{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:26:21Z","timestamp":1791390381336,"version":"4.3.3"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"am","delay-in-days":347,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017017","name":"Hamill Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017017","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY-002520"],"award-info":[{"award-number":["EY-002520"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY030447"],"award-info":[{"award-number":["EY030447"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["T32 EY007001"],"award-info":[{"award-number":["T32 EY007001"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["EY 5R01EY026202"],"award-info":[{"award-number":["EY 5R01EY026202"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA125123"],"award-info":[{"award-number":["P30CA125123"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001315","name":"Sid W. Richardson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001315","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005589","name":"Center for the Study of Democratic Politics, Princeton University","doi-asserted-by":"publisher","award":["P30 EY021725"],"award-info":[{"award-number":["P30 EY021725"]}],"id":[{"id":"10.13039\/100005589","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jtos.2023.08.004","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T20:49:36Z","timestamp":1692996576000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["TNF is a critical cytokine in age-related dry eye disease"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7241-9711","authenticated-orcid":false,"given":"Yashaswini","family":"Kelagere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-8950","authenticated-orcid":false,"given":"Kaitlin K.","family":"Scholand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica N.","family":"DeJong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4079-4813","authenticated-orcid":false,"given":"Andrea I.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0785-9822","authenticated-orcid":false,"given":"Zhiyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2243-119X","authenticated-orcid":false,"given":"Roger A.","family":"Astley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle C.","family":"Callegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-2957","authenticated-orcid":false,"given":"Dawn ME.","family":"Bowdish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen P.","family":"Makarenkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-5494","authenticated-orcid":false,"given":"Cintia S.","family":"de Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2023.08.004_bib1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri1184","article-title":"Signalling pathways of the TNF superfamily: a double-edged sword","volume":"3","author":"Aggarwal","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jtos.2023.08.004_bib2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1074-7613(00)80020-5","article-title":"Cathepsin S required for normal MHC class II peptide loading and germinal center development","volume":"10","author":"Shi","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.jtos.2023.08.004_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.exer.2009.10.008","article-title":"Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sj\u00f6gren's syndrome-like exocrinopathy","volume":"90","author":"Schenke-Layland","year":"2010","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2023.08.004_bib4","article-title":"Cathepsin S is a novel target for age-related dry eye","volume":"214","author":"Yu","year":"2021","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2023.08.004_bib5","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/art.38633","article-title":"Tear cathepsin S as a candidate biomarker for Sjogren's syndrome","volume":"66","author":"Hamm-Alvarez","year":"2014","journal-title":"Arthritis Rheumatol"},{"issue":"Suppl 1","key":"10.1016\/j.jtos.2023.08.004_bib6","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"The journals of gerontology Series A, Biological sciences and medical sciences"},{"key":"10.1016\/j.jtos.2023.08.004_bib7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.freeradbiomed.2010.05.019","article-title":"Differential inflammatory responses in aging and disease: TNF-alpha and IL-6 as possible biomarkers","volume":"49","author":"de Gonzalo-Calvo","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jtos.2023.08.004_bib8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00062752-200105000-00001","article-title":"Aging and proinflammatory cytokines","volume":"8","author":"Bruunsgaard","year":"2001","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.jtos.2023.08.004_bib9","first-page":"278","article-title":"Elevated levels of tumor necrosis factor alpha and mortality in centenarians","volume":"115","author":"Bruunsgaard","year":"2003","journal-title":"AmJMed"},{"key":"10.1016\/j.jtos.2023.08.004_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1046\/j.1365-2249.2003.02137.x","article-title":"Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people","volume":"132","author":"Bruunsgaard","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jtos.2023.08.004_bib11","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.exger.2004.01.009","article-title":"Inflammatory mediators in the elderly","volume":"39","author":"Krabbe","year":"2004","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jtos.2023.08.004_bib12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.exer.2003.09.003","article-title":"The role of the lacrimal functional