{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:40:25Z","timestamp":1793932825227,"version":"4.8.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003195","name":"Ministerie van Economische Zaken","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003195","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001721","name":"Rijksuniversiteit Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002999","name":"Ministerie van Volksgezondheid, Welzijn en Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.jtos.2021.05.006","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T12:36:53Z","timestamp":1621859813000},"page":"107-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":135,"special_numbering":"C","title":["The physical and mental burden of dry eye disease: A large population-based study investigating the relationship with health-related quality of life and its determinants"],"prefix":"10.1016","volume":"21","author":[{"given":"Mathias Kaurstad","family":"Morthen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2276-1770","authenticated-orcid":false,"given":"Morten Schjerven","family":"Magno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor Paaske","family":"Utheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1949-2298","authenticated-orcid":false,"given":"Harold","family":"Snieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3227-2620","authenticated-orcid":false,"given":"Christopher J.","family":"Hammond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelle","family":"Vehof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jtos.2021.05.006_bib1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"issue":"7","key":"10.1016\/j.jtos.2021.05.006_bib2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s40273-016-0389-9","article-title":"Health, health-related quality of life, and quality of life: what is the difference?","volume":"34","author":"Karimi","year":"2016","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.jtos.2021.05.006_bib3","series-title":"Health-related quality of life and well-being","year":"2010"},{"issue":"2","key":"10.1016\/j.jtos.2021.05.006_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s40135-013-0009-1","article-title":"Dry eye disease: impact on quality of life and vision","volume":"1","author":"Uchino","year":"2013","journal-title":"Curr Ophthalmol Rep"},{"issue":"3","key":"10.1016\/j.jtos.2021.05.006_bib5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1542-0124(12)70043-5","article-title":"Utility assessment to measure the impact of dry eye disease","volume":"4","author":"Buchholz","year":"2006","journal-title":"Ocul Surf"},{"issue":"4","key":"10.1016\/j.jtos.2021.05.006_bib6","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ajo.2013.12.023","article-title":"Dry eye in the Beaver Dam offspring study: prevalence, risk factors, and health-related quality of life","volume":"157","author":"Paulsen","year":"2014","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2021.05.006_bib7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1167\/iovs.03-0915","article-title":"The relative burden of dry eye in patients' lives: comparisons to a U.S. Normative sample","volume":"46","author":"Mertzanis","year":"2005","journal-title":"Invest Opthalmol Vis Sci"},{"issue":"7","key":"10.1016\/j.jtos.2021.05.006_bib8","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1097\/ICO.0000000000000464","article-title":"Depression, stress, quality of life, and dry eye disease in Korean women","volume":"34","author":"Na","year":"2015","journal-title":"Cornea"},{"issue":"2","key":"10.1016\/j.jtos.2021.05.006_bib9","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jtos.2015.11.002","article-title":"Economic and humanistic burden of dry eye disease in Europe, North America, and Asia: a systematic literature review","volume":"14","author":"Mcdonald","year":"2016","journal-title":"Ocul Surf"},{"issue":"1","key":"10.1016\/j.jtos.2021.05.006_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/s12955-018-0999-3","article-title":"Quality of life measures and health utility values among dry eye subgroups","volume":"16","author":"Shigeyasu","year":"2018","journal-title":"Health Qual Life Outcome"},{"issue":"4","key":"10.1016\/j.jtos.2021.05.006_bib11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10384-010-0812-2","article-title":"Association between clinical diagnostic tests and health-related quality of life surveys in patients with dry eye syndrome","volume":"54","author":"Mizuno","year":"2010","journal-title":"Jpn J Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2021.05.006_bib12","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1111\/aos.12204","article-title":"Comparison on the vision-related quality of life between outpatients and general population with dry eye syndrome","volume":"92","author":"Le","year":"2014","journal-title":"Acta Ophthalmol"},{"issue":"6","key":"10.1016\/j.jtos.2021.05.006_bib13","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.ajo.2014.08.021","article-title":"Prevalence of and risk factors associated with dry eye: the Korea national health and nutrition examination survey 2010\u20132011","volume":"158","author":"Ahn","year":"2014","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"10.1016\/j.jtos.2021.05.006_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189840","article-title":"A comparison of health-related quality of life (HRQoL) across four systemic autoimmune rheumatic diseases (SARDs)","volume":"12","author":"Greenfield","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.jtos.2021.05.006_bib15","article-title":"Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in The Netherlands","author":"Vehof","year":"2020","journal-title":"Ocul Surf"},{"issue":"9","key":"10.1016\/j.jtos.2021.05.006_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076121","article-title":"Patient reported differences in