{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:36:59Z","timestamp":1790743019990,"version":"4.1.0"},"reference-count":284,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.jtos.2014.01.004","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T01:15:36Z","timestamp":1397610936000},"page":"178-201","source":"Crossref","is-referenced-by-count":64,"title":["Interfacial Phenomena and the Ocular Surface"],"prefix":"10.1016","volume":"12","author":[{"given":"Bernardo","family":"Ya\u00f1ez-Soto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Mannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan R.","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas L.","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2014.01.004_bib1","doi-asserted-by":"crossref","unstructured":"Berg JC. An Introduction to Interfaces & Colloids. The Bridge to Nanosciences: World Scientific, 2010","DOI":"10.1142\/7579"},{"key":"10.1016\/j.jtos.2014.01.004_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0039-6028(01)01587-4","article-title":"Biomedical surface science: Foundations to frontiers","volume":"500","author":"Castner","year":"2002","journal-title":"Surface Science"},{"key":"10.1016\/j.jtos.2014.01.004_bib3","series-title":"Crying: The natural and cultural history of tears","author":"Lutz","year":"2001"},{"key":"10.1016\/j.jtos.2014.01.004_bib4","series-title":"Surgery for the dry eye. Developments in ophthalmology","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000131066","article-title":"The normal tear film","author":"Tiffany","year":"2008"},{"key":"10.1016\/j.jtos.2014.01.004_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cca.2005.12.035","article-title":"Laboratory findings in tear fluid analysis","volume":"369","author":"Ohashi","year":"2006","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jtos.2014.01.004_bib6","first-page":"100","article-title":"Tear biochemistry: a review","volume":"69","author":"Gillan","year":"2010","journal-title":"S\u00a0Afr Optom"},{"key":"10.1016\/j.jtos.2014.01.004_bib7","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1016\/j.jprot.2012.04.053","article-title":"In-depth analysis of the human tear proteome","volume":"75","author":"Zhou","year":"2012","journal-title":"J\u00a0Proteomics"},{"key":"10.1016\/j.jtos.2014.01.004_bib8","article-title":"Normative Values for the Tear Film of the Rabbit, Dog and Human","volume":"54","author":"Motta","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/02713680490516099","article-title":"The thickness of the tear film","volume":"29","author":"King-Smith","year":"2004","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib10","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.1167\/iovs.13-11920","article-title":"Measurement of tear film thickness using ultrahigh resolution optical coherence tomography","volume":"54","author":"Werkmeister","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.jtos.2014.01.004_bib11","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1364\/BOE.1.001127","article-title":"Non-invasive in\u00a0vivo measurement of the tear film using spatial autocorrelation in a live mammal model","volume":"1","author":"Azartash","year":"2010","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.jtos.2014.01.004_bib12","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/eye.1993.96","article-title":"Comparison of tear film thickness in three species determined by the glass fibre method and confocal microscopy","volume":"7","author":"Prydal","year":"1993","journal-title":"Eye"},{"key":"10.1016\/j.jtos.2014.01.004_bib13","first-page":"1996","article-title":"Study of precorneal tear film thickness and structure by interferometry and confocal microscopy","volume":"33","author":"Prydal","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib14","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.preteyeres.2004.04.003","article-title":"Changes in the tear film and ocular surface from dry eye syndrome","volume":"23","author":"Johnson","year":"2004","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib15","first-page":"291","article-title":"The mucocutaneous junction of the lidmargin and the distribution of the tear fluid","volume":"66","author":"Wolff","year":"1946","journal-title":"Trans Ophthalmol Soc U K"},{"key":"10.1016\/j.jtos.2014.01.004_bib16","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0021-9797(82)90136-9","article-title":"Tear film rupture","volume":"89","author":"Lin","year":"1982","journal-title":"J\u00a0Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/imammb\/dqp019","article-title":"A\u00a0model for wetting and evaporation of a post-blink precorneal tear film","volume":"27","author":"Winter","year":"2010","journal-title":"Math Med Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib18","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0021-9797(03)00449-1","article-title":"Surfactant driven flows overlying a hydrophobic epithelium: film rupture in the presence of slip","volume":"264","author":"Zhang","year":"2003","journal-title":"J\u00a0Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib19","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1016\/S0039-6257(00)00203-4","article-title":"The ocular surface and tear film and their dysfunction in dry eye disease","volume":"45","author":"Rolando","year":"2001","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib20","first-page":"381","article-title":"Structure and composition of rat precorneal tear film. A study by an in\u00a0vivo cryofixation","volume":"38","author":"Chen","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib21","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1167\/iovs.03-0178","article-title":"Examination of murine tear film","volume":"44","author":"Tran","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib22","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0014-4835(73)90064-X","article-title":"Formation and rupture of the tear film","volume":"15","author":"Holly","year":"1973","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0021-9797(85)90375-3","article-title":"Mechanism of tear film rupture and formation of dry spots on cornea","volume":"106","author":"Sharma","year":"1985","journal-title":"J\u00a0Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/imammb\/dqm004","article-title":"Single-equation models for the tear film in a blink cycle: realistic lid motion","volume":"24","author":"Heryudono","year":"2007","journal-title":"Math Med Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib25","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.nano.2010.06.002","article-title":"Nanoscale phase dynamics of the normal tear film","volume":"6","author":"Khanal","year":"2010","journal-title":"Nanomed Nanotechnol Biol Med"},{"key":"10.1016\/j.jtos.2014.01.004_bib26","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0021-9797(03)00200-5","article-title":"Analysis of tear film rupture: effect of non-Newtonian rheology","volume":"262","author":"Zhang","year":"2003","journal-title":"J\u00a0Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/0892702031000152118","article-title":"Rupture analysis of the corneal mucus layer of the tear film","volume":"30","author":"Zhang","year":"2004","journal-title":"Molecular Simulation"},{"key":"10.1016\/j.jtos.2014.01.004_bib28","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1167\/iovs.08-2459","article-title":"The contribution of lipid layer movement to tear film thinning and breakup","volume":"50","author":"King-Smith","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib29","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1167\/iovs.13-11878","article-title":"Tear film breakup and structure studied by simultaneous video recording of fluorescence and tear film lipid layer, TFLL, images","volume":"54","author":"King-Smith","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib30","first-page":"79","article-title":"A\u00a0compositional based model for the tear film lipid layer","volume":"95","author":"McCulley","year":"1997","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.jtos.2014.01.004_bib31","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cis.2013.06.001","article-title":"Evaporation-driven instability of the precorneal tear film","volume":"206","author":"Peng","year":"2014","journal-title":"Adv Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib32","first-page":"221","article-title":"Report of the National Eye Institute\/Industry workshop on clinical trials in dry eyes","volume":"21","author":"Lemp","year":"1995","journal-title":"CLAO J"},{"key":"10.1016\/j.jtos.2014.01.004_bib33","series-title":"Ocular Surface Disease: Cornea, Conjunctiva and Tear Film","first-page":"67","article-title":"Meibomian gland disease: Treatment","author":"Foulks","year":"2013"},{"key":"10.1016\/j.jtos.2014.01.004_bib34","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/978-1-4615-2417-5_83","article-title":"Tear osmolarity: a new gold standard?","volume":"350","author":"Farris","year":"1994","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib35","series-title":"Ocular Surface Disease: Cornea, Conjunctiva and Tear Film","first-page":"77","article-title":"Dry eye disease: epidemiology and pathophysiology","author":"Lemp","year":"2013"},{"key":"10.1016\/j.jtos.2014.01.004_bib36","series-title":"Ocular Surface Disease: Cornea, Conjunctiva and Tear Film. Philadelphia","first-page":"171","article-title":"Oculodermal surface disease","author":"Vieira","year":"2013"},{"key":"10.1016\/j.jtos.2014.01.004_bib37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jtos.2011.10.001","article-title":"Common ocular surface disorders in patients in intensive care