unit in the pathophysiology of dry eye","volume":"78","author":"Stern","year":"2004","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2023.08.004_bib13","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.4049\/jimmunol.1201216","article-title":"Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL\/6 mice","volume":"189","author":"Bombardieri","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2023.08.004_bib14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.molimm.2014.05.006","article-title":"Discerning the kinetics of autoimmune manifestations in a model of Sjogren's syndrome","volume":"62","author":"Karnell","year":"2014","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jtos.2023.08.004_bib15","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/art.20060","article-title":"Association of transforming growth factor beta 1 and tumor necrosis factor alpha polymorphisms with anti-SSB\/La antibody secretion in patients with primary Sj\u00f6gren's syndrome","volume":"50","author":"Gottenberg","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jtos.2023.08.004_bib16","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1136\/annrheumdis-2015-207731","article-title":"Germline variation of TNFAIP3 in primary Sj\u00f6gren's syndrome-associated lymphoma","volume":"75","author":"Nocturne","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jtos.2023.08.004_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6728694","article-title":"TNFAIP3 gene polymorphisms in three common autoimmune diseases: systemic lupus erythematosus, rheumatoid arthritis, and primary sjogren syndrome-association with disease susceptibility and clinical phenotypes in Italian patients","author":"Ciccacci","year":"2019","journal-title":"Journal of immunology research"},{"key":"10.1016\/j.jtos.2023.08.004_bib18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12950-019-0209-z","article-title":"SNP variations in IL10, TNF\u03b1 and TNFAIP3 genes in patients with dry eye syndrome and Sjogren's syndrome","volume":"16","author":"Ben-Eli","year":"2019","journal-title":"J Inflamm"},{"key":"10.1016\/j.jtos.2023.08.004_bib19","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1167\/iovs.03-0958","article-title":"Inflammatory mediators in autoimmune lacrimal gland disease in MRL\/Mpj mice","volume":"45","author":"Jabs","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.08.004_bib20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ajpath.2020.10.013","article-title":"Modulation of oxidative stress and inflammation in the aged lacrimal gland","volume":"191","author":"de Souza","year":"2021","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2023.08.004_bib21","first-page":"416","article-title":"Comparative analysis of age-related changes in lacrimal glands and meibomian glands of a C57BL\/6 male mouse model","volume":"21","author":"Yoon Chr","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2023.08.004_bib22","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ajpath.2013.11.019","article-title":"Ocular surface disease and dacryoadenitis in aging C57BL\/6 mice","volume":"184","author":"McClellan","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2023.08.004_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109251","article-title":"Ectopic lymphoid structures in the aged lacrimal glands","volume":"248","author":"Galletti","year":"2023","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jtos.2023.08.004_bib24","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1113\/JP280637","article-title":"Biological sex, not reproductive cycle, influences peripheral blood immune cell prevalence in mice","volume":"599","author":"Breznik","year":"2021","journal-title":"J Physiol"},{"key":"10.1016\/j.jtos.2023.08.004_bib25","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41385-020-0290-x","article-title":"Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNF\u03b1-dependent but microbiota-independent tertiary lymphoid tissue formation","volume":"13","author":"Ligon","year":"2020","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jtos.2023.08.004_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-32366-6","article-title":"Commensal microbiota induces colonic barrier structure and functions that contribute to homeostasis","volume":"8","author":"Hayes","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtos.2023.08.004_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2017.03.002","article-title":"Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction","volume":"21","author":"Thevaranjan","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jtos.2023.08.004_bib28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/intimm\/dxu102","article-title":"Anti-TNF therapy: past, present and future","volume":"27","author":"Monaco","year":"2015","journal-title":"Int Immunol"},{"issue":"Suppl 1","key":"10.1016\/j.jtos.2023.08.004_bib29","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1097\/ICO.0b013e31826a80ea","article-title":"Effectiveness of topical infliximab in a mouse model of experimental dry eye","volume":"31","author":"Li","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2023.08.004_bib30","doi-asserted-by":"crossref","first-page":"7557","DOI":"10.1167\/iovs.12-11515","article-title":"Neutralization of ocular surface TNF-alpha reduces ocular surface and lacrimal gland inflammation induced by in vivo dry eye","volume":"54","author":"Ji","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.08.004_bib31","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3341\/kjo.2016.30.4.302","article-title":"The effect of TNF-alpha blocker HL036337 and its best concentration to inhibit dry eye inflammation","volume":"30","author":"Choi","year":"2016","journal-title":"Kor J Ophthalmol : KJO."