{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:49:24Z","timestamp":1790279364455,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["IG 2021"],"award-info":[{"award-number":["IG 2021"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["25987"],"award-info":[{"award-number":["25987"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002555","name":"Aircast Foundation","doi-asserted-by":"publisher","award":["IG 2019"],"award-info":[{"award-number":["IG 2019"]}],"id":[{"id":"10.13039\/100002555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002555","name":"Aircast Foundation","doi-asserted-by":"publisher","award":["23244"],"award-info":[{"award-number":["23244"]}],"id":[{"id":"10.13039\/100002555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Airc Italian Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014835","name":"Istituto Nazionale Tumori IRCCS &quot;Fondazione G. Pascale&quot;","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jto.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thoracic Oncology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jtho.2022.07.007","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T11:54:58Z","timestamp":1659009298000},"page":"1276-1286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Cytisine Therapy Improved Smoking Cessation in\u00a0the Randomized Screening and Multiple Intervention on Lung Epidemics Lung Cancer Screening Trial"],"prefix":"10.1016","volume":"17","author":[{"given":"Ugo","family":"Pastorino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Ladisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Trussardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Sabia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Rolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Valsecchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta E.","family":"Ledda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Milanese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Suatoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Boeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Sozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Marchian\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Munarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Boffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvano","family":"Gallus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Apolone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtho.2022.07.007_bib1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ejca.2018.07.005","article-title":"Cancer incidence and mortality patterns in Europe: estimates for 40 countries and 25 major cancers in 2018","volume":"103","author":"Ferlay","year":"2018","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jtho.2022.07.007_bib2","first-page":"7","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jtho.2022.07.007_bib4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"Reduced lung-cancer mortality with low-dose computed tomographic screening","volume":"365","author":"Aberle","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtho.2022.07.007_bib5","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1911793","article-title":"Reduced lung-cancer mortality with volume CT screening in a randomized trial","volume":"382","author":"de Koning","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtho.2022.07.007_bib6","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1093\/annonc\/mdz117","article-title":"Prolonged lung cancer screening reduced 10-year mortality in the MILD trial: new confirmation of lung cancer screening efficacy","volume":"30","author":"Pastorino","year":"2019","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jtho.2022.07.007_bib7","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1016\/j.amepre.2015.04.004","article-title":"Smoking and all-cause mortality in older adults: results from the CHANCES consortium","volume":"49","author":"M\u00fcezzinler","year":"2015","journal-title":"Am J Prev Med"},{"key":"10.1016\/j.jtho.2022.07.007_bib8","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/j.jtho.2019.05.044","article-title":"Lung cancer incidence and mortality with extended follow-up in the national lung screening trial","volume":"14","year":"2019","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.jtho.2022.07.007_bib9","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJMsa1211127","article-title":"50-year trends in smoking-related mortality in the United States","volume":"368","author":"Thun","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtho.2022.07.007_bib10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1056\/NEJMra1308383","article-title":"Global effects of smoking, of quitting, and of taxing tobacco","volume":"370","author":"Jha","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtho.2022.07.007_bib11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jtho.2021.12.005","article-title":"Quitting smoking at or around diagnosis improves the overall survival of lung cancer patients: a systematic review and meta-analysis","volume":"17","author":"Caini","year":"2022","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.jtho.2022.07.007_bib12","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jtho.2016.02.011","article-title":"Stopping smoking reduces mortality in low-dose computed tomography screening participants","volume":"11","author":"Pastorino","year":"2016","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.jtho.2022.07.007_bib13","first-page":"CD008286","article-title":"Combined pharmacotherapy and behavioural interventions for smoking cessation","volume":"3","author":"Stead","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jtho.2022.07.007_bib14","series-title":"Treating Tobacco Use and Dependence: 2008 Update","year":"2008"},{"key":"10.1016\/j.jtho.2022.07.007_bib16","first-page":"13","article-title":"Treatment of nicotinism with the Bulgarian drug, tabex","volume":"2","author":"Stoyanov","year":"1965","journal-title":"Chimpharm Sofia"},{"key":"10.1016\/j.jtho.2022.07.007_bib17","doi-asserted-by":"crossref","first-page":"f5198","DOI":"10.1136\/bmj.f5198","article-title":"Cytisine, the world\u2019s oldest smoking cessation aid","volume":"347","author":"Prochaska","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.jtho.2022.07.007_bib18","first-page":"2016","article-title":"Nicotine receptor partial agonists for smoking