{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:34:39Z","timestamp":1781249679151,"version":"3.54.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["jtocrr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JTO Clinical and Research Reports"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jtocrr.2025.100804","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:16:38Z","timestamp":1739319398000},"page":"100804","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trends in Mesothelioma Mortality in the United States Between 1999 and 2020"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7870-2964","authenticated-orcid":false,"given":"Alexander J.","family":"Didier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinesh","family":"Gheeya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asrar","family":"Alahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regan","family":"Memmott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Shields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Presley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan","family":"Roof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtocrr.2025.100804_bib1","first-page":"32","article-title":"Peritoneal mesothelioma: a review","volume":"9","author":"Bridda","year":"2007","journal-title":"MedGenMed"},{"key":"10.1016\/j.jtocrr.2025.100804_bib2","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.jtho.2023.01.095","article-title":"Global incidence, risk factors, and temporal trends of mesothelioma: a population-based study","volume":"18","author":"Huang","year":"2023","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.jtocrr.2025.100804_bib4","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1200\/JCO.21.01567","article-title":"New Era for malignant pleural mesothelioma: updates on therapeutic options","volume":"40","author":"Tsao","year":"2022","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jtocrr.2025.100804_bib5","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1007\/s00268-019-05132-6","article-title":"Largely unchanged annual incidence and overall survival of pleural mesothelioma in the USA","volume":"43","author":"Keshava","year":"2019","journal-title":"World J Surg"},{"key":"10.1016\/j.jtocrr.2025.100804_bib7","doi-asserted-by":"crossref","first-page":"645","DOI":"10.15585\/mmwr.mm7119a1","article-title":"Malignant mesothelioma mortality in women - United States, 1999\u20132020","volume":"71","author":"Mazurek","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jtocrr.2025.100804_bib8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.15585\/mmwr.mm6608a3","article-title":"Malignant mesothelioma mortality - United States, 1999\u20132015","volume":"66","author":"Mazurek","year":"2017","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jtocrr.2025.100804_bib9","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1186\/s12885-024-12426-z","article-title":"Patterns and trends in melanoma mortality in the United States, 1999\u20132020","volume":"24","author":"Didier","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jtocrr.2025.100804_bib10","doi-asserted-by":"crossref","DOI":"10.6004\/jnccn.2024.7004","article-title":"Demographic disparities in lung cancer mortality and trends in the United States from 1999 through 2020: a population-based CDC database analysis","volume":"22","author":"Didier","year":"2024","journal-title":"J Natl Compr Canc Netw"},{"issue":"154","key":"10.1016\/j.jtocrr.2025.100804_bib11","first-page":"1","article-title":"NCHS urban-rural classification scheme for counties","volume":"2","author":"Ingram","year":"2012","journal-title":"Vital Health Stat"},{"key":"10.1016\/j.jtocrr.2025.100804_bib12","first-page":"1","article-title":"Age standardization of death rates: implementation of the year 2000 standard","volume":"47","author":"Anderson","year":"1998","journal-title":"Natl Vital Stat Rep"},{"key":"10.1016\/j.jtocrr.2025.100804_bib13","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z","article-title":"Permutation tests for joinpoint regression with applications to cancer rates","volume":"19","author":"Kim","year":"2000","journal-title":"Stat Med"},{"key":"10.1016\/j.jtocrr.2025.100804_bib14","first-page":"348","article-title":"Interrupted time series regression for the evaluation of public health interventions: a tutorial","volume":"46","author":"Bernal","year":"2017","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jtocrr.2025.100804_bib15","article-title":"Malignant pleural mesothelioma epidemiology in the United States from 2000 to 2016","volume":"13","author":"Thomas","year":"2021","journal-title":"Cureus"},{"key":"10.1016\/j.jtocrr.2025.100804_bib16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/ajim.23062","article-title":"Workshop summary: potential usefulness and feasibility of a US National Mesothelioma Registry","volume":"63","author":"Cummings","year":"2020","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.jtocrr.2025.100804_bib17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/ajim.23069","article-title":"An overview of existing mesothelioma registries worldwide, and the need for a US Registry","volume":"63","author":"van Gerwen","year":"2020","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.jtocrr.2025.100804_bib18","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1158\/2159-8290.CD-19-1220","article-title":"Biological mechanisms and clinical significance of BAP1 mutations in human cancer","volume":"10","author":"Carbone","year":"2020","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jtocrr.2025.100804_bib19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/carcin\/bgu227","article-title":"Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival","volume":"36","author":"Baumann","year":"2015","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jtocrr.2025.100804_bib20","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2018.79.0352","article-title":"A subset of mesotheliomas with improved survival occurring in carriers of BAP1 and other germline mutations","volume":"36","author":"Pastorino","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jtocrr.2025.100804_bib21","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s10552-009-9328-9","article-title":"Pleural