},{"key":"10.1016\/j.jtos.2023.08.004_bib32","series-title":"The national academies collection: reports funded by national Institutes of health. Guide for the Care and use of laboratory animals","year":"2011"},{"key":"10.1016\/j.jtos.2023.08.004_bib33","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.lfs.2015.10.025","article-title":"Men and mice: relating their ages","volume":"152","author":"Dutta","year":"2016","journal-title":"Life Sci"},{"key":"10.1016\/j.jtos.2023.08.004_bib34","series-title":"Chapter 20 - mouse models in aging research. The mouse in biomedical research","first-page":"637","author":"Flurkey","year":"2007"},{"key":"10.1016\/j.jtos.2023.08.004_bib35","first-page":"1264","article-title":"Prevalence of and risk factors for dry eye syndrome","volume":"118","author":"Moss","year":"2000","journal-title":"ArchOphthalmol"},{"key":"10.1016\/j.jtos.2023.08.004_bib36","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0002-9394(03)00218-6","article-title":"Prevalence of dry eye syndrome among US women","volume":"136","author":"Schaumberg","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2023.08.004_bib37","doi-asserted-by":"crossref","first-page":"64605","DOI":"10.18632\/oncotarget.11872","article-title":"Interferon-gamma deficiency protects against aging-related goblet cell loss","volume":"7","author":"Volpe","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jtos.2023.08.004_bib38","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1167\/iovs.07-0069","article-title":"Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by Interferon-{gamma","volume":"48","author":"de Paiva","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.08.004_bib39","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/mi.2013.61","article-title":"CD8(+) cells regulate the T helper-17 response in an experimental murine model of Sjogren syndrome","volume":"7","author":"Zhang","year":"2014","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jtos.2023.08.004_bib40","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ajo.2008.08.032","article-title":"Tear cytokine profiles in dysfunctional tear syndrome","volume":"147","author":"Lam","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2023.08.004_bib41","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1167\/iovs.18-25822","article-title":"InflammAging at ocular surface: clinical and biomolecular analyses in healthy volunteers","volume":"60","author":"Di Zazzo","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.08.004_bib42","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1167\/iovs.17-23358","article-title":"Age-related changes to human tear composition","volume":"59","author":"Micera","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.08.004_bib43","first-page":"190","article-title":"Lipopolysaccharide induces expression of genes encoding pro- inflammatory cytokines and the elastin-degrading enzyme, cathepsin S, in human cervical smooth-muscle cells","volume":"7","author":"Watari","year":"2000","journal-title":"JSocGynecolInvestig"},{"key":"10.1016\/j.jtos.2023.08.004_bib44","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/mi.2016.83","article-title":"Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells","volume":"10","author":"Coursey","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jtos.2023.08.004_bib45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cytogfr.2014.02.001","article-title":"Lymphotoxin and TNF: how it all began-a tribute to the travelers","volume":"25","author":"Ruddle","year":"2014","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jtos.2023.08.004_bib46","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0171-2985(11)80543-7","article-title":"TNF-induced activation of NF-kappa B","volume":"193","author":"Schutze","year":"1995","journal-title":"Immunobiology"},{"key":"10.1016\/j.jtos.2023.08.004_bib47","first-page":"S146","article-title":"Anti-TNF therapy for other inflammatory conditions","volume":"20","author":"Tutuncu","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jtos.2023.08.004_bib48","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1177\/0022034519837240","article-title":"Targeted TNF-\u03b1 overexpression drives salivary gland inflammation","volume":"98","author":"Limaye","year":"2019","journal-title":"J Dent Res"},{"key":"10.1016\/j.jtos.2023.08.004_bib49","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1740-2557-2-6","article-title":"Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis","volume":"2","author":"Trousdale","year":"2005","journal-title":"J Autoimmune Dis"},{"key":"10.1016\/j.jtos.2023.08.004_bib50","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/labinvest.2016.141","article-title":"Pathogenic role of endogenous TNF-alpha in the development of Sjogren's-like sialadenitis and secretory dysfunction in non-obese diabetic mice","volume":"97","author":"Zhou","year":"2017","journal-title":"Lab Invest"},{"key":"10.1016\/j.jtos.2023.08.004_bib51","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ophtha.2022.12.001","article-title":"Which dry eye? The case for precise diagnostic terminology in Ophthalmology","volume":"130","author":"Galor","year":"2023","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2023.08.004_bib52","first-page":"970","article-title":"Salivary cytokine profiles in primary Sjogren's syndrome differ from those in non-Sjogren sicca in terms of TNF-alpha levels and Th-1\/Th-2 