{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:17:36Z","timestamp":1778746656709,"version":"3.51.4"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1308000"],"award-info":[{"award-number":["2017YFC1308000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770466"],"award-info":[{"award-number":["81770466"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070483"],"award-info":[{"award-number":["82070483"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600362"],"award-info":[{"award-number":["81600362"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","award":["QML20170602"],"award-info":[{"award-number":["QML20170602"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thermal Biology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jtherbio.2020.102817","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T03:41:44Z","timestamp":1610077304000},"page":"102817","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Changing of haemostatic system in a pig model during different types of hypothermic circulatory arrest"],"prefix":"10.1016","volume":"95","author":[{"given":"Li","family":"Lei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan","family":"Xinliang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gong","family":"Ming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Xiaolong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yuyong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Zining","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Haiyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Hongjia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtherbio.2020.102817_bib1","first-page":"S7","article-title":"Recombinant activated factor VII: its mechanism of action and role in the control of hemorrhage","volume":"49","author":"Allen","year":"2002","journal-title":"Can. J. Anaesth."},{"key":"10.1016\/j.jtherbio.2020.102817_bib3","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.athoracsur.2006.06.072","article-title":"Thrombin during cardiopulmonary bypass","volume":"82","author":"Edmunds","year":"2006","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.jtherbio.2020.102817_bib4","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/ejcts\/ezx133","article-title":"Hypothermia and cerebral protection strategies in aortic arch surgery: a comparative effectiveness analysis from the STS Adult Cardiac Surgery Database","volume":"52","author":"Englum","year":"2017","journal-title":"Eur. J. Cardio. Thorac. Surg."},{"key":"10.1016\/j.jtherbio.2020.102817_bib6","article-title":"The hemostatic disturbance in patients with acute aortic dissection: a prospective observational study","volume":"95","author":"Guan","year":"2016","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.jtherbio.2020.102817_bib7","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.athoracsur.2015.08.047","article-title":"Changes in the hemostatic system of patients with acute aortic dissection undergoing aortic arch surgery","volume":"101","author":"Guan","year":"2016","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.jtherbio.2020.102817_bib8","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/01.moh.0000130314.33410.d7","article-title":"Thrombin generation assays: accruing clinical relevance","volume":"11","author":"Hemker","year":"2004","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.jtherbio.2020.102817_bib9","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1111\/j.1537-2995.2004.04144.x","article-title":"The independent association of massive blood loss with mortality in cardiac surgery","volume":"44","author":"Karkouti","year":"2004","journal-title":"Transfusion"},{"key":"10.1016\/j.jtherbio.2020.102817_bib12","first-page":"E1","article-title":"Near fatal hemorrhage in traumatic bilateral leg amputation with coagulopathy, acidosis, and hypothermia and salvage therapy with recombinant factor VIIa","volume":"63","author":"Korte","year":"2007","journal-title":"J. Trauma"},{"key":"10.1016\/j.jtherbio.2020.102817_bib13","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/00000542-200210000-00014","article-title":"Hemostatic activation and inflammatory response during cardiopulmonary bypass: impact of heparin management","volume":"97","author":"Koster","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jtherbio.2020.102817_bib14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13019-017-0613-5","article-title":"Consumption coagulopathy in acute aortic dissection: principles of management","volume":"12","author":"Liu","year":"2017","journal-title":"J. Cardiothorac. Surg."},{"key":"10.1016\/j.jtherbio.2020.102817_bib15","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1046\/j.1538-7836.2003.00298.x","article-title":"What is all that thrombin for?","volume":"1","author":"Mann","year":"2003","journal-title":"J THROMB HAEMOST"},{"key":"10.1016\/j.jtherbio.2020.102817_bib16","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0735-1097(02)02005-3","article-title":"Acute type A aortic dissection in the elderly: clinical characteristics, management, and outcomes in the current era","volume":"40","author":"Mehta","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jtherbio.2020.102817_bib17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/hc0202.102246","article-title":"Predicting death in patients with acute type a aortic dissection","volume":"105","author":"Mehta","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jtherbio.2020.102817_bib18","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/j.1537-2995.2010.02630.x","article-title":"The effect of plasma transfusion on morbidity and mortality: a systematic review and meta-analysis","volume":"50","author":"Murad","year":"2010","journal-title":"Transfusion"},{"key":"10.1016\/j.jtherbio.2020.102817_bib19","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1161\/CIRCULATIONAHA.107.698977","article-title":"Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery","volume":"116","author":"Murphy","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jtherbio.2020.102817_bib21","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.ejcts.2007.01.034","article-title":"Surgical and long-term mortality in 2634 consecutive patients operated on the proximal thoracic aorta","volume":"31","author":"Olsson","year":"2007","journal-title":"Eur. J. Cardio. Thorac. Surg."},{"key":"10.1016\/j.jtherbio.2020.102817_bib24","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1053\/jcan.2002.124140","article-title":"The antithrombin III-saving effect of reduced systemic heparinization and heparin-coated circuits","volume":"16","author":"Ranucci","year":"2002","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"10.1016\/j.jtherbio.2020.102817_bib26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.atherosclerosis.2005.06.031","article-title":"Preoperative antithrombin III activity predicts outcome after surgical repair of acute type A aortic dissection","volume":"186","author":"Sodeck","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jtherbio.2020.102817_bib27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jtcvs.2004.09.005","article-title":"Contemporary results of surgery in acute type A aortic dissection: the International Registry of Acute Aortic Dissection experience","volume":"129","author":"Trimarchi","year":"2005","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.jtherbio.2020.102817_bib28","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/bja\/aen175","article-title":"Effect of haemodilution, acidosis, and hypothermia on the activity of recombinant factor VIIa (NovoSeven)","volume":"101","author":"Viuff","year":"2008","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.jtherbio.2020.102817_bib30","first-page":"163","article-title":"Consensus on hypothermia in aortic arch surgery","volume":"2","author":"Yan","year":"2013","journal-title":"Ann. Cardiothorac. Surg."}],"updated-by":[{"DOI":"10.1016\/j.jtherbio.2021.102974","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000}}],"container-title":["Journal of Thermal Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645652030588X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645652030588X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:01:33Z","timestamp":1778745693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645652030588X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":21,"alternative-id":["S030645652030588X"],"URL":"https:\/\/doi.org\/10.1016\/j.jtherbio.2020.102817","relation":{},"ISSN":["0306-4565"],"issn-type":[{"value":"0306-4565","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changing of haemostatic system in a pig model during different types of hypothermic circulatory arrest","name":"articletitle","label":"Article Title"},{"value":"Journal of Thermal Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtherbio.2020.102817","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102817"}}