{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:24:08Z","timestamp":1779927848996,"version":"3.53.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council of Singapore","doi-asserted-by":"crossref","award":["NMRC\\CSA\\045\\2012"],"award-info":[{"award-number":["NMRC\\CSA\\045\\2012"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council of Singapore","doi-asserted-by":"crossref","award":["NMRC\/CSA\/017\/2017"],"award-info":[{"award-number":["NMRC\/CSA\/017\/2017"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["theocularsurfacejournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.jtos.2018.06.005","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T14:40:22Z","timestamp":1529592022000},"page":"441-447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Altered expression level of inflammation-related genes and long-term changes in ocular surface after trabeculectomy, a prospective cohort study"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3986-6552","authenticated-orcid":false,"given":"L.","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.H.","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.T.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2018.06.005_bib1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"BJO (Br J Ophthalmol)"},{"key":"10.1016\/j.jtos.2018.06.005_bib2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000458487","article-title":"Ocular surface and external filtration surgery: mutual relationships","volume":"59","author":"Baudouin","year":"2017","journal-title":"Dev Ophthalmol"},{"key":"10.1016\/j.jtos.2018.06.005_bib3","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.2147\/OPTH.S134570","article-title":"Ocular lubricant use in medically and surgically treated glaucoma: a retrospective longitudinal analysis","volume":"11","author":"Iyer","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.jtos.2018.06.005_bib4","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/eye.2013.144","article-title":"Effect of chronic anti-glaucoma medications and trabeculectomy on tear osmolarity","volume":"27","author":"Lee","year":"2013","journal-title":"Eye"},{"key":"10.1016\/j.jtos.2018.06.005_bib5","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.1167\/iovs.10-6532","article-title":"Proteomic profiling of inflammatory signaling molecules in the tears of patients on chronic glaucoma medication","volume":"52","author":"Wong","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2018.06.005_bib6","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jfo.2014.06.005","article-title":"Glaucoma medications, preservatives and the ocular surface","volume":"37","author":"Aptel","year":"2014","journal-title":"J Fr Ophtalmol"},{"issue":"3","key":"10.1016\/j.jtos.2018.06.005_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jtos.2018.03.002","article-title":"Exploring topical anti-glaucoma medication effects on the ocular surface in the context of the current understanding of dry eye","volume":"16","author":"Wong","year":"2018","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2018.06.005_bib8","first-page":"187","article-title":"Ocular surface disease in posttrabeculectomy\/mitomycin C patients","volume":"9","author":"Lam","year":"2015","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.jtos.2018.06.005_bib9","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1167\/iovs.15-16555","article-title":"Correlation between the inflammatory marker HLA-DR and signs and symptoms in moderate to severe dry eye disease","volume":"58","author":"Brignole-Baudouin","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jtos.2018.06.005_bib10","first-page":"782","article-title":"Flow cytometric analysis of HLA-DR, IL-6 and IL-8 expression by conjunctival epithelial cells from patients with prolonged topical antiglaucoma treatments","volume":"26","author":"Bensoussan","year":"2003","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.jtos.2018.06.005_bib11","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3109\/02713688808997247","article-title":"HLA DR and DQ distribution in normal human ocular structures","volume":"7","author":"Baudouin","year":"1988","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2018.06.005_bib12","doi-asserted-by":"crossref","first-page":"45312","DOI":"10.1038\/srep45312","article-title":"Tissue resident memory T cells in the human conjunctiva and immune signatures in human dry eye disease","volume":"7","author":"Bose","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtos.2018.06.005_bib13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S1542-0124(12)70053-8","article-title":"Development and validation of a short global dry eye symptom index","volume":"5","author":"Schaumberg","year":"2007","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2018.06.005_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.clae.2016.06.006","article-title":"Measurement variability of the TearLab Osmolarity System. Contact lens & anterior eye","volume":"39","author":"Szczesna-Iskander","year":"2016","journal-title":"J Br Contact Lens Assoc"},{"key":"10.1016\/j.jtos.2018.06.005_bib15","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.2147\/OPTH.S110180","article-title":"Agreement of noninvasive tear break-up time measurement between tomey RT-7000 auto refractor-keratometer