{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:13:09Z","timestamp":1788606789155,"version":"build-2803163510"},"reference-count":123,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY012963"],"award-info":[{"award-number":["EY012963"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY020889"],"award-info":[{"award-number":["EY020889"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jtos.2019.06.001","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T22:21:12Z","timestamp":1559686872000},"page":"374-383","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Thrombospondin-1 in ocular surface health and disease"],"prefix":"10.1016","volume":"17","author":[{"given":"William","family":"Foulsham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Dohlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharad K.","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukako","family":"Taketani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan Bir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Masli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Dana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2019.06.001_bib1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.1176009","article-title":"The extracellular matrix: not just pretty fibrils","volume":"326","author":"Hynes","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jtos.2019.06.001_bib2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009712","article-title":"The thrombospondins","volume":"3","author":"Adams","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jtos.2019.06.001_bib3","doi-asserted-by":"crossref","first-page":"8609","DOI":"10.1016\/S0021-9258(17)34336-3","article-title":"Isolation and characterization of a high molecular weight glycoprotein from human blood platelets","volume":"253","author":"Lawler","year":"1978","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtos.2019.06.001_bib4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1189\/jlb.1102574","article-title":"Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation","volume":"74","author":"Streilein","year":"2003","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jtos.2019.06.001_bib5","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/02713683.2013.877936","article-title":"Matricellular protein thrombospondins: influence on ocular angiogenesis, wound healing and immuneregulation","volume":"39","author":"Masli","year":"2014","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2019.06.001_bib6","doi-asserted-by":"crossref","first-page":"6708","DOI":"10.1167\/iovs.11-9013","article-title":"Thrombospondin-1 (TSP1)\u2013Null and TSP2-null mice exhibit lower intraocular pressures","volume":"53","author":"Haddadin","year":"2012","journal-title":"Investig Opthalmol Vis. Sci."},{"key":"10.1016\/j.jtos.2019.06.001_bib7","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1167\/iovs.03-0940","article-title":"Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis","volume":"45","author":"Cursiefen","year":"2004","journal-title":"Investig Ophthalmol Vis Sci."},{"key":"10.1016\/j.jtos.2019.06.001_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2005.05.001","article-title":"Thrombospondin 1, thrombospondin 2 and the eye","volume":"25","author":"Hiscott","year":"2006","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2019.06.001_bib9","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/296069","article-title":"Thrombospondin-1: multiple paths to inflammation","volume":"2011","author":"Lopez-Dee","year":"2011","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jtos.2019.06.001_bib10","doi-asserted-by":"crossref","first-page":"40679","DOI":"10.1074\/jbc.M302014200","article-title":"Recognition of the N-terminal modules of thrombospondin-1 and thrombospondin-2 by \u03b16\u03b21 integrin","volume":"278","author":"Calzada","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtos.2019.06.001_bib11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.critrevonc.2003.09.009","article-title":"Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth","volume":"49","author":"Sid","year":"2004","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.jtos.2019.06.001_bib12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.200206062","article-title":"Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication","volume":"159","author":"Tan","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jtos.2019.06.001_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/71517","article-title":"Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1","volume":"6","author":"Jim\u00e9nez","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.jtos.2019.06.001_bib14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.abb.2008.07.015","article-title":"Human thrombospondin's (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: a molecular modeling study","volume":"478","author":"Floquet","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jtos.2019.06.001_bib15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1083\/jcb.200209138","article-title":"The face of TSR revealed: an extracellular signaling domain is exposed","volume":"159","author":"Silverstein","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jtos.2019.06.001_bib16","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1172\/JCI1684","article-title":"Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia","volume":"101","author":"Lawler","year":"1998","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jtos.2019.06.001_bib17","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0092-8674(00)81460-9","article-title":"Thrombospondin-1 is a major activator of TGF-beta1 in vivo","volume":"93","author":"Crawford","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.jtos.2019.06.001_bib18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/1479-5876-10-183","article-title":"TGF-\u03b2 \u2013 an excellent servant but a bad master","volume":"10","author":"Kubiczkova","year":"2012","journal-title":"J