{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:24:00Z","timestamp":1761513840959,"version":"3.40.5"},"reference-count":34,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jto.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thoracic Oncology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jtho.2016.05.037","type":"journal-article","created":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T10:35:16Z","timestamp":1467455716000},"page":"1538-1549","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Patterns of Locoregional Relapses in Patients with Contemporarily Staged Stage III-N2 NSCLC Treated with Induction Chemotherapy and Resection: Implications for Postoperative Radiotherapy Target Volumes"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8483-850X","authenticated-orcid":false,"given":"Charlotte","family":"Billiet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"De Ruysscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Decaluw\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Vansteenkiste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Dooms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe M.","family":"Deroose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"De Leyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Hendrikx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Bulens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Le P\u00e9choux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Mebis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtho.2016.05.037_bib1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jtho.2016.05.037_bib2","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1200\/JCO.2015.62.6812","article-title":"Phase III study of surgery versus definitive concurrent chemoradiotherapy boost in patients with resectable stage IIIA(N2) and selected IIIB non\u2013small-cell lung cancer after\u00a0induction chemotherapy and concurrent chemoradiotherapy (ESPATUE)","volume":"33","author":"Eberhardt","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jtho.2016.05.037_bib3","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0140-6736(15)60294-X","article-title":"Induction chemoradiation in stage IIIA\/N2 non-small-cell lung cancer: a phase 3 randomised trial","volume":"386","author":"Pless","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jtho.2016.05.037_bib4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3816\/CLC.2009.n.027","volume":"10","author":"Vokes","year":"2009","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.jtho.2016.05.037_bib5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1470-2045(14)71207-0","volume":"16","author":"Bradley","year":"2015","journal-title":"Lancet Oncol"},{"issue":"suppl 6","key":"10.1016\/j.jtho.2016.05.037_bib6","doi-asserted-by":"crossref","first-page":"vi89","DOI":"10.1093\/annonc\/mdt241","article-title":"Early and locally advanced non-small cell lung cancer (NSCLC): ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"24","author":"Vansteenkiste","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jtho.2016.05.037_bib7","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/sj.bjc.6603075","article-title":"Prognostic factors affecting long-term outcomes in patients with resected stage IIIA PN2 non-small-cell lung cancer: 5-year follow-up of a phase II study","volume":"94","author":"Betticher","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jtho.2016.05.037_bib8","doi-asserted-by":"crossref","first-page":"110S","DOI":"10.1378\/chest.117.4_suppl_1.110S","article-title":"Postoperative adjuvant therapy for patients\u00a0with resected non-small-cell lung cancer: still\u00a0controversial after all these years","volume":"117","author":"Wagner","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.jtho.2016.05.037_bib9","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.ijrobp.2008.01.044","volume":"72","author":"Douillard","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jtho.2016.05.037_bib10","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1200\/JCO.2014.58.5380","article-title":"Postoperative radiotherapy for pathologic N2 non-small-cell lung cancer\u00a0treated with adjuvant chemotherapy: a review of\u00a0the National Cancer Data Base","volume":"33","author":"Robinson","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jtho.2016.05.037_bib11","first-page":"CD002142","article-title":"Postoperative radiotherapy for non-small cell lung cancer","volume":"18","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jtho.2016.05.037_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.radonc.2013.08.011","article-title":"Modern post-operative radiotherapy for stage III non-small cell lung cancer may improve local control and survival: a meta-analysis","volume":"110","author":"Billiet","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.jtho.2016.05.037_bib13","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.radonc.2014.11.019","article-title":"Erratum: Modern post-operative radiotherapy for stage III non-small cell lung cancer may improve local control and survival:\u00a0a meta-analysis","volume":"113","author":"Billiet","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.jtho.2016.05.037_bib14","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.radonc.2010.09.020","article-title":"Cardiopulmonary morbidity and quality of life in non-small cell lung cancer patients treated with or without postoperative radiotherapy","volume":"98","author":"Kepka","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.jtho.2016.05.037_bib15","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/ejcts\/ezu028","article-title":"Revised ESTS guidelines for preoperative mediastinal lymph node staging for non-small-cell lung cancer","volume":"45","author":"De Leyn","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jtho.2016.05.037_bib16","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1200\/JCO.2007.13.9030","article-title":"Lung adjuvant cisplatin evaluation: a pooled analysis by the\u00a0LACE Collaborative Group","volume":"26","author":"Pignon","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jtho.2016.05.037_bib17","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/JTO.0b013e31812f3c1a","article-title":"The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours","volume":"2","author":"Goldstraw","year":"2007","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.jtho.2016.05.037_bib18","doi-asserted-by":"crossref","first-page":"879","DOI":"10.7326\/0003-4819-139-11-200311180-00013","article-title":"Test