and Oculus Keratograph 5M","volume":"10","author":"Lee","year":"2016","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.jtos.2018.06.005_bib16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/cxo.12357","article-title":"Effects of wearing a daily disposable lens on tear film: a randomised controlled trial","volume":"99","author":"Chong","year":"2016","journal-title":"Clin Exp Optom"},{"key":"10.1016\/j.jtos.2018.06.005_bib17","doi-asserted-by":"crossref","first-page":"8013","DOI":"10.1167\/iovs.13-12802","article-title":"Corneal staining characteristics in limited zones compared with whole cornea documentation for the detection of dry eye subtypes","volume":"54","author":"Fenner","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jtos.2018.06.005_bib18","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","article-title":"TFOS DEWS II diagnostic methodology report","volume":"15","author":"Wolffsohn","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2018.06.005_bib19","doi-asserted-by":"crossref","DOI":"10.3791\/55591","article-title":"A non-invasive way to isolate and phenotype cells from the conjunctiva","author":"Bose","year":"2017","journal-title":"JoVE"},{"key":"10.1016\/j.jtos.2018.06.005_bib20","first-page":"63","article-title":"Development and evaluation of a Pan-Sarcoma fusion gene detection assay using the NanoString nCounter platform","volume":"20","author":"Chang","year":"2018","journal-title":"J Mod Dynam"},{"key":"10.1016\/j.jtos.2018.06.005_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-1-4939-7652-2_14","article-title":"Multiplexed detection and quantitation of extracellular vesicle RNA expression using NanoString","volume":"1740","author":"Shukla","year":"2018","journal-title":"Meth Mol Biol"},{"key":"10.1016\/j.jtos.2018.06.005_bib22","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jtos.2018.06.005_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000448117","article-title":"Hyperosmolarity and benzalkonium chloride differently stimulate inflammatory markers in conjunctiva-derived epithelial cells in vitro","volume":"58","author":"Warcoin","year":"2017","journal-title":"Ophthalmic Res"},{"key":"10.1016\/j.jtos.2018.06.005_bib24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.preteyeres.2014.10.001","article-title":"Clinical staining of the ocular surface: mechanisms and interpretations","volume":"44","author":"Bron","year":"2015","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2018.06.005_bib25","doi-asserted-by":"crossref","first-page":"795","DOI":"10.4049\/jimmunol.1401414","article-title":"Focal adhesion kinase-mediated activation of glycogen synthase kinase 3beta regulates IL-33 receptor internalization and IL-33 signaling","volume":"194","author":"Zhao","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2018.06.005_bib26","doi-asserted-by":"crossref","first-page":"697","DOI":"10.4239\/wjd.v5.i5.697","article-title":"Targeting inflammation in diabetes: newer therapeutic options","volume":"5","author":"Agrawal","year":"2014","journal-title":"World J Diabetes"},{"key":"10.1016\/j.jtos.2018.06.005_bib27","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/cbdd.12779","article-title":"2-Prenylated m-dimethoxybenzenes as potent inhibitors of 15-lipo-oxygenase: inhibitory mechanism and SAR studies","volume":"88","author":"Jabbari","year":"2016","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.jtos.2018.06.005_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.plefa.2017.01.004","article-title":"Identification and profiling of specialized pro-resolving mediators in human tears by lipid mediator metabolomics","volume":"117","author":"English","year":"2017","journal-title":"Prostagl Leukot Essent Fat Acids"},{"key":"10.1016\/j.jtos.2018.06.005_bib29","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1001\/archophthalmol.2012.1067","article-title":"Regulation of leukotriene B4 secretion by human corneal, conjunctival, and meibomian gland epithelial cells","volume":"130","author":"Sahin","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2018.06.005_bib30","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1189\/jlb.3A0717-311R","article-title":"Myd88 is required for disease development in a primary Sjogren's syndrome mouse model","volume":"102","author":"Kiripolsky","year":"2017","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jtos.2018.06.005_bib31","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/ICU.0b013e3283543b61","article-title":"Nerve growth factor therapy for corneal disease","volume":"23","author":"Lambiase","year":"2012","journal-title":"Curr Opin Ophthalmol"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012418301101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012418301101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T03:32:50Z","timestamp":1538623970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012418301101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S1542012418301101"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2018.06.005","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered expression level of inflammation-related genes and long-term changes in ocular surface after trabeculectomy, a prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2018.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}