units","volume":"10","author":"Grixti","year":"2012","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2014.01.004_bib38","series-title":"Ocular Surface Disease: Cornea, Conjunctiva and Tear Film","first-page":"91","article-title":"Seasonal and perennial allergic conjunctivitis","author":"De Freitas","year":"2013"},{"key":"10.1016\/j.jtos.2014.01.004_bib39","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S0161-6420(85)33967-2","article-title":"Staging of conjunctival squamous metaplasia by impression cytology","volume":"92","author":"Tseng","year":"1985","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2014.01.004_bib40","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S1542-0124(12)70148-9","article-title":"Inflammation in dry eye","volume":"2","author":"Stern","year":"2004","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2014.01.004_bib41","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.preteyeres.2012.06.002","article-title":"Tear analysis in ocular surface diseases","volume":"31","author":"Zhou","year":"2012","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib42","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/00003226-200210000-00007","article-title":"Use of the dry eye questionnaire to measure symptoms of ocular irritation in patients with aqueous tear deficient dry eye","volume":"21","author":"Begley","year":"2002","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2014.01.004_bib43","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/00006324-199302000-00011","article-title":"Schirmer test. I. A review","volume":"70","author":"Cho","year":"1993","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib44","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1755-3768.1973.tb06027.x","article-title":"Lissamine green","volume":"51","author":"Norn","year":"1973","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.jtos.2014.01.004_bib45","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1755-3768.1962.tb02387.x","article-title":"Vital staining of cornea and conjunctiva","volume":"40","author":"Norn","year":"1962","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.jtos.2014.01.004_bib46","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1755-3768.1993.tb04631.x","article-title":"Human basic tear fluid osmolality","volume":"71","author":"White","year":"1993","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.jtos.2014.01.004_bib47","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0892-8967(92)90042-C","article-title":"The precorneal tear film and \u201cdry eyes.\u201d","volume":"19","author":"Forst","year":"1992","journal-title":"Int Contact Lens Clin"},{"key":"10.1016\/j.jtos.2014.01.004_bib48","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3109\/02713689609008906","article-title":"Tear meniscus measurement in the diagnosis of dry eye","volume":"15","author":"Mainstone","year":"1996","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s40135-013-0008-2","article-title":"Dry eye and biomarkers: present and future","volume":"1","author":"Deschamps","year":"2013","journal-title":"Curr Ophthalmol Rep"},{"key":"10.1016\/j.jtos.2014.01.004_bib50","doi-asserted-by":"crossref","first-page":"7725","DOI":"10.1167\/iovs.11-7266","article-title":"Proinflammatory cytokine profiling of tears from dry eye patients by means of antibody microarrays","volume":"52","author":"Boehm","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib51","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1136\/bjo.2010.185256","article-title":"Association of tear proteins with Meibomian gland disease and dry eye symptoms","volume":"95","author":"Tong","year":"2011","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib52","doi-asserted-by":"crossref","first-page":"e51979","DOI":"10.1371\/journal.pone.0051979","article-title":"Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome","volume":"7","author":"Aluru","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.jtos.2014.01.004_bib53","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1167\/iovs.04-0448","article-title":"SELDI-TOF-MS ProteinChip array profiling of tears from patients with dry eye","volume":"46","author":"Grus","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib54","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1167\/iovs.11-7627","article-title":"Correlation of tear inflammatory cytokines and matrix metalloproteinases with four dry eye diagnostic tests","volume":"53","author":"VanDerMeid","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib55","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00003226-199307000-00010","article-title":"Ocular water evaporation and the dry eye: a new measuring device","volume":"12","author":"Mathers","year":"1993","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2014.01.004_bib56","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/02713689308999470","article-title":"An instrument for quantifying Meibomian lipid on the lid margin: the Meibometer","volume":"12","author":"Chew","year":"1993","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib57","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00006324-198906000-00008","article-title":"An instrument for in\u00a0vivo tear film interferometry","volume":"66","author":"Doane","year":"1989","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib58","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S0161-6420(82)34736-3","article-title":"Ocular ferning test. A qualitative test for mucus deficiency","volume":"89","author":"Tabbara","year":"1982","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2014.01.004_bib59","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/978-1-4615-2417-5_60","article-title":"Mucopolysaccharide degrading enzymes (MPDE) in the tear fluid: a new diagnostic test for rapid detection of acute ocular infections","volume":"350","author":"Romano","year":"1994","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib60","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1755-3768.1969.tb03711.x","article-title":"Desiccation of the precorneal film. I. Corneal wetting time","volume":"47","author":"Norn","year":"1969","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.jtos.2014.01.004_bib61","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.exer.2013.08.010","article-title":"Tear film stability: A review","volume":"17","author":"Sweeney","year":"2013","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib62","first-page":"258","article-title":"Corneal desiccation despite normal tear volume","volume":"2","author":"Lemp","year":"1970","journal-title":"Ann Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/02713688508999960","article-title":"A\u00a0non-invasive instrument for clinical assessment of the pre-corneal tear film stability","volume":"4","author":"Mengher","year":"1985","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib64","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clae.2012.04.002","article-title":"Clinical evaluation of the Oculus Keratograph","volume":"35","author":"Best","year":"2012","journal-title":"Cont Lens Anterior Eye"},{"key":"10.1016\/j.jtos.2014.01.004_bib65","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1001\/archopht.1977.04450030087010","article-title":"Interpretation of tear film breakup","volume":"95","author":"Vanley","year":"1977","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib66","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/01.ico.0000154378.67495.40","article-title":"The effect of instilled fluorescein solution volume on the values and repeatability of TBUT measurements","volume":"24","author":"Johnson","year":"2005","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2014.01.004_bib67","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.clae.2011.07.005","article-title":"A\u00a0new modified fluorescein strip: Its repeatability and usefulness in tear film break-up time analysis","volume":"35","author":"Pult","year":"2012","journal-title":"Cont Lens Anterior Eye"},{"key":"10.1016\/j.jtos.2014.01.004_bib68","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/ICO.0b013e31816583f6","article-title":"The Ocular Protection Index","volume":"27","author":"Ousler","year":"2008","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2014.01.004_bib69","first-page":"905","article-title":"Surface phenomena of tear films","volume":"66","author":"McDonald","year":"1968","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"S81","key":"10.1016\/j.jtos.2014.01.004_bib70","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1755-3768.1965.tb05459.x","article-title":"The precorneal film","volume":"43","author":"Ehlers","year":"1965","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.jtos.2014.01.004_bib71","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1001\/archopht.1965.00970030235017","article-title":"Some physiological aspects of the precorneal tear film","volume":"73","author":"Mishima","year":"1965","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib72","first-page":"65","article-title":"The preocular tear film; a small but highly complex part of the eye","volume":"80","author":"Holly","year":"2005","journal-title":"Arch Sociedad Espanola Oftalmologia"},{"key":"10.1016\/j.jtos.2014.01.004_bib73","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.biomaterials.2006.08.049","article-title":"Nanomedicine for implants: A review of studies and necessary experimental tools","volume":"28","author":"Liu","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.jtos.2014.01.004_bib74","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1021\/la702284b","article-title":"Characterization of the cell surface and cell wall chemistry of drinking water bacteria by combining XPS, FTIR