{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:09:28Z","timestamp":1783386568982,"version":"3.54.6"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH\/NEI","doi-asserted-by":"publisher","award":["R01EY026947"],"award-info":[{"award-number":["R01EY026947"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.jtos.2018.12.003","type":"journal-article","created":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T20:27:01Z","timestamp":1544905621000},"page":"356-359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Characterization of the thickness of the tear film lipid layer using high resolution microscopy"],"prefix":"10.1016","volume":"17","author":[{"given":"Yuqiang","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1519-7734","authenticated-orcid":false,"given":"Jason J.","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Supplement C","key":"10.1016\/j.jtos.2018.12.003_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.preteyeres.2017.02.002","article-title":"Advances in thickness measurements and dynamic visualization of the tear film using non-invasive optical approaches","volume":"58","author":"Bai","year":"2017","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"10.1016\/j.jtos.2018.12.003_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00006324-199701000-00014","article-title":"Importance of the lipid layer in human tear film stability and evaporation","volume":"74","author":"Craig","year":"1997","journal-title":"Optom Vis Sci"},{"issue":"11","key":"10.1016\/j.jtos.2018.12.003_bib3","doi-asserted-by":"crossref","first-page":"7272","DOI":"10.1167\/iovs.14-15512","article-title":"Antimicrobial role of human meibomian lipids at the ocular surface","volume":"55","author":"Mudgil","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.jtos.2018.12.003_bib4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1475-1313.1991.tb00193.x","article-title":"Tear production and evaporation in the normal eye","volume":"11","author":"Tomlinson","year":"1991","journal-title":"Ophthalmic Physiol Optic"},{"issue":"10","key":"10.1016\/j.jtos.2018.12.003_bib5","first-page":"2942","article-title":"Tear evaporation from the ocular surface","volume":"33","author":"Tsubota","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"10.1016\/j.jtos.2018.12.003_bib6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00006324-198906000-00008","article-title":"An instrument for in vivo tear film interferometry","volume":"66","author":"Doane","year":"1989","journal-title":"Optom Vis Sci"},{"issue":"1","key":"10.1016\/j.jtos.2018.12.003_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00006324-199901000-00025","article-title":"Three interferometric methods for measuring the thickness of layers of the tear film","volume":"76","author":"King-Smith","year":"1999","journal-title":"Optom Vis Sci"},{"issue":"2","key":"10.1016\/j.jtos.2018.12.003_bib8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1542-0124(12)70157-X","article-title":"Assessment of tear film dynamics: quantification approach","volume":"3","author":"Tomlinson","year":"2005","journal-title":"Ocul Surf"},{"issue":"5","key":"10.1016\/j.jtos.2018.12.003_bib9","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1167\/iovs.09-4387","article-title":"Application of a novel interferometric method to investigate the relation between lipid layer thickness and tear film thinning","volume":"51","author":"King-Smith","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.jtos.2018.12.003_bib10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.exer.2003.09.020","article-title":"Non-invasive methods of assessing the tear film","volume":"78","author":"Yokoi","year":"2004","journal-title":"Exp Eye Res"},{"issue":"6","key":"10.1016\/j.jtos.2018.12.003_bib11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0002-9394(14)70378-2","article-title":"Correlation of tear lipid layer interference patterns with the diagnosis and severity of dry eye","volume":"122","author":"Yokoi","year":"1996","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"10.1016\/j.jtos.2018.12.003_bib12","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/00003226-199407000-00012","article-title":"Tear film lipid layer thickness as a function of blinking","volume":"13","author":"Korb","year":"1994","journal-title":"Cornea"},{"issue":"1","key":"10.1016\/j.jtos.2018.12.003_bib13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12938-017-0426-8","article-title":"Image-based quantitative analysis of tear film lipid layer thickness for meibomian gland evaluation","volume":"16","author":"Hwang","year":"2017","journal-title":"Biomed Eng Online"},{"issue":"2","key":"10.1016\/j.jtos.2018.12.003_bib14","first-page":"249","article-title":"A spectral-discrimination method for tear-film lipid-layer thickness estimation from fringe pattern images","volume":"47","author":"Khamene","year":"2000","journal-title":"IEEE (Inst Electr Electron Eng) Trans Biomed Eng"},{"key":"10.1016\/j.jtos.2018.12.003_bib15","series-title":"Lacrimal gland, tear film, and dry eye syndromes 2","first-page":"297","article-title":"Tear film interferometry as a diagnostic tool for evaluating normal and dry-eye tear film","author":"Doane","year":"1998"},{"issue":"4","key":"10.1016\/j.jtos.2018.12.003_bib16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1542-0124(11)70033-7","article-title":"High resolution microscopy of the lipid layer of the tear film","volume":"9","author":"King-Smith","year":"2011","journal-title":"Ocul Surf"},{"issue":"4","key":"10.1016\/j.jtos.2018.12.003_bib17","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1167\/iovs.14-14076","article-title":"Tear film interferometry and corneal surface roughness","volume":"55","author":"King-Smith","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.jtos.2018.12.003_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jtos.2017.09.007","article-title":"Mechanisms, imaging and structure of tear film breakup","volume":"16","author":"King-Smith","year":"2018","journal-title":"Ocul Surf"},{"issue":"1","key":"10.1016\/j.jtos.2018.12.003_bib19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00006324-199701000-00014","article-title":"Importance of the lipid layer in human tear film stability and evaporation","volume":"74","author":"Craig","year":"1997","journal-title":"Optom Vis Sci"},{"issue":"12","key":"10.1016\/j.jtos.2018.12.003_bib20","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1194\/jlr.M900252-JLR200","article-title":"Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum","volume":"50","author":"Butovich","year":"2009","journal-title":"JLR (J Lipid Res)"},{"key":"10.1016\/j.jtos.2018.12.003_bib21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.exer.2015.05.002","article-title":"The real reason for having a meibomian lipid layer covering the outer surface of the tear film \u2013 a review","volume":"137","author":"Millar","year":"2015","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2018.12.003_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.exer.2013.06.016","article-title":"An investigation of the likely role of (O-acyl) \u03c9-hydroxy fatty acids in meibomian lipid films using (O-oleyl) \u03c9-hydroxy palmitic acid as a model","volume":"115","author":"Schuett","year":"2013","journal-title":"Exp Eye Res"},{"issue":"11","key":"10.1016\/j.jtos.2018.12.003_bib23","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1063\/1.1749243","article-title":"Oil lenses on water and the nature of monomolecular expanded films","volume":"1","author":"Langmuir","year":"1933","journal-title":"J Chem Phys"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012418303380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012418303380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:34:09Z","timestamp":1761539649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012418303380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S1542012418303380"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2018.12.003","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of the thickness of the tear film lipid layer using high resolution microscopy","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2018.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}