{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:51:28Z","timestamp":1793040688801,"version":"4.5.0"},"reference-count":141,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006441","name":"Center for Outcomes Research and Evaluation, Yale School of Medicine","doi-asserted-by":"publisher","award":["P30CA125123"],"award-info":[{"award-number":["P30CA125123"]}],"id":[{"id":"10.13039\/100006441","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY11915"],"award-info":[{"award-number":["EY11915"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY020799"],"award-info":[{"award-number":["EY020799"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA125123"],"award-info":[{"award-number":["P30CA125123"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY002520"],"award-info":[{"award-number":["EY002520"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012010","name":"Alkek Center for Molecular Discovery, Baylor College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001315","name":"Sid W. Richardson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001315","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009550","name":"Society of Clinical Psychology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017017","name":"Hamill Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017017","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jtos.2019.12.006","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T19:14:15Z","timestamp":1579029255000},"page":"326-334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["Immune - Goblet cell interaction in the conjunctiva"],"prefix":"10.1016","volume":"18","author":[{"given":"Jehan","family":"Alam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia S.","family":"de Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Pflugfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2019.12.006_bib1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ajo.2017.06.033","article-title":"Prevalence of diagnosed dry eye disease in the United States among adults aged 18 Years and older","volume":"182","author":"Farrand","year":"2017","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2019.12.006_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/IIO.0000000000000162","article-title":"Tear volume-based diagnostic classification for tear dysfunction","volume":"57","author":"Pflugfelder","year":"2017","journal-title":"Int Ophthalmol Clin"},{"issue":"6","key":"10.1016\/j.jtos.2019.12.006_bib3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1350-9462(02)00038-1","article-title":"Regulation of mucin and fluid secretion by conjunctival epithelial cells","volume":"21","author":"Dartt","year":"2002","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/mi.2010.82","article-title":"Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13","volume":"4","author":"de Paiva","year":"2011","journal-title":"Mucosal Immunol"},{"issue":"8","key":"10.1016\/j.jtos.2019.12.006_bib5","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1167\/iovs.14-15496","article-title":"IL-13 stimulates proliferation and expression of mucin and immunomodulatory genes in cultured conjunctival goblet cells","volume":"56","author":"Tukler Henriksson","year":"2015","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2019.12.006_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-4615-5359-5_32","article-title":"Cellular origin of mucins of the ocular surface tear film","volume":"438","author":"Gipson","year":"1998","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib7","first-page":"703","article-title":"Quantification of MUC2 and MUC5AC transcripts in human conjunctiva","volume":"41","author":"McKenzie","year":"2000","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.jtos.2019.12.006_bib8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00003226-200301000-00010","article-title":"MUC7 expression in the human lacrimal gland and conjunctiva","volume":"22","author":"Jumblatt","year":"2003","journal-title":"Cornea"},{"issue":"1","key":"10.1016\/j.jtos.2019.12.006_bib9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1167\/iovs.13-13194","article-title":"The ocular surface phenotype of Muc5ac and Muc5b null mice","volume":"55","author":"Marko","year":"2014","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib10","first-page":"1004","article-title":"Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjogren syndrome","volume":"43","author":"Argueso","year":"2002","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.jtos.2019.12.006_bib11","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.exer.2007.01.018","article-title":"Assay of mucins in human tear fluid","volume":"84","author":"Spurr-Michaud","year":"2007","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2019.12.006_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.preteyeres.2016.04.005","article-title":"Goblet cells of the conjunctiva: a review of recent findings","volume":"54","author":"Gipson","year":"2016","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2019.12.006_bib13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.preteyeres.2018.11.007","article-title":"Reconsidering the central role of mucins in dry eye and ocular surface diseases","volume":"71","author":"Baudouin","year":"2019","journal-title":"Prog Retin Eye Res"},{"issue":"5","key":"10.1016\/j.jtos.2019.12.006_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18050978","article-title":"Goblet