{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:33:46Z","timestamp":1790627626126,"version":"4.1.0"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H03245"],"award-info":[{"award-number":["22H03245"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jtos.2024.11.001","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T14:15:37Z","timestamp":1731507337000},"page":"523-534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Adipose-derived mesenchymal stromal cells: A study on safety and efficacy in ocular inflammation"],"prefix":"10.1016","volume":"34","author":[{"given":"Robert M.","family":"Rusch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Sakakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Nonaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinri","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirayama","family":"Masatoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuno","family":"Negishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Okano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0992-4862","authenticated-orcid":false,"given":"Shigeto","family":"Shimmura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jtos.2024.11.001_bib1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s12015-011-9229-7","article-title":"The origins of mesenchymal stromal cell heterogeneity","volume":"7","author":"Pevsner-Fischer","year":"2011","journal-title":"Stem Cell Reviews and Reports"},{"issue":"4","key":"10.1016\/j.jtos.2024.11.001_bib2","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.4049\/jimmunol.180.4.2581","article-title":"Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type","volume":"180","author":"Sasaki","year":"2008","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/hc0102.101442","article-title":"Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart","volume":"105","author":"Toma","year":"2002","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.jtos.2024.11.001_bib4","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1182\/blood-2007-02-069716","article-title":"Immunomodulatory properties of mesenchymal stromal cells","volume":"110","author":"Nauta","year":"2007","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jtos.2024.11.001_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00281-011-0267-7","article-title":"The immunomodulatory properties of mesenchymal stem cells","volume":"33","author":"Marigo","year":"2011","journal-title":"Semin Immunopathol"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib6","doi-asserted-by":"crossref","first-page":"e2062","DOI":"10.1038\/cddis.2015.327","article-title":"Mesenchymal stem cells and immunomodulation: current status and future prospects","volume":"7","author":"Gao","year":"2016","journal-title":"Cell Death Dis"},{"issue":"9","key":"10.1016\/j.jtos.2024.11.001_bib7","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1161\/STROKEAHA.115.009854","article-title":"Intravenous bone marrow stem cell grafts preferentially migrate to spleen and abrogate chronic inflammation in stroke","volume":"46","author":"Acosta","year":"2015","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.jtos.2024.11.001_bib8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.imlet.2015.08.007","article-title":"Mesenchymal stem cells for the treatment of neurological diseases: immunoregulation beyond neuroprotection","volume":"168","author":"Laroni","year":"2015","journal-title":"Immunol Lett"},{"issue":"10","key":"10.1016\/j.jtos.2024.11.001_bib9","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.2174\/1389450117666160307143226","article-title":"Tumor stroma manipulation by MSC","volume":"17","author":"Grisendi","year":"2016","journal-title":"Curr Drug Targets"},{"issue":"5","key":"10.1016\/j.jtos.2024.11.001_bib10","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3892\/ijmm.2016.2536","article-title":"Myogenic differentiation potential of human tonsil-derived mesenchymal stem cells and their potential for use to promote skeletal muscle regeneration","volume":"37","author":"Park","year":"2016","journal-title":"Int J Mol Med"},{"issue":"10","key":"10.1016\/j.jtos.2024.11.001_bib11","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1002\/stem.187","article-title":"Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging","volume":"27","author":"Kidd","year":"2009","journal-title":"Stem Cell"},{"issue":"11","key":"10.1016\/j.jtos.2024.11.001_bib12","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1634\/stemcells.2007-0637","article-title":"Concise review: mesenchymal stem\/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views","volume":"25","author":"Phinney","year":"2007","journal-title":"Stem Cell"},{"key":"10.1016\/j.jtos.2024.11.001_bib13","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1038\/emm.2013.94","article-title":"Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine","volume":"45","author":"Murphy","year":"2013","journal-title":"Exp Mol Med"},{"issue":"2","key":"10.1016\/j.jtos.2024.11.001_bib14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/BF02256058","article-title":"Characterization and functionality of cell surface molecules on human mesenchymal stem cells","volume":"10","author":"Majumdar","year":"2003","journal-title":"J Biomed