spectroscopy, modeling, and potentiometric titrations","volume":"24","author":"Ojeda","year":"2008","journal-title":"Langmuir"},{"key":"10.1016\/j.jtos.2014.01.004_bib75","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1021\/ac071560k","article-title":"TOF-SIMS analysis of a 576 micropatterned copolymer array to reveal surface moieties that control wettability","volume":"80","author":"Urquhart","year":"2008","journal-title":"Anal Chem"},{"key":"10.1016\/j.jtos.2014.01.004_bib76","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1002\/pmic.200800115","article-title":"Cluster TOF-SIMS imaging: A new light for in situ metabolomics?","volume":"8","author":"Mas","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.jtos.2014.01.004_bib77","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.apsusc.2008.05.289","article-title":"The chemical composition of animal cells reconstructed from 2D and 3D ToF-SIMS analysis","volume":"255","author":"Breitenstein","year":"2008","journal-title":"Appl Surf Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib78","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1366\/000370204322729441","article-title":"Surface-enhanced Raman spectroscopy as a tool for probing specific biochemical components in bacteria","volume":"58","author":"Zeiri","year":"2004","journal-title":"Appl Spectrosc"},{"key":"10.1016\/j.jtos.2014.01.004_bib79","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1021\/ac034689c","article-title":"Discrimination of bacteria using surface-enhanced Raman spectroscopy","volume":"76","author":"Jarvis","year":"2004","journal-title":"Anal Chem"},{"key":"10.1016\/j.jtos.2014.01.004_bib80","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0006-3495(99)76910-9","article-title":"Atomic force microscopy of the submolecular architecture of hydrated ocular mucins","volume":"77","author":"McMaster","year":"1999","journal-title":"Biophys J"},{"key":"10.1016\/j.jtos.2014.01.004_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2012.00483","article-title":"Scanning ion conductance microscopy: a nanotechnology for biological studies in live cells","volume":"3","author":"Liu","year":"2013","journal-title":"Front Physiol"},{"key":"10.1016\/j.jtos.2014.01.004_bib82","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/S0142-9612(00)00077-6","article-title":"Surface plasmon resonance analysis of dynamic biological interactions with biomaterials","volume":"21","author":"Green","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.jtos.2014.01.004_bib83","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1007\/s11095-012-0761-1","article-title":"Interfacial interaction between transmembrane ocular mucins and adhesive polymers and dendrimers analyzed by surface plasmon resonance","volume":"29","author":"Bravo-Osuna","year":"2012","journal-title":"Pharm Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib84","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3109\/1061186X.2010.521941","article-title":"High throughput surface characterization: A review of a new tool for screening prospective biomedical material arrays","volume":"18","author":"Davies","year":"2010","journal-title":"J\u00a0Drug Targeting"},{"key":"10.1016\/j.jtos.2014.01.004_bib85","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1002\/adma.200700949","article-title":"High throughput surface characterisation of a combinatorial material library","volume":"19","author":"Urquhart","year":"2007","journal-title":"Adv Mater"},{"key":"10.1016\/j.jtos.2014.01.004_bib86","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/sia.2498","article-title":"Applications of XPS in bioengineering","volume":"38","author":"McArthur","year":"2006","journal-title":"Surf Interface Anal"},{"key":"10.1016\/j.jtos.2014.01.004_bib87","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev.biophys.050708.133634","article-title":"Advances in imaging secondary ion mass spectrometry for biological samples","volume":"38","author":"Boxer","year":"2009","journal-title":"Ann Rev Biophys"},{"key":"10.1016\/j.jtos.2014.01.004_bib88","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.bbamem.2006.02.011","article-title":"Applications of ATR-FTIR spectroscopic imaging to biomedical samples","volume":"1758","author":"Kazarian","year":"2006","journal-title":"Biochim Biophys Acta (BBA)-Biomembranes"},{"key":"10.1016\/j.jtos.2014.01.004_bib89","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1039\/b708461g","article-title":"SERS as a bioassay platform: fundamentals, design, and applications","volume":"37","author":"Porter","year":"2008","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.jtos.2014.01.004_bib90","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s00216-003-2111-y","article-title":"Label-free screening of bio-molecular interactions","volume":"377","author":"Cooper","year":"2003","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.jtos.2014.01.004_bib91","first-page":"680","article-title":"The use of atomic force microscopy for the observation of corneal epithelium surface","volume":"41","author":"Tsilimbaris","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib92","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.micron.2012.01.012","article-title":"Scanning ion conductance microscopy for imaging biological samples in liquid: A comparative study with atomic force microscopy and scanning electron microscopy","volume":"43","author":"Ushiki","year":"2012","journal-title":"Micron"},{"key":"10.1016\/j.jtos.2014.01.004_bib93","first-page":"774","article-title":"De la sensibilite et du dessechement de la cornee","volume":"158","author":"Marx","year":"1921","journal-title":"Ann Ocul (Paris)"},{"key":"10.1016\/j.jtos.2014.01.004_bib94","first-page":"5","article-title":"La couche de liquid pre-corneenne","volume":"53","author":"Rollet","year":"1936","journal-title":"Arch Ophtalmol (Paris)"},{"key":"10.1016\/j.jtos.2014.01.004_bib95","first-page":"334","article-title":"Sur le dessechement de la cornee","volume":"163","author":"Hoen","year":"1926","journal-title":"Ann Ocul (Paris)"},{"key":"10.1016\/j.jtos.2014.01.004_bib96","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0014-4835(71)80028-3","article-title":"Wettability and wetting of corneal epithelium","volume":"11","author":"Holly","year":"1971","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib97","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1001\/archopht.1970.00990030091017","article-title":"The precorneal tear film: I. Factors in spreading and maintaining a continuous tear film over the corneal surface","volume":"83","author":"Lemp","year":"1970","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib98","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/j.1755-3768.1969.tb03712.x","article-title":"Desiccation of the precorneal film. II. Permanent discontinuity and dellen","volume":"47","author":"Norn","year":"1969","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.jtos.2014.01.004_bib99","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0021-9797(74)90355-5","article-title":"Surface chemistry of tear film component analogs","volume":"49","author":"Holly","year":"1974","journal-title":"J\u00a0Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib100","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0014-4835(77)90269-X","article-title":"Surface activity determination of aqueous tear components in dry eye patients and normals","volume":"24","author":"Holly","year":"1977","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib101","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00006324-198201000-00007","article-title":"Biochemical and surface characteristics of human tear proteins","volume":"59","author":"Holly","year":"1982","journal-title":"Am J Optom Physiol Opt"},{"key":"10.1016\/j.jtos.2014.01.004_bib102","first-page":"552","article-title":"Biophysical aspects of epithelial adhesion to stroma","volume":"17","author":"Holly","year":"1978","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib103","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00004397-197301310-00007","article-title":"Formation and stability of the tear film","volume":"13","author":"Holly","year":"1973","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.jtos.2014.01.004_bib104","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/00006324-198004000-00008","article-title":"Tear film physiology","volume":"57","author":"Holly","year":"1980","journal-title":"Am J Optom Physiol Opt"},{"key":"10.1016\/j.jtos.2014.01.004_bib105","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0021-9290(74)90013-X","article-title":"A\u00a0surface tension gradient mechanism for driving the pre-corneal tear film after a blink","volume":"7","author":"Berger","year":"1974","journal-title":"J\u00a0Biomech"},{"key":"10.1016\/j.jtos.2014.01.004_bib106","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0021-9797(82)90235-1","article-title":"Marangoni convection in a tear film","volume":"85","author":"Lin","year":"1982","journal-title":"J\u00a0Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib107","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1136\/bjo.65.12.833","article-title":"Surface changes in the anaesthetic conjunctiva in man, with special reference to the production of mucus from a non-goblet-cell source","volume":"65","author":"Dilly","year":"1981","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib108","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/00006324-199010000-00001","article-title":"On the evaluation of the corneal epithelial surface by scanning electron microscopy","volume":"67","author":"Doughty","year":"1990","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib109","first-page":"570","article-title":"Surface