{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:53:47Z","timestamp":1787237627614,"version":"build-2736575974"},"reference-count":130,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001315","name":"Sid W. Richardson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001315","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jtos.2019.10.006","type":"journal-article","created":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T10:01:10Z","timestamp":1571565670000},"page":"335-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"title":["The gut-eye-lacrimal gland-microbiome axis in Sj\u00f6gren Syndrome"],"prefix":"10.1016","volume":"18","author":[{"given":"Claudia M.","family":"Trujillo-Vargas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehan","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Pflugfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Britton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia S.","family":"de Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2019.10.006_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jtos.2019.10.006_bib2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.immuni.2017.04.008","article-title":"Homeostatic Immunity and the Microbiota","volume":"46","author":"Belkaid","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.jtos.2019.10.006_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12223-014-0342-2","article-title":"The oral microbiome diversity and its relation to human diseases","volume":"60","author":"He","year":"2015","journal-title":"Folia microbiologica"},{"key":"10.1016\/j.jtos.2019.10.006_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrurol.2014.361","article-title":"The microbiome of the urinary tract--a role beyond infection","volume":"12","author":"Whiteside","year":"2015","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.jtos.2019.10.006_bib5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3920\/BM2014.0103","article-title":"The history of probiotics: the untold story","volume":"6","author":"Ozen","year":"2015","journal-title":"Beneficial microbes"},{"key":"10.1016\/j.jtos.2019.10.006_bib6","first-page":"523","article-title":"Immunological function of food-restricted germfree and specific pathogen-free mice","volume":"40","author":"Tazume","year":"1991","journal-title":"Jikken Dobutsu"},{"key":"10.1016\/j.jtos.2019.10.006_bib7","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.4014\/jmb.1501.01039","article-title":"Use of Germ-Free Animal Models in Microbiota-Related Research","volume":"25","author":"Al-Asmakh","year":"2015","journal-title":"J Microbiol Biotechnol"},{"key":"10.1016\/j.jtos.2019.10.006_bib8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1538\/expanim.45.155","article-title":"Histochemical, lectin-histochemical and morphometrical characteristics of intestinal goblet cells of germfree and conventional mice","volume":"45","author":"Kandori","year":"1996","journal-title":"Exp Anim"},{"key":"10.1016\/j.jtos.2019.10.006_bib9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41579-018-0014-3","article-title":"Why does the microbiome affect behaviour?","volume":"16","author":"Johnson","year":"2018","journal-title":"Nature reviews Microbiology"},{"key":"10.1016\/j.jtos.2019.10.006_bib10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2982.2010.01620.x","article-title":"Reduced anxiety-like behavior and central neurochemical change in germ-free mice","volume":"23","author":"Neufeld","year":"2011","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jtos.2019.10.006_bib11","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.physbeh.2014.10.032","article-title":"Chronic exposure to low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons","volume":"139","author":"de La Serre","year":"2015","journal-title":"Physiology & behavior"},{"key":"10.1016\/j.jtos.2019.10.006_bib12","doi-asserted-by":"crossref","first-page":"G368","DOI":"10.1152\/ajpgi.2001.280.3.G368","article-title":"Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats","volume":"280","author":"Husebye","year":"2001","journal-title":"American journal of physiology Gastrointestinal and liver physiology"},{"key":"10.1016\/j.jtos.2019.10.006_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12967-016-1105-4","article-title":"Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility","volume":"15","author":"Ge","year":"2017","journal-title":"Journal of translational medicine"},{"key":"10.1016\/j.jtos.2019.10.006_bib14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2004.063388","article-title":"Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice","volume":"558","author":"Sudo","year":"2004","journal-title":"The Journal of physiology"},{"key":"10.1016\/j.jtos.2019.10.006_bib15","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.brainres.2018.01.012","article-title":"Gut bacteria interaction with vagal afferents","volume":"1693","author":"Cawthon","year":"2018","journal-title":"Brain research"},{"key":"10.1016\/j.jtos.2019.10.006_bib16","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41390-018-0270-y","article-title":"Absence of gut microbial colonization attenuates the sympathoadrenal response to hypoglycemic stress in mice: implications for human neonates","volume":"85","author":"Giri","year":"2019","journal-title":"Pediatric