Transl Med"},{"key":"10.1016\/j.jtos.2019.06.001_bib19","first-page":"18","article-title":"The role of the TGF-\u03b2 family in wound healing, burns and scarring: a review","volume":"2","author":"Penn","year":"2012","journal-title":"Int J Burns Trauma"},{"key":"10.1016\/j.jtos.2019.06.001_bib20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.matbio.2015.05.006","article-title":"The extracellular matrix and transforming growth factor-\u03b21: tale of a strained relationship","volume":"47","author":"Hinz","year":"2015","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jtos.2019.06.001_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.etp.2008.04.010","article-title":"A TSP-1 synthetic peptide inhibits bleomycin-induced lung fibrosis in mice","volume":"61","author":"Chen","year":"2009","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.jtos.2019.06.001_bib22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1523-1755.2004.00395.x","article-title":"Thrombospondin-1 is a major activator of TGF-\u03b2 in fibrotic renal disease in the rat in vivo","volume":"65","author":"Daniel","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.jtos.2019.06.001_bib23","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1182\/blood-2010-07-294447","article-title":"Thrombospondin-1 is not the major activator of TGF-\u03b21 in thrombopoietin-induced myelofibrosis","volume":"117","author":"Evrard","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jtos.2019.06.001_bib24","doi-asserted-by":"crossref","first-page":"17933","DOI":"10.1074\/jbc.275.24.17933","article-title":"Activation of platelet-transforming growth factor \u03b2-1 in the absence of thrombospondin-1","volume":"275","author":"Abdelouahed","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtos.2019.06.001_bib25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","article-title":"Transforming growth factor-\u03b2 regulation of immune responses","volume":"24","author":"Li","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib26","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0002-9440(10)65183-8","article-title":"Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36","volume":"155","author":"Yehualaeshet","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2019.06.001_bib27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0092-8674(00)80545-0","article-title":"The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis","volume":"96","author":"Munger","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jtos.2019.06.001_bib28","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1083\/jcb.136.5.1151","article-title":"Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta","volume":"136","author":"Nunes","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jtos.2019.06.001_bib29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1600-065X.2007.00565.x","article-title":"\u201cYin-Yang\u201d functions of transforming growth factor-beta and T regulatory cells in immune regulation","volume":"220","author":"Wan","year":"2007","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jtos.2019.06.001_bib30","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022236","article-title":"Regulation of the immune response by TGF-\u03b2: from conception to autoimmunity and infection","volume":"9","author":"Sanjabi","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jtos.2019.06.001_bib31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1359-6101(99)00029-5","article-title":"Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology","volume":"11","author":"Murphy-Ullrich","year":"2000","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jtos.2019.06.001_bib32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/imr.12035","article-title":"The Th17 family: flexibility follows function","volume":"252","author":"Basu","year":"2013","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jtos.2019.06.001_bib33","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.autrev.2013.12.004","article-title":"Th17 and regulatory T cell balance in autoimmune and inflammatory diseases","volume":"13","author":"Noack","year":"2014","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jtos.2019.06.001_bib34","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/imm.12517","article-title":"Thrombospondin-1-dependent immune regulation by transforming growth factor-\u03b22-exposed antigen-presenting cells","volume":"146","author":"Mir","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.jtos.2019.06.001_bib35","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1084\/jem.20030705","article-title":"Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation","volume":"198","author":"Doyen","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jtos.2019.06.001_bib36","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.4049\/jimmunol.177.6.3534","article-title":"Thrombospondin\/CD47 interaction: a pathway to generate regulatory T cells from human CD4+ CD25- T cells in response to inflammation","volume":"177","author":"Grimbert","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib37","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.4049\/jimmunol.178.9.5930","article-title":"Interactions between CD47 and thrombospondin reduce inflammation","volume":"178","author":"Lamy","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib38","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006627","article-title":"Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2","volume":"2","author":"Lawler","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.jtos.2019.06.001_bib39","doi-asserted-by":"crossref","first-page":"6624","DOI":"10.1073\/pnas.87.17.6624","article-title":"A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin","volume":"87","author":"Good","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jtos.2019.06.001_bib40","doi-asserted-by":"crossref","first-page":"32167","DOI":"10.1074\/jbc.M003834200","article-title":"Thrombospondin