cells contribute to ocular surface immune tolerance-implications for dry eye disease","volume":"18","author":"Barbosa","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120284","article-title":"Immunomodulatory cross-talk between conjunctival goblet cells and dendritic cells","volume":"10","author":"Contreras-Ruiz","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.jtos.2019.12.006_bib16","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/intimm\/dxy045","article-title":"Goblet cell produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow derived cells","volume":"30","author":"Xiao","year":"2018","journal-title":"Int Immunol"},{"issue":"6","key":"10.1016\/j.jtos.2019.12.006_bib17","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3109\/02713688409000793","article-title":"Vitamin A is present as retinol in the tears of humans and rabbits","volume":"3","author":"Ubels","year":"1984","journal-title":"Curr Eye Res"},{"issue":"8","key":"10.1016\/j.jtos.2019.12.006_bib18","first-page":"1261","article-title":"Retinol secretion by the lacrimal gland","volume":"27","author":"Ubels","year":"1986","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib19","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/s41385-018-0127-z","article-title":"Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells","volume":"12","author":"Bian","year":"2019","journal-title":"Mucosal Immunol"},{"issue":"12","key":"10.1016\/j.jtos.2019.12.006_bib20","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1167\/iovs.15-17627","article-title":"Aqueous tear deficiency increases conjunctival interferon-gamma (IFN-gamma) expression and goblet cell loss","volume":"56","author":"Pflugfelder","year":"2015","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.jtos.2019.12.006_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00004397-199803810-00013","article-title":"Vitamin A deficiency and its effects on the eye","volume":"38","author":"Harris","year":"1998","journal-title":"Int Ophthalmol Clin"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.survophthal.2014.10.001","article-title":"Retinoic acid and the ocular surface","volume":"60","author":"Samarawickrama","year":"2015","journal-title":"Surv Ophthalmol"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib23","first-page":"299","article-title":"Conjunctival goblet cell density in normal subjects and in dry eye syndromes","volume":"14","author":"Ralph","year":"1975","journal-title":"Investig Ophthalmol"},{"issue":"7","key":"10.1016\/j.jtos.2019.12.006_bib24","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/archopht.1984.01040030851031","article-title":"Conjunctival goblet cell densities in ocular surface disease","volume":"102","author":"Nelson","year":"1984","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2019.12.006_bib25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0161-6420(97)30330-3","article-title":"Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation","volume":"104","author":"Pflugfelder","year":"1997","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.jtos.2019.12.006_bib26","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/bmt.2009.312","article-title":"Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye","volume":"45","author":"Wang","year":"2010","journal-title":"Bone Marrow Transplant"},{"issue":"10","key":"10.1016\/j.jtos.2019.12.006_bib27","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.oftal.2014.04.013","article-title":"Conjunctival impression cytology in patients with normal and impaired OSDI scores","volume":"89","author":"Zuazo","year":"2014","journal-title":"Arch Soc Esp Oftalmol"},{"issue":"9","key":"10.1016\/j.jtos.2019.12.006_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092760","article-title":"Severity of sjogren's syndrome keratoconjunctivitis sicca increases with increased percentage of conjunctival antigen-presenting cells","volume":"19","author":"Pflugfelder","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.jtos.2019.12.006_bib29","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1167\/iovs.15-17627","article-title":"Aqueous tear deficiency increases conjunctival interferon-gamma (IFN-\u03b3) expression and goblet cell loss","volume":"56","author":"Pflugfelder","year":"2015","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib30","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jtos.2018.07.002","article-title":"Microbial keratitis in Stevens-Johnson syndrome: clinical and microbiological profile","volume":"16","author":"Bagga","year":"2018","journal-title":"Ocul Surf"},{"issue":"5","key":"10.1016\/j.jtos.2019.12.006_bib31","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0002-9394(88)90243-7","article-title":"Corneal infection in mucosal scarring disorders and Sjogren's syndrome","volume":"105","author":"Ormerod","year":"1988","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"10.1016\/j.jtos.2019.12.006_bib32","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0161-6420(86)33528-0","article-title":"The autoimmune nature of aqueous tear deficiency","volume":"93","author":"Pflugfelder","year":"1986","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.jtos.2019.12.006_bib33","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1167\/iovs.07-0069","article-title":"Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma","volume":"48","author":"De