research"},{"issue":"5","key":"10.1016\/j.jtos.2019.10.006_bib17","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/dev.21827","article-title":"Gonadal steroid hormone secretion during the juvenile period depends on host-specific microbiota and contributes to the development of odor preference","volume":"61","author":"Kamimura","year":"2019","journal-title":"Dev Psychobiol"},{"key":"10.1016\/j.jtos.2019.10.006_bib18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41398-018-0240-5","article-title":"Gut microbiota regulates mouse behaviors through glucocorticoid receptor pathway genes in the hippocampus","volume":"8","author":"Luo","year":"2018","journal-title":"Translational psychiatry"},{"key":"10.1016\/j.jtos.2019.10.006_bib19","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1080\/19490976.2017.1353849","article-title":"Serum cortisol mediates the relationship between fecal Ruminococcus and brain N-acetylaspartate in the young pig","volume":"8","author":"Mudd","year":"2017","journal-title":"Gut microbes"},{"key":"10.1016\/j.jtos.2019.10.006_bib20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.maturitas.2017.06.025","article-title":"Estrogen-gut microbiome axis: Physiological and clinical implications","volume":"103","author":"Baker","year":"2017","journal-title":"Maturitas"},{"key":"10.1016\/j.jtos.2019.10.006_bib21","article-title":"Phytoestrogens and the intestinal microbiome","volume":"67","author":"Kolatorova","year":"2018","journal-title":"Physiological research"},{"key":"10.1016\/j.jtos.2019.10.006_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/1479-5876-10-253","article-title":"Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study","volume":"10","author":"Flores","year":"2012","journal-title":"Journal of translational medicine"},{"key":"10.1016\/j.jtos.2019.10.006_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/19490976.2018.1474321","article-title":"The enteric microbiota regulates jejunal Paneth cell number and function without impacting intestinal stem cells","volume":"10","author":"Schoenborn","year":"2019","journal-title":"Gut microbes"},{"key":"10.1016\/j.jtos.2019.10.006_bib24","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.micinf.2006.04.001","article-title":"Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines\/chemokines in human sebocytes","volume":"8","author":"Nagy","year":"2006","journal-title":"Microbes and infection"},{"key":"10.1016\/j.jtos.2019.10.006_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/nu9060559","article-title":"Lactobacillus reuteri I5007 Modulates Intestinal Host Defense Peptide Expression in the Model of IPEC-J2 Cells and Neonatal Piglets","volume":"9","author":"Liu","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jtos.2019.10.006_bib26","doi-asserted-by":"crossref","first-page":"15061","DOI":"10.1073\/pnas.1307855110","article-title":"Complement modulates the cutaneous microbiome and inflammatory milieu","volume":"110","author":"Chehoud","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.jtos.2019.10.006_bib27","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1038\/sj.emboj.7601867","article-title":"Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species","volume":"26","author":"Kumar","year":"2007","journal-title":"The EMBO journal"},{"key":"10.1016\/j.jtos.2019.10.006_bib28","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3920\/BM2016.0156","article-title":"Lactobacillus fermentum IM12 attenuates inflammation in mice by inhibiting NF-kappaB-STAT3 signalling pathway","volume":"8","author":"Lim","year":"2017","journal-title":"Beneficial microbes"},{"key":"10.1016\/j.jtos.2019.10.006_bib29","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.1225152","article-title":"Compartmentalized control of skin immunity by resident commensals","volume":"337","author":"Naik","year":"2012","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.jtos.2019.10.006_bib30","first-page":"471","article-title":"The response of the lymphatic tissue to the microbial flora. Studies on germfree mice","volume":"42","author":"Bauer","year":"1963","journal-title":"The American journal of pathology"},{"key":"10.1016\/j.jtos.2019.10.006_bib31","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.immuni.2014.03.005","article-title":"Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation","volume":"40","author":"Goto","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jtos.2019.10.006_bib32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/mi.2009.5","article-title":"IL-17 disrupts corneal barrier following desiccating stress","volume":"2","author":"de Paiva","year":"2009","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jtos.2019.10.006_bib33","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/odi.12598","article-title":"IL-17: overview and role in oral immunity and microbiome","volume":"23","author":"Abusleme","year":"2017","journal-title":"Oral diseases"},{"key":"10.1016\/j.jtos.2019.10.006_bib34","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1002\/eji.200535244","article-title":"Impaired regulatory T cell function in germ-free mice","volume":"36","author":"Ostman","year":"2006","journal-title":"European journal of