{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:09:43Z","timestamp":1782504583963,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jto.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thoracic Oncology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jtho.2025.10.008","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:28:12Z","timestamp":1761121692000},"page":"103501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Genomic Landscape of NSCLC in Systemic Sclerosis Reveals Frequent TP53 Mutations and a Paucity of Actionable Oncogenes"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8073-8803","authenticated-orcid":false,"given":"Igor","family":"Odintsov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M.","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biagio","family":"Ricciuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Pecci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M.","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Dellaripa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette M.","family":"Sholl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtho.2025.10.008_bib1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s12016-021-08889-8","article-title":"Current concepts on the pathogenesis of systemic sclerosis","volume":"64","author":"Truchetet","year":"2023","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jtho.2025.10.008_bib2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S2213-2600(19)30480-1","article-title":"Systemic sclerosis-associated interstitial lung disease","volume":"8","author":"Perelas","year":"2020","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jtho.2025.10.008_bib3","first-page":"121","article-title":"The major histopathologic pattern of pulmonary fibrosis in scleroderma is nonspecific interstitial pneumonia","volume":"19","author":"Kim","year":"2002","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"10.1016\/j.jtho.2025.10.008_bib4","first-page":"1136","article-title":"Incidence of lung cancer in systemic sclerosis","volume":"12","author":"Peters-Golden","year":"1985","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jtho.2025.10.008_bib5","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1093\/rheumatology\/keae433","article-title":"Systemic sclerosis and cancer in the UK: an epidemiological analysis using the clinical practice research datalink","volume":"64","author":"Pauling","year":"2025","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jtho.2025.10.008_bib6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3109\/03009742.2011.618145","article-title":"Cancer risk among patients with systemic sclerosis: a nationwide population study in Taiwan","volume":"41","author":"Kuo","year":"2012","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.jtho.2025.10.008_bib7","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/1097-0142(19950901)76:5<910::AID-CNCR2820760528>3.0.CO;2-T","article-title":"Incidence of cancer among patients with systemic sclerosis","volume":"76","author":"Rosenthal","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.jtho.2025.10.008_bib8","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1136\/ard.62.8.728","article-title":"Risk of cancer in patients with scleroderma: a population based cohort study","volume":"62","author":"Hill","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jtho.2025.10.008_bib9","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/mr\/roae084","article-title":"Incidence of and predictive factors for lung cancer in patients with rheumatoid arthritis: a retrospective long-term follow-up study","volume":"35","author":"Mori","year":"2025","journal-title":"Mod Rheumatol"},{"key":"10.1016\/j.jtho.2025.10.008_bib10","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.21037\/jtd-20-2462","article-title":"Association between systemic lupus erythematosus and lung cancer: results from a pool of cohort studies and Mendelian randomization analysis","volume":"12","author":"Peng","year":"2020","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.jtho.2025.10.008_bib11","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1136\/annrheumdis-2013-203305","article-title":"Primary Sjogren\u2019s syndrome and malignancy risk: a systematic review and meta-analysis","volume":"73","author":"Liang","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jtho.2025.10.008_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/2397198318766825","article-title":"Interstitial lung disease is associated with an increased risk of lung cancer in systemic sclerosis: longitudinal data from the Canadian Scleroderma Research Group","volume":"3","author":"Sakr","year":"2018","journal-title":"J Scleroderma Relat Disord"},{"key":"10.1016\/j.jtho.2025.10.008_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djw295","article-title":"Proportion of never-smoker non-small cell lung cancer patients at three diverse institutions","volume":"109","author":"Pelosof","year":"2017","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jtho.2025.10.008_bib14","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1001\/jamaoncol.2020.6362","article-title":"Proportion of never smokers among men and women with lung cancer in 7 US states","volume":"7","author":"Siegel","year":"2021","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jtho.2025.10.008_bib15","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature13385","article-title":"Comprehensive molecular profiling of lung adenocarcinoma","volume":"511","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jtho.2025.10.008_bib16","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2012.08.024","article-title":"Genomic landscape of non-small cell lung cancer in smokers and never-smokers","volume":"150","author":"Govindan","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jtho.2025.10.008_bib17","doi-asserted-by":"crossref","first-page":"e1S","DOI":"10.1378\/chest.12-2345","article-title":"Epidemiology of lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"143","author":"Alberg","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.jtho.2025.10.008_bib18","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.ejca.2012.03.007","article-title":"Lung cancer in never smokers--a review","volume":"48","author":"Couraud","year":"2012","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jtho.2025.10.008_bib19","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.87062","article-title":"Institutional implementation of clinical tumor profiling on an unselected cancer population","volume":"1","author":"Sholl","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.jtho.2025.10.008_bib20","doi-asserted-by":"crossref","first-page":"751","DOI":"10.5858\/arpa.2016-0527-OA","article-title":"Validation of OncoPanel: a targeted next-generation sequencing assay for the detection of somatic variants in