{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:01:07Z","timestamp":1780081267368,"version":"3.54.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006954","name":"Tufts Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jtos.2020.04.007","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T11:34:16Z","timestamp":1587641656000},"page":"94-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["The utility of anterior segment optical coherence tomography angiography for the assessment of limbal stem cell deficiency"],"prefix":"10.1016","volume":"19","author":[{"given":"William W.","family":"Binotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo M.","family":"Nos\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9268-1461","authenticated-orcid":false,"given":"N. Dilruba","family":"Koseoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela M.","family":"Dieckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Kenyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9313-2939","authenticated-orcid":false,"given":"Pedram","family":"Hamrah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2020.04.007_bib1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/eye.1989.22","article-title":"Concept and application of limbal stem cells","volume":"3","author":"Tseng","year":"1989","journal-title":"Eye"},{"key":"10.1016\/j.jtos.2020.04.007_bib2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/stem.2191","article-title":"Cell adhesion molecules and stem cell-niche-interactions in the limbal stem cell niche","volume":"34","author":"Polisetti","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.jtos.2020.04.007_bib3","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/sj.eye.6700573","article-title":"Stem cell differentiation and the effects of deficiency","volume":"17","author":"Dua","year":"2003","journal-title":"Eye"},{"key":"10.1016\/j.jtos.2020.04.007_bib4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.cr.7310137","article-title":"Niche regulation of corneal epithelial stem cells at the limbus","volume":"17","author":"Li","year":"2007","journal-title":"Cell Res"},{"key":"10.1016\/j.jtos.2020.04.007_bib5","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/sj.eye.6702895","article-title":"Ocular surface changes in limbal stem cell deficiency caused by chemical injury: a histologic study of excised pannus from recipients of cultured corneal epithelium","volume":"22","author":"Fatima","year":"2008","journal-title":"Eye"},{"key":"10.1016\/j.jtos.2020.04.007_bib6","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.ajo.2012.09.013","article-title":"Severe limbal stem cell deficiency from contact lens wear: patient clinical features","volume":"155","author":"Chan","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib7","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.ajo.2006.01.018","article-title":"Limbal stem cell deficiency after subconjunctival mitomycin C injection for trabeculectomy","volume":"141","author":"Sauder","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib8","first-page":"2131","article-title":"Preservative toxicity in glaucoma medication: clinical evaluation of benzalkonium chloride-free 0.5% timolol eye drops","volume":"7","author":"Rosin","year":"2013","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/IJG.0000000000000279","article-title":"The impact of glaucoma medications on corneal wound healing","volume":"25","author":"Pinheiro","year":"2016","journal-title":"J Glaucoma"},{"key":"10.1016\/j.jtos.2020.04.007_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ophtha.2013.06.049","article-title":"Neutrophil collagenase, gelatinase, and myeloperoxidase in tears of patients with stevens-johnson syndrome and ocular cicatricial pemphigoid","volume":"121","author":"Arafat","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2020.04.007_bib11","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1080\/09273948.2018.1455879","article-title":"Incidence and clinical characteristics of ocular involvement in mucous membrane pemphigoid","volume":"27","author":"Hong","year":"2019","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.jtos.2020.04.007_bib12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jtos.2018.12.002","article-title":"Management of advanced ocular surface disease in patients with severe atopic keratoconjunctivitis","volume":"17","author":"Jabbehdari","year":"2019","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2020.04.007_bib13","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.ophtha.2010.11.021","article-title":"Congenital aniridia variant: minimally abnormal irides with severe limbal stem cell deficiency","volume":"118","author":"Skeens","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2020.04.007_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.preteyeres.2006.09.001","article-title":"Regulation of corneal angiogenesis in limbal stem cell deficiency","volume":"25","author":"Ma","year":"2006","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2020.04.007_bib15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jtos.2015.12.002","article-title":"Niche regulation of limbal epithelial stem cells: relationship between inflammation and regeneration","volume":"14","author":"Tseng","year":"2016","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2020.04.007_bib16","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1001\/archophthalmol.2011.378","article-title":"Characterization of limbal stem cell deficiency by in vivo laser scanning confocal microscopy: a microstructural approach","volume":"130","author":"Deng","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib17","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.ajo.2015.06.026","article-title":"Limbal basal cell density decreases in limbal stem cell deficiency","volume":"160","author":"Chan","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib18","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1136\/bjo.2005.073916","article-title":"Impression cytology of the ocular surface","volume":"89","author":"Singh","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jtos.2012.05.001","article-title":"Goblet cells