{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:49:04Z","timestamp":1793659744322,"version":"4.5.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970769"],"award-info":[{"award-number":["81970769"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jtos.2023.12.002","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T18:25:09Z","timestamp":1702578309000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["A PEDF peptide mimetic effectively relieves dry eye in a diabetic murine model by restoring corneal nerve, barrier, and lacrimal gland function"],"prefix":"10.1016","volume":"32","author":[{"given":"Shuangping","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin James","family":"Barnstable","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozhen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Tombran-Tink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2023.12.002_bib1","series-title":"Diabetes res clin pract","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the international diabetes federation diabetes atlas","author":"Saeedi","year":"2019"},{"issue":"3","key":"10.1016\/j.jtos.2023.12.002_bib2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/jdi.12302","article-title":"Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: role of mitophagy","volume":"6","author":"Tang","year":"2015","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.jtos.2023.12.002_bib3","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/1497449","article-title":"Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment","volume":"2021","author":"Samsu","year":"2021","journal-title":"BioMed Res Int"},{"issue":"8","key":"10.1016\/j.jtos.2023.12.002_bib4","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/jdi.13480","article-title":"Update in the epidemiology, risk factors, screening, and treatment of diabetic retinopathy","volume":"12","author":"Lin","year":"2021","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.jtos.2023.12.002_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2147\/CIA.S190713","article-title":"Influence of diabetes mellitus on anterior segment of the eye","volume":"14","author":"Han","year":"2019","journal-title":"Clin Interv Aging"},{"issue":"4","key":"10.1016\/j.jtos.2023.12.002_bib6","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/ceo.12690","article-title":"Impact of diabetes mellitus on the ocular surface: a review","volume":"44","author":"Misra","year":"2016","journal-title":"Clin Exp Ophthalmol"},{"issue":"24","key":"10.1016\/j.jtos.2023.12.002_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21249478","article-title":"Toll-like receptor 7 is required for lacrimal gland autoimmunity and type 1 diabetes development in male nonobese diabetic mice","volume":"21","author":"Debreceni","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jtos.2023.12.002_bib8","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2023.12.002_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.visres.2017.03.002","article-title":"Diabetic complications in the cornea","volume":"139","author":"Ljubimov","year":"2017","journal-title":"Vis Res"},{"key":"10.1016\/j.jtos.2023.12.002_bib10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2415-8-10","article-title":"Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients","volume":"8","author":"Manaviat","year":"2008","journal-title":"BMC Ophthalmol"},{"issue":"14","key":"10.1016\/j.jtos.2023.12.002_bib11","doi-asserted-by":"crossref","first-page":"ORSF81","DOI":"10.1167\/iovs.13-12979","article-title":"Effects of diabetes on the eye","volume":"54","author":"Lutty","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"10.1016\/j.jtos.2023.12.002_bib12","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1007\/s10792-019-01110-y","article-title":"Diabetes mellitus is associated with dry eye syndrome: a meta-analysis","volume":"39","author":"Yoo","year":"2019","journal-title":"Int Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2023.12.002_bib13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jtos.2017.10.006","article-title":"The impact of diabetes on corneal nerve morphology and ocular surface integrity","volume":"16","author":"Markoulli","year":"2018","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2023.12.002_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/bs.pmbts.2015.04.001","article-title":"Overview of the cornea: structure, function, and development","volume":"134","author":"Eghrari","year":"2015","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"3","key":"10.1016\/j.jtos.2023.12.002_bib15","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jcrs.2010.12.037","article-title":"Anatomy and physiology of the cornea","volume":"37","author":"DelMonte","year":"2011","journal-title":"J Cataract Refract Surg"},{"issue":"7","key":"10.1016\/j.jtos.2023.12.002_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071398","article-title":"Dry eye management: targeting the ocular surface microenvironment","volume":"18","author":"Zhang","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2023.12.002_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2019.05.003","article-title":"Corneal nerves in health and disease","volume":"73","author":"Al-Aqaba","year":"2019","journal-title":"Prog Retin Eye Res"},{"issue":"5","key":"10.1016\/j.jtos.2023.12.002_bib18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0014-4835(03)00050-2","article-title":"Corneal nerves: structure, contents and function","volume":"76","author":"M\u00fcller","year":"2003","journal-title":"Exp Eye