Paiva","year":"2007","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.jtos.2019.12.006_bib34","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/mi.2015.53","article-title":"Interaction of IFN-gamma with cholinergic agonists to modulate rat and human goblet cell function","volume":"9","author":"Garcia-Posadas","year":"2016","journal-title":"Mucosal Immunol"},{"issue":"6","key":"10.1016\/j.jtos.2019.12.006_bib35","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.ajpath.2016.02.004","article-title":"Interferon-gamma-Induced unfolded protein response in conjunctival goblet cells as a cause of mucin deficiency in sjogren syndrome","volume":"186","author":"Coursey","year":"2016","journal-title":"Am J Pathol"},{"issue":"2","key":"10.1016\/j.jtos.2019.12.006_bib36","first-page":"643","article-title":"Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome","volume":"51","author":"Yoon","year":"2010","journal-title":"Investig Ophthalmol"},{"issue":"11","key":"10.1016\/j.jtos.2019.12.006_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078508","article-title":"Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease","volume":"8","author":"Coursey","year":"2013","journal-title":"PLoS One"},{"issue":"11s","key":"10.1016\/j.jtos.2019.12.006_bib38","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.ophtha.2017.07.010","article-title":"The pathophysiology of dry eye disease: what we know and future directions for Research","volume":"124","author":"Pflugfelder","year":"2017","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1016\/j.jtos.2019.12.006_bib39","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/S0161-6420(91)32154-7","article-title":"Immunopathology of atopic keratoconjunctivitis","volume":"98","author":"Foster","year":"1991","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib40","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0002-9394(14)71404-7","article-title":"Conjunctival epithelial cell hypermitosis and goblet cell hyperplasia in atopic keratoconjunctivitis","volume":"116","author":"Roat","year":"1993","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib41","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1001\/archopht.120.3.330","article-title":"Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine","volume":"120","author":"Kunert","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2019.12.006_bib42","first-page":"Cd010051","article-title":"Topical cyclosporine A therapy for dry eye syndrome","volume":"9","author":"de Paiva","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib43","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0002-9394(03)00326-X","article-title":"The comparison of efficacies of topical corticosteroids and nonsteroidal anti-inflammatory drops on dry eye patients: a clinical and immunocytochemical study","volume":"136","author":"Avunduk","year":"2003","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2019.12.006_bib44","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ajo.2008.08.015","article-title":"A comparison of vitamin a and cyclosporine a 0.05% eye drops for treatment of dry eye syndrome","volume":"147","author":"Kim","year":"2009","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"10.1016\/j.jtos.2019.12.006_bib45","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1089\/jop.2018.0047","article-title":"Suppression of Th1-mediated keratoconjunctivitis sicca by lifitegrast","volume":"34","author":"Guimaraes de Souza","year":"2018","journal-title":"J Ocul Pharmacol Ther : Off J Assoc Ocular Pharmacol Ther"},{"issue":"6","key":"10.1016\/j.jtos.2019.12.006_bib46","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0002-9394(14)71688-5","article-title":"Prevalence of dry eye among the elderly","volume":"124","author":"Schein","year":"1997","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"10.1016\/j.jtos.2019.12.006_bib47","first-page":"2469","article-title":"Self-reported assessment of dry eye in a population-based setting","volume":"38","author":"Bandeen-Roche","year":"1997","journal-title":"Investig Ophthalmol"},{"issue":"6","key":"10.1016\/j.jtos.2019.12.006_bib48","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/S0161-6420(98)96016-X","article-title":"The epidemiology of dry eye in Melbourne, Australia","volume":"105","author":"McCarty","year":"1998","journal-title":"Ophthalmology"},{"issue":"9","key":"10.1016\/j.jtos.2019.12.006_bib49","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1001\/archopht.118.9.1264","article-title":"Prevalence of and risk factors for dry eye syndrome","volume":"118","author":"Moss","year":"2000","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2019.12.006_bib50","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0002-9394(03)00218-6","article-title":"Prevalence of dry eye syndrome among US women","volume":"136","author":"Schaumberg","year":"2003","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"10.1016\/j.jtos.2019.12.006_bib51","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0161-6420(03)00262-8","article-title":"Prevalence of dry eye among an elderly Chinese population in Taiwan: the Shihpai Eye Study","volume":"110","author":"Lin","year":"2003","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib52","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1046\/j.1442-9071.2003.00634.x","article-title":"Prevalence and associations of dry eye syndrome in an older population: the Blue Mountains Eye Study","volume":"31","author":"Chia","year":"2003","journal-title":"Clin