immunology"},{"key":"10.1016\/j.jtos.2019.10.006_bib35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1084\/jem.20160961","article-title":"Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors","volume":"214","author":"He","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.jtos.2019.10.006_bib36","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/19490976.2015.1056973","article-title":"A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function","volume":"6","author":"Telesford","year":"2015","journal-title":"Gut microbes"},{"key":"10.1016\/j.jtos.2019.10.006_bib37","doi-asserted-by":"crossref","first-page":"12649","DOI":"10.1038\/s41598-018-30114-4","article-title":"Human-origin probiotic cocktail increases short-chain fatty acid production via modulation of mice and human gut microbiome","volume":"8","author":"Nagpal","year":"2018","journal-title":"Scientific reports"},{"key":"10.1016\/j.jtos.2019.10.006_bib38","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neulet.2016.02.009","article-title":"Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?","volume":"625","author":"Bourassa","year":"2016","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jtos.2019.10.006_bib39","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jtos.2019.10.006_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201073","article-title":"Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid","volume":"13","author":"Yuille","year":"2018","journal-title":"PloS one"},{"key":"10.1016\/j.jtos.2019.10.006_bib41","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.jtos.2019.10.006_bib42","first-page":"2818","article-title":"Anti-inflammatory properities of butyrate on the ocular surface epithelium","volume":"60","author":"Hernandez","year":"2019","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.jtos.2019.10.006_bib43","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3109\/02713688709034860","article-title":"The immune response of the lacrimal gland to antigenic exposure","volume":"6","author":"Allansmith","year":"1987","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2019.10.006_bib44","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1167\/iovs.17-22119","article-title":"Role of Microbiota in Strengthening Ocular Mucosal Barrier Function Through Secretory IgA","volume":"58","author":"Kugadas","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2019.10.006_bib45","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cell.2018.11.035","article-title":"Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10","volume":"176","author":"Rojas","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jtos.2019.10.006_bib46","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1016\/j.ajpath.2018.08.009","article-title":"Antibiotic-Induced Dysbiosis of Gut Microbiota Impairs Corneal Nerve Regeneration by Affecting CCR2-Negative Macrophage Distribution","volume":"188","author":"Liu","year":"2018","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2019.10.006_bib47","article-title":"Antibiotic-induced dysbiosis of gut microbiota impairs corneal development in postnatal mice by affecting CCR2 negative macrophage distribution","author":"Wu","year":"2019","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jtos.2019.10.006_bib48","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev-genom-083115-022438","article-title":"The Microbiome and Human Biology","volume":"18","author":"Knight","year":"2017","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1016\/j.jtos.2019.10.006_bib49","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"Schloss","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jtos.2019.10.006_bib50","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40168-019-0620-y","article-title":"A review of 10 years of human microbiome research activities at the US National Institutes of Health, Fiscal Years 2007-2016","volume":"7","author":"Team NIHHMPA","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.jtos.2019.10.006_bib51","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.jtos.2019.10.006_bib52","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1128\/AEM.70.3.1723-1734.2004","article-title":"Microbial diversity and heterogeneity in sandy subsurface soils","volume":"70","author":"Zhou","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jtos.2019.10.006_bib53","doi-asserted-by":"crossref","first-page":"D633","DOI":"10.1093\/nar\/gkt1244","article-title":"Ribosomal Database Project: data and tools for high throughput rRNA analysis","volume":"42","author":"Cole","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jtos.2019.10.006_bib54","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/nar\/29.1.173","article-title":"The RDP-II (Ribosomal Database Project)","volume":"29","author":"Maidak","year":"2001","journal-title":"Nucleic Acids Res"},{"issue":"Suppl","key":"10.1016\/j.jtos.2019.10.006_bib55","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1093\/nar\/20.suppl.2199","article-title":"The Ribosomal Database Project","volume":"20","author":"Olsen","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jtos.2019.10.006_bib56","doi-asserted-by":"crossref","first-page":"23561","DOI":"10.1038\/srep23561","article-title":"Altered Mucosal Microbiome Diversity and Disease Severity in Sjogren Syndrome","volume":"6","author":"de Paiva","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtos.2019.10.006_bib57","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1167\/iovs.16-19803","article-title":"Paucibacterial Microbiome and Resident