Res"},{"issue":"3","key":"10.1016\/j.jtos.2023.12.002_bib19","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1167\/iovs.13-12068","article-title":"Expression of cholecystokinin, gastrin, and their receptors in the mouse cornea","volume":"55","author":"Gonzalez-Coto","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.jtos.2023.12.002_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.disamonth.2021.101135","article-title":"Diabetic keratopathy","volume":"67","author":"Yeung","year":"2021","journal-title":"Dis Mon"},{"issue":"2","key":"10.1016\/j.jtos.2023.12.002_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S1542-0124(12)70070-8","article-title":"Mechanisms involved in injury and repair of the murine lacrimal gland: role of programmed cell death and mesenchymal stem cells","volume":"8","author":"Zoukhri","year":"2010","journal-title":"Ocul Surf"},{"issue":"4","key":"10.1016\/j.jtos.2023.12.002_bib22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.preteyeres.2004.04.003","article-title":"Changes in the tear film and ocular surface from dry eye syndrome","volume":"23","author":"Johnson","year":"2004","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"10.1016\/j.jtos.2023.12.002_bib23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00004397-198702710-00002","article-title":"Tear film physiology","volume":"27","author":"Holly","year":"1987","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.jtos.2023.12.002_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000131066","article-title":"The normal tear film","volume":"41","author":"Tiffany","year":"2008","journal-title":"Dev Ophthalmol"},{"issue":"5","key":"10.1016\/j.jtos.2023.12.002_bib25","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.ajpath.2020.01.007","article-title":"Identification of lacrimal gland postganglionic innervation and its regulation of tear secretion","volume":"190","author":"Jin","year":"2020","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.jtos.2023.12.002_bib26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.preteyeres.2009.04.003","article-title":"Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases","volume":"28","author":"Dartt","year":"2009","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"10.1016\/j.jtos.2023.12.002_bib27","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1152\/physiolgenomics.00011.2004","article-title":"Microarray analysis of the rat lacrimal gland following the loss of parasympathetic control of secretion","volume":"18","author":"Nguyen","year":"2004","journal-title":"Physiol Genom"},{"issue":"10","key":"10.1016\/j.jtos.2023.12.002_bib28","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.1167\/iovs.06-1486","article-title":"Evaluation of novel dry eye model: preganglionic parasympathetic denervation in rabbit","volume":"48","author":"Toshida","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.12.002_bib29","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cca.2017.10.032","article-title":"Extremely low level of serum pigment epithelium-derived factor is a special biomarker of Chinese osteogenesis imperfecta patients with SERPINF1 mutations","volume":"478","author":"Wang","year":"2018","journal-title":"Clin Chim Acta"},{"issue":"8","key":"10.1016\/j.jtos.2023.12.002_bib30","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrn1176","article-title":"PEDF: a multifaceted neurotrophic factor","volume":"4","author":"Tombran-Tink","year":"2003","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"10.1016\/j.jtos.2023.12.002_bib31","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.exer.2005.10.016","article-title":"Focus on molecules: pigment epithelium-derived factor (PEDF)","volume":"82","author":"Becerra","year":"2006","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2023.12.002_bib32","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jtos.2020.12.007","article-title":"Pigment epithelium-derived factor (PEDF) plays anti-inflammatory roles in the pathogenesis of dry eye disease","volume":"20","author":"Ma","year":"2021","journal-title":"Ocul Surf"},{"issue":"1\u20133","key":"10.1016\/j.jtos.2023.12.002_bib33","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.2741\/1686","article-title":"The neuroprotective and angiogenesis inhibitory serpin, PEDF: new insights into phylogeny, function, and signaling","volume":"10","author":"Tombran-Tink","year":"2005","journal-title":"Front Biosci"},{"issue":"6","key":"10.1016\/j.jtos.2023.12.002_bib34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S1471-4914(03)00074-1","article-title":"Therapeutic prospects for PEDF: more than a promising angiogenesis inhibitor","volume":"9","author":"Tombran-Tink","year":"2003","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jtos.2023.12.002_bib35","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.2119\/molmed.2012.00008","article-title":"Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice","volume":"18","author":"Liu","year":"2012","journal-title":"Mol Med"},{"key":"10.1016\/j.jtos.2023.12.002_bib36","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.canlet.2018.10.031","article-title":"Pigment epithelium-derived factor inhibits lung cancer migration and invasion by upregulating exosomal thrombospondin 1","volume":"442","author":"Huang","year":"2019","journal-title":"Cancer Lett"},{"issue":"11","key":"10.1016\/j.jtos.2023.12.002_bib37","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1042\/CS20130463","article-title":"PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases","volume":"128","author":"He","year":"2015","journal-title":"Clin Sci (Lond)"},{"issue":"7","key":"10.1016\/j.jtos.2023.12.002_bib38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/iovs.62.7.18","article-title":"PEDF gene deletion disrupts corneal innervation and ocular surface function","volume":"62","author":"Shang","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"10.1016\/j.jtos.2023.12.002_bib39","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.2337\/db14-0163","article-title":"Substance P promotes diabetic corneal epithelial wound healing through molecular mechanisms mediated via the neurokinin-1 receptor","volume":"63","author":"Yang","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jtos.2023.12.002_bib40","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.freeradbiomed.2021.02.036","article-title":"Hyperglycemia-induced severe mitochondrial bioenergetic deficit of lacrimal gland contributes to the early onset of dry eye in diabetic mice","volume":"166","author":"Qu","year":"2021","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.jtos.2023.12.002_bib41","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.2119\/molmed.2012.00008","article-title":"Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice","volume":"18","author":"Liu","year":"2012","journal-title":"Mol Med"},{"issue":"4","key":"10.1016\/j.jtos.2023.12.002_bib42","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.exer.2006.04.014","article-title":"A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres","volume":"83","author":"Li","year":"2006","journal-title":"Exp Eye Res"},{"issue":"3","key":"10.1016\/j.jtos.2023.12.002_bib43","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1080\/02713683.2020.1805770","article-title":"PEDF attenuates ocular surface damage in diabetic mice model through its antioxidant properties","volume":"46","author":"Liu","year":"2021","journal-title":"Curr Eye Res"},{"issue":"6","key":"10.1016\/j.jtos.2023.12.002_bib44","first-page":"532","article-title":"Reliability of the non-contact corneal aesthesiometer and its comparison with the Cochet-Bonnet aesthesiometer","volume":"18","author":"Murphy","year":"1998","journal-title":"Ophthalmic Physiol Opt"},{"issue":"3","key":"10.1016\/j.jtos.2023.12.002_bib45","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1167\/iovs.16-20926","article-title":"Subconjunctival bevacizumab injection impairs corneal innervations and epithelial wound healing in mice","volume":"58","author":"Dong","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"10.1016\/j.jtos.2023.12.002_bib46","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1167\/iovs.17-23397","article-title":"MyD88 deficiency protects against dry eye-induced damage","volume":"59","author":"Reins","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.jtos.2023.12.002_bib47","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/s41598-018-19578-6","article-title":"A new dry eye mouse model produced by exorbital and intraorbital lacrimal gland excision","volume":"8","author":"Shinomiya","year":"2018","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.jtos.2023.12.002_bib48","doi-asserted-by":"crossref","first-page":"BIO168","DOI":"10.1167\/iovs.17-21831","article-title":"Evaluating corneal fluorescein staining using a novel automated method","volume":"58","author":"Amparo","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"10.1016\/j.jtos.2023.12.002_bib49","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1167\/iovs.19-26631","article-title":"The effects of aging on corneal and ocular surface homeostasis in mice","volume":"60","author":"De Silva","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.12.002_bib50","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-1-4939-9086-3_12","article-title":"Isolation and propagation of lacrimal gland putative epithelial progenitor cells","volume":"1940","author":"Makarenkova","year":"2019","journal-title":"Methods Mol Biol"},{"issue":"10","key":"10.1016\/j.jtos.2023.12.002_bib51","doi-asserted-by":"crossref","first-page":"e210","DOI":"10.2337\/dc14-0860","article-title":"Dry eye syndrome in subjects with diabetes and association with neuropathy","volume":"37","author":"Achtsidis","year":"2014","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.jtos.2023.12.002_bib52","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international dry eye WorkShop (2007)","volume":"5","year":"2007","journal-title":"Ocul Surf"},{"issue":"11","key":"10.1016\/j.jtos.2023.12.002_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22116133","article-title":"Aged mice devoid of the M(3) muscarinic acetylcholine receptor develop mild dry eye disease","volume":"22","author":"Musayeva","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.jtos.2023.12.002_bib54","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S1471-4914(03)00074-1","article-title":"Therapeutic prospects for PEDF: more than a promising angiogenesis inhibitor","volume":"9","author":"Tombran-Tink","year":"2003","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jtos.2023.12.002_bib55","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/978-3-319-17121-0_93","article-title":"Pigment epithelium-derived factor, a protective factor for photoreceptors in vivo","volume":"854","author":"Polato","year":"2016","journal-title":"Adv Exp Med Biol"},{"issue":"7","key":"10.1016\/j.jtos.2023.12.002_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133777","article-title":"Delayed treatment with a small pigment epithelium derived factor (PEDF) peptide prevents the progression of diabetic renal