Exp Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2019.12.006_bib53","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1001\/archopht.122.2.151","article-title":"Dry eye signs and symptoms in women with premature ovarian failure","volume":"122","author":"Smith","year":"2004","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib54","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archopht.122.3.369","article-title":"Incidence of dry eye in an older population","volume":"122","author":"Moss","year":"2004","journal-title":"Arch Ophthalmol"},{"issue":"6","key":"10.1016\/j.jtos.2019.12.006_bib55","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1001\/archophthalmol.2009.103","article-title":"Prevalence of dry eye disease among US men: estimates from the Physicians' Health Studies","volume":"127","author":"Schaumberg","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"10","key":"10.1016\/j.jtos.2019.12.006_bib56","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1097\/OPX.0b013e3182271297","article-title":"Age-related changes in tear menisci imaged by optical coherence tomography","volume":"88","author":"Cui","year":"2011","journal-title":"Optom Vis Sci"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib57","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/00003226-199907000-00003","article-title":"Results of a population-based questionnaire on the symptoms and lifestyles associated with dry eye","volume":"18","author":"Shimmura","year":"1999","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2019.12.006_bib58","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.exer.2018.01.024","article-title":"Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL\/6 mice","volume":"169","author":"Stepp","year":"2018","journal-title":"Exp Eye Res"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib59","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1600-0420.2005.00472.x","article-title":"Age-related differential expression of apoptosis-related genes in conjunctival epithelial cells","volume":"83","author":"Giebel","year":"2005","journal-title":"Acta Ophthalmol Scand"},{"issue":"11","key":"10.1016\/j.jtos.2019.12.006_bib60","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1136\/bjo.2008.155820","article-title":"Age-related changes of human conjunctiva on in vivo confocal microscopy","volume":"94","author":"Zhu","year":"2010","journal-title":"British J Ophthalmol"},{"issue":"5","key":"10.1016\/j.jtos.2019.12.006_bib61","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1167\/iovs.18-25822","article-title":"InflammAging at ocular surface: clinical and biomolecular analyses in healthy volunteers","volume":"60","author":"Di Zazzo","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.jtos.2019.12.006_bib62","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1167\/iovs.17-23358","article-title":"Age-Related changes to human tear composition","volume":"59","author":"Micera","year":"2018","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"7","key":"10.1016\/j.jtos.2019.12.006_bib63","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1167\/iovs.19-26631","article-title":"The effects of aging on corneal and ocular surface homeostasis in mice","volume":"60","author":"De Silva","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"10.1016\/j.jtos.2019.12.006_bib64","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.3109\/07420520903398518","article-title":"Plasma levels of interferon-gamma correlate with age-related disturbances of circadian rhythms and survival in a non-human primate","volume":"26","author":"Cayetanot","year":"2009","journal-title":"Chronobiol Int"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib65","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.mad.2008.11.004","article-title":"Interferon-gamma induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells","volume":"130","author":"Kim","year":"2009","journal-title":"Mech Ageing Dev"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib66","doi-asserted-by":"crossref","first-page":"e348","DOI":"10.1097\/TXD.0000000000000762","article-title":"Differences in proinflammatory cytokines and monocyte subtypes in older as compared with younger kidney transplant recipients","volume":"4","author":"Liang","year":"2018","journal-title":"Transplant Direct"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib67","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ajpath.2013.11.019","article-title":"Ocular surface disease and dacryoadenitis in aging C57BL\/6 mice","volume":"184","author":"McClellan","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2019.12.006_bib68","first-page":"380","article-title":"Changes in the spatial expression of genes with aging in the mouse RPE\/choroid","volume":"11","author":"Ogawa","year":"2005","journal-title":"Mol Vis"},{"key":"10.1016\/j.jtos.2019.12.006_bib69","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.brainres.2008.07.067","article-title":"Upregulation of cathepsin S in the aging and pathological nervous system of mice","volume":"1232","author":"Wendt","year":"2008","journal-title":"Brain Res"},{"issue":"9","key":"10.1016\/j.jtos.2019.12.006_bib70","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/gerona\/glr094","article-title":"Elevated interferon gamma signaling contributes to impaired regeneration in the aged liver","volume":"66","author":"Singh","year":"2011","journal-title":"J Gerontol Ser A, Biol Sciences Med