698","article-title":"Heat-shock protein 70 (Hsp 70) expression in four limpets of the genus Lottia: interspecific variation in constitutive and inducible synthesis correlates with in situ exposure to heat stress","volume":"215","author":"Dong","year":"2008","journal-title":"Biol. Bull."},{"key":"10.1016\/j.jtherbio.2019.102452_bib10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.33549\/physiolres.931844","article-title":"Some current insights into oxidative stress","volume":"59","author":"Durackova","year":"2010","journal-title":"Physiol. Res."},{"key":"10.1016\/j.jtherbio.2019.102452_bib11","series-title":"Heat Shock Proteins and Whole Body Adaptation to Extreme Environments","author":"Evgen'ev","year":"2014"},{"key":"10.1016\/j.jtherbio.2019.102452_bib12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.physiol.61.1.243","article-title":"Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology","volume":"61","author":"Feder","year":"1999","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib13","first-page":"28","article-title":"Tissue-specific HSP70 response in animals undergoing heat stress","volume":"268","author":"Flanagan","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib14","doi-asserted-by":"crossref","first-page":"9560","DOI":"10.1073\/pnas.0510992103","article-title":"Variation in the sensitivity of organismal body temperature to climate change over local and geographic scales","volume":"103","author":"Gilman","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jtherbio.2019.102452_bib15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jtherbio.2018.03.007","article-title":"Prolonged environment-induced hyperthermia alters autophagy in oxidative skeletal muscle in Sus scrofa","volume":"74","author":"Ganesan","year":"2018","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib16","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jtherbio.2012.08.004","article-title":"Thermal physiology of laboratory mice: defining thermoneutrality","volume":"37","author":"Gordon","year":"2012","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jtherbio.2019.02.015","article-title":"Brown adipose tissue plays thermoregulatory role within the thermoneutral zone in Mongolian gerbils (Meriones unguiculatus)","volume":"81","author":"Guo","year":"2019","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib18","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S1095-6433(01)00500-1","article-title":"From molecular and cellular to integrative heat defense during exposure to chronic heat","volume":"131","author":"Horowitz","year":"2002","journal-title":"Comp. Biochem. Physiol. A"},{"key":"10.1016\/j.jtherbio.2019.102452_bib19","first-page":"101","article-title":"Thyroid hormones mediate metabolic rate and oxidative, anti-oxidative balance at different temperatures in Mongolian gerbils (Meriones unguiculatus)","volume":"216","author":"Khakisahneh","year":"2019","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.jtherbio.2019.102452_bib20","first-page":"20141097","article-title":"Global variation in thermal tolerances and vulnerability of endotherms to climate change","volume":"281","author":"Khaliq","year":"2014","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.jtherbio.2019.102452_bib21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jtherbio.2019.04.012","article-title":"The adaptogenic anti-ageing potential of resveratrol against heat stress mediated liver injury in aged rats: role of HSP70 and NF-kB signalling","volume":"83","author":"Khafagaa","year":"2019","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1146\/annurev-ento-011613-162107","article-title":"Insect heat shock proteins during stress and diapause","volume":"60","author":"King","year":"2015","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1242\/jeb.205.2.273","article-title":"Whole-body hyperthermia-induced thermotolerance is associated with the induction of Heat Shock Protein 70 in mice","volume":"205","author":"King","year":"2002","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib24","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1152\/japplphysiol.01040.2005","article-title":"Time course of cytokine, corticosterone, and tissue injury responses in mice during heat strain recovery","volume":"100","author":"Leon","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1023\/A:1007053504960","article-title":"Effect of different whole body hyperthermic sessions on the heat shock response in mice liver and brain","volume":"204","author":"Leoni","year":"2000","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jtherbio.2019.102452_bib26","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jtherbio.2013.08.006","article-title":"Correlation between heat shock protein 32 and chronic heat-induced liver injury in developing mice","volume":"38","author":"Li","year":"2013","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib27","doi-asserted-by":"crossref","first-page":"12492","DOI":"10.1073\/pnas.91.26.12492","article-title":"Comparison of the heat shock response in ethnically and ecologically different human populations","volume":"91","author":"Lyashko","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jtherbio.2019.102452_bib28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12192-015-0652-6","article-title":"Geographic variation in thermal tolerance and strategies of heat shock protein expression in the land snail Theba pisana in relation to genetic structure","volume":"21","author":"Mizrahi","year":"2016","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.jtherbio.2019.102452_bib29","series-title":"The Physiological Ecology of Vertebrates","author":"McNab","year":"2002"},{"key":"10.1016\/j.jtherbio.2019.102452_bib30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1461-0248.2008.01258.x","article-title":"Oxidative stress as a mediator of life history trade-offs: mechanisms, measurements and interpretation","volume":"12","author":"Monaghan","year":"2009","journal-title":"Ecol. Lett."