DNA Virome of the Healthy Conjunctiva","volume":"57","author":"Doan","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2019.10.006_bib58","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1167\/iovs.10-6939","article-title":"Diversity of bacteria at healthy human conjunctiva","volume":"52","author":"Dong","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2019.10.006_bib59","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrmicro3552","article-title":"Gut biogeography of the bacterial microbiota","volume":"14","author":"Donaldson","year":"2016","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jtos.2019.10.006_bib60","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3389\/fmicb.2017.00797","article-title":"Differences in Microbiota Membership along the Gastrointestinal Tract of Piglets and Their Differential Alterations Following an Early-Life Antibiotic Intervention","volume":"8","author":"Mu","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jtos.2019.10.006_bib61","doi-asserted-by":"crossref","first-page":"132ra52","DOI":"10.1126\/scitranslmed.3003605","article-title":"Temporal dynamics of the human vaginal microbiota","volume":"4","author":"Gajer","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jtos.2019.10.006_bib62","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jtos.2019.10.006_bib63","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tig.2017.10.001","article-title":"Functional Genomics of Host-Microbiome Interactions in Humans","volume":"34","author":"Luca","year":"2018","journal-title":"Trends Genet"},{"key":"10.1016\/j.jtos.2019.10.006_bib64","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.1124234","article-title":"Metagenomic analysis of the human distal gut microbiome","volume":"312","author":"Gill","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jtos.2019.10.006_bib65","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jtos.2019.10.006_bib66","article-title":"Sjogren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice","volume":"19","author":"Wang","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2019.10.006_bib67","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jaut.2018.06.004","article-title":"Protective role of commensal bacteria in Sjogren Syndrome","volume":"93","author":"Zaheer","year":"2018","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jtos.2019.10.006_bib68","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature12331","article-title":"Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota","volume":"500","author":"Atarashi","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jtos.2019.10.006_bib69","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1198469","article-title":"Induction of colonic regulatory T cells by indigenous Clostridium species","volume":"331","author":"Atarashi","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jtos.2019.10.006_bib70","doi-asserted-by":"crossref","first-page":"13829","DOI":"10.1038\/s41598-017-14243-w","article-title":"Contributions of MyD88-dependent receptors and CD11c-positive cells to corneal epithelial barrier function against Pseudomonas aeruginosa","volume":"7","author":"Metruccio","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtos.2019.10.006_bib71","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1167\/iovs.17-23397","article-title":"MyD88 Deficiency Protects Against Dry Eye-Induced Damage","volume":"59","author":"Reins","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"13","key":"10.1016\/j.jtos.2019.10.006_bib72","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1167\/iovs.19-27939","article-title":"Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide","volume":"60","author":"Wang","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2019.10.006_bib73","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.immuni.2015.07.014","article-title":"Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site","volume":"43","author":"Horai","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jtos.2019.10.006_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2014.02.004","article-title":"T cell epitope mimicry between Sjogren's syndrome Antigen A (SSA)\/Ro60 and oral, gut, skin and vaginal bacteria","volume":"152","author":"Szymula","year":"2014","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jtos.2019.10.006_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19102935","article-title":"Immune Response Targeting Sjogren's Syndrome Antigen Ro52 Suppresses Tear Production in Female Mice","volume":"19","author":"Trzeciak","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"Suppl 112","key":"10.1016\/j.jtos.2019.10.006_bib76","first-page":"41","article-title":"Immune response against the coiled coil domain of Sjogren's syndrome associated autoantigen Ro52 induces salivary gland dysfunction","volume":"36","author":"Sroka","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jtos.2019.10.006_bib77","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jaut.2018.10.009","article-title":"Shared gut, but distinct oral microbiota composition in primary Sjogren's syndrome and systemic lupus erythematosus","volume":"97","author":"van der Meulen","year":"2019","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jtos.2019.10.006_bib78","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103241","article-title":"Outer