Sci"},{"issue":"11","key":"10.1016\/j.jtos.2019.12.006_bib71","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.4049\/jimmunol.164.11.5652","article-title":"Mouse CD8+ CD122+ T cells with intermediate TCR increasing with age provide a source of early IFN-gamma production","volume":"164","author":"Takayama","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2019.12.006_bib72","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann NY Acad Sci"},{"issue":"9","key":"10.1016\/j.jtos.2019.12.006_bib73","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1167\/iovs.10-7081","article-title":"Interferon-gamma exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways","volume":"52","author":"Zhang","year":"2011","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib74","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.ajpath.2011.06.030","article-title":"Desiccating stress induces CD4+ T-cell-mediated Sjogren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-gamma","volume":"179","author":"Zhang","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2019.12.006_bib75","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.exer.2013.11.011","article-title":"Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye","volume":"118","author":"Zhang","year":"2014","journal-title":"Exp Eye Res"},{"issue":"6\u20137","key":"10.1016\/j.jtos.2019.12.006_bib76","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.biochi.2007.04.013","article-title":"Dendritic cells and interferon-mediated autoimmunity","volume":"89","author":"Gottenberg","year":"2007","journal-title":"Biochimie"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib77","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ajpath.2013.11.019","article-title":"Ocular surface disease and dacryoadenitis in aging C57BL\/6 mice","volume":"184","author":"McClellan","year":"2014","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.jtos.2019.12.006_bib78","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00702-010-0475-7","article-title":"Interferon-gamma-inducible kynurenines\/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders","volume":"118","author":"Oxenkrug","year":"2011","journal-title":"J Neural Transm"},{"key":"10.1016\/j.jtos.2019.12.006_bib79","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s11357-011-9316-3","article-title":"The dominant human conjunctival epithelial CD8alphabeta+ T cell population is maintained with age but the number of CD4+ T cells increases","volume":"34","author":"Williams","year":"2012","journal-title":"Age (Dordr)"},{"issue":"40","key":"10.1016\/j.jtos.2019.12.006_bib80","doi-asserted-by":"crossref","first-page":"64605","DOI":"10.18632\/oncotarget.11872","article-title":"Interferon-gamma deficiency protects against aging-related goblet cell loss","volume":"7","author":"Volpe","year":"2016","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib81","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1172\/JCI29176","article-title":"SPDEF regulates goblet cell hyperplasia in the airway epithelium","volume":"117","author":"Park","year":"2007","journal-title":"J Clin Investig"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib82","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.yexcr.2009.09.020","article-title":"SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells","volume":"316","author":"Noah","year":"2010","journal-title":"Exp Cell Res"},{"issue":"1","key":"10.1016\/j.jtos.2019.12.006_bib83","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ajpath.2013.03.017","article-title":"Spdef null mice lack conjunctival goblet cells and provide a model of dry eye","volume":"183","author":"Marko","year":"2013","journal-title":"Am J Pathol"},{"issue":"10","key":"10.1016\/j.jtos.2019.12.006_bib84","first-page":"2914","article-title":"SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production","volume":"119","author":"Chen","year":"2009","journal-title":"J Clin Investig"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib85","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/mi.2010.82","article-title":"Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13","volume":"4","author":"De Paiva","year":"2011","journal-title":"Mucosal Immunol"},{"issue":"Supplement_3","key":"10.1016\/j.jtos.2019.12.006_bib86","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1513\/AnnalsATS.201802-128AW","article-title":"Airway epithelial differentiation and mucociliary clearance","volume":"15","author":"Whitsett","year":"2018","journal-title":"Ann Am Thorac Soc"},{"issue":"5","key":"10.1016\/j.jtos.2019.12.006_bib87","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1172\/JCI79422","article-title":"Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation","volume":"125","author":"Rajavelu","year":"2015","journal-title":"J Clin Investig"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib88","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98222","article-title":"Goblet cell loss abrogates ocular surface immune tolerance","volume":"3","author":"Ko","year":"2018","journal-title":"JCI Insight"},{"issue":"6157","key":"10.1016\/j.jtos.2019.12.006_bib89","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1126\/science.1237910","article-title":"Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals","volume":"342","author":"Shan","year":"2013","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.jtos.2019.12.006_bib90","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.4049\/jimmunol.164.9.4543","article-title":"In