features of the conjunctiva and cornea","volume":"24","author":"Nichols","year":"1983","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib110","first-page":"777","article-title":"Wettability of the corneal surface: a reappraisal","volume":"5","author":"Cope","year":"1986","journal-title":"Curr EyeRes"},{"key":"10.1016\/j.jtos.2014.01.004_bib111","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000309798","article-title":"A\u00a0new hypothesis on tear film stability","volume":"195","author":"Liotet","year":"1987","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.jtos.2014.01.004_bib112","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1755-3768.1990.tb01901.x","article-title":"Measurement of wettability of the corneal epithelium","volume":"68","author":"Tiffany","year":"1990","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.jtos.2014.01.004_bib113","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1076\/ceyr.19.1.4.5341","article-title":"Components responsible for the surface tension of human tears","volume":"19","author":"Nagyova","year":"1999","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib114","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/01932699208943328","article-title":"Surface properties of normal and damaged corneal epithelia","volume":"13","author":"Sharma","year":"1992","journal-title":"J\u00a0Dispersion Sci Technol"},{"key":"10.1016\/j.jtos.2014.01.004_bib115","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0301-4622(93)80036-I","article-title":"Energetics of corneal epithelial cell-ocular mucus-tear film interactions: some surface-chemical pathways of corneal defense","volume":"47","author":"Sharma","year":"1993","journal-title":"Biophys Chem"},{"issue":"6-7","key":"10.1016\/j.jtos.2014.01.004_bib116","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1080\/01932699808913229","article-title":"Acid-base interactions in the cornea-tear film system: surface chemistry of corneal wetting, cleaning, lubrication, hydration and defense","volume":"19","author":"Sharma","year":"1998","journal-title":"J\u00a0Dispersion Sci Technol"},{"key":"10.1016\/j.jtos.2014.01.004_bib117","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/imammb\/dqp023","article-title":"Tear film dynamics on an eye-shaped domain I: pressure boundary conditions","volume":"27","author":"Maki","year":"2010","journal-title":"Math Med Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib118","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1017\/S002211200999382X","article-title":"Tear film dynamics on an eye-shaped domain. Part 2. Flux boundary conditions","volume":"647","author":"Maki","year":"2010","journal-title":"J\u00a0Fluid Mechan"},{"key":"10.1016\/j.jtos.2014.01.004_bib119","first-page":"65","article-title":"2007 Report of the International Dry Eye Workshop (DEWS)","volume":"5","author":"No authors reported","year":"2007","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2014.01.004_bib120","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/01.ico.0000214802.40313.fa","article-title":"Dysfunctional tear syndrome: a Delphi approach to treatment recommendations","volume":"25","author":"Behrens","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2014.01.004_bib121","first-page":"2533","article-title":"Morphologic evaluation of Meibomian glands in chronic graft-versus-host disease using in\u00a0vivo laser confocal microscopy","volume":"17","author":"Ban","year":"2011","journal-title":"Mol Vis"},{"key":"10.1016\/j.jtos.2014.01.004_bib122","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/eye.1991.65","article-title":"Meibomian gland disease. Classification and grading of lid changes","volume":"5","author":"Bron","year":"1991","journal-title":"Eye"},{"key":"10.1016\/j.jtos.2014.01.004_bib123","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1542-0124(12)70150-7","article-title":"The contribution of Meibomian disease to dry eye","volume":"2","author":"Bron","year":"2004","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2014.01.004_bib124","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.exer.2003.09.019","article-title":"Functional aspects of the tear film lipid layer","volume":"78","author":"Bron","year":"2004","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib125","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.survophthal.2007.04.009","article-title":"The correlation between the tear film lipid layer and dry eye disease","volume":"52","author":"Foulks","year":"2007","journal-title":"Surv. Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib126","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1080\/02713680902972366","article-title":"The effect of Meibomian lipids and tear proteins on evaporation rate under controlled in\u00a0vitro conditions","volume":"34","author":"Herok","year":"2009","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib127","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1542-0124(11)70033-7","article-title":"High resolution microscopy of the lipid layer of the tear film","volume":"9","author":"King-Smith","year":"2011","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2014.01.004_bib128","first-page":"4874","article-title":"Effect of androgen deficiency on the human Meibomian gland and ocular surface","volume":"85","author":"Krenzer","year":"2000","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jtos.2014.01.004_bib129","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1023\/A:1017987608937","article-title":"The lipid layer: the outer surface of the ocular surface tear film","volume":"21","author":"McCulley","year":"2001","journal-title":"Biosci Rep"},{"key":"10.1016\/j.jtos.2014.01.004_bib130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1542-0124(12)70138-6","article-title":"Meibomian gland function and the tear lipid layer","volume":"1","author":"McCulley","year":"2003","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2014.01.004_bib131","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0014-4835(03)00203-3","article-title":"The lipid layer of tears: dependent on Meibomian gland function","volume":"78","author":"McCulley","year":"2004","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib132","doi-asserted-by":"crossref","first-page":"7350","DOI":"10.1167\/iovs.11-7391","article-title":"Analysis of the composition of lipid in human meibum from normal infants, children, adolescents, adults, and adults with Meibomian gland dysfunction using 1H-NMR spectroscopy","volume":"52","author":"Shrestha","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib133","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1167\/iovs.10-6997f","article-title":"The International Workshop on Meibomian Gland Dysfunction: report of the diagnosis subcommittee","volume":"52","author":"Tomlinson","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib134","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/ICO.0b013e3181da5778","article-title":"The association of Meibomian gland dysfunction and other common ocular diseases with dry eye: a population-based study in Spain","volume":"30","author":"Viso","year":"2011","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2014.01.004_bib135","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cis.2013.03.007","article-title":"Water-evaporation reduction by duplex films: application to the human tear film","volume":"197-8","author":"Cerretani","year":"2013","journal-title":"Adv Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib136","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clae.2010.03.002","article-title":"Tear film evaporation - effect of age and gender","volume":"33","author":"Guillon","year":"2010","journal-title":"Cont Lens Anterior Eye"},{"key":"10.1016\/j.jtos.2014.01.004_bib137","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/OPX.0b013e318181ae60","article-title":"Contributions of evaporation and other mechanisms to tear film thinning and break-up","volume":"85","author":"King-Smith","year":"2008","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib138","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.1167\/iovs.12-10033","article-title":"The use of fluorescent quenching in studying the contribution of evaporation to tear thinning","volume":"53","author":"Nichols","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib139","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00004397-199403410-00005","article-title":"Human tear film electrolyte concentrations in health and dry-eye disease","volume":"34","author":"Gilbard","year":"1994","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.jtos.2014.01.004_bib140","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.ajo.2010.10.032","article-title":"Tear osmolarity in the diagnosis and management of dry eye disease","volume":"151","author":"Lemp","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib141","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/00003226-199811000-00002","article-title":"The pathology of dry eye: the interaction between the ocular surface and lacrimal glands","volume":"17","author":"Stern","year":"1998","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2014.01.004_bib142","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.exer.2003.09.003","article-title":"The role of the lacrimal functional unit in the pathophysiology of dry eye","volume":"78","author":"Stern","year":"2004","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib143","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.optm.2009.02.010","article-title":"Advancements in anti-inflammatory therapy for dry eye