{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T15:22:35Z","timestamp":1769354555600,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jtos.2023.06.007","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T22:57:28Z","timestamp":1686869848000},"page":"406-415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Transitory alkali exposure on meibomian gland orifices induces meibomian gland dysfunction"],"prefix":"10.1016","volume":"29","author":[{"given":"Jinghua","family":"Bu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kechun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongrong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuli","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9815-9623","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2023.06.007_bib1","first-page":"537","article-title":"Meibomian gland studies: histologic and ultrastructural investigations","volume":"20","author":"Jester","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.06.007_bib2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0039-6257(96)80064-6","article-title":"Meibomian gland dysfunction","volume":"40","author":"Driver","year":"1996","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jtos.2023.06.007_bib3","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jtos.2017.03.006","article-title":"TFOS DEWS II tear film report","volume":"15","author":"Willcox","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2023.06.007_bib4","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1167\/iovs.10-6997b","article-title":"The international workshop on meibomian gland dysfunction: report of the definition and classification subcommittee","volume":"52","author":"Nelson","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.06.007_bib5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1542-0124(12)70150-7","article-title":"The contribution of meibomian disease to dry eye","volume":"2","author":"Bron","year":"2004","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2023.06.007_bib6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ajpath.2015.09.019","article-title":"Meibomian gland absence related dry eye in ectodysplasin A mutant mice","volume":"186","author":"Wang","year":"2016","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2023.06.007_bib7","first-page":"1190","article-title":"Meibomian gland changes in the rhino (hrrhhrrh) mouse","volume":"29","author":"Jester","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.06.007_bib8","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1167\/iovs.13-13335","article-title":"A role for ELOVL4 in the mouse meibomian gland and sebocyte cell biology","volume":"55","author":"McMahon","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.06.007_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099328","article-title":"Oxidative stress induced age dependent meibomian gland dysfunction in Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice","volume":"9","author":"Ibrahim","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jtos.2023.06.007_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2015.10.008","article-title":"Sj\u00f6gren's syndrome associated dry eye in a mouse model is ameliorated by topical application of integrin \u03b14 antagonist GW559090","volume":"143","author":"Contreras-Ruiz","year":"2016","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2023.06.007_bib11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ydbio.2011.05.005","article-title":"Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells","volume":"356","author":"Kenchegowda","year":"2011","journal-title":"Dev Biol"},{"key":"10.1016\/j.jtos.2023.06.007_bib12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jtos.2019.06.002","article-title":"Hyperlipidemia induces meibomian gland dysfunction","volume":"17","author":"Bu","year":"2019","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2023.06.007_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2156-12-91","article-title":"A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene","volume":"12","author":"Kuramoto","year":"2011","journal-title":"BMC Genet"},{"key":"10.1016\/j.jtos.2023.06.007_bib14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ajpath.2017.09.016","article-title":"Loss of \u03b2 epithelial sodium channel function in meibomian glands produces pseudohypoaldosteronism 1-like ocular disease in mice","volume":"188","author":"Yu","year":"2018","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2023.06.007_bib15","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.jtos.2020.08.008","article-title":"A randomized, sham-controlled trial of intraductal meibomian gland probing with or without topical antibiotic\/steroid for obstructive meibomian gland dysfunction","volume":"18","author":"Kheirkhah","year":"2020","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2023.06.007_bib16","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/S0161-6420(89)32753-9","article-title":"Tear film and ocular surface changes after closure of the meibomian gland orifices in the rabbit","volume":"96","author":"Gilbard","year":"1989","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2023.06.007_bib17","first-page":"1077","article-title":"Evaluation of a rat meibomian gland dysfunction model induced by closure of meibomian gland orifices","volume":"11","author":"Dong","year":"2018","journal-title":"Int J Ophthalmol"},{"key":"10.1016\/j.jtos.2023.06.007_bib18","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/ICO.0000000000001460","article-title":"Meibomian glands and ocular surface changes after closure of meibomian gland orifices in rabbits","volume":"37","author":"Eom","year":"2018","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2023.06.007_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aas9164","article-title":"Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice","volume":"10","author":"Reyes","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jtos.2023.06.007_bib20","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jtos.2017.04.003","article-title":"Ocular surface alkali injury damages meibomian glands in