vivo behavior of peptide-specific T cells during mucosal tolerance induction: antigen introduced through the mucosa of the conjunctiva elicits prolonged antigen-specific T cell priming followed by anergy","volume":"164","author":"Egan","year":"2000","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.jtos.2019.12.006_bib91","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/cei.12759","article-title":"Desiccating stress-induced disruption of ocular surface immune tolerance drives dry eye disease","volume":"184","author":"Guzman","year":"2016","journal-title":"Clin Exp Immunol"},{"issue":"11","key":"10.1016\/j.jtos.2019.12.006_bib92","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1167\/iovs.11-7655","article-title":"Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome","volume":"52","author":"Corrales","year":"2011","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib93","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1124\/pr.111.005538","article-title":"Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application","volume":"64","author":"Koppaka","year":"2012","journal-title":"Pharmacol Rev"},{"issue":"12","key":"10.1016\/j.jtos.2019.12.006_bib94","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1074\/jbc.274.12.7674","article-title":"Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB","volume":"274","author":"Na","year":"1999","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.jtos.2019.12.006_bib95","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1002\/eji.200535366","article-title":"An essential role for Rxr alpha in the development of Th2 responses","volume":"35","author":"Du","year":"2005","journal-title":"Eur J Immunol"},{"issue":"9","key":"10.1016\/j.jtos.2019.12.006_bib96","article-title":"Increased conjunctival monocyte\/macrophage antigen presenting cells in Pinkie RXRa deficient mice with accelerated dry eye","volume":"60","author":"Pflugfelder","year":"2019","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"13","key":"10.1016\/j.jtos.2019.12.006_bib97","doi-asserted-by":"crossref","first-page":"7715","DOI":"10.1167\/iovs.15-17768","article-title":"Vitamin D activation and function in human corneal epithelial cells during TLR-induced inflammation","volume":"56","author":"Reins","year":"2015","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.jtos.2019.12.006_bib98","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.3892\/mmr.2014.2041","article-title":"Decreased PPAR-gamma expression in the conjunctiva and increased expression of TNF-alpha and IL-1beta in the conjunctiva and tear fluid of dry eye mice","volume":"9","author":"Chen","year":"2014","journal-title":"Mol Med Rep"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib99","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1001\/archophthalmol.2011.69","article-title":"Effects of age and dysfunction on human meibomian glands","volume":"129","author":"Nien","year":"2011","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2019.12.006_bib100","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10456-018-9604-y","article-title":"Time-dependent LXR\/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization","volume":"21","author":"Mukwaya","year":"2018","journal-title":"Angiogenesis"},{"issue":"9","key":"10.1016\/j.jtos.2019.12.006_bib101","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.tem.2013.04.004","article-title":"Retinoid X receptors in macrophage biology","volume":"24","author":"Roszer","year":"2013","journal-title":"Trends Endocrinol Metab: TEM (Trends Endocrinol Metab)"},{"issue":"10","key":"10.1016\/j.jtos.2019.12.006_bib102","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1097\/ICO.0b013e318299549c","article-title":"Long-term supplementation with n-6 and n-3 PUFAs improves moderate-to-severe keratoconjunctivitis sicca: a randomized double-blind clinical trial","volume":"32","author":"Sheppard","year":"2013","journal-title":"Cornea"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib103","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jtos.2016.08.001","article-title":"PPARgamma regulates mouse meibocyte differentiation and lipid synthesis","volume":"14","author":"Jester","year":"2016","journal-title":"Ocul Surf"},{"issue":"8","key":"10.1016\/j.jtos.2019.12.006_bib104","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1136\/bjophthalmol-2018-312849","article-title":"Altered retinoid metabolism gene expression in chronic Stevens-Johnson syndrome","volume":"103","author":"Srividya","year":"2019","journal-title":"British J Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2019.12.006_bib105","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1038\/s41598-019-43714-5","article-title":"Elevated cytokine levels in tears and saliva of patients with primary Sjogren's syndrome correlate with clinical ocular and oral manifestations","volume":"9","author":"Chen","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtos.2019.12.006_bib106","first-page":"862","article-title":"Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease","volume":"16","author":"Enriquez-de-Salamanca","year":"2010","journal-title":"Mol Vis"},{"issue":"11","key":"10.1016\/j.jtos.2019.12.006_bib107","doi-asserted-by":"crossref","first-page":"4824","DOI":"10.1167\/iovs.16-19757","article-title":"Tear interferon-gamma as a biomarker for evaporative dry eye