of the normal human bulbar conjunctiva and their assessment by impression cytology sampling","volume":"10","author":"Doughty","year":"2012","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2020.04.007_bib20","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jtos.2017.11.002","article-title":"The diagnosis of limbal stem cell deficiency","volume":"16","author":"Le","year":"2018","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2020.04.007_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/ICU.0000000000000387","article-title":"Diagnosis of corneal limbal stem cell deficiency","volume":"28","author":"Kim","year":"2017","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib22","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1126\/science.1957169","article-title":"Optical coherence tomography","volume":"254","author":"Huang","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.jtos.2020.04.007_bib23","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1364\/OE.20.004710","article-title":"Split-spectrum amplitude-decorrelation angiography with optical coherence tomography","volume":"20","author":"Jia","year":"2012","journal-title":"Optic Express"},{"key":"10.1016\/j.jtos.2020.04.007_bib24","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1136\/bjophthalmol-2015-307338","article-title":"En face optical coherence tomography angiography for corneal neovascularisation","volume":"100","author":"Ang","year":"2016","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib25","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1136\/bjophthalmol-2015-307706","article-title":"Optical coherence tomography angiography and indocyanine green angiography for corneal vascularisation","volume":"100","author":"Ang","year":"2016","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib26","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1167\/iovs.17-22035","article-title":"Imaging of corneal neovascularization: optical coherence tomography angiography and fluorescence angiography","volume":"59","author":"Brunner","year":"2018","journal-title":"IOVS (Investig Ophthalmol Vis Sci)"},{"key":"10.1016\/j.jtos.2020.04.007_bib27","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/ICO.0000000000001820","article-title":"Global consensus on definition, classification, diagnosis, and staging of limbal stem cell deficiency","volume":"38","author":"Deng","year":"2019","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2020.04.007_bib28","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1364\/BOE.7.000816","article-title":"Projection-resolved optical coherence tomographic angiography","volume":"7","author":"Zhang","year":"2016","journal-title":"Biomed Optic Express"},{"key":"10.1016\/j.jtos.2020.04.007_bib29","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jtos.2020.04.007_bib30","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behav Res Methods"},{"key":"10.1016\/j.jtos.2020.04.007_bib31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/08820530902801478","article-title":"Limbal stem cell deficiency and corneal neovascularization","volume":"24","author":"Lim","year":"2009","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1136\/bjo.18.6.305","article-title":"Certain clinical features of the normal limbus","volume":"18","author":"Graves","year":"1934","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib33","doi-asserted-by":"crossref","first-page":"7470","DOI":"10.1167\/iovs.13-12614","article-title":"Marginal corneal vascular arcades","volume":"54","author":"Zheng","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2020.04.007_bib34","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12886-016-0342-x","article-title":"Measurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy","volume":"16","author":"Le","year":"2016","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib35","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/ceo.12832","article-title":"Correlation between the existence of the palisades of Vogt and limbal epithelial thickness in limbal stem cell deficiency","volume":"45","author":"Le","year":"2017","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib36","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ajo.2018.03.034","article-title":"Spectral-domain optical coherence tomography in limbal stem cell deficiency. A case-control study","volume":"190","author":"Banayan","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib37","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/S0161-6420(95)30842-1","article-title":"Cytologic evidence of corneal diseases with limbal stem cell deficiency","volume":"102","author":"Puangsricharern","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2020.04.007_bib38","first-page":"571","article-title":"Diagnosis and management of neurotrophic keratitis","volume":"8","author":"Sacchetti","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.jtos.2020.04.007_bib39","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/ICO.0b013e3181e2d0f5","article-title":"Management of focal limbal stem cell deficiency associated with soft contact lens wear","volume":"30","author":"Jeng","year":"2011","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2020.04.007_bib40","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jtos.2016.06.003","article-title":"Contact lens-induced limbal stem cell deficiency","volume":"14","author":"Rossen","year":"2016","journal-title":"Ocul Surf"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012420300689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012420300689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:42:25Z","timestamp":1761540145000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012420300689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":40,"alternative-id":["S1542012420300689"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2020.04.007","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The utility of anterior segment optical coherence tomography angiography for the assessment of limbal stem cell deficiency","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2020.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}