type 1 repeats interact with matrix metalloproteinase 2","volume":"275","author":"Bein","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtos.2019.06.001_bib41","doi-asserted-by":"crossref","first-page":"12485","DOI":"10.1073\/pnas.171460498","article-title":"Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor","volume":"98","author":"Rodriguez-Manzaneque","year":"2001","journal-title":"Proc Natl Acad Sci Unit States Am"},{"key":"10.1016\/j.jtos.2019.06.001_bib42","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1023\/A:1009018702832","article-title":"Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: effect on human microvascular endothelial cell proliferation and angiogenesis","volume":"3","author":"Gupta","year":"1999","journal-title":"Angiogenesis"},{"key":"10.1016\/j.jtos.2019.06.001_bib43","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/jcp.20904","article-title":"Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1)","volume":"210","author":"Greenaway","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jtos.2019.06.001_bib44","doi-asserted-by":"crossref","first-page":"H1344","DOI":"10.1152\/ajpheart.01246.2008","article-title":"Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina","volume":"296","author":"Sun","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jtos.2019.06.001_bib45","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1096\/fj.09-131649","article-title":"Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level","volume":"23","author":"Zhang","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.jtos.2019.06.001_bib46","doi-asserted-by":"crossref","first-page":"8733","DOI":"10.1074\/jbc.M109.085605","article-title":"Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds","volume":"285","author":"Colombo","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtos.2019.06.001_bib47","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0026-895X(24)12032-9","article-title":"Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat","volume":"55","author":"Dawson","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jtos.2019.06.001_bib48","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1091\/mbc.e07-07-0649","article-title":"Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells","volume":"19","author":"Oganesian","year":"2008","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jtos.2019.06.001_bib49","doi-asserted-by":"crossref","first-page":"26069","DOI":"10.1074\/jbc.M605040200","article-title":"CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1","volume":"281","author":"Isenberg","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtos.2019.06.001_bib50","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4161\/cc.10.1.14324","article-title":"CD47 applies the brakes to angiogenesis via vascular endothelial growth factor receptor-2","volume":"10","author":"Kaur","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jtos.2019.06.001_bib51","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0002-9440(10)64243-5","article-title":"The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1\/TSP2-null mice","volume":"161","author":"Agah","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2019.06.001_bib52","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0923-1811(02)00150-0","article-title":"Thrombospondin-1 promotes fibroblast-mediated collagen gel contraction caused by activation of latent transforming growth factor beta-1","volume":"31","author":"Sakai","year":"2003","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jtos.2019.06.001_bib53","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0022-4804(02)96485-1","article-title":"Thrombospondin-1 promotes proliferative healing through stabilization of PDGF","volume":"107","author":"Krishnaswami","year":"2002","journal-title":"J Surg Res"},{"key":"10.1016\/j.jtos.2019.06.001_bib54","first-page":"1851","article-title":"Thrombospondin 1 synthesis and function in wound repair","volume":"148","author":"DiPietro","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2019.06.001_bib55","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1093\/emboj\/19.13.3272","article-title":"Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice","volume":"19","author":"Streit","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.jtos.2019.06.001_bib56","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s12079-009-0077-z","article-title":"The role of thrombospondins in wound healing, ischemia, and the foreign body reaction","volume":"3","author":"Kyriakides","year":"2009","journal-title":"J Cell Commun Signal"},{"key":"10.1016\/j.jtos.2019.06.001_bib57","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1167\/iovs.05-1305","article-title":"Unique distribution of thrombospondin-1 in human ocular surface epithelium","volume":"47","author":"Sekiyama","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jtos.2019.06.001_bib58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s004410050877","article-title":"Immunolocalisation of thrombospondin 1 in human, bovine and rabbit cornea","volume":"289","author":"Hiscott","year":"1997","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jtos.2019.06.001_bib59","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.exer.2011.06.018","article-title":"Localization of thrombospondin-1 and myofibroblasts during corneal wound repair","volume":"93","author":"Matsuba","year":"2011","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2019.06.001_bib60","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.bbrc.2004.01.146","article-title":"Thrombospondin-1 accelerates wound healing of corneal epithelia","volume":"315","author":"Uno","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jtos.2019.06.001_bib61","doi-asserted-by":"crossref","first-page":"6262","DOI":"10.1167\/iovs.13-11710","article-title":"Role of thrombospondin-1 in repair of penetrating corneal wounds","volume":"54","author":"Blanco-Mezquita","year":"2013","journal-title":"Investig. Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2019.06.001_bib62","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jtos.2018.07.005","article-title":"The immunoregulatory role of corneal epithelium-derived thrombospondin-1 in dry eye disease","volume":"16","author":"Tan","year":"2018","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2019.06.001_bib63","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1089\/jop.2015.0029","article-title":"Inflammatory cytokine-mediated regulation of thrombospondin-1 and CD36 in conjunctival cells","volume":"31","author":"Soriano-Roman\u00ed","year":"2015","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.1016\/j.jtos.2019.06.001_bib64","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/mi.2009.21","article-title":"Role of Th17 cells in the immunopathogenesis of dry eye disease","volume":"2","author":"Chauhan","year":"2009","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib65","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.4049\/jimmunol.182.3.1247","article-title":"Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression","volume":"182","author":"Chauhan","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajo.2017.06.033","article-title":"Prevalence of diagnosed dry eye disease in the United States among adults aged 18 Years and older","author":"Farrand","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2019.06.001_bib67","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jtos.2017.08.003","article-title":"TFOS DEWS II report executive summary","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2019.06.001_bib68","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1001\/archophthalmol.2011.364","article-title":"Dry eye disease","volume":"130","author":"Stevenson","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2019.06.001_bib69","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.preteyeres.2012.02.003","article-title":"Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye disease","volume":"31","author":"Barabino","year":"2012","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2019.06.001_bib70","first-page":"176","article-title":"Desiccating stress induces T cell-mediated sj\u00f6gren\u2019s syndrome-like lacrimal keratoconjunctivitis","author":"Niederkorn","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib71","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1167\/iovs.14-14481","article-title":"CCR7 is critical for the induction and maintenance of Th17 immunity in dry eye disease","volume":"55","author":"Kodati","year":"2014","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2019.06.001_bib72","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1167\/iovs.08-2417","article-title":"Characterization of effector T cells in dry eye disease","volume":"50","author":"El Annan","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jtos.2019.06.001_bib73","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jtos.2017.05.013","article-title":"Review: the function of regulatory T cells at the ocular surface","volume":"15","author":"Foulsham","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2019.06.001_bib74","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jtos.2019.06.001_bib75","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1189\/jlb.1012524","article-title":"Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress","volume":"94","author":"Gandhi","year":"2013","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jtos.2019.06.001_bib76","doi-asserted-by":"crossref","first-page":"6994","DOI":"10.4049\/jimmunol.178.11.6994","article-title":"Role of thrombospondin-1 in T cell response to ocular pigment epithelial cells","volume":"178","author":"Futagami","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib77","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.2353\/ajpath.2009.081058","article-title":"Sj\u00f6gren\u2019s syndrome-like ocular surface disease in thrombospondin-1 deficient mice","volume":"175","author":"Turpie","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2019.06.001_bib78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075937","article-title":"Conjunctival inflammation in thrombospondin-1 deficient mouse model of sj\u00f6gren\u2019s syndrome","volume":"8","author":"Contreras-Ruiz","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jtos.2019.06.001_bib79","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/s41385-018-0002-y","article-title":"Alteration in nerves and neurotransmitter stimulation of lacrimal gland secretion in the TSP-1-\/- mouse model of aqueous deficiency dry eye","volume":"11","author":"Bhattacharya","year":"2018","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib80","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103191","article-title":"Thrombospondin-1 is necessary for the development and repair of corneal nerves","volume":"19","author":"Tatematsu","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2019.06.001_bib81","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.exer.2013.08.011","article-title":"The role of corneal afferent neurons in regulating tears under normal and dry eye conditions","volume":"117","author":"Meng","year":"2013","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2019.06.001_bib82","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3928\/1081597X-20160603-01","article-title":"Long-term effects of LASIK on corneal innervation and tear neuropeptides and the associations with dry eye","volume":"32","author":"Chao","year":"2016","journal-title":"J Refract Surg"},{"key":"10.1016\/j.jtos.2019.06.001_bib83","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/cei.12919","article-title":"Thrombospondin-derived peptide attenuates Sj\u00f6gren\u2019s syndrome-associated ocular surface inflammation in mice","volume":"188","author":"Contreras