Sci"},{"issue":"12","key":"10.1016\/j.jtos.2024.11.001_bib15","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.1182\/blood-2006-05-025098","article-title":"Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells","volume":"108","author":"Ruster","year":"2006","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.jtos.2024.11.001_bib16","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jtos.2024.11.001_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/scrt544","article-title":"The cerebral embolism evoked by intra-arterial delivery of allogeneic bone marrow mesenchymal stem cells in rats is related to cell dose and infusion velocity","volume":"6","author":"Cui","year":"2015","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"10.1016\/j.jtos.2024.11.001_bib18","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.stem.2009.02.001","article-title":"Mesenchymal stem cell homing: the devil is in the details","volume":"4","author":"Karp","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jtos.2024.11.001_bib19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.isci.2019.05.004","article-title":"Mesenchymal stromal cell homing: mechanisms and strategies for improvement","volume":"15","author":"Ullah","year":"2019","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib20","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s13287-018-1076-x","article-title":"Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration","volume":"9","author":"Scarfe","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jtos.2024.11.001_bib21","first-page":"19","article-title":"Fate of intravenously injected mesenchymal stem cells and significance for clinical application","volume":"130","author":"Wagner","year":"2013","journal-title":"Adv Biochem Eng Biotechnol"},{"issue":"10","key":"10.1016\/j.jtos.2024.11.001_bib22","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1161\/CIRCULATIONAHA.105.537480","article-title":"Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction","volume":"112","author":"Kraitchman","year":"2005","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.jtos.2024.11.001_bib23","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/stem.2614","article-title":"Concise review: MSC adhesion cascade-insights into homing and transendothelial migration","volume":"35","author":"Nitzsche","year":"2017","journal-title":"Stem Cell"},{"issue":"4","key":"10.1016\/j.jtos.2024.11.001_bib24","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1159\/000143110","article-title":"Homing of mesenchymal stem cells","volume":"35","author":"Henschler","year":"2008","journal-title":"Transfus Med Hemother"},{"issue":"10","key":"10.1016\/j.jtos.2024.11.001_bib25","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/gt.2008.39","article-title":"Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells","volume":"15","author":"Spaeth","year":"2008","journal-title":"Gene Ther"},{"issue":"3","key":"10.1016\/j.jtos.2024.11.001_bib26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1167\/tvst.9.3.26","article-title":"Reproducible derivation and expansion of corneal mesenchymal stromal cells for therapeutic applications","volume":"9","author":"Jabbehdari","year":"2020","journal-title":"Transl Vis Sci Technol"},{"issue":"2","key":"10.1016\/j.jtos.2024.11.001_bib27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1167\/iovs.04-1154","article-title":"Characterization and distribution of bone marrow-derived cells in mouse cornea","volume":"46","author":"Nakamura","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2024.11.001_bib28","first-page":"99","article-title":"Differentiation of rabbit bone marrow mesenchymal stem cells into corneal epithelial cells in vivo and ex vivo","volume":"15","author":"Gu","year":"2009","journal-title":"Mol Vis"},{"issue":"3","key":"10.1016\/j.jtos.2024.11.001_bib29","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/art.1780360304","article-title":"Use of a chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis","volume":"36","author":"Moreland","year":"1993","journal-title":"Arthritis Rheum"},{"issue":"8","key":"10.1016\/j.jtos.2024.11.001_bib30","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/art.1780380812","article-title":"A randomized, double-blind, placebo-controlled study of CD4 monoclonal antibody therapy in early rheumatoid arthritis","volume":"38","author":"van der Lubbe","year":"1995","journal-title":"Arthritis Rheum"},{"issue":"9894","key":"10.1016\/j.jtos.2024.11.001_bib31","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0140-6736(13)60954-X","article-title":"Immunopathogenic mechanisms of systemic autoimmune disease","volume":"382","author":"Wahren-Herlenius","year":"2013","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.jtos.2024.11.001_bib32","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1182\/blood-2002-07-2104","article-title":"Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide","volume":"101","author":"Krampera","year":"2003","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib33","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4049\/jimmunol.0902007","article-title":"Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype","volume":"185","author":"Ghannam","year":"2010","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.jtos.2024.11.001_bib34","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1634\/stemcells.2008-0687","article-title":"Reciprocal interactions between human mesenchymal stem