cessation","volume":"2016","author":"Cahill","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jtho.2022.07.007_bib19","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1111\/add.14721","article-title":"Cytisine for nicotine addiction treatment: a review of pharmacology, therapeutics and an update of clinical trial evidence for smoking cessation","volume":"114","author":"Tutka","year":"2019","journal-title":"Addiction"},{"key":"10.1016\/j.jtho.2022.07.007_bib20","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1056\/NEJMoa1407764","article-title":"Cytisine versus nicotine for smoking cessation","volume":"371","author":"Walker","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtho.2022.07.007_bib22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1360-0443.2004.00995.x","article-title":"Outcome criteria in smoking cessation trials: proposal for a common standard","volume":"100","author":"West","year":"2005","journal-title":"Addiction"},{"key":"10.1016\/j.jtho.2022.07.007_bib23","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/ntr\/ntz132","article-title":"Biochemical verification of tobacco use and abstinence: 2019 update","volume":"22","author":"Benowitz","year":"2020","journal-title":"Nicotine Tob Res"},{"key":"10.1016\/j.jtho.2022.07.007_bib26","first-page":"777","article-title":"Cytisine for the treatment of nicotine addiction: from molecule to therapeutic efficacy","volume":"58","author":"Tutka","year":"2006","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.jtho.2022.07.007_bib27","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1021\/jm050069n","article-title":"Varenicline: an\u00a0alpha4beta2 nicotinic receptor partial agonist for\u00a0smoking cessation","volume":"48","author":"Coe","year":"2005","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.jtho.2022.07.007_bib29","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.drugpo.2018.05.012","article-title":"The effectiveness of cytisine versus Nicotine Replacement Treatment for smoking cessation in the Russian Federation","volume":"58","author":"Castaldelli-Maia","year":"2018","journal-title":"Int J Drug Policy"},{"key":"10.1016\/j.jtho.2022.07.007_bib30","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1136\/thoraxjnl-2013-203246","article-title":"Cytisine and the failure to market and regulate for human health","volume":"68","author":"Aveyard","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.jtho.2022.07.007_bib32","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/add.13464","article-title":"Getting cytisine licensed for use world-wide: a call to action","volume":"111","author":"Walker","year":"2016","journal-title":"Addiction"},{"key":"10.1016\/j.jtho.2022.07.007_bib33","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1093\/ntr\/ntab073","article-title":"A\u00a0multicenter, double-blind, randomized, placebo-controlled phase 2b trial of cytisinicline in adult smokers (The ORCA-1 Trial)","volume":"23","author":"Nides","year":"2021","journal-title":"Nicotine Tob Res"},{"key":"10.1016\/j.jtho.2022.07.007_bib34","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1056\/NEJMoa1102035","article-title":"Placebo-controlled trial of cytisine for smoking cessation","volume":"365","author":"West","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtho.2022.07.007_bib35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1375\/jsc.3.1.57","article-title":"A\u00a0double-blind randomised placebo-controlled trial of cytisine for smoking cessation in medium-dependent workers","volume":"3","author":"Vinnikov","year":"2008","journal-title":"J\u00a0Smok Cess"},{"key":"10.1016\/j.jtho.2022.07.007_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta18330","article-title":"What is the clinical effectiveness and cost-effectiveness of cytisine compared with varenicline for smoking cessation? A systematic review and economic evaluation","volume":"18","author":"Leaviss","year":"2014","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.jtho.2022.07.007_bib37","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1001\/jama.2021.7621","article-title":"Effect of cytisine vs varenicline on smoking cessation: a randomized clinical trial","volume":"326","author":"Courtney","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jtho.2022.07.007_bib38","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1111\/add.15489","article-title":"Cytisine versus varenicline for smoking cessation in New Zealand indigenous M\u0101ori: a randomized controlled trial","volume":"116","author":"Walker","year":"2021","journal-title":"Addiction"},{"key":"10.1016\/j.jtho.2022.07.007_bib39","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1001\/archinte.167.16.1791","article-title":"A\u00a0double-blind, placebo-controlled, randomized trial of bupropion for smoking cessation in primary care","volume":"167","author":"Fossati","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jtho.2022.07.007_bib40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ypmed.2019.02.016","article-title":"Combining smoking cessation interventions with LDCT lung cancer screening: a systematic review","volume":"121","author":"Iaccarino","year":"2019","journal-title":"Prev Med"},{"key":"10.1016\/j.jtho.2022.07.007_bib41","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.chest.2021.02.072","article-title":"Feasibility and safety of lung cancer screening and prevention program during the COVID-19 pandemic","volume":"160","author":"Milanese","year":"2021","journal-title":"Chest"}],"container-title":["Journal of Thoracic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155608642200346X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155608642200346X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:27:13Z","timestamp":1778819233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S155608642200346X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S155608642200346X"],"URL":"https:\/\/doi.org\/10.1016\/j.jtho.2022.07.007","relation":{},"ISSN":["1556-0864"],"issn-type":[{"value":"1556-0864","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytisine Therapy Improved Smoking Cessation in\u00a0the Randomized Screening and Multiple Intervention on Lung Epidemics Lung Cancer Screening Trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Thoracic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtho.2022.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Association for the Study of Lung Cancer. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}