syndrome","volume":"80","author":"McCabe","year":"2009","journal-title":"Optometry"},{"key":"10.1016\/j.jtos.2014.01.004_bib144","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1056\/NEJM199906033402201","article-title":"Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation","volume":"340","author":"Tsubota","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtos.2014.01.004_bib145","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0161-6420(01)00694-7","article-title":"Cultivated corneal epithelial stem cell transplantation in ocular surface disorders","volume":"108","author":"Koizumi","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2014.01.004_bib146","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jtos.2012.08.004","article-title":"Citation analysis of the dry eye literature","volume":"11","author":"Nichols","year":"2013","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2014.01.004_bib147","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/eye.1997.161","article-title":"Reflections on the tears","volume":"11","author":"Bron","year":"1997","journal-title":"Eye"},{"key":"10.1016\/j.jtos.2014.01.004_bib148","series-title":"Intermolecular and surface forces: revised third edition","author":"Israelachvili","year":"2011"},{"key":"10.1016\/j.jtos.2014.01.004_bib149","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/S0006-3495(02)73934-9","article-title":"Heterogeneity and persistence length in human ocular mucins","volume":"83","author":"Round","year":"2002","journal-title":"Biophys J"},{"key":"10.1016\/j.jtos.2014.01.004_bib150","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s10719-008-9136-6","article-title":"Glycan structures of ocular surface mucins in man, rabbit and dog display species differences","volume":"25","author":"Royle","year":"2008","journal-title":"Glycoconj J"},{"key":"10.1016\/j.jtos.2014.01.004_bib151","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1001\/archpedi.1959.02070010519001","article-title":"Surface properties in relation to atelectasis and hyaline membrane disease","volume":"97","author":"Avery","year":"1959","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jtos.2014.01.004_bib152","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0022-3476(65)80193-7","article-title":"Surface properties and lipids from lungs of infants with hyaline membrane disease","volume":"66","author":"Adams","year":"1965","journal-title":"J\u00a0Pediatrics"},{"key":"10.1016\/j.jtos.2014.01.004_bib153","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1164\/ajrccm.161.4.16142","article-title":"Surfactant deficiency in hyaline membrane disease: the story of discovery","volume":"161","author":"Avery","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtos.2014.01.004_bib154","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJM199303253281208","article-title":"Pulmonary surfactant therapy","volume":"328","author":"Wood","year":"1993","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtos.2014.01.004_bib155","first-page":"3100","article-title":"Tear lipocalins potential lipid scavengers for the corneal surface","volume":"40","author":"Glasgow","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib156","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1046\/j.1475-097X.2002.00389.x","article-title":"Surface activity of tear fluid in patients with primary Sjogren's syndrome","volume":"22","author":"Zhao","year":"2002","journal-title":"Clin Physiol Funct Imaging"},{"key":"10.1016\/j.jtos.2014.01.004_bib157","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1034\/j.1600-0420.1998.760409.x","article-title":"Surface activity of tear fluid in normal subjects","volume":"76","author":"Zhao","year":"1998","journal-title":"Acta Ophthalmol Scand"},{"key":"10.1016\/j.jtos.2014.01.004_bib158","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev.matsci.38.060407.132425","article-title":"Solid-surface characterization by wetting","volume":"39","author":"Marmur","year":"2009","journal-title":"Annu Rev Mater Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib159","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1103\/RevModPhys.57.827","article-title":"Wetting: statics and dynamics","volume":"57","author":"De Gennes","year":"1985","journal-title":"Rev Mod Physics"},{"key":"10.1016\/j.jtos.2014.01.004_bib160","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0001-8686(02)00004-0","article-title":"Analysis of different approaches for evaluation of surface energy of microbial cells by contact angle goniometry","volume":"98","author":"Sharma","year":"2002","journal-title":"Adv Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib161","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1006\/exer.1998.0600","article-title":"Physical properties of stimulated and unstimulated tears","volume":"68","author":"Pandit","year":"1999","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib162","first-page":"192","article-title":"Recherches physico-chimiques sur les larmes par rapport a l'emploi des collyres","volume":"54","author":"Cerrano","year":"1910","journal-title":"Arch Ital Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib163","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1001\/archopht.1969.00990020370014","article-title":"Measurement of the surface tension of tears","volume":"82","author":"Miller","year":"1969","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib164","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0039-6257(77)90087-X","article-title":"Tear physiology and dry eyes","volume":"22","author":"Holly","year":"1977","journal-title":"Surv Ophthalmol"},{"issue":"Suppl","key":"10.1016\/j.jtos.2014.01.004_bib165","first-page":"200","article-title":"Dynamic tensive properties of human tears and tear components as obtained with the pulsating bubble surfactometer (ARVO abstract)","volume":"24","author":"Holly","year":"1983","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib166","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3109\/02713688909000031","article-title":"Tear film stability and tear surface tension","volume":"8","author":"Tiffany","year":"1989","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib167","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1001\/archopht.1969.00990020539019","article-title":"The oils of the Meibomian glands: physical and surface characteristics","volume":"82","author":"Brown","year":"1969","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib168","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00916437","article-title":"Biophysical characteristics of the Meibomian lipid layer underin\u00a0vitro conditions","volume":"16","author":"Kaercher","year":"1992","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib169","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0014-4835(78)90164-1","article-title":"Individual variations in human Meibomian lipid composition","volume":"27","author":"Tiffany","year":"1978","journal-title":"Exp Eye Res"},{"issue":"Pt A","key":"10.1016\/j.jtos.2014.01.004_bib170","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/978-1-4615-0717-8_58","article-title":"Interface properties of simplified tear-like fluids in relation to lipid and aqueous layers composition","volume":"506","author":"Miano","year":"2002","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib171","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1076\/ceyr.25.1.55.9965","article-title":"The role of different phospholipids on tear break-up time using a model eye","volume":"25","author":"Peters","year":"2002","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib172","first-page":"341","article-title":"Purification and chemical characterization of the high molecular weight of glycoconjugate fraction of the bovine tear film and comparison to mucins from other sources","author":"Ball","year":"2002","journal-title":"Kluwer Academic"},{"key":"10.1016\/j.jtos.2014.01.004_bib173","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1167\/iovs.09-3563","article-title":"Mucin-type O-glycans in tears of normal subjects and patients with non-Sjogren's dry eye","volume":"50","author":"Guzman-Aranguez","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib174","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-1-4615-5359-5_33","article-title":"Soluble mucin and the physical properties of tears","volume":"438","author":"Tiffany","year":"1998","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib175","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jcis.2005.06.058","article-title":"Mucin at solution\/air and solid\/solution interfaces","volume":"293","author":"Maheshwari","year":"2006","journal-title":"J\u00a0Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib176","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/01.ico.0000164779.87795.3c","article-title":"The surface activity of purified ocular mucin at the air-liquid interface and interactions with meibomian lipids","volume":"25","author":"Millar","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2014.01.004_bib177","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0014-4835(05)80178-2","article-title":"New members of the lipocalin family in human tear fluid","volume":"55","author":"Delaire","year":"1992","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib178","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1167\/iovs.05-0569","article-title":"Tear lipocalin: evidence for a scavenging function to remove lipids from the human corneal surface","volume":"46","author":"Gasymov","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"Suppl","key":"10.1016\/j.jtos.2014.01.004_bib179","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/15027732.1986.12461416","article-title":"Tear fluid proteins in Sj\u00f6gren's