cells and gammadelta T cells or invariant natural killer T cells","volume":"27","author":"Prigione","year":"2009","journal-title":"Stem Cell"},{"issue":"7","key":"10.1016\/j.jtos.2024.11.001_bib35","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1182\/blood-2004-09-3696","article-title":"Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells","volume":"105","author":"Glennie","year":"2005","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jtos.2024.11.001_bib36","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1634\/stemcells.2005-0008","article-title":"Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells","volume":"24","author":"Krampera","year":"2006","journal-title":"Stem Cell"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib37","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1182\/blood-2005-07-2657","article-title":"Human mesenchymal stem cells modulate B-cell functions","volume":"107","author":"Corcione","year":"2006","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.jtos.2024.11.001_bib38","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1182\/blood-2005-07-2775","article-title":"Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation","volume":"107","author":"Spaggiari","year":"2006","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib39","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/01.tp.0000244572.24780.54","article-title":"Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle","volume":"83","author":"Ramasamy","year":"2007","journal-title":"Transplantation"},{"issue":"5","key":"10.1016\/j.jtos.2024.11.001_bib40","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1634\/stemcells.2007-0878","article-title":"Immunogenicity of human mesenchymal stem cells in HLA-class I-restricted T-cell responses against viral or tumor-associated antigens","volume":"26","author":"Morandi","year":"2008","journal-title":"Stem Cell"},{"issue":"9624","key":"10.1016\/j.jtos.2024.11.001_bib41","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0140-6736(08)60690-X","article-title":"Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study","volume":"371","author":"Le Blanc","year":"2008","journal-title":"Lancet"},{"issue":"9419","key":"10.1016\/j.jtos.2024.11.001_bib42","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0140-6736(04)16104-7","article-title":"Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells","volume":"363","author":"Le Blanc","year":"2004","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bcmd.2007.06.021","article-title":"Application of multipotent mesenchymal stromal cells in pediatric patients following allogeneic stem cell transplantation","volume":"40","author":"Muller","year":"2008","journal-title":"Blood Cells Mol Dis"},{"issue":"9","key":"10.1016\/j.jtos.2024.11.001_bib44","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.bbmt.2010.03.017","article-title":"Platelet-lysate-expanded mesenchymal stromal cells as a salvage therapy for severe resistant graft-versus-host disease in a pediatric population","volume":"16","author":"Lucchini","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"issue":"30","key":"10.1016\/j.jtos.2024.11.001_bib45","doi-asserted-by":"crossref","first-page":"eaba6884","DOI":"10.1126\/sciadv.aba6884","article-title":"Shattering barriers toward clinically meaningful MSC therapies","volume":"6","author":"Levy","year":"2020","journal-title":"Sci Adv"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib46","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13287-022-02751-0","article-title":"Current status of clinical trials assessing mesenchymal stem cell therapy for graft versus host disease: a systematic review","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000496809","article-title":"Clinical use of mesenchymal stromal cells in the treatment of acute graft-versus-host disease","volume":"46","author":"Elgaz","year":"2019","journal-title":"Transfus Med Hemother"},{"issue":"3","key":"10.1016\/j.jtos.2024.11.001_bib48","first-page":"225","article-title":"Treatment of severe steroid resistant acute GVHD with mesenchymal stromal cells (MSC)","volume":"3","author":"Resnick","year":"2013","journal-title":"Am J Blood Res"},{"issue":"16","key":"10.1016\/j.jtos.2024.11.001_bib49","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1200\/JCO.2010.33.7212","article-title":"Long-term survival and late deaths after allogeneic hematopoietic cell transplantation","volume":"29","author":"Wingard","year":"2011","journal-title":"J Clin Oncol"},{"issue":"10","key":"10.1016\/j.jtos.2024.11.001_bib50","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1136\/bjo.83.10.1125","article-title":"Dry eye after haematopoietic stem cell transplantation","volume":"83","author":"Ogawa","year":"1999","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003495-200363010-00001","article-title":"Intestinal graft-versus-host disease: mechanisms and management","volume":"63","author":"Takatsuka","year":"2003","journal-title":"Drugs"},{"issue":"11","key":"10.1016\/j.jtos.2024.11.001_bib52","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/bmt.2012.53","article-title":"Hepatic GVHD leading to cirrhosis after allogeneic hematopoietic SCT","volume":"47","author":"Xhaard","year":"2012","journal-title":"Bone Marrow Transplant"},{"issue":"15","key":"10.1016\/j.jtos.2024.11.001_bib53","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1182\/blood-2011-03-344390","article-title":"Global