mice","volume":"15","author":"Mizoguchi","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2023.06.007_bib21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/BCR.0b013e31829b0037","article-title":"Alkali-related ocular burns: a case series and review","volume":"35","author":"Bunker","year":"2014","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jtos.2023.06.007_bib22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.exer.2017.06.011","article-title":"Ocular surface inflammation impairs structure and function of meibomian gland","volume":"163","author":"Mizoguchi","year":"2017","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2023.06.007_bib23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jtos.2016.09.002","article-title":"Current and upcoming therapies for ocular surface chemical injuries","volume":"15","author":"Baradaran-Rafii","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2023.06.007_bib24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1542-0124(12)70139-8","article-title":"Meibomian gland dysfunction: a clinical scheme for description, diagnosis, classification, and grading","volume":"1","author":"Foulks","year":"2003","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2023.06.007_bib25","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/sctm.18-0037","article-title":"Biomarkers for progenitor and differentiated epithelial cells in the human meibomian gland","volume":"7","author":"Xie","year":"2018","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.jtos.2023.06.007_bib26","first-page":"660","article-title":"In vivo biomicroscopy and photography of meibomian glands in a rabbit model of meibomian gland dysfunction","volume":"22","author":"Jester","year":"1982","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.06.007_bib27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1139\/o90-063","article-title":"Differential expression of the epidermal K1 and K10 keratin genes during mouse embryo development","volume":"68","author":"Ouellet","year":"1990","journal-title":"Biochemistry and cell biology = Biochimie et biologie cellulaire"},{"key":"10.1016\/j.jtos.2023.06.007_bib28","first-page":"168","article-title":"A unique lineage gives rise to the meibomian gland","volume":"22","author":"Call","year":"2016","journal-title":"Mol Vis"},{"key":"10.1016\/j.jtos.2023.06.007_bib29","doi-asserted-by":"crossref","first-page":"825","DOI":"10.18632\/aging.100615","article-title":"Absence of ductal hyper-keratinization in mouse age-related meibomian gland dysfunction (ARMGD)","volume":"5","author":"Parfitt","year":"2013","journal-title":"Aging"},{"key":"10.1016\/j.jtos.2023.06.007_bib30","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jtos.2016.08.001","article-title":"PPAR\u03b3 regulates mouse meibocyte differentiation and lipid synthesis","volume":"14","author":"Jester","year":"2016","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2023.06.007_bib31","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1038\/sj.jid.5700336","article-title":"Peroxisome proliferator-activated receptors increase human sebum production","volume":"126","author":"Trivedi","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jtos.2023.06.007_bib32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/ICO.0000000000000393","article-title":"Evaluation of dry eye and meibomian gland dysfunction with meibography in patients with rosacea","volume":"34","author":"Palamar","year":"2015","journal-title":"Cornea"},{"issue":"Pt 4","key":"10.1016\/j.jtos.2023.06.007_bib33","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/eye.1991.65","article-title":"Meibomian gland disease. Classification and grading of lid changes","volume":"5","author":"Bron","year":"1991","journal-title":"Eye (London, England)"},{"key":"10.1016\/j.jtos.2023.06.007_bib34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jtos.2014.12.002","article-title":"Meibomian glands and ocular surface inflammation","volume":"13","author":"Suzuki","year":"2015","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2023.06.007_bib35","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1167\/iovs.10-6997c","article-title":"The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland","volume":"52","author":"Knop","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.06.007_bib36","first-page":"936","article-title":"Meibomian gland dysfunction. II. The role of keratinization in a rabbit model of MGD","volume":"30","author":"Jester","year":"1989","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"Suppl 1","key":"10.1016\/j.jtos.2023.06.007_bib37","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12886-015-0132-x","article-title":"Meibomian gland dysfunction: hyperkeratinization or atrophy?","volume":"15","author":"Jester","year":"2015","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.jtos.2023.06.007_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/iovs.62.10.13","article-title":"High-fat diet induces inflammation of meibomian gland","volume":"62","author":"Bu","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.06.007_bib39","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/vop.12171","article-title":"Ocular alkaline injury in four dogs - presentation, treatment, and follow-up - a case series","volume":"18","author":"Busse","year":"2015","journal-title":"Vet Ophthalmol"},{"key":"10.1016\/j.jtos.2023.06.007_bib40","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1038\/eye.2008.414","article-title":"Surgical rehabilitation following severe ocular burns","volume":"23","author":"Tuft","year":"2009","journal-title":"Eye (Lond)"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012423000678?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012423000678?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T23:25:31Z","timestamp":1716420331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012423000678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":40,"alternative-id":["S1542012423000678"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2023.06.007","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transitory alkali exposure on meibomian gland orifices induces meibomian gland dysfunction","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2023.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}