{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:50:24Z","timestamp":1790211024940,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jtos.2024.09.008","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T06:33:37Z","timestamp":1727418817000},"page":"430-440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["BMAL1 deficiency provokes dry mouth and eyes by down-regulating ITPR2\/3"],"prefix":"10.1016","volume":"34","author":[{"given":"Xiaozhao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingming","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2649-8241","authenticated-orcid":false,"given":"Ying","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2024.09.008_bib1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.preteyeres.2018.02.001","article-title":"Basal Tear Osmolarity as a metric to estimate body hydration and dry eye severity","volume":"64","author":"Willshire","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2024.09.008_bib2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s12016-014-8431-1","article-title":"The differential diagnosis of dry eyes, dry mouth, and parotidomegaly: a comprehensive review","volume":"49","author":"Cornec","year":"2015","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jtos.2024.09.008_bib3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1752-7325.2006.tb02572.x","article-title":"Prevalence of xerostomia in population-based samples: a systematic review","volume":"66","author":"Orellana","year":"2006","journal-title":"J Publ Health Dent"},{"key":"10.1016\/j.jtos.2024.09.008_bib4","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0161-6420(03)00262-8","article-title":"Prevalence of dry eye among an elderly Chinese population in Taiwan: the Shihpai Eye Study","volume":"110","author":"Lin","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2024.09.008_bib5","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s12016-014-8438-7","article-title":"Current approach to dry eye disease","volume":"49","author":"Valim","year":"2015","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jtos.2024.09.008_bib6","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s11882-004-0077-2","article-title":"Dry eye: diagnosis and current treatment strategies","volume":"4","author":"O'Brien","year":"2004","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jtos.2024.09.008_bib7","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00784-021-04120-2","article-title":"The association between oral dryness and use of dry-mouth interventions in Sj\u00f6gren's syndrome patients","volume":"26","author":"Assy","year":"2022","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.jtos.2024.09.008_bib8","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature09253","article-title":"Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes","volume":"466","author":"Marcheva","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jtos.2024.09.008_bib9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fendo.2020.00349","article-title":"High-fat diet alters circadian rhythms in mammary glands of pubertal mice","volume":"11","author":"Sundaram","year":"2020","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jtos.2024.09.008_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41580-019-0179-2","article-title":"Molecular mechanisms and physiological importance of circadian rhythms","volume":"21","author":"Patke","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jtos.2024.09.008_bib11","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1101\/gad.249417.114","article-title":"Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock","volume":"28","author":"Ye","year":"2014","journal-title":"Genes Dev"},{"key":"10.1016\/j.jtos.2024.09.008_bib12","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1113\/jphysiol.1972.sp009721","article-title":"Circadian rhythms in human salivary flow rate and composition","volume":"220","author":"Dawes","year":"1972","journal-title":"J Physiol"},{"issue":"Pt 5","key":"10.1016\/j.jtos.2024.09.008_bib13","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/eye.1987.95","article-title":"Fluorophotometric measurements of tear turnover rate in normal healthy persons: evidence for a circadian rhythm","volume":"1","author":"Webber","year":"1987","journal-title":"Eye"},{"key":"10.1016\/j.jtos.2024.09.008_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0248199","article-title":"Core circadian clock transcription factor BMAL1 regulates mammary epithelial cell growth, differentiation, and milk component synthesis","volume":"16","author":"Casey","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.jtos.2024.09.008_bib15","doi-asserted-by":"crossref","DOI":"10.1242\/dev.157966","article-title":"PER2 regulation of mammary gland development","volume":"145","author":"McQueen","year":"2018","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.jtos.2024.09.008_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12470","article-title":"BMAL1 deficiency promotes skeletal mandibular hypoplasia via OPG downregulation","volume":"51","author":"Zhou","year":"2018","journal-title":"Cell Prolif"},{"key":"10.1016\/j.jtos.2024.09.008_bib17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.stemcr.2017.11.017","article-title":"BMAL1 deficiency contributes to mandibular dysplasia by upregulating