and organ-specific chronic graft-versus-host disease severity according to the 2005 NIH Consensus Criteria","volume":"118","author":"Arai","year":"2011","journal-title":"Blood"},{"issue":"4 Suppl","key":"10.1016\/j.jtos.2024.11.001_bib54","first-page":"S177","article-title":"Ocular graft vs. host disease","volume":"3","author":"Kim","year":"2005","journal-title":"Ocul Surf"},{"issue":"5","key":"10.1016\/j.jtos.2024.11.001_bib55","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.4103\/ijo.IJO_2016_20","article-title":"Update on ocular graft-versus-host disease","volume":"69","author":"Nair","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.jtos.2024.11.001_bib56","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.09394","article-title":"MHC-compatible bone marrow stromal\/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model","volume":"5","author":"Ogawa","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.jtos.2024.11.001_bib57","first-page":"598","article-title":"Four cases of corneal perforation in patients with chronic graft-versus-host disease","volume":"17","author":"Inagaki","year":"2011","journal-title":"Mol Vis"},{"issue":"11","key":"10.1016\/j.jtos.2024.11.001_bib58","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3109\/02713683.2010.516466","article-title":"Mesenchymal stem cells and potential applications in treating ocular disease","volume":"35","author":"Joe","year":"2010","journal-title":"Curr Eye Res"},{"issue":"2","key":"10.1016\/j.jtos.2024.11.001_bib59","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jtos.2019.01.006","article-title":"The therapeutic application of mesenchymal stem cells at the ocular surface","volume":"17","author":"Sahu","year":"2019","journal-title":"Ocul Surf"},{"issue":"21","key":"10.1016\/j.jtos.2024.11.001_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113254","article-title":"Therapeutic potential of mesenchymal stem cells in the treatment of ocular graft-versus-host disease","volume":"23","author":"Harrell","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.jtos.2024.11.001_bib61","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/stmcls\/sxad027","article-title":"Subconjunctival administration of mesenchymal stem cells alleviates ocular inflammation in a murine model of corneal alkali burn","volume":"41","author":"Chen","year":"2023","journal-title":"Stem Cell"},{"key":"10.1016\/j.jtos.2024.11.001_bib62","series-title":"Evaluation of PROCHYMAL\u00ae adult human stem cells for treatment-resistant moderate-to-severe crohn's disease","author":"Mesoblast","year":"2022"},{"issue":"2","key":"10.1016\/j.jtos.2024.11.001_bib63","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jtos.2019.01.001","article-title":"Subconjunctival injection of mesenchymal stromal cells protects the cornea in an experimental model of GVHD","volume":"17","author":"Martinez-Carrasco","year":"2019","journal-title":"Ocul Surf"},{"issue":"7","key":"10.1016\/j.jtos.2024.11.001_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073745","article-title":"Positive effects of oral antibiotic administration in murine chronic graft-versus-host disease","volume":"22","author":"Sato","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.jtos.2024.11.001_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094895","article-title":"MSCs become collagen-type I producing cells with different phenotype in allogeneic and syngeneic bone marrow transplantation","volume":"22","author":"Rusch","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib66","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1089\/scd.2018.0058","article-title":"Immunological properties of neural crest cells derived from human induced pluripotent stem cells","volume":"28","author":"Fujii","year":"2019","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jtos.2024.11.001_bib67","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.2147\/OPTH.S178113","article-title":"A novel scale for describing corneal staining","volume":"12","author":"Woods","year":"2018","journal-title":"Clin Ophthalmol"},{"issue":"3","key":"10.1016\/j.jtos.2024.11.001_bib68","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1600-0420.2007.01049.x","article-title":"Safety, penetration and efficacy of topically applied bevacizumab: evaluation of eyedrops in corneal neovascularization after chemical burn","volume":"86","author":"Yoeruek","year":"2008","journal-title":"Acta Ophthalmol"},{"issue":"11","key":"10.1016\/j.jtos.2024.11.001_bib69","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/labinvest.2015.113","article-title":"Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea","volume":"95","author":"Pajoohesh-Ganji","year":"2015","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15682-1","article-title":"The Semaphorin 3A inhibitor SM-345431 preserves corneal nerve and epithelial integrity in a murine dry eye model","volume":"7","author":"Yamazaki","year":"2017","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jtos.2024.11.001_bib71","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1111\/j.1582-4934.2008.00297.x","article-title":"Stratified epithelial sheets engineered from a single adult murine corneal\/limbal progenitor cell","volume":"12","author":"Kawakita","year":"2008","journal-title":"J Cell