disease","volume":"57","author":"Jackson","year":"2016","journal-title":"Investig Ophthalmol Visual Sci"},{"issue":"6","key":"10.1016\/j.jtos.2019.12.006_bib108","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/tvst.5.6.16","article-title":"Lower vitamin D level and distinct tear cytokine profile were observed in patients with mild dry eye signs but exaggerated symptoms","volume":"5","author":"Shetty","year":"2016","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.jtos.2019.12.006_bib109","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cyto.2016.08.026","article-title":"A distinct cytokines profile in tear film of dry eye disease (DED) patients with HIV infection","volume":"88","author":"Agrawal","year":"2016","journal-title":"Cytokine"},{"key":"10.1016\/j.jtos.2019.12.006_bib110","first-page":"797","article-title":"Cytokines in tear fluid of patients with ocular graft-versus-host disease after allogeneic stem cell transplantation","volume":"18","author":"Riemens","year":"2012","journal-title":"Mol Vis"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib111","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/ICO.0000000000000721","article-title":"Differential profiling of T-cell cytokines as measured by protein microarray across dry eye subgroups","volume":"35","author":"Meadows","year":"2016","journal-title":"Cornea"},{"issue":"10\u201312","key":"10.1016\/j.jtos.2019.12.006_bib112","first-page":"435","article-title":"[The evaluation of chosen cytokines in induction of ocular changes in Sjogren's syndrome of dry eye]","volume":"109","author":"Zywalewska-Gorna","year":"2007","journal-title":"Klin Ocz"},{"key":"10.1016\/j.jtos.2019.12.006_bib113","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.12659\/MSM.912010","article-title":"Tear luminex analysis in dry eye patients","volume":"24","author":"Zhao","year":"2018","journal-title":"Med Sci Monit : Int Med J Exp Clin Res"},{"issue":"2","key":"10.1016\/j.jtos.2019.12.006_bib114","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1167\/iovs.09-3425","article-title":"Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome","volume":"51","author":"Yoon","year":"2010","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.jtos.2019.12.006_bib115","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/01.ico.0000133994.22392.47","article-title":"Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca","volume":"24","author":"Strong","year":"2005","journal-title":"Cornea"},{"issue":"7","key":"10.1016\/j.jtos.2019.12.006_bib116","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.4049\/jimmunol.176.7.3950","article-title":"Desiccating stress induces T cell-mediated sjogren's syndrome-like lacrimal keratoconjunctivitis","volume":"176","author":"Niederkorn","year":"2006","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.jtos.2019.12.006_bib117","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1167\/iovs.07-0069","article-title":"Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by Interferon-{gamma}","volume":"48","author":"de Paiva","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"10.1016\/j.jtos.2019.12.006_bib118","first-page":"2561","article-title":"Expression of th-1 chemokines and chemokine receptors on the ocular surface of C57BL\/6 mice: effects of desiccating stress","volume":"48","author":"Yoon","year":"2007","journal-title":"Investig Ophthalmol"},{"issue":"9","key":"10.1016\/j.jtos.2019.12.006_bib119","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1136\/bjo.2008.153700","article-title":"Spontaneous T cell mediated keratoconjunctivitis in Aire-deficient mice","volume":"93","author":"Yeh","year":"2009","journal-title":"British J Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2019.12.006_bib120","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/rheumatology\/kep357","article-title":"Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice","volume":"49","author":"de Paiva","year":"2010","journal-title":"Rheumatology"},{"issue":"6","key":"10.1016\/j.jtos.2019.12.006_bib121","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/ICU.0000000000000208","article-title":"Sjogren syndrome: what and where are we looking for?","volume":"26","author":"de Paiva","year":"2015","journal-title":"Curr Opin Ophthalmol"},{"issue":"7","key":"10.1016\/j.jtos.2019.12.006_bib122","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.4049\/jimmunol.1101442","article-title":"Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis","volume":"187","author":"Schaumburg","year":"2011","journal-title":"J Immunol"},{"issue":"12","key":"10.1016\/j.jtos.2019.12.006_bib123","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029017","article-title":"Disruption of TGF-beta signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca","volume":"6","author":"de Paiva","year":"2011","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.jtos.2019.12.006_bib124","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1167\/iovs.10-7081","article-title":"Interferon-gamma exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways","volume":"52","author":"Zhang","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"10.1016\/j.jtos.2019.12.006_bib125","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1097\/ICO.0b013e31823f789e","article-title":"Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye","volume":"31","author":"de Paiva","year":"2012","journal-title":"Cornea"},{"issue":"Suppl 