MMP3","volume":"10","author":"Zhao","year":"2018","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.jtos.2024.09.008_bib18","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41418-021-00919-4","article-title":"Circadian rhythm modulates endochondral bone formation via MTR1\/AMPKbeta1\/BMAL1 signaling axis","volume":"29","author":"Yu","year":"2022","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jtos.2024.09.008_bib19","first-page":"96","article-title":"Improvement of corneal barrier function by the P2Y(2) agonist INS365 in a rat dry eye model","volume":"42","author":"Fujihara","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2024.09.008_bib20","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1097\/ICO.0000000000002410","article-title":"Effect of topical anesthesia on the secretory activity of the main lacrimal gland","volume":"39","author":"Singh","year":"2020","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2024.09.008_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115073","article-title":"Melatonin regulates the immune response and improves Sj\u00f6gren's syndrome-like symptoms in NOD\/Ltj Mice","volume":"201","author":"Liu","year":"2022","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jtos.2024.09.008_bib22","doi-asserted-by":"crossref","first-page":"A305","DOI":"10.1016\/j.autrev.2009.11.004","article-title":"The geoepidemiology of Sj\u00f6gren's syndrome","volume":"9","author":"Mavragani","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jtos.2024.09.008_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj8892","article-title":"Synthetic gene circuits for preventing disruption of the circadian clock due to interleukin-1-induced inflammation","volume":"8","author":"Pferdehirt","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.jtos.2024.09.008_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2021.102611","article-title":"Short-chain fatty acid butyrate induces IL-10-producing B cells by regulating circadian-clock-related genes to ameliorate Sj\u00f6gren's syndrome","volume":"119","author":"Kim","year":"2021","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jtos.2024.09.008_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099205","article-title":"Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye","volume":"9","author":"Inaba","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jtos.2024.09.008_bib26","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1161\/CIRCULATIONAHA.113.002764","article-title":"Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes","volume":"128","author":"Signore","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jtos.2024.09.008_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/0022034513505768","article-title":"The circadian clock in oral health and diseases","volume":"93","author":"Papagerakis","year":"2014","journal-title":"Journal of dental research"},{"key":"10.1016\/j.jtos.2024.09.008_bib28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41556-019-0441-z","article-title":"Circadian control of the secretory pathway maintains collagen homeostasis","volume":"22","author":"Chang","year":"2020","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jtos.2024.09.008_bib29","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1038\/s41418-023-01152-x","article-title":"Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation","volume":"30","author":"Chen","year":"2023","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jtos.2024.09.008_bib30","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1172\/JCI70720","article-title":"Abolished InsP3R2 function inhibits sweat secretion in both humans and mice","volume":"124","author":"Klar","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jtos.2024.09.008_bib31","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.immuni.2016.12.011","article-title":"Lymphocyte circadian clocks control lymph node trafficking and adaptive immune responses","volume":"46","author":"Druzd","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.jtos.2024.09.008_bib32","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrrheum.2015.31","article-title":"Clocking in: chronobiology in rheumatoid arthritis","volume":"11","author":"Buttgereit","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jtos.2024.09.008_bib33","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hed.20419","article-title":"Optimal nocturnal humidification for xerostomia","volume":"28","author":"Hay","year":"2006","journal-title":"Head Neck"},{"key":"10.1016\/j.jtos.2024.09.008_bib34","doi-asserted-by":"crossref","first-page":"e451","DOI":"10.1038\/emm.2017.285","article-title":"Sleep deprivation disrupts the lacrimal system and induces dry eye disease","volume":"50","author":"Li","year":"2018","journal-title":"Exp Mol Med"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012424001046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012424001046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T06:04:22Z","timestamp":1733465062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012424001046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":34,"alternative-id":["S1542012424001046"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2024.09.008","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BMAL1 deficiency provokes dry mouth and eyes by down-regulating ITPR2\/3","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2024.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}