Mol Med"},{"issue":"5","key":"10.1016\/j.jtos.2024.11.001_bib72","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.1469-7580.2009.01065.x","article-title":"Morphological and immunocytochemical characteristics indicate the yield of early progenitors and represent a quality control for human mesenchymal stem cell culturing","volume":"214","author":"Haasters","year":"2009","journal-title":"J Anat"},{"key":"10.1016\/j.jtos.2024.11.001_bib73","doi-asserted-by":"crossref","DOI":"10.1100\/2012\/793823","article-title":"Mechanisms underlying the osteo- and adipo-differentiation of human mesenchymal stem cells","volume":"2012","author":"Zhang","year":"2012","journal-title":"Sci World J"},{"key":"10.1016\/j.jtos.2024.11.001_bib74","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3389\/fcell.2020.00561","article-title":"Chondrogenesis of human mesenchymal stem\/stromal cells: a comparative transcriptome approach","volume":"8","author":"Robert","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib75","doi-asserted-by":"crossref","first-page":"26","DOI":"10.15283\/ijsc17015","article-title":"CD73, CD90, CD105 and cadherin-11 RT-PCR screening for mesenchymal stem cells from cryopreserved human cord tissue","volume":"11","author":"Pham","year":"2018","journal-title":"Int J Stem Cells"},{"issue":"3","key":"10.1016\/j.jtos.2024.11.001_bib76","first-page":"164","article-title":"Phenotypic characterizations and comparison of adult dental stem cells with adipose-derived stem cells","volume":"1","author":"Alipour","year":"2010","journal-title":"Int J Prev Med"},{"issue":"3","key":"10.1016\/j.jtos.2024.11.001_bib77","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1159\/000129013","article-title":"Phenotypic characterization of mesenchymal stem cells from various tissues","volume":"35","author":"Rojewski","year":"2008","journal-title":"Transfus Med Hemother"},{"issue":"4","key":"10.1016\/j.jtos.2024.11.001_bib78","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"issue":"7","key":"10.1016\/j.jtos.2024.11.001_bib79","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0301-472X(02)00812-3","article-title":"Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies","volume":"30","author":"Quirici","year":"2002","journal-title":"Exp Hematol"},{"issue":"8","key":"10.1016\/j.jtos.2024.11.001_bib80","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1182\/blood.V88.8.3230.bloodjournal8883230","article-title":"An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin","volume":"88","author":"Cooke","year":"1996","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.jtos.2024.11.001_bib81","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.bbmt.2016.07.012","article-title":"Novel scoring criteria for the evaluation of ocular graft-versus-host disease in a preclinical allogeneic hematopoietic stem cell transplantation animal model","volume":"22","author":"Perez","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib82","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0161-6420(83)34604-2","article-title":"Ocular manifestations of graft-vs-host disease","volume":"90","author":"Franklin","year":"1983","journal-title":"Ophthalmology"},{"issue":"Suppl 1","key":"10.1016\/j.jtos.2024.11.001_bib83","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12886-015-0138-4","article-title":"Mesenchymal stem cells for treating ocular surface diseases","volume":"15","author":"Zhang","year":"2015","journal-title":"BMC Ophthalmol"},{"issue":"16","key":"10.1016\/j.jtos.2024.11.001_bib84","doi-asserted-by":"crossref","DOI":"10.3390\/cells11162549","article-title":"Corneal regeneration using adipose-derived mesenchymal stem cells","volume":"11","author":"Alio Del Barrio","year":"2022","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.jtos.2024.11.001_bib85","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.4049\/jimmunol.168.6.3088","article-title":"Murine sclerodermatous graft-versus-host disease, a model for human scleroderma: cutaneous cytokines, chemokines, and immune cell activation","volume":"168","author":"Zhang","year":"2002","journal-title":"J Immunol"},{"issue":"11","key":"10.1016\/j.jtos.2024.11.001_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22116114","article-title":"Cascade of inflammatory, fibrotic processes, and stress-induced senescence in chronic GVHD-related dry eye disease","volume":"22","author":"Ogawa","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2024.11.001_bib87","article-title":"Recent advances in ocular graft-versus-host disease","volume":"14","author":"Cheng","year":"2023","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.jtos.2024.11.001_bib88","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/art.22414","article-title":"Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis","volume":"56","author":"van Amelsfort","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.jtos.2024.11.001_bib89","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/cei.12423","article-title":"Mesenchymal stem cells suppress CD8+ T cell-mediated activation by suppressing natural killer group 2, member D protein receptor expression and secretion of prostaglandin E2, indoleamine 2, 3-dioxygenase and transforming growth factor-beta","volume":"178","author":"Li","year":"2014","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"10.1016\/j.jtos.2024.11.001_bib90","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/stem.2509","article-title":"Mesenchymal