ratios","volume":"29","author":"Kang","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jtos.2023.08.004_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.109057","article-title":"Inflammation-related molecules in tears of patients with chronic ocular pain and dry eye disease","volume":"219","author":"Blanco-V\u00e1zquez","year":"2022","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2023.08.004_bib54","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/s41385-018-0127-z","article-title":"Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells","volume":"12","author":"Bian","year":"2019","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jtos.2023.08.004_bib55","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/s41598-019-57266-1","article-title":"Improvement of conjunctival cytological grade and tear production in Ankylosing Spondylitis patients under TNF inhibitors: a long-term follow-up","volume":"10","author":"Usuba","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtos.2023.08.004_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005368","article-title":"TNF drives monocyte dysfunction with age and results in impaired anti-pneumococcal immunity","volume":"12","author":"Puchta","year":"2016","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jtos.2023.08.004_bib57","first-page":"21","article-title":"Rapamycin eyedrops increased CD4(+)Foxp3(+) cells and prevented goblet cell loss in the aged ocular surface","author":"Trujillo-Vargas","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2023.08.004_bib58","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/intimm\/7.4.517","article-title":"Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs","volume":"7","author":"Platzer","year":"1995","journal-title":"Int Immunol"},{"key":"10.1016\/j.jtos.2023.08.004_bib59","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4049\/jimmunol.157.1.12","article-title":"IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha","volume":"157","author":"Daftarian","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2023.08.004_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051035","article-title":"Low expression of IL-10 in circulating bregs and inverted IL-10\/TNF-\u03b1 ratio in tears of patients with perennial allergic conjunctivitis: a preliminary study","volume":"20","author":"Salazar","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2023.08.004_bib61","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1365-2222.2006.02499.x","article-title":"Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures","volume":"36","author":"Leonardi","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jtos.2023.08.004_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics13132184","article-title":"Tear cytokine levels in sicca syndrome-related dry eye: a meta-analysis","volume":"13","author":"Aljohani","year":"2023","journal-title":"Diagnostics"},{"key":"10.1016\/j.jtos.2023.08.004_bib63","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.4049\/jimmunol.0804324","article-title":"Secondary lymphoid organs: responding to genetic and environmental cues in ontogeny and the immune response","volume":"183","author":"Ruddle","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2023.08.004_bib64","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/ar2210","article-title":"B cells in Sj\u00f6gren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue","volume":"9","author":"Hansen","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jtos.2023.08.004_bib65","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.3390\/ijms19103117","article-title":"Dysregulated marginal zone B cell compartment in a mouse model of sj\u00f6gren's syndrome with ocular inflammation","volume":"19","author":"Singh","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2023.08.004_bib66","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13692","article-title":"B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reaction","volume":"21","author":"Lee","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.jtos.2023.08.004_bib67","first-page":"21","article-title":"Innate immunity and biological therapies for the treatment of sj\u00f6gren's syndrome","author":"Srivastava","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2023.08.004_bib68","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1167\/iovs.16-19159","article-title":"Rapamycin eye drops suppress lacrimal gland inflammation in a murine model of sjogren's syndrome","volume":"58","author":"Shah","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.08.004_bib69","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.4049\/jimmunol.1101442","article-title":"Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis","volume":"187","author":"Schaumburg","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2023.08.004_bib70","first-page":"249","article-title":"HL036 ophthalmic solution, a topical TNF-\u03b1 inhibitor, significantly improves signs and symptoms of dry eye in a phase 2 clinical trial (VELOS-1)","volume":"60","author":"Shin","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012423001088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012423001088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:46:27Z","timestamp":1761540387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012423001088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":70,"alternative-id":["S1542012423001088"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2023.08.004","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TNF is a critical cytokine in age-related dry eye disease","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2023.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}