Ruiz","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib84","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/ijms20010009","article-title":"Topical application of TGF-\u03b2-activating peptide, KRFK, prevents inflammatory manifestations in the TSP-1-deficient mouse model of chronic ocular inflammation","volume":"20","author":"Soriano-Roman\u00ed","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2019.06.001_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120284","article-title":"Immunomodulatory cross-talk between conjunctival goblet cells and dendritic cells","volume":"10","author":"Contreras-Ruiz","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jtos.2019.06.001_bib86","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.ophtha.2014.01.033","article-title":"Polymorphism in THBS1 gene is associated with post-refractive surgery chronic ocular surface inflammation","volume":"121","author":"Contreras-Ruiz","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2019.06.001_bib87","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1189\/jlb.3A0815-357RR","article-title":"Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease","volume":"100","author":"Smith","year":"2016","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jtos.2019.06.001_bib88","doi-asserted-by":"crossref","first-page":"842","DOI":"10.2174\/138945008785909310","article-title":"CD47 in the immune response: role of thrombospondin and SIRP-alpha reverse signaling","volume":"9","author":"Sarfati","year":"2008","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.jtos.2019.06.001_bib89","first-page":"50","volume":"vol. 92","author":"Cursiefen","year":"2007"},{"key":"10.1016\/j.jtos.2019.06.001_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2012.07.002","article-title":"Pathogenesis of herpes stromal keratitis--a focus on corneal neovascularization","volume":"33","author":"Gim\u00e9nez","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2019.06.001_bib91","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.it.2017.11.007","article-title":"When clarity is crucial: regulating ocular surface immunity","volume":"39","author":"Foulsham","year":"2018","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib92","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1084\/jem.20092277","article-title":"Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes","volume":"208","author":"Cursiefen","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.jtos.2019.06.001_bib93","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","article-title":"Lymphangiogenesis: molecular mechanisms and future promise","volume":"140","author":"Tammela","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jtos.2019.06.001_bib94","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/71517","article-title":"Signals leading to apoptosis-dependent inhibition of neovascularizationby thrombospondin-1","volume":"6","author":"Jim\u00e9nez","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.jtos.2019.06.001_bib95","doi-asserted-by":"crossref","first-page":"38923","DOI":"10.1074\/jbc.M110.172304","article-title":"Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47","volume":"285","author":"Kaur","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtos.2019.06.001_bib96","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/00003226-200009000-00008","article-title":"Twenty-five-year panorama of corneal immunology: emerging concepts in the immunopathogenesis of microbial keratitis, peripheral ulcerative keratitis, and corneal transplant rejection","volume":"19","author":"Dana","year":"2000","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2019.06.001_bib97","series-title":"Eye banking statistical report","author":"Eye Bank Associtaion of America","year":"2017"},{"key":"10.1016\/j.jtos.2019.06.001_bib98","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.4049\/jimmunol.1600251","article-title":"Alloimmunity and tolerance in corneal transplantation","volume":"196","author":"Amouzegar","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib99","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1001\/archopht.1992.01080220054021","article-title":"The collaborative corneal transplantation studies (CCTS): effectiveness of histocompatibility matching in high-risk corneal transplantation","volume":"110","year":"1992","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2019.06.001_bib100","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1097\/00007890-199910150-00011","article-title":"Detection of minor alloantigen-specific cytotoxic T cells after rejection of murine orthotopic corneal allografts: evidence that graft antigens are recognized exclusively via the indirect pathway","volume":"68","author":"Sano","year":"1999","journal-title":"Transplantation"},{"key":"10.1016\/j.jtos.2019.06.001_bib101","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.4049\/jimmunol.173.7.4464","article-title":"Relevance of the direct pathway of sensitization in corneal transplantation is dictated by the graft bed micronenvironment","volume":"173","author":"Huq","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib102","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1167\/iovs.02-0838","article-title":"The corneal stroma is endowed with a significant number of resident dendritic cells","volume":"44","author":"Hamrah","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jtos.2019.06.001_bib103","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.4049\/jimmunol.1001133","article-title":"Thrombospondin-1 derived from APCs regulates their capacity for allosensitization","volume":"185","author":"Saban","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib104","first-page":"626","article-title":"The chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking","volume":"13","author":"Jin","year":"2007","journal-title":"Mol