Membrane Protein of Gut Commensal Microorganism Induces Autoantibody Production and Extra-Intestinal Gland Inflammation in Mice","volume":"19","author":"Yanagisawa","year":"2018","journal-title":"International journal of molecular sciences"},{"key":"10.1016\/j.jtos.2019.10.006_bib79","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.exer.2018.01.024","article-title":"Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL\/6 mice","volume":"169","author":"Stepp","year":"2018","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2019.10.006_bib80","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.optom.2016.06.002","article-title":"The potential role of neuropathic mechanisms in dry eye syndromes","volume":"10","author":"McMonnies","year":"2017","journal-title":"Journal of optometry"},{"key":"10.1016\/j.jtos.2019.10.006_bib81","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1053\/j.gastro.2016.07.044","article-title":"The Effect of Microbiota and the Immune System on the Development and Organization of the Enteric Nervous System","volume":"151","author":"Obata","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtos.2019.10.006_bib82","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1128\/jcm.1.2.147-149.1975","article-title":"Bacteriology of normal and infected conjunctiva","volume":"1","author":"Perkins","year":"1975","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jtos.2019.10.006_bib83","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1167\/iovs.07-0588","article-title":"Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes","volume":"48","author":"Graham","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2019.10.006_bib84","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1167\/iovs.12-9922","article-title":"Comparative ocular microbial communities in humans with and without blepharitis","volume":"53","author":"Lee","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2019.10.006_bib85","doi-asserted-by":"crossref","first-page":"9880","DOI":"10.1038\/s41598-017-10494-9","article-title":"Temporal Stability and Composition of the Ocular Surface Microbiome","volume":"7","author":"Ozkan","year":"2017","journal-title":"Scientific reports"},{"key":"10.1016\/j.jtos.2019.10.006_bib86","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.1167\/iovs.17-22957","article-title":"The Influence of Age and Sex on Ocular Surface Microbiota in Healthy Adults","volume":"58","author":"Wen","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2019.10.006_bib87","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jtos.2019.02.001","article-title":"Commensal microflora in human conjunctiva; characteristics of microflora in the patients with chronic ocular graft-versus-host disease","volume":"17","author":"Shimizu","year":"2019","journal-title":"The ocular surface"},{"key":"10.1016\/j.jtos.2019.10.006_bib88","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jtos.2018.11.005","article-title":"Biogeography of the human ocular microbiota","volume":"17","author":"Ozkan","year":"2019","journal-title":"The ocular surface"},{"key":"10.1016\/j.jtos.2019.10.006_bib89","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3389\/fmicb.2018.01117","article-title":"IL-1R and MyD88 Contribute to the Absence of a Bacterial Microbiome on the Healthy Murine Cornea","volume":"9","author":"Wan","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jtos.2019.10.006_bib90","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2147\/OPTH.S166547","article-title":"Effect of clinical parameters on the ocular surface microbiome in children and adults","volume":"12","author":"Cavuoto","year":"2018","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.jtos.2019.10.006_bib91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1399-302X.2003.180101.x","article-title":"Oral microbiota associated with hyposalivation of different origins","volume":"18","author":"Almstah","year":"2003","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.jtos.2019.10.006_bib92","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.archoralbio.2016.06.016","article-title":"A preliminary study of the oral microbiota in Chinese patients with Sjogren's syndrome","volume":"70","author":"Li","year":"2016","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.jtos.2019.10.006_bib93","doi-asserted-by":"crossref","first-page":"31119","DOI":"10.3402\/jom.v8.31119","article-title":"Microbiological and bioinformatics analysis of primary Sjogren's syndrome patients with normal salivation","volume":"8","author":"Siddiqui","year":"2016","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.jtos.2019.10.006_bib94","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1093\/rheumatology\/key215","article-title":"Dysbiosis of the buccal mucosa microbiome in primary Sjogren's syndrome patients","volume":"57","author":"van der Meulen","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jtos.2019.10.006_bib95","doi-asserted-by":"crossref","first-page":"e5649","DOI":"10.7717\/peerj.5649","article-title":"Molecular analysis of oral microflora in patients with primary Sjogren's syndrome by using high-throughput sequencing","volume":"6","author":"Zhou","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.jtos.2019.10.006_bib96","first-page":"4895","article-title":"Oral microbial flora of patients with Sicca