performance of positron emission tomography and computed tomography for mediastinal staging in patients with non-small-cell lung cancer: a meta- analysis","volume":"139","author":"Gould","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtho.2016.05.037_bib19","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ejcts.2006.08.008","article-title":"ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer","volume":"30","author":"Lardinois","year":"2006","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jtho.2016.05.037_bib20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.lungcan.2005.01.001","article-title":"Complete resection in lung cancer surgery: proposed definition","volume":"49","author":"Rami-Porta","year":"2005","journal-title":"Lung Cancer"},{"key":"10.1016\/j.jtho.2016.05.037_bib21","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/JTO.0b013e3181a0d82e","article-title":"The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition\u00a0of the TNM classification for lung cancer","volume":"4","author":"Rusch","year":"2009","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.jtho.2016.05.037_bib22","first-page":"19","article-title":"Rationale for extended lymphadenectomy for lung cancer","volume":"5","author":"Hata","year":"1990","journal-title":"Theor Surg"},{"key":"10.1016\/j.jtho.2016.05.037_bib23","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S1278-3218(01)00135-4","article-title":"Estimation of the probability of mediastinal involvement: a statistical definition of the clinical target volume for 3-dimensional conformal radiotherapy in non-small-cell lung cancer?","volume":"5","author":"Giraud","year":"2001","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.jtho.2016.05.037_bib24","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0003-4975(00)01673-8","article-title":"Mediastinal lymph node dissection improves survival in patients with stages II and IIIa non-small cell lung cancer","volume":"70","author":"Keller","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtho.2016.05.037_bib25","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.ijrobp.2006.02.007","article-title":"Patterns of failure after resection of non-small-cell lung cancer: implications for postoperative radiation therapy volumes","volume":"65","author":"Kelsey","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jtho.2016.05.037_bib26","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.ijrobp.2013.12.048","article-title":"Patterns of local-regional failure in completely resected stage IIIA(N2) non-small\u00a0cell lung cancer cases: implications for postoperative radiation therapy clinical target volume design","volume":"88","author":"Feng","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jtho.2016.05.037_bib27","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1164\/rccm.201209-1651OC","article-title":"Characteristics of lung cancers detected by computer tomography screening in the randomized NELSON trial","volume":"187","author":"Horeweg","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtho.2016.05.037_bib28","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.ijrobp.2011.07.018","article-title":"Local failure in resected N1 lung cancer: implications for adjuvant therapy","volume":"83","author":"Higgins","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jtho.2016.05.037_bib29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0169-5002(01)00207-0","article-title":"Overall survival and\u00a0local recurrence of 406 completely resected stage IIIa-N2 non-small cell lung cancer patients: questionnaire survey of the Japan Clinical Oncology Group\u00a0to plan for clinical trials","volume":"34","author":"Ichinose","year":"2001","journal-title":"Lung Cancer"},{"key":"10.1016\/j.jtho.2016.05.037_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0167-8140(01)00478-9","article-title":"Adjuvant radiotherapy in non-small cell lung cancer with pathological stage I: Definitive results of a phase III randomized trial","volume":"62","author":"Trodella","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.jtho.2016.05.037_bib31","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ijrobp.2014.12.028","article-title":"Nodal stage of surgically resected non-small cell lung cancer and its effect on recurrence patterns and overall survival","volume":"91","author":"Varlotto","year":"2015","journal-title":"Int\u00a0J\u00a0Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jtho.2016.05.037_bib32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.radonc.2013.05.023","article-title":"Target volume for postoperative radiotherapy in non-small cell lung cancer: results from a prospective trial","volume":"108","author":"Kepka","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.jtho.2016.05.037_bib33","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.ijrobp.2009.02.072","article-title":"Variations in target volume definition for postoperative radiotherapy in stage III non- small-cell lung cancer: analysis of an international contouring study","volume":"76","author":"Spoelstra","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jtho.2016.05.037_bib34","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1200\/JCO.2006.09.6263","article-title":"Need for a new trial to evaluate adjuvant postoperative radiotherapy in non-small- cell lung cancer patients with N2\u00a0mediastinal involvement","volume":"25","author":"Le P\u00e9choux","year":"2007","journal-title":"J\u00a0Clin Oncol"}],"container-title":["Journal of Thoracic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556086416305895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556086416305895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T16:00:58Z","timestamp":1536595258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1556086416305895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S1556086416305895"],"URL":"https:\/\/doi.org\/10.1016\/j.jtho.2016.05.037","relation":{},"ISSN":["1556-0864"],"issn-type":[{"type":"print","value":"1556-0864"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patterns of Locoregional Relapses in Patients with Contemporarily Staged Stage III-N2 NSCLC Treated with Induction Chemotherapy and Resection: Implications for Postoperative Radiotherapy Target Volumes","name":"articletitle","label":"Article Title"},{"value":"Journal of Thoracic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtho.2016.05.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}