{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:40:05Z","timestamp":1792640405932,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21904098"],"award-info":[{"award-number":["21904098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LGD22H120002"],"award-info":[{"award-number":["LGD22H120002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY22H120002"],"award-info":[{"award-number":["LY22H120002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jtos.2023.12.005","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T23:48:56Z","timestamp":1702943336000},"page":"21-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Metabolic signatures of tear extracellular vesicles caused by herpes simplex keratitis"],"prefix":"10.1016","volume":"31","author":[{"given":"Huixiang","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tucan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9884-0312","authenticated-orcid":false,"given":"Liang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2023.12.005_bib1","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1038\/s41433-020-01153-x","article-title":"Update on Herpes simplex keratitis management","volume":"34","author":"Sibley","year":"2020","journal-title":"Eye"},{"key":"10.1016\/j.jtos.2023.12.005_bib2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41587-020-00781-8","article-title":"Targeting herpes simplex virus with CRISPR\u2013Cas9 cures herpetic stromal keratitis in mice","volume":"39","author":"Yin","year":"2021","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jtos.2023.12.005_bib3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.preteyeres.2006.05.001","article-title":"Herpes simplex keratitis","volume":"25","author":"Kaye","year":"2006","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2023.12.005_bib4","doi-asserted-by":"crossref","first-page":"25487","DOI":"10.1021\/acsami.5b08644","article-title":"Surface-engineered contact lens as an advanced theranostic platform for modulation and detection of viral infection","volume":"7","author":"Mak","year":"2015","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.jtos.2023.12.005_bib5","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.immuni.2020.10.013","article-title":"Production of the cytokine VEGF-A by CD4(+) T and myeloid cells disrupts the corneal nerve landscape and promotes herpes stromal keratitis","volume":"53","author":"Yun","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jtos.2023.12.005_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009950","article-title":"Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis","volume":"17","author":"Sharma","year":"2021","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jtos.2023.12.005_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01850-18","article-title":"Biogenesis of extracellular vesicles during herpes simplex virus 1 infection: role of the CD63 tetraspanin","volume":"93","author":"Dogrammatzis","year":"2019","journal-title":"J Virol"},{"key":"10.1016\/j.jtos.2023.12.005_bib8","first-page":"95","article-title":"Diverse populations of extracellular vesicles with opposite functions during herpes simplex virus 1 infection","author":"Dogrammatzis","year":"2021","journal-title":"J Virol"},{"key":"10.1016\/j.jtos.2023.12.005_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12915-019-0678-9","article-title":"Viral hijacking of cellular metabolism","volume":"17","author":"Thaker","year":"2019","journal-title":"BMC Biol"},{"key":"10.1016\/j.jtos.2023.12.005_bib10","first-page":"97","article-title":"The lacrimal gland and its veil of tears","volume":"13","author":"Walcott","year":"1998","journal-title":"News Physiol Sci"},{"key":"10.1016\/j.jtos.2023.12.005_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109409","article-title":"Human tear metabolites associated with nucleoside-signalling pathways in bacterial keratitis","volume":"228","author":"Shrestha","year":"2023","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2023.12.005_bib12","article-title":"Metabolomic alterations in the tear fluids of patients with superior limbic keratoconjunctivitis","volume":"8","author":"Zong","year":"2021","journal-title":"Front Med"},{"key":"10.1016\/j.jtos.2023.12.005_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.123932","article-title":"Validation of metabolomic and lipidomic analyses of human tears using ultra-high-performance liquid chromatography tandem mass spectrometry","volume":"253","author":"Catanese","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.jtos.2023.12.005_bib14","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1021\/pr2004874","article-title":"Characterization of the human tear metabolome by LC-MS\/MS","volume":"10","author":"Chen","year":"2011","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jtos.2023.12.005_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtct.2020.12.018","article-title":"Tear lipid metabolites as potential diagnostic biomarkers for ocular chronic graft-versus-host disease","volume":"27","author":"Ma","year":"2021","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.jtos.2023.12.005_bib16","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.survophthal.2020.09.008","article-title":"A systematic review on advances in diagnostics for herpes simplex keratitis","volume":"66","author":"Poon","year":"2021","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jtos.2023.12.005_bib17","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1021\/acs.jproteome.0c00138","article-title":"Detection of tear components using matrix-assisted laser desorption ionization\/time-of-flight mass spectrometry for rapid dry eye diagnosis","volume":"19","author":"Zhang","year":"2020","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jtos.2023.12.005_bib18","doi-asserted-by":"crossref","first-page":"11720","DOI":"10.1021\/acsnano.2c02531","article-title":"Discovering the secret of diseases by incorporated tear exosomes analysis via rapid-isolation system: iTEARS","volume":"16","author":"Hu","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jtos.2023.12.005_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg1137","article-title":"Interaction network of extracellular vesicles building universal analysis via eye tears: iNEBULA","volume":"9","author":"Hu","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.jtos.2023.12.005_bib20","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02194-22","article-title":"Postinfection metabolic reprogramming of the murine trigeminal ganglion limits herpes simplex virus-1 replication","volume":"13","author":"Patil","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.jtos.2023.12.005_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1167717","article-title":"Emerging diversity in extracellular vesicles and their roles in cancer","volume":"13","author":"Sohal","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.jtos.2023.12.005_bib22","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/ceo.13319","article-title":"Clinical translation of recommendations from randomized trials for management of herpes simplex virus