syndrome","volume":"18","author":"Zhou","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jtos.2019.10.006_bib97","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218319","article-title":"Dysbiotic salivary microbiota in dry mouth and primary Sjogren's syndrome patients","volume":"14","author":"Rusthen","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jtos.2019.10.006_bib98","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13075-017-1446-2","article-title":"Severe intestinal dysbiosis is prevalent in primary Sjogren's syndrome and is associated with systemic disease activity","volume":"19","author":"Mandl","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jtos.2019.10.006_bib99","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005855","article-title":"Impact of Microbiota on Resistance to Ocular Pseudomonas aeruginosa-Induced Keratitis","volume":"12","author":"Kugadas","year":"2016","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jtos.2019.10.006_bib100","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.immuni.2017.06.014","article-title":"An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal gammadelta T Cells","volume":"47","author":"St Leger","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.jtos.2019.10.006_bib101","article-title":"Changes in the Eye Microbiota Associated with Contact Lens","volume":"7","author":"Shin","year":"2016","journal-title":"Wearing. mBio."},{"key":"10.1016\/j.jtos.2019.10.006_bib102","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3389\/fcimb.2019.00202","article-title":"How Ocular Surface Microbiota Debuts in Type 2 Diabetes Mellitus","volume":"9","author":"Li","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jtos.2019.10.006_bib103","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/02713683.2017.1406528","article-title":"Distribution and Diversity of Ocular Microbial Communities in Diabetic Patients Compared with Healthy Subjects","volume":"43","author":"Ham","year":"2018","journal-title":"Curr Eye Res"},{"issue":"4","key":"10.1016\/j.jtos.2019.10.006_bib104","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1007\/s12026-016-8786-x","article-title":"Detection of autoantibodies against aquaporin-5 in the sera of patients with primary Sj\u00f6gren's syndrome","volume":"64","author":"Alam","year":"2016","journal-title":"Immunol Res"},{"key":"10.1016\/j.jtos.2019.10.006_bib105","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/1471-2180-9-259","article-title":"Defining the healthy \"core microbiome\" of oral microbial communities","volume":"9","author":"Zaura","year":"2009","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jtos.2019.10.006_bib106","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1755-8794-4-22","article-title":"Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health","volume":"4","author":"Crielaard","year":"2011","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.jtos.2019.10.006_bib107","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature11209","article-title":"A framework for human microbiome research","volume":"486","author":"Human Microbiome Project","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jtos.2019.10.006_bib108","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4161\/gmic.27651","article-title":"Ecology and metabolism of the beneficial intestinal commensal bacterium Faecalibacterium prausnitzii","volume":"5","author":"Miquel","year":"2014","journal-title":"Gut microbes"},{"key":"10.1016\/j.jtos.2019.10.006_bib109","first-page":"645739","article-title":"Gut microbial dysbiosis in individuals with Sj\u00f6gren\u2019s disease","author":"Mendez","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.jtos.2019.10.006_bib110","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ajo.2009.09.013","article-title":"A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sjogren's Syndrome International Registry","volume":"149","author":"Whitcher","year":"2010","journal-title":"Am JOphthalmol"},{"key":"10.1016\/j.jtos.2019.10.006_bib111","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1902\/jop.2015.150006","article-title":"Impact of oral commensal bacteria on degradation of periodontal connective tissue in mice","volume":"86","author":"Irie","year":"2015","journal-title":"J Periodontol"},{"key":"10.1016\/j.jtos.2019.10.006_bib112","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/omi.12194","article-title":"Establishment of oral bacterial communities in germ-free mice and the influence of recipient age","volume":"33","author":"Wu","year":"2018","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.jtos.2019.10.006_bib113","first-page":"137","article-title":"Effect of castration on the appearance of diabetes in NOD mouse","volume":"30","author":"Makino","year":"1981","journal-title":"Jikken Dobutsu"},{"issue":"9","key":"10.1016\/j.jtos.2019.10.006_bib114","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s00125-019-4910-5","article-title":"Targeting gut microbiota and barrier function with prebiotics to alleviate autoimmune manifestations in NOD mice","volume":"62","author":"Hansen","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.jtos.2019.10.006_bib115","doi-asserted-by":"crossref","first-page":"701","DOI":"10.4049\/jimmunol.1502465","article-title":"Cutting Edge: Commensal Microbiota Has Disparate Effects on Manifestations of Polyglandular