and peritoneal mesotheliomas in SEER: age effects and temporal trends, 1973\u20132005","volume":"20","author":"Moolgavkar","year":"2009","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.jtocrr.2025.100804_bib22","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0140-6736(20)32714-8","article-title":"First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial","volume":"397","author":"Baas","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jtocrr.2025.100804_bib23","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1055\/s-0035-1549449","article-title":"Asbestos-related lung cancer and malignant mesothelioma of the pleura: selected current issues","volume":"36","author":"Markowitz","year":"2015","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.jtocrr.2025.100804_bib24","first-page":"208","article-title":"The history of OSHA\u2019s asbestos rule makings and some distinctive approaches that they introduced for regulating occupational exposure to toxic substances","volume":"62","author":"Martonik","year":"2001","journal-title":"AIHAJ"},{"key":"10.1016\/j.jtocrr.2025.100804_bib25","unstructured":"McDonald L. Economy begins to rebound as the US expands efforts to strengthen domestic critical mineral supply chains. 2022, Am Ceramic SOC 600 N Cleveland Ave, Westerville, OH 43082 USA:31\u201331."},{"key":"10.1016\/j.jtocrr.2025.100804_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5334\/aogh.4012","article-title":"Asbestos consumption and malignant mesothelioma mortality trends in the major user countries","volume":"89","author":"Gariazzo","year":"2023","journal-title":"Ann Glob Health"},{"key":"10.1016\/j.jtocrr.2025.100804_bib27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3322\/caac.21572","article-title":"Mesothelioma: scientific clues for prevention, diagnosis, and therapy","volume":"69","author":"Carbone","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jtocrr.2025.100804_bib28","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1179\/oeh.2007.13.4.398","article-title":"Incidence and descriptive epidemiology of mesothelioma in the United States, 1999\u20132002","volume":"13","author":"Larson","year":"2007","journal-title":"Int J Occup Environ Health"},{"key":"10.1016\/j.jtocrr.2025.100804_bib29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.thorsurg.2020.08.002","article-title":"Taken together: effective multimodal approaches for malignant pleural mesothelioma","volume":"30","author":"Song","year":"2020","journal-title":"Thorac Surg Clin"},{"key":"10.1016\/j.jtocrr.2025.100804_bib30","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/risa.12887","article-title":"Ambient asbestos fiber concentrations and long-term trends in pleural mesothelioma incidence between urban and rural areas in the United States (1973\u20132012)","volume":"38","author":"Glynn","year":"2018","journal-title":"Risk Anal"},{"key":"10.1016\/j.jtocrr.2025.100804_bib31","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3109\/08958378.2015.1118172","article-title":"Historical ambient airborne asbestos concentrations in the United States - an analysis of published and unpublished literature (1960s-2000s)","volume":"27","author":"Abelmann","year":"2015","journal-title":"Inhal Toxicol"},{"key":"10.1016\/j.jtocrr.2025.100804_bib32","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.healthplace.2018.08.010","article-title":"Rural dwellers are less likely to survive cancer - an international review and meta-analysis","volume":"53","author":"Carriere","year":"2018","journal-title":"Health Place"},{"key":"10.1016\/j.jtocrr.2025.100804_bib33","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/cam4.4917","article-title":"Racial inequity and other social disparities in the diagnosis and management of bladder cancer","volume":"12","author":"Hasan","year":"2023","journal-title":"Cancer Med"},{"key":"10.1016\/j.jtocrr.2025.100804_bib34","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/JTO.0b013e31819f2e0e","article-title":"Screening for malignant pleural mesothelioma and lung cancer in individuals with a history of asbestos exposure","volume":"4","author":"Roberts","year":"2009","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.jtocrr.2025.100804_bib35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1183\/09031936.00073606","article-title":"Chest CT screening of asbestos-exposed workers: lung lesions and incidental findings","volume":"29","author":"Vierikko","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jtocrr.2025.100804_bib36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1148\/rg.241035058","article-title":"Malignant pleural mesothelioma: evaluation with CT, MR imaging, and PET","volume":"24","author":"Wang","year":"2004","journal-title":"RadioGraphics"},{"key":"10.1016\/j.jtocrr.2025.100804_bib37","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1148\/radiol.2331031133","article-title":"Asbestos-related pleuropulmonary diseases: evaluation with low-dose four-detector row spiral CT","volume":"233","author":"Remy-Jardin","year":"2004","journal-title":"Radiology"}],"container-title":["JTO Clinical and Research Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666364325000207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666364325000207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T02:10:13Z","timestamp":1747102213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666364325000207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2666364325000207"],"URL":"https:\/\/doi.org\/10.1016\/j.jtocrr.2025.100804","relation":{},"ISSN":["2666-3643"],"issn-type":[{"value":"2666-3643","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trends in Mesothelioma Mortality in the United States Between 1999 and 2020","name":"articletitle","label":"Article Title"},{"value":"JTO Clinical and Research Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtocrr.2025.100804","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the International Association for the Study of Lung Cancer.","name":"copyright","label":"Copyright"}],"article-number":"100804"}}