syndrome","volume":"61","author":"Janssen","year":"1986","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.jtos.2014.01.004_bib180","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1194\/jlr.M006239","article-title":"Interaction of phospholipid transfer protein with human tear fluid mucins","volume":"51","author":"Setala","year":"2010","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib181","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/01.ico.0000138837.52694.37","article-title":"Surface pressure measurements of human tears and individual tear film components indicate that proteins are major contributors to the surface pressure","volume":"24","author":"Tragoulias","year":"2005","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2014.01.004_bib182","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1167\/iovs.10-5445","article-title":"Surfactant properties of human Meibomian lipids","volume":"52","author":"Mudgil","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib183","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00004397-197301310-00013","article-title":"The mucin-deficient dry eye. Int","volume":"13","author":"Lemp","year":"1973","journal-title":"Ophthalmol Clin"},{"key":"10.1016\/j.jtos.2014.01.004_bib184","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0014-4835(76)90228-1","article-title":"The glycoprotein (mucus) content of tears from normals and dry eye patients","volume":"22","author":"Dohlman","year":"1976","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib185","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/11.1.14","article-title":"Morphological aspects of extracellular polysaccharides","volume":"11","author":"Bennett","year":"1963","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1016\/j.jtos.2014.01.004_bib186","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0022-5320(67)80200-4","article-title":"The stereo ultrastructure of the external and internal surface of the cornea","volume":"18","author":"Blumcke","year":"1967","journal-title":"J\u00a0Ultrastruct Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib187","first-page":"464","article-title":"Demonstration of the mucous layer of the tear film by electron microscopy","volume":"26","author":"Nichols","year":"1985","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib188","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/bjo.2003.026583","article-title":"Human preocular mucins reflect changes in surface physiology","volume":"88","author":"Berry","year":"2004","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib189","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1136\/bjo.86.12.1412","article-title":"Commensal ocular bacteria degrade mucins","volume":"86","author":"Berry","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib190","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.exer.2013.07.027","article-title":"Tear film mucins: front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins","volume":"117","author":"Hodges","year":"2013","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib191","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1350-9462(96)00022-5","article-title":"Mucin genes expressed by the ocular surface epithelium","volume":"16","author":"Gipson","year":"1997","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib192","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1128\/IAI.62.5.1799-1804.1994","article-title":"Modulation of Pseudomonas aeruginosa adherence to the corneal surface by mucus","volume":"62","author":"Fleiszig","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.jtos.2014.01.004_bib193","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.exer.2007.01.018","article-title":"Assay of mucins in human tear fluid","volume":"84","author":"Spurr-Michaud","year":"2007","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib194","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00003226-200301000-00010","article-title":"MUC7 expression in the human lacrimal gland and conjunctiva","volume":"22","author":"Jumblatt","year":"2003","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2014.01.004_bib195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(03)31001-0","article-title":"Role of mucins in the function of the corneal and conjunctival epithelia","volume":"231","author":"Gipson","year":"2003","journal-title":"Int Rev Cytol"},{"key":"10.1016\/j.jtos.2014.01.004_bib196","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1542-0124(12)70149-0","article-title":"Character of ocular surface mucins and their alteration in dry eye disease","volume":"2","author":"Gipson","year":"2004","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2014.01.004_bib197","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/1523-1747.ep12540891","article-title":"Glycocalyx of epidermal cells in\u00a0vitro: Demonstration and enzymatic removal","volume":"64","author":"Fritsch","year":"1975","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jtos.2014.01.004_bib198","first-page":"218","article-title":"Characteristics of a glycoprotein in the ocular surface glycocalyx","volume":"33","author":"Gipson","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib199","first-page":"337","article-title":"Human corneal and conjunctival epithelia produce a mucin-like glycoprotein for the apical surface","volume":"36","author":"Watanabe","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib200","first-page":"1818","article-title":"Human corneal and conjunctival epithelia express MUC1 mucin","volume":"36","author":"Inatomi","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib201","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-4615-5359-5_32","article-title":"Cellular origin of mucins of the ocular surface tear film","volume":"438","author":"Gipson","year":"1998","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib202","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1167\/iovs.02-0862","article-title":"MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope","volume":"44","author":"Argueso","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib203","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/02713680802699408","article-title":"Expression of membrane-associated mucins in limbal stem cell deficiency and after transplantation of cultivated limbal epithelium","volume":"34","author":"Pauklin","year":"2009","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib204","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1167\/iovs.07-1081","article-title":"Release of membrane-associated mucins from ocular surface epithelia","volume":"49","author":"Blalock","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib205","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/978-1-4615-5359-5_38","article-title":"Corneal epithelial tight junctions and the localization of surface mucin","volume":"438","author":"Edelhauser","year":"1998","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib206","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/bjo.82.1.88","article-title":"CA 19-9 ELISA test: a new method for studying mucus changes in tears","volume":"82","author":"Garcher","year":"1998","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib207","first-page":"2602","article-title":"Alteration of mucin in human conjunctival epithelia in dry eye","volume":"39","author":"Danjo","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib208","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10384-004-0111-x","article-title":"Sialic acid in human tear fluid decreases in dry eye","volume":"48","author":"Nakamura","year":"2004","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib209","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.exer.2006.01.031","article-title":"MUC1 splice variants in human ocular surface tissues: possible differences between dry eye patients and normal controls","volume":"83","author":"Imbert","year":"2006","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib210","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1021\/cr00088a006","article-title":"Interfacial Lifshitz-van der Waals and polar interactions in macroscopic systems","volume":"88","author":"Van Oss","year":"1988","journal-title":"Chem Rev"},{"key":"10.1016\/j.jtos.2014.01.004_bib211","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1021\/la00082a018","article-title":"Additive and nonadditive surface tension components and the interpretation of contact angles","volume":"4","author":"Van Oss","year":"1988","journal-title":"Langmuir"},{"key":"10.1016\/j.jtos.2014.01.004_bib212","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1021\/bm000145y","article-title":"Exploring the molecular adhesion of ocular mucins","volume":"2","author":"Berry","year":"2001","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jtos.2014.01.004_bib213","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1167\/iovs.07-1038","article-title":"Antiadhesive character of mucin O-glycans at the apical surface of corneal epithelial cells","volume":"49","author":"Sumiyoshi","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib214","first-page":"522","article-title":"Meibomian gland studies: comparison of steer and human lipids","volume":"20","author":"Nicolaides","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib215","series-title":"The Preocular Tear Film in Health, Disease & Contact Lens Wear","first-page":"597","article-title":"The influence of composition on physical properties of Meibomian secretion","author":"Tiffany","year":"1986"},{"key":"10.1016\/j.jtos.2014.01.004_bib216","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1167\/iovs.03-0260","article-title":"Computer-synthesis of an interference color chart of human