Autoimmune Inflammation","volume":"197","author":"Hansen","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2019.10.006_bib116","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jaut.2006.11.003","article-title":"Novel animal models for Sjogren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice","volume":"27","author":"Sharma","year":"2006","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jtos.2019.10.006_bib117","doi-asserted-by":"crossref","first-page":"385","DOI":"10.4049\/jimmunol.160.1.385","article-title":"Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice","volume":"160","author":"Contractor","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2019.10.006_bib118","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/gut.50.2.170","article-title":"Microflora reactive IL-10 producing regulatory T cells are present in the colon of IL-2 deficient mice but lack efficacious inhibition of IFN-gamma and TNF-alpha production","volume":"50","author":"Waidmann","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.jtos.2019.10.006_bib119","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0016-5085(03)00672-3","article-title":"Bacteroides vulgatus protects against escherichia coli-induced colitis in gnotobiotic interleukin-2-deficient mice","volume":"125","author":"Waidmann","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtos.2019.10.006_bib120","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/1074-7613(95)90180-9","article-title":"Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment","volume":"3","author":"Willerford","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.jtos.2019.10.006_bib121","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.exer.2010.12.005","article-title":"Toll-like receptor activation modulates antimicrobial peptide expression by ocular surface cells","volume":"92","author":"Redfern","year":"2011","journal-title":"ExpEye Res"},{"key":"10.1016\/j.jtos.2019.10.006_bib122","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.immuni.2015.09.007","article-title":"Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine","volume":"43","author":"Haghikia","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jtos.2019.10.006_bib123","doi-asserted-by":"crossref","DOI":"10.1038\/srep39026","article-title":"Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice","volume":"6","author":"Cho","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtos.2019.10.006_bib124","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyw020","article-title":"Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior","volume":"19","author":"Luczynski","year":"2016","journal-title":"Int J Neuropsychopharmacol"},{"issue":"2","key":"10.1016\/j.jtos.2019.10.006_bib125","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/imm.12948","article-title":"Salivary gland-protective regulatory T cell dysfunction underlies female-specific sialadenitis in the nonobese diabetic mouse model of Sjogren syndrome","volume":"155","author":"Barr","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.jtos.2019.10.006_bib126","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1167\/iovs.18-25772","article-title":"Sex Effects on Gene Expression in Lacrimal Glands of Mouse Models of Sjogren Syndrome","volume":"59","author":"Tellefsen","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2019.10.006_bib127","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1136\/annrheumdis-2014-206297","article-title":"Interaction between innate immunity and Ro52-induced antibody causes Sj\u00f6gren's syndrome-like disorder in mice","volume":"75","author":"Szczerba","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jtos.2019.10.006_bib128","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2174\/1574884712666170704145046","article-title":"Aging eye microbiota in Dry Eye Syndrome in patients treated with Enterococcus faecium and Saccharomyces boulardii","volume":"12","author":"Chisari","year":"2017","journal-title":"Curr Clin Pharmacol"},{"key":"10.1016\/j.jtos.2019.10.006_bib129","first-page":"e181","article-title":"The mixture of bifidobacterium associated with fructo-oligosaccharides reduces the damage of the ocular surface","volume":"168","author":"Chisari","year":"2017","journal-title":"Clin Ter"},{"key":"10.1016\/j.jtos.2019.10.006_bib130","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jtos.2015.12.005","article-title":"Dietary Supplementation with a Combination of Lactoferrin, Fish Oil, and Enterococcus faecium WB2000 for Treating Dry Eye: A Rat Model and Human Clinical Study","volume":"14","author":"Kawashima","year":"2016","journal-title":"The ocular surface"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012419303489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012419303489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:37:31Z","timestamp":1761539851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012419303489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":130,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S1542012419303489"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2019.10.006","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The gut-eye-lacrimal gland-microbiome axis in Sj\u00f6gren Syndrome","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2019.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}