Vis"},{"key":"10.1016\/j.jtos.2019.06.001_bib105","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4049\/jimmunol.0903180","article-title":"Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation","volume":"184","author":"Dietrich","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2019.06.001_bib106","first-page":"1293","article-title":"The critical role of lymph nodes in corneal alloimmunization and graft rejection","volume":"42","author":"Yamagami","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jtos.2019.06.001_bib107","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1167\/iovs.03-1380","article-title":"Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival","volume":"45","author":"Cursiefen","year":"2004","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"10.1016\/j.jtos.2019.06.001_bib108","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1167\/iovs.13-13681","article-title":"Thrombospondin-1 polymorphisms influence risk of corneal allograft rejection","volume":"55","author":"Winton","year":"2014","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"10.1016\/j.jtos.2019.06.001_bib109","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0002-9440(10)65256-X","article-title":"Active transforming growth factor-beta in wound repair: determination using a new assay","volume":"154","author":"Yang","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2019.06.001_bib110","first-page":"1309","article-title":"Repair in avascular tissues: fibrosis in the transparent structures of the eye and thrombospondin 1","volume":"14","author":"Hiscott","year":"1999","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.jtos.2019.06.001_bib111","first-page":"493","article-title":"Impairment of thrombospondin-1 expression during epithelial wound healing in corneas of vitamin A-deficient mice","volume":"20","author":"Uno","year":"2005","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.jtos.2019.06.001_bib112","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/exer.1997.0419","article-title":"Effects of hepatocyte growth factor, transforming growth factor-beta1 and epidermal growth factor on bovine corneal epithelial cells under epithelial-keratocyte interaction in reconstruction culture","volume":"66","author":"Nishimura","year":"1998","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2019.06.001_bib113","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.visres.2017.03.002","article-title":"Diabetic complications in the cornea","volume":"139","author":"Ljubimov","year":"2017","journal-title":"Vis Res"},{"key":"10.1016\/j.jtos.2019.06.001_bib114","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/bbrc.1999.1903","article-title":"Thrombospondin-1, a natural inhibitor of angiogenesis, is present in vitreous and aqueous humor and is modulated by hyperglycemia","volume":"267","author":"Sheibani","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jtos.2019.06.001_bib115","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/archophthalmol.2009.53","article-title":"Modulation of thrombospondin 1 and pigment epithelium\u2013derived factor levels in vitreous fluid of patients with diabetes","volume":"127","author":"Wang","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2019.06.001_bib116","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0002-9394(14)77829-8","article-title":"Diabetic keratopathy as a manifestation of peripheral neuropathy","volume":"96","author":"Schultz","year":"1983","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2019.06.001_bib117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/5140823","article-title":"Neuronal changes in the diabetic cornea: perspectives for neuroprotection","volume":"2016","author":"Bikbova","year":"2016","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.jtos.2019.06.001_bib118","first-page":"1483","article-title":"Isolation and characterization of corneal endothelial cells from wild type and thrombospondin-1 deficient mice","volume":"13","author":"Scheef","year":"2007","journal-title":"Mol Vis"},{"key":"10.1016\/j.jtos.2019.06.001_bib119","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2147\/OPTH.S80475","article-title":"Herpes simplex keratitis: challenges in diagnosis and clinical management","volume":"11","author":"Azher","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.jtos.2019.06.001_bib120","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.survophthal.2012.01.005","article-title":"Herpes simplex epithelial and stromal keratitis: an epidemiologic update","volume":"57","author":"Farooq","year":"2012","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jtos.2019.06.001_bib121","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/bjo.82.2.107","article-title":"Corneal transplantation for herpes simplex keratitis","volume":"82","author":"Larkin","year":"1998","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jtos.2019.06.001_bib122","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1167\/iovs.15-17894","article-title":"High-risk corneal graft rejection in the setting of previous corneal herpes simplex virus (HSV)-1 infection","volume":"57","author":"Kuffova","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jtos.2019.06.001_bib123","first-page":"163","article-title":"Suppression of thrombospondin 1 and 2 production by herpes simplex virus 1 infection in cultured keratocytes","volume":"11","author":"Choudhary","year":"2005","journal-title":"Mol Vis"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012419300308?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012419300308?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:36:48Z","timestamp":1761539808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012419300308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":123,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1542012419300308"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2019.06.001","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombospondin-1 in ocular surface health and disease","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2019.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}