tear lipid layer, by a colorimetric approach","volume":"44","author":"Goto","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib217","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1167\/iovs.09-4387","article-title":"Application of a novel interferometric method to investigate the relation between lipid layer thickness and tear film thinning","volume":"51","author":"King-Smith","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib218","first-page":"1017","article-title":"Apoptosis in the corneal epithelium","volume":"37","author":"Ren","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib219","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1444-0938.1986.tb04562.x","article-title":"Tear-side regulation of desquamation in the rabbit corneal epithelium: A specular microscopy study","volume":"69","author":"O\u2019Leary","year":"1986","journal-title":"Clin Exp Optom"},{"key":"10.1016\/j.jtos.2014.01.004_bib220","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3109\/02713689309029226","article-title":"Temporal sequence of changes in tear film composition during sleep","volume":"12","author":"Tan","year":"1993","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib221","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0014-4835(61)80006-7","article-title":"The oily layer of the tear film and evaporation from the corneal surface","volume":"1","author":"Mishima","year":"1961","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib222","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1001\/archopht.1969.00990020543020","article-title":"Hydrodynamics of blinking: In\u00a0vitro study of the interaction of the superficial oily layer and the tears","volume":"82","author":"Brown","year":"1969","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib223","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1167\/iovs.12-10987","article-title":"Structural and rheological properties of meibomian lipid","volume":"54","author":"Rosenfeld","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib224","first-page":"79","article-title":"A\u00a0compositional based model for the tear film lipid layer","volume":"95","author":"McCulley","year":"1997","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.jtos.2014.01.004_bib225","series-title":"Thin Liquid Films. Fundamentals and Applications","first-page":"497","article-title":"The hydrodynamic stability of thin films","author":"Maldarelli","year":"1988"},{"key":"10.1016\/j.jtos.2014.01.004_bib226","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1021\/j150246a002","article-title":"On the influence of thin surface films on the evaporation of water","volume":"28","author":"Hedestrand","year":"1924","journal-title":"J\u00a0Phys Chem"},{"key":"10.1016\/j.jtos.2014.01.004_bib227","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0016-0032(43)90904-4","article-title":"Rates of evaporation of water through compressed monolayers on water","volume":"235","author":"Langmuir","year":"1943","journal-title":"J\u00a0Franklin Inst"},{"key":"10.1016\/j.jtos.2014.01.004_bib228","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0001-8686(86)80004-5","article-title":"The effects of monolayers on the evaporation of liquids","volume":"25","author":"Barnes","year":"1986","journal-title":"Adv Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib229","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/cbf.290130307","article-title":"Lipid films in water conservation of biological systems","volume":"13","author":"Tiffany","year":"1995","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.jtos.2014.01.004_bib230","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0021-9797(86)90003-2","article-title":"The role of lipid abnormalities, aqueous and mucus deficiencies in the tear film breakup, and implications for tear substitutes and contact lens tolerance","volume":"111","author":"Sharma","year":"1986","journal-title":"J\u00a0Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib231","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0927-7765(99)00038-7","article-title":"A\u00a0thin film analog of the corneal mucus layer of the tear film: an enigmatic long range non-classical DLVO interaction in the breakup of thin polymer films","volume":"14","author":"Sharma","year":"1999","journal-title":"Colloids Surf B. Biointerfaces"},{"key":"10.1016\/j.jtos.2014.01.004_bib232","first-page":"267","article-title":"Observations of tear film break up on model eyes","volume":"17","author":"Fatt","year":"1991","journal-title":"CLAO J"},{"key":"10.1016\/j.jtos.2014.01.004_bib233","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/ICL.0b013e318193f4fc","article-title":"Factors affecting evaporation rates of tear film components measured in\u00a0vitro","volume":"35","author":"Borchman","year":"2009","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.jtos.2014.01.004_bib234","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/978-1-4615-5359-5_50","article-title":"Meibomian gland lipids, evaporation, and tear film stability","volume":"438","author":"Mathers","year":"1998","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib235","first-page":"613","article-title":"Evaporation rate of water from the precorneal tear film and cornea in the rabbit","volume":"8","author":"Iwata","year":"1969","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib236","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S1542-0124(12)70186-6","article-title":"Inputs and outputs of the lacrimal system: review of production and evaporative loss","volume":"7","author":"Tomlinson","year":"2009","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2014.01.004_bib237","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00006324-199701000-00014","article-title":"Importance of the lipid layer in human tear film stability and evaporation","volume":"74","author":"Craig","year":"1997","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib238","first-page":"S2461","article-title":"Effect of Meibomian lipid layer on evaporation of tears","volume":"16","author":"Miano","year":"2004","journal-title":"J\u00a0Physics: Condensed Matter"},{"key":"10.1016\/j.jtos.2014.01.004_bib239","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1167\/iovs.12-10487","article-title":"Do lipids retard the evaporation of the tear fluid?","volume":"53","author":"Rantamaki","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib240","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1167\/iovs.13-12408","article-title":"Melting points - the key to the anti-evaporative effect of the tear film wax esters","volume":"54","author":"Rantam\u00e4ki","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib241","doi-asserted-by":"crossref","first-page":"6294","DOI":"10.1167\/iovs.09-4772","article-title":"Evidence for the major contribution of evaporation to tear film thinning between blinks","volume":"51","author":"Kimball","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib242","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1463-5224.2005.00347.x","article-title":"Tear film breakup times in young healthy cats before and after anesthesia","volume":"8","author":"Cullen","year":"2005","journal-title":"Vet Ophthalmol"},{"issue":"s1","key":"10.1016\/j.jtos.2014.01.004_bib243","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1463-5224.2011.00916.x","article-title":"Tear-film osmolarity in normal cats and cats with conjunctivitis","volume":"14","author":"Davis","year":"2011","journal-title":"Vet Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib244","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1463-5224.2005.00362.x","article-title":"Qualitative tear film and conjunctival goblet cell assessment of cats with corneal sequestra","volume":"8","author":"Grahn","year":"2005","journal-title":"Vet Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib245","first-page":"27","article-title":"Epiphora and lacrimal system dysfunction in the horse","volume":"10","author":"Harling","year":"1988","journal-title":"Equine Pract"},{"key":"10.1016\/j.jtos.2014.01.004_bib246","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2460\/ajvr.70.3.394","article-title":"Effects of feline herpesvirus type 1 on tear film break-up time, Schirmer tear test results, and conjunctival goblet cell density in experimentally infected cats","volume":"70","author":"Lim","year":"2009","journal-title":"Am J\u00a0Vet Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib247","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0195-5616(90)50071-6","article-title":"Qualitative tear film disease","volume":"20","author":"Moore","year":"1990","journal-title":"Vet Clin North Am: Small Anim Pract"},{"key":"10.1016\/j.jtos.2014.01.004_bib248","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1463-5224.2001.00122.x","article-title":"The effect of third eyelid gland removal on the ocular surface of dogs","volume":"4","author":"Saito","year":"2001","journal-title":"Vet Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib249","first-page":"1","article-title":"Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis","volume":"2","author":"Trousdale","year":"2005","journal-title":"J\u00a0Autoimmune Dis"},{"key":"10.1016\/j.jtos.2014.01.004_bib250","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1444-0938.2012.00801.x","article-title":"Tear film break-up time in rabbits","volume":"96","author":"Wei","year":"2013","journal-title":"Clin Exp Optom"},{"key":"10.1016\/j.jtos.2014.01.004_bib251","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.1021\/la804095y","article-title":"Contact line pinning by microfabricated patterns: Effects of microscale