stromal cell secretion of programmed death-1 ligands regulates T cell mediated immunosuppression","volume":"35","author":"Davies","year":"2017","journal-title":"Stem Cell"},{"issue":"4","key":"10.1016\/j.jtos.2024.11.001_bib91","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.intimp.2013.02.020","article-title":"Impact of different mesenchymal stromal cell types on T-cell activation, proliferation and migration","volume":"15","author":"Najar","year":"2013","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"10.1016\/j.jtos.2024.11.001_bib92","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1182\/blood.V99.10.3838","article-title":"Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli","volume":"99","author":"Di Nicola","year":"2002","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.jtos.2024.11.001_bib93","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s12276-023-00949-7","article-title":"Mesenchymal stem cell-derived extracellular vesicles subvert Th17 cells by destabilizing RORgammat through posttranslational modification","volume":"55","author":"Jung","year":"2023","journal-title":"Exp Mol Med"},{"issue":"4","key":"10.1016\/j.jtos.2024.11.001_bib94","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010088","article-title":"A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype","volume":"5","author":"Waterman","year":"2010","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.jtos.2024.11.001_bib95","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1111\/j.1600-6143.2009.02721.x","article-title":"Infusion of mesenchymal stem cells and rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft tolerance","volume":"9","author":"Ge","year":"2009","journal-title":"Am J Transplant"},{"issue":"9","key":"10.1016\/j.jtos.2024.11.001_bib96","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/stem.1432","article-title":"Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages","volume":"31","author":"Melief","year":"2013","journal-title":"Stem Cell"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib97","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jds.2021.08.012","article-title":"Migration and phenotype switching of macrophages at early-phase of bone-formation by secretomes from bone marrow derived mesenchymal stem cells using rat calvaria bone defect model","volume":"17","author":"Katagiri","year":"2022","journal-title":"J Dent Sci"},{"issue":"6","key":"10.1016\/j.jtos.2024.11.001_bib98","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19061801","article-title":"Role of human macrophage polarization in inflammation during infectious diseases","volume":"19","author":"Atri","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jtos.2024.11.001_bib99","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.immuni.2011.01.020","article-title":"Th17 cells express interleukin-10 receptor and are controlled by Foxp3(-) and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner","volume":"34","author":"Huber","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.jtos.2024.11.001_bib100","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fimmu.2017.00093","article-title":"Arginine metabolism in myeloid cells shapes innate and adaptive immunity","volume":"8","author":"Rodriguez","year":"2017","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.jtos.2024.11.001_bib101","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1002\/art.33423","article-title":"Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model","volume":"64","author":"Li","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.1016\/j.jtos.2024.11.001_bib102","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.4252\/wjsc.v12.i12.1529","article-title":"Mesenchymal stem cells secretome: the cornerstone of cell-free regenerative medicine","volume":"12","author":"Gonzalez-Gonzalez","year":"2020","journal-title":"World J Stem Cells"},{"issue":"1","key":"10.1016\/j.jtos.2024.11.001_bib103","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-14115-y","article-title":"Development of secretome-based strategies to improve cell culture protocols in tissue engineering","volume":"12","author":"Cases-Perera","year":"2022","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.jtos.2024.11.001_bib104","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2015.12.018","article-title":"Not single but periodic injections of synovial mesenchymal stem cells maintain viable cells in knees and inhibit osteoarthritis progression in rats","volume":"24","author":"Ozeki","year":"2016","journal-title":"Osteoarthritis Cartilage"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012424001150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012424001150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T06:05:03Z","timestamp":1733465103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012424001150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":104,"alternative-id":["S1542012424001150"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2024.11.001","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adipose-derived mesenchymal stromal cells: A study on safety and efficacy in ocular inflammation","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2024.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}