injury","volume":"10","author":"Awad","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jtos.2023.12.002_bib57","doi-asserted-by":"crossref","first-page":"F891","DOI":"10.1152\/ajprenal.00149.2013","article-title":"Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury","volume":"305","author":"Awad","year":"2013","journal-title":"Am J Physiol Ren Physiol"},{"issue":"12","key":"10.1016\/j.jtos.2023.12.002_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9123956","article-title":"Diabetic corneal neuropathy","volume":"9","author":"Mansoor","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtos.2023.12.002_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100904","article-title":"Corneal endothelial dysfunction: evolving understanding and treatment options","volume":"82","author":"Price","year":"2021","journal-title":"Prog Retin Eye Res"},{"issue":"6","key":"10.1016\/j.jtos.2023.12.002_bib60","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1167\/iovs.11-7210","article-title":"Cholinergic agonists activate P2X7 receptors to stimulate protein secretion by the rat lacrimal gland","volume":"52","author":"Dartt","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"10.1016\/j.jtos.2023.12.002_bib61","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/j.ajpath.2020.09.002","article-title":"High-fat diet-induced functional and pathologic changes in lacrimal gland","volume":"190","author":"He","year":"2020","journal-title":"Am J Pathol"},{"issue":"10","key":"10.1016\/j.jtos.2023.12.002_bib62","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1167\/iovs.08-1830","article-title":"Roles of caspase 1 and extracellular signal-regulated kinase in inflammation-induced inhibition of lacrimal gland protein secretion","volume":"49","author":"Zoukhri","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"10.1016\/j.jtos.2023.12.002_bib63","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3109\/10799893.2015.1030412","article-title":"Signaling pathway of MAPK\/ERK in cell proliferation, differentiation, migration, senescence and apoptosis","volume":"35","author":"Sun","year":"2015","journal-title":"J Recept Signal Transduct Res"},{"issue":"8","key":"10.1016\/j.jtos.2023.12.002_bib64","first-page":"9001","article-title":"Human-specific CHRFAM7A protects against radiotherapy-induced lacrimal gland injury by inhibiting the p38\/JNK signalling pathway and oxidative stress","volume":"10","author":"Zhang","year":"2017","journal-title":"Int J Clin Exp Pathol"},{"issue":"2","key":"10.1016\/j.jtos.2023.12.002_bib65","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3109\/02713680903453494","article-title":"The therapeutic effect of DA-6034 on ocular inflammation via suppression of MMP-9 and inflammatory cytokines and activation of the MAPK signaling pathway in an experimental dry eye model","volume":"35","author":"Seo","year":"2010","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2023.12.002_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.109171","article-title":"Deletion of the Pedf gene leads to inflammation, photoreceptor loss and vascular disturbances in the retina","volume":"222","author":"Chen","year":"2022","journal-title":"Exp Eye Res"},{"issue":"8","key":"10.1016\/j.jtos.2023.12.002_bib67","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s00417-019-04394-z","article-title":"Type I pig collagen enhances the efficacy of PEDF 34-mer peptide in a mouse model of laser-induced choroidal neovascularization","volume":"257","author":"Kim","year":"2019","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2023.12.002_bib68","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1159\/000492990","article-title":"Pigment epithelium-derived factor and its phosphomimetic mutant induce JNK-dependent apoptosis and P38-mediated migration arrest","volume":"49","author":"Konson","year":"2018","journal-title":"Cell Physiol Biochem : international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"issue":"4","key":"10.1016\/j.jtos.2023.12.002_bib69","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.bbrc.2006.07.188","article-title":"PEDF induces apoptosis in human endothelial cells by activating p38 MAP kinase dependent cleavage of multiple caspases","volume":"348","author":"Chen","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.jtos.2023.12.002_bib70","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2165\/00003088-199529020-00006","article-title":"Clinical pharmacokinetics of various topical ophthalmic delivery systems","volume":"29","author":"Frangie","year":"1995","journal-title":"Clin Pharmacokinet"},{"issue":"9","key":"10.1016\/j.jtos.2023.12.002_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27092926","article-title":"Effect of aucubin-containing eye drops on tear hyposecretion and lacrimal gland damage induced by urban particulate matter in rats","volume":"27","author":"Park","year":"2022","journal-title":"Molecules"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012423001544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012423001544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:49:58Z","timestamp":1761540598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012423001544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":71,"alternative-id":["S1542012423001544"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2023.12.002","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A PEDF peptide mimetic effectively relieves dry eye in a diabetic murine model by restoring corneal nerve, barrier, and lacrimal gland function","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2023.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}