topography","volume":"25","author":"Kalinin","year":"2009","journal-title":"Langmuir"},{"key":"10.1016\/j.jtos.2014.01.004_bib252","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev.matsci.38.060407.132434","article-title":"Wetting and roughness","volume":"38","author":"Qu\u00e9r\u00e9","year":"2008","journal-title":"Annu Rev Mater Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib253","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1039\/B514811C","article-title":"Soft contact: measurement and interpretation of contact angles","volume":"2","author":"Marmur","year":"2006","journal-title":"Soft Matter"},{"key":"10.1016\/j.jtos.2014.01.004_bib254","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/08927010600562328","article-title":"Super-hydrophobicity fundamentals: implications to biofouling prevention","volume":"22","author":"Marmur","year":"2006","journal-title":"Biofouling"},{"key":"10.1016\/j.jtos.2014.01.004_bib255","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jcis.2005.09.009","article-title":"Influence of physical and chemical heterogeneity shape on thin film rupture","volume":"295","author":"Simmons","year":"2006","journal-title":"J\u00a0Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib256","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1021\/la0012586","article-title":"Spontaneous dewetting and ordered patterns in evaporating thin liquid films on homogeneous and heterogeneous substrates","volume":"17","author":"Kargupta","year":"2001","journal-title":"Langmuir"},{"key":"10.1016\/j.jtos.2014.01.004_bib257","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1140\/epje\/e2004-00008-5","article-title":"Many paths to dewetting of thin films: anatomy and physiology of surface instability","volume":"12","author":"Sharma","year":"2003","journal-title":"Eur Phys J E Soft Matter"},{"key":"10.1016\/j.jtos.2014.01.004_bib258","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1103\/PhysRevLett.84.931","article-title":"Instability and morphology of thin liquid films on chemically heterogeneous substrates","volume":"84","author":"Konnur","year":"2000","journal-title":"Phys Rev Lett"},{"key":"10.1016\/j.jtos.2014.01.004_bib259","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000265970","article-title":"The microvilli structure of the corneal epithelium of the rabbit in relation to cell function","volume":"4","author":"Hoffmann","year":"1972","journal-title":"Ophthalmic Res"},{"key":"10.1016\/j.jtos.2014.01.004_bib260","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1569-2590(05)10003-2","article-title":"The cornea: epithelium and stroma","volume":"10","author":"Ehlers","year":"2005","journal-title":"Adv Organ Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib261","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/jcp.22302","article-title":"Fundamental role of microvilli in the main functions of differentiated cells: outline of an universal regulating and signaling system at the cell periphery","volume":"226","author":"Lange","year":"2010","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.jtos.2014.01.004_bib262","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/sj.eye.6702873","article-title":"Impression cytology with scanning electron microscopy: a new method in the study of conjunctival microvilli","volume":"22","author":"Cennamo","year":"2007","journal-title":"Eye"},{"key":"10.1016\/j.jtos.2014.01.004_bib263","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1167\/iovs.05-0804","article-title":"Conjunctival surface changes in patients with Sjogren's syndrome: a transmission electron microscopy study","volume":"47","author":"Koufakis","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib264","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/bmt.2011.89","article-title":"Mucosal microvilli in dry eye patients with chronic GVHD","volume":"47","author":"Tatematsu","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtos.2014.01.004_bib265","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1021\/ja0279693","article-title":"Two-level structured self-adaptive surfaces with reversibly tunable properties","volume":"125","author":"Minko","year":"2003","journal-title":"J\u00a0Am Chem Soc"},{"key":"10.1016\/j.jtos.2014.01.004_bib266","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1021\/la0532149","article-title":"The \u201clotus effect\u201d explained: two reasons why two length scales of topography are important","volume":"22","author":"Gao","year":"2006","journal-title":"Langmuir"},{"key":"10.1016\/j.jtos.2014.01.004_bib267","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nchem.1090","article-title":"Exploring and exploiting chemistry at the cell surface","volume":"3","author":"Mager","year":"2011","journal-title":"Nat Chem"},{"key":"10.1016\/j.jtos.2014.01.004_bib268","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1167\/iovs.07-0770","article-title":"The ocular surface: The challenge to enable and protect vision: The Friedenwald Lecture","volume":"48","author":"Gipson","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib269","first-page":"1957","article-title":"Kinetics of corneal epithelium turnover in\u00a0vivo. Studies of lovastatin","volume":"31","author":"Cenedella","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib270","series-title":"An Introduction to Rheology","author":"Barnes","year":"1989"},{"issue":"4","key":"10.1016\/j.jtos.2014.01.004_bib271","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/aic.690010409","article-title":"Flow of non-newtonian fluids\u2014correlation of the laminar, transition, and turbulent-flow regions","volume":"1","author":"Metzner","year":"1955","journal-title":"AICHE J"},{"key":"10.1016\/j.jtos.2014.01.004_bib272","first-page":"829","article-title":"Interfacial rheological properties of adsorbed surfactant films with applications to emulsion and foam stability","volume":"Vol 29","author":"Malhotra","year":"1988"},{"key":"10.1016\/j.jtos.2014.01.004_bib273","doi-asserted-by":"crossref","first-page":"14238","DOI":"10.1021\/la302731z","article-title":"Consequences of interfacial viscoelasticity on thin film stability","volume":"28","author":"Rosenfeld","year":"2012","journal-title":"Langmuir"},{"key":"10.1016\/j.jtos.2014.01.004_bib274","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev-fluid-120710-101042","article-title":"Dynamics of the tear film","volume":"44","author":"Braun","year":"2012","journal-title":"Annu Rev Fluid Mechan"},{"key":"10.1016\/j.jtos.2014.01.004_bib275","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0021-9797(86)90181-5","article-title":"An analytical nonlinear theory of thin film rupture and its application to wetting films","volume":"113","author":"Sharma","year":"1986","journal-title":"J\u00a0Colloid Interface Sci"},{"key":"10.1016\/j.jtos.2014.01.004_bib276","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1115\/1.1289997","article-title":"Nonlinear theory of tear film rupture","volume":"122","author":"Gorla","year":"2000","journal-title":"J\u00a0Biomech Eng"},{"key":"10.1016\/j.jtos.2014.01.004_bib277","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/BF00137947","article-title":"The viscosity of human tears","volume":"15","author":"Tiffany","year":"1991","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.jtos.2014.01.004_bib278","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/978-1-4615-5359-5_58","article-title":"The kinetics of lid motion and its effects on the tear film","volume":"438","author":"Berke","year":"1998","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib279","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/978-1-4615-2417-5_40","article-title":"Composition and biophysical properties of the tear film: knowledge and uncertainty","volume":"350","author":"Tiffany","year":"1994","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib280","series-title":"The Preocular Tear Film in Health, Disease and Contact Lens Wear","first-page":"728","article-title":"The role of mucous glycoproteins in the tear film","author":"Kaura","year":"1986"},{"key":"10.1016\/j.jtos.2014.01.004_bib281","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.proghi.2006.03.001","article-title":"Mucins and TFF peptides of the tear film and lacrimal apparatus","volume":"41","author":"Paulsen","year":"2006","journal-title":"Prog Histochem Cytochem"},{"issue":"Pt A","key":"10.1016\/j.jtos.2014.01.004_bib282","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/978-1-4615-0717-8_81","article-title":"The role of lipocalin in determining the physical properties of tears","volume":"506","author":"Tiffany","year":"2002","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jtos.2014.01.004_bib283","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbapap.2005.08.023","article-title":"Human tear viscosity: an interactive role for proteins and lipids","volume":"175","author":"Gouveia","year":"2005","journal-title":"Biochim Biophys Acta (BBA)-Proteins and Proteomics"},{"key":"10.1016\/j.jtos.2014.01.004_bib284","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1615\/InterJFluidMechRes.v31.i6.20","article-title":"Rheological effects on tear film rupture","volume":"31","author":"Gorla","year":"2004","journal-title":"Int J\u00a0Fluid Mechan Res"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012414000731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012414000731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T07:29:38Z","timestamp":1746170978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012414000731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":284,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S1542012414000731"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2014.01.004","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}