},{"key":"10.1016\/j.jtherbio.2019.102452_bib31","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1242\/jcs.115.14.2809","article-title":"Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins","volume":"115","author":"Nollen","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jtherbio.2019.102452_bib32","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s11745-014-3900-0","article-title":"Lipidomics reveals mitochondrial membrane remodeling associated with acute thermoregulation in a rodent with a wide thermoneutral zone","volume":"49","author":"Pan","year":"2014","journal-title":"Lipids"},{"key":"10.1016\/j.jtherbio.2019.102452_bib33","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1146\/annurev.ge.27.120193.002253","article-title":"The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins","volume":"27","author":"Parsell","year":"1993","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.jtherbio.2019.102452_bib34","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1095\/biolreprod.108.071779","article-title":"A single, mild, transient scrotal heat stress causes hypoxia and oxidative stress in mouse testes, which induces germ cell death","volume":"80","author":"Paul","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jtherbio.2019.102452_bib35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2527\/jas.52339","article-title":"Heat stress reduces barrier function and alters intestinal metabolism in growing pigs","volume":"4","author":"Pearce","year":"2012","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.jtherbio.2019.102452_bib36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s12192-011-0287-1","article-title":"Effects of chronic heat stress on the expressions of heat shock proteins 60, 70, 90, A2, and HSC70 in the rabbit testis","volume":"17","author":"Pei","year":"2012","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.jtherbio.2019.102452_bib37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s12192-010-0240-8","article-title":"Response of mice to continuous 5-day passive hyperthermia resembles human heat acclimation","volume":"16","author":"Sareh","year":"2011","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.jtherbio.2019.102452_bib38","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1242\/jeb.01705","article-title":"Ectothermy and endothermy: evolutionary perspectives of thermo protection by HSPs","volume":"208","author":"Shabtay","year":"2005","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib39","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/1749-4877.12179","article-title":"Implication of metabolomic profiles to wide thermoneutral zone in Mongolian gerbils (Meriones unguiculatus)","volume":"11","author":"Shi","year":"2016","journal-title":"Integr. Zool."},{"key":"10.1016\/j.jtherbio.2019.102452_bib40","first-page":"42","article-title":"Environmental metabolomics reveal geographic variation in aerobic metabolism and metabolic substrates in Mongolian gerbils (Meriones unguiculatus)","volume":"14","author":"Shi","year":"2015","journal-title":"Comp. Biochem. Physiol. D"},{"key":"10.1016\/j.jtherbio.2019.102452_bib41","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1046\/j.1461-0248.2003.00528.x","article-title":"The evolutionary and ecological role of heat shock proteins","volume":"6","author":"Sorensen","year":"2003","journal-title":"Ecol. Lett."},{"key":"10.1016\/j.jtherbio.2019.102452_bib42","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1111\/j.1365-294X.2009.04354.x","article-title":"Seasonal and latitudinal acclimatization of cardiac transcriptome responses to thermal stress in porcelain crabs, Petrolisthes cinctipes","volume":"18","author":"Stillman","year":"2009","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib43","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1086\/316740","article-title":"Time course and magnitude of synthesis of heat-shock proteins in congeneric marine snails (Genus Tegula) from different tidal heights","volume":"73","author":"Tomanek","year":"2000","journal-title":"Physiol. Biochem. Zool."},{"key":"10.1016\/j.jtherbio.2019.102452_bib44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4098\/AT.arch.00-21","article-title":"Metabolism and thermoregulation in the Mongolian gerbil Meriones unguiculatus","volume":"45","author":"Wang","year":"2000","journal-title":"Acta Theriol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jtherbio.2019.06.008","article-title":"Effects of air temperatures on antioxidant defense and immunity in Mongolian gerbils","volume":"84","author":"Xu","year":"2019","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cbpa.2016.01.015","article-title":"Water deprivation up-regulates urine osmolality and renal aquaporin 2 in Mongolian gerbils (Meriones unguiculatus)","volume":"194","author":"Xu","year":"2016","journal-title":"Comp. Biochem. Physiol. A"},{"key":"10.1016\/j.jtherbio.2019.102452_bib47","first-page":"4242","article-title":"Effects of reproduction on immuno-suppression and oxidative damage, and hence support or otherwise for their roles as mechanisms underpinning life history trade-offs, are tissue and assay dependent","volume":"216","author":"Yang","year":"2013","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.jtherbio.2019.102452_bib48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cbpa.2010.01.008","article-title":"Effect of heat stress on the porcine small intestine: a morphological and gene expression study","volume":"156","author":"Yu","year":"2010","journal-title":"Comp. Biochem. Physiol. A"},{"key":"10.1016\/j.jtherbio.2019.102452_bib49","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1360\/N052015-00223","article-title":"Studies of behavioral and physiological ecology in Mongolian gerbils (Meriones unguiculatus)","volume":"46","author":"Zhang","year":"2016","journal-title":"Sci. Sin. Vitae"},{"key":"10.1016\/j.jtherbio.2019.102452_bib50","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cbpa.2015.07.017","article-title":"Effect of temperature on oxidative stress, antioxidant levels and uncoupling protein expression in striped hamsters","volume":"189","author":"Zhou","year":"2015","journal-title":"Comp. Biochem. Physiol. A"}],"container-title":["Journal of Thermal Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306456519304000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306456519304000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:40:27Z","timestamp":1778632827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306456519304000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":50,"alternative-id":["S0306456519304000"],"URL":"https:\/\/doi.org\/10.1016\/j.jtherbio.2019.102452","relation":{},"ISSN":["0306-4565"],"issn-type":[{"value":"0306-4565","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HSP70 plays a role in the defense of acute and chronic heat stress in Mongolian gerbils (Meriones unguiculatus)","name":"articletitle","label":"Article Title"},{"value":"Journal of Thermal Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtherbio.2019.102452","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102452"}}