keratitis","volume":"46","author":"Cabrera-Aguas","year":"2018","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.jtos.2023.12.005_bib23","doi-asserted-by":"crossref","first-page":"14099","DOI":"10.1021\/acs.analchem.1c05378","article-title":"Highly selective purification of plasma extracellular vesicles using titanium dioxide microparticles for depicting the metabolic signatures of diabetic retinopathy","volume":"94","author":"Pan","year":"2022","journal-title":"Anal Chem"},{"key":"10.1016\/j.jtos.2023.12.005_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.10","article-title":"MetOrigin: discriminating the origins of microbial metabolites for integrative analysis of the gut microbiome and metabolome","volume":"1","author":"Yu","year":"2022","journal-title":"iMeta"},{"key":"10.1016\/j.jtos.2023.12.005_bib25","doi-asserted-by":"crossref","first-page":"W71","DOI":"10.1093\/nar\/gkq329","article-title":"MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data","volume":"38","author":"Xia","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jtos.2023.12.005_bib26","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.21873\/anticanres.14290","article-title":"Oncogenic miRNAs identified in tear exosomes from metastatic breast cancer patients","volume":"40","author":"Inubushi","year":"2020","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jtos.2023.12.005_bib27","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.tim.2012.08.005","article-title":"A cultured affair: HSV latency and reactivation in neurons","volume":"20","author":"Wilson","year":"2012","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.jtos.2023.12.005_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010536","article-title":"Fashionably late: temporal regulation of HSV-1 late gene transcription","volume":"18","author":"Heath","year":"2022","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jtos.2023.12.005_bib29","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1080\/21505594.2021.1982373","article-title":"Pathogenesis and virulence of herpes simplex virus","volume":"12","author":"Zhu","year":"2021","journal-title":"Virulence"},{"key":"10.1016\/j.jtos.2023.12.005_bib30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jtos.2018.10.002","article-title":"Pathogenesis of herpes simplex keratitis: the host cell response and ocular surface sequelae to infection and inflammation","volume":"17","author":"Lobo","year":"2019","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2023.12.005_bib31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1086\/599329","article-title":"Prevalence and clinical consequences of herpes simplex virus type 1 DNA in human cornea tissues","volume":"200","author":"Remeijer","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jtos.2023.12.005_bib32","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.tim.2020.03.003","article-title":"Herpes simplex virus-1 in the brain: the dark side of a sneaky infection","volume":"28","author":"Marcocci","year":"2020","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.jtos.2023.12.005_bib33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.addr.2020.03.002","article-title":"An emerging focus on lipids in extracellular vesicles","volume":"159","author":"Skotland","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jtos.2023.12.005_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.636175","article-title":"Roles of gut microbial metabolites in diabetic kidney disease","volume":"12","author":"Fang","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jtos.2023.12.005_bib35","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1136\/gutjnl-2020-323314","article-title":"Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health","volume":"70","author":"Brial","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jtos.2023.12.005_bib36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41392-020-00311-7","article-title":"NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.jtos.2023.12.005_bib37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/jat\/27.1.43","article-title":"An improved HPLC analysis of the metabolite furoic acid in the urine of workers occupationally exposed to furfural","volume":"27","author":"Tan","year":"2003","journal-title":"J Anal Toxicol"},{"key":"10.1016\/j.jtos.2023.12.005_bib38","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s00253-011-3632-5","article-title":"Microbial degradation of furanic compounds: biochemistry, genetics, and impact","volume":"92","author":"Wierckx","year":"2011","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.jtos.2023.12.005_bib39","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1167\/iovs.10-6939","article-title":"Diversity of bacteria at healthy human conjunctiva","volume":"52","author":"Dong","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2023.12.005_bib40","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1097\/HJH.0000000000000134","article-title":"Antihypertensive drugs methyldopa, labetalol, hydralazine, and clonidine improve trophoblast interaction with endothelial cellular networks in vitro","volume":"32","author":"Xu","year":"2014","journal-title":"J Hypertens"},{"key":"10.1016\/j.jtos.2023.12.005_bib41","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fnins.2020.00308","article-title":"Metabolomic profiling revealed potential biomarkers in patients with moyamoya disease","volume":"14","author":"Geng","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jtos.2023.12.005_bib42","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.virol.2015.02.038","article-title":"Viral activation of cellular metabolism","volume":"479\u2013480","author":"Sanchez","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.jtos.2023.12.005_bib43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.preteyeres.2014.03.001","article-title":"Taurine: the comeback of a nutraceutical in the prevention of retinal degenerations","volume":"41","author":"Froger","year":"2014","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2023.12.005_bib44","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.cmet.2022.06.008","article-title":"Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8(+) T cells","volume":"34","author":"Elia","year":"2022","journal-title":"Cell Metabol"},{"key":"10.1016\/j.jtos.2023.12.005_bib45","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41590-019-0372-7","article-title":"SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity","volume":"20","author":"Keiran","year":"2019","journal-title":"Nat Immunol"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012423001568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012423001568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:49:05Z","timestamp":1761540545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012423001568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":45,"alternative-id":["S1542012423001568"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2023.12.005","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic signatures of tear extracellular vesicles caused by herpes simplex keratitis","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2023.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}