dry eye disease between men and women: impact, management, and patient satisfaction","volume":"8","author":"Schaumberg","year":"2013","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.jtos.2021.05.006_bib17","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1089\/jwh.2018.7041","article-title":"Dry eye disease: consideration for women's health","volume":"28","author":"Matossian","year":"2019","journal-title":"J Wom Health"},{"issue":"1","key":"10.1016\/j.jtos.2021.05.006_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10654-007-9204-4","article-title":"Universal risk factors for multifactorial diseases","volume":"23","author":"Stolk","year":"2008","journal-title":"Eur J Epidemiol"},{"issue":"9","key":"10.1016\/j.jtos.2021.05.006_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137203","article-title":"Representativeness of the LifeLines cohort study","volume":"10","author":"Klijs","year":"2015","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.jtos.2021.05.006_bib20","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/ije\/dyu229","article-title":"Cohort Profile: LifeLines, a three-generation cohort study and biobank","volume":"44","author":"Scholtens","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"3","key":"10.1016\/j.jtos.2021.05.006_bib21","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","article-title":"TFOS DEWS II diagnostic methodology report","volume":"15","author":"Wolffsohn","year":"2017","journal-title":"Ocul Surf"},{"issue":"1","key":"10.1016\/j.jtos.2021.05.006_bib22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ajo.2006.02.038","article-title":"Validation and repeatability of a short questionnaire for dry eye syndrome","volume":"142","author":"Gulati","year":"2006","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"10.1016\/j.jtos.2021.05.006_bib23","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"issue":"5","key":"10.1016\/j.jtos.2021.05.006_bib24","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3109\/07853890109002089","article-title":"The RAND-36 measure of health-related quality of life","volume":"33","author":"Hays","year":"2001","journal-title":"Ann Med"},{"issue":"3","key":"10.1016\/j.jtos.2021.05.006_bib25","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/aje\/kwu136","article-title":"Changes in Body weight and health-related quality of life: 2 cohorts of US women","volume":"180","author":"Pan","year":"2014","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jtos.2021.05.006_bib26","series-title":"Institute TH","article-title":"SF-36 Physical and mental summary scales: a user's manual","author":"Ware","year":"1997"},{"issue":"11","key":"10.1016\/j.jtos.2021.05.006_bib27","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0895-4356(98)00097-3","article-title":"Translation, validation, and norming of the Dutch language version of the SF-36 health survey in community and chronic disease populations","volume":"51","author":"Aaronson","year":"1998","journal-title":"J Clin Epidemiol"},{"issue":"6","key":"10.1016\/j.jtos.2021.05.006_bib28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1167\/tvst.7.6.35","article-title":"The relationship of dry eye disease with depression and anxiety: a naturalistic observational study","volume":"7","author":"Kitazawa","year":"2018","journal-title":"Transl Vis Sci Technol"},{"issue":"1","key":"10.1016\/j.jtos.2021.05.006_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/s12886-018-0671-z","article-title":"Coping with dry eyes: a qualitative approach","volume":"18","author":"Yeo","year":"2018","journal-title":"BMC Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2021.05.006_bib30","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0002-9394(03)00218-6","article-title":"Prevalence of dry eye syndrome among US women","volume":"136","author":"Schaumberg","year":"2003","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2021.05.006_bib31","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jtos.2018.01.001","article-title":"Sex differences in clinical characteristics of dry eye disease","volume":"16","author":"Vehof","year":"2018","journal-title":"Ocul Surf"},{"issue":"2","key":"10.1016\/j.jtos.2021.05.006_bib32","article-title":"Gender Differences in the utilization of health care services","volume":"49","author":"Bertakis","year":"2000","journal-title":"J Fam Pract"},{"key":"10.1016\/j.jtos.2021.05.006_bib33","series-title":"Women and dry eye - shining a light on this essential dry eye disease segment","author":"McDonald","year":"2016"},{"key":"10.1016\/j.jtos.2021.05.006_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtos.2020.05.006","article-title":"TFOS European ambassador meeting: unmet needs and future scientific and clinical solutions for ocular surface diseases","author":"Erickson","year":"2020","journal-title":"Ocul Surf"},{"issue":"4","key":"10.1016\/j.jtos.2021.05.006_bib35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/ICU.0b013e32833a8c15","article-title":"Impact of dry eye disease and treatment on quality of life","volume":"21","author":"Friedman","year":"2010","journal-title":"Curr Opin Ophthalmol"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012421000458?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012421000458?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:45:13Z","timestamp":1761540313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012421000458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":35,"alternative-id":["S1542012421000458"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2021.05.006","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The physical and mental burden of dry eye disease: A large population-based study investigating the relationship with health-related quality of life and its determinants","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2021.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}