1","key":"10.1016\/j.jtos.2019.12.006_bib126","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1097\/ICO.0b013e31826a80ea","article-title":"Effectiveness of topical infliximab in a mouse model of experimental dry eye","volume":"31","author":"Li","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2019.12.006_bib127","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.exer.2013.11.011","article-title":"Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye","volume":"118","author":"Zhang","year":"2014","journal-title":"Exp Eye Res"},{"issue":"11","key":"10.1016\/j.jtos.2019.12.006_bib128","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078508","article-title":"Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease","volume":"8","author":"Coursey","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib129","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/s41385-018-0127-z","article-title":"Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells","volume":"12","author":"Bian FX","year":"2019","journal-title":"Mucosal Immunol"},{"issue":"10","key":"10.1016\/j.jtos.2019.12.006_bib130","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1167\/iovs.15-17249","article-title":"Improvement of outcome measures of dry eye by a novel integrin antagonist in the murine desiccating stress model","volume":"56","author":"Krauss","year":"2015","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.jtos.2019.12.006_bib131","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1167\/iovs.14-15668","article-title":"Age-related conjunctival disease in the C57BL\/6.NOD-Aec1Aec2 Mouse Model of Sjogren Syndrome develops independent of lacrimal dysfunction","volume":"56","author":"You","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"16","key":"10.1016\/j.jtos.2019.12.006_bib132","article-title":"Interferon-gamma-Induced unfolded protein response in conjunctival goblet cells as a cause of mucin deficiency in sjogren syndrome","volume":"S0002\u20139440","author":"Coursey","year":"2016","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2019.12.006_bib133","doi-asserted-by":"crossref","first-page":"4727415","DOI":"10.1155\/2016\/4727415","article-title":"Therapeutic efficacy of topically applied antioxidant medicinal plant extracts in a mouse model of experimental dry eye","volume":"2016","author":"Choi","year":"2016","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib134","doi-asserted-by":"crossref","DOI":"10.1038\/mi.2016.83","article-title":"Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells","volume":"10","author":"Coursey","year":"2017","journal-title":"Mucosal Immunol"},{"issue":"3","key":"10.1016\/j.jtos.2019.12.006_bib135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174764","article-title":"Preclinical mouse model to monitor live Muc5b-producing conjunctival goblet cell density under pharmacological treatments","volume":"12","author":"Portal","year":"2017","journal-title":"PLoS One"},{"issue":"14","key":"10.1016\/j.jtos.2019.12.006_bib136","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1167\/iovs.17-22852","article-title":"Topical application of mizoribine suppresses CD4+ T-cell-mediated pathogenesis in murine dry eye","volume":"58","author":"Zhang","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.jtos.2019.12.006_bib137","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1167\/iovs.12-10648","article-title":"Therapeutic effect of topical adiponectin in a mouse model of desiccating stress-induced dry eye","volume":"54","author":"Li","year":"2013","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.jtos.2019.12.006_bib138","doi-asserted-by":"crossref","first-page":"E565","DOI":"10.3390\/ijms19020565","article-title":"Sjogren-Like lacrimal keratoconjunctivitis in germ-free mice","volume":"19","author":"Wang","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"18","key":"10.1016\/j.jtos.2019.12.006_bib139","article-title":"Protective role of commensal bacteria in Sjogren Syndrome","volume":"S0896\u20138411","author":"Zaheer","year":"2018","journal-title":"J Autoimmun"},{"issue":"8","key":"10.1016\/j.jtos.2019.12.006_bib140","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/jop.2018.0032","article-title":"Comparison of 0.1%, 0.18%, and 0.3% hyaluronic acid eye drops in the treatment of experimental dry eye","volume":"34","author":"You","year":"2018","journal-title":"J Ocul Pharmacol Ther : Off J Assoc Ocular Pharmacol Ther"},{"issue":"7","key":"10.1016\/j.jtos.2019.12.006_bib141","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1167\/iovs.19-27144","article-title":"Expression and role of nucleotide-binding oligomerization domain 2 (NOD2) in the ocular surface of murine dry eye","volume":"60","author":"Li","year":"2019","journal-title":"Investig Ophthalmol Visual Sci"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012420300136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012420300136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:28:26Z","timestamp":1778617706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012420300136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":141,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S1542012420300136"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2019.12.006","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune - Goblet cell interaction in the conjunctiva","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2019.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}