cancer","volume":"141","author":"Garcia","year":"2017","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jtho.2025.10.008_bib21","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/s41379-022-01083-x","article-title":"Deriving tumor purity from cancer next generation sequencing data: applications for quantitative ERBB2 (HER2) copy number analysis and germline inference of BRCA1 and BRCA2 mutations","volume":"35","author":"Siegmund","year":"2022","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jtho.2025.10.008_bib22","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jtho.2025.10.008_bib23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.lungcan.2012.09.018","article-title":"Frequency of well-identified oncogenic driver mutations in lung adenocarcinoma of smokers varies with histological subtypes and graduated smoking dose","volume":"79","author":"Li","year":"2013","journal-title":"Lung Cancer"},{"key":"10.1016\/j.jtho.2025.10.008_bib24","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.3389\/fimmu.2018.03112","article-title":"Intriguing relationships between cancer and systemic sclerosis: role of the immune system and other contributors","volume":"9","author":"Maria","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtho.2025.10.008_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0306995","article-title":"Pre-existing autoimmune disease as a risk factor for immune-related adverse events in cancer patients receiving immune checkpoint inhibitors","volume":"19","author":"Sumimoto","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.jtho.2025.10.008_bib26","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.chest.2021.12.656","article-title":"Clinical outcomes of immune checkpoint inhibitor therapy in patients with advanced non-small cell lung cancer and preexisting interstitial lung diseases: a systematic review and meta-analysis","volume":"161","author":"Zhang","year":"2022","journal-title":"Chest"},{"key":"10.1016\/j.jtho.2025.10.008_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejca.2024.114148","article-title":"A systematic review and meta-analysis of observational studies and uncontrolled trials reporting on the use of checkpoint blockers in patients with cancer and pre-existing autoimmune disease","volume":"207","author":"Lopez-Olivo","year":"2024","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jtho.2025.10.008_bib28","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1038\/s41388-018-0245-9","article-title":"APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer","volume":"37","author":"Wang","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.jtho.2025.10.008_bib29","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41586-022-04972-y","article-title":"Mechanisms of APOBEC3 mutagenesis in human cancer cells","volume":"607","author":"Petljak","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jtho.2025.10.008_bib30","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.4049\/jimmunol.1501504","article-title":"APOBEC3 proteins in viral immunity","volume":"195","author":"Stavrou","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jtho.2025.10.008_bib31","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.4049\/jimmunol.1201184","article-title":"IFN-\u03b1 induces APOBEC3G, F, and A in immature dendritic cells and limits HIV-1 spread to CD4+ T cells","volume":"190","author":"Mohanram","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.jtho.2025.10.008_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2018.12.018","article-title":"Type I interferon dysregulation in Systemic Sclerosis","volume":"132","author":"Skaug","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.jtho.2025.10.008_bib33","doi-asserted-by":"crossref","first-page":"7893","DOI":"10.1038\/s41598-021-87024-1","article-title":"Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus","volume":"11","author":"Perez-Bercoff","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtho.2025.10.008_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2020.108649","article-title":"Expression of APOBEC family members as regulators of endogenous retroelements and malignant transformation in systemic autoimmunity","volume":"223","author":"Mavragani","year":"2021","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jtho.2025.10.008_bib35","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41568-023-00658-3","article-title":"Translating p53-based therapies for cancer into the clinic","volume":"24","author":"Peuget","year":"2024","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jtho.2025.10.008_bib36","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nrgastro.2017.1","article-title":"Clonal evolution of colorectal cancer in IBD","volume":"14","author":"Choi","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jtho.2025.10.008_bib37","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.cell.2020.06.036","article-title":"Somatic evolution in non-neoplastic IBD-affected colon","volume":"182","author":"Olafsson","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jtho.2025.10.008_bib38","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1038\/s41467-025-59923-8","article-title":"APOBEC affects tumor evolution and age at onset of lung cancer in smokers","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.jtho.2025.10.008_bib39","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1053\/j.gastro.2012.07.009","article-title":"Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation","volume":"143","author":"Chiba","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtho.2025.10.008_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.768098","article-title":"Cancer Evo-Dev: a theory of inflammation-induced oncogenesis","volume":"12","author":"Liu","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtho.2025.10.008_bib41","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1093\/rheumatology\/keab190","article-title":"Incidence and prevalence of systemic sclerosis globally: a comprehensive systematic review and meta-analysis","volume":"60","author":"Bairkdar","year":"2021","journal-title":"Rheumatology (Oxford)"}],"container-title":["Journal of Thoracic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556086425028552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556086425028552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:28:00Z","timestamp":1778819280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1556086425028552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1556086425028552"],"URL":"https:\/\/doi.org\/10.1016\/j.jtho.2025.10.008","relation":{},"ISSN":["1556-0864"],"issn-type":[{"value":"1556-0864","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Genomic Landscape of NSCLC in Systemic Sclerosis Reveals Frequent TP53 Mutations and a Paucity of Actionable Oncogenes","name":"articletitle","label":"Article Title"},{"value":"Journal of Thoracic Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtho.2025.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103501"}}