{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:26:22Z","timestamp":1792167982426,"version":"4.4.0"},"reference-count":187,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973908"],"award-info":[{"award-number":["81973908"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jtos.2024.12.010","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T03:17:35Z","timestamp":1735615055000},"page":"25-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Systems biology of dry eye: Unraveling molecular mechanisms through multi-omics integration"],"prefix":"10.1016","volume":"36","author":[{"given":"Zhirui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib1","first-page":"334","article-title":"TFOS DEWS II definition and classification report","volume":"17","author":"Craig","year":"2019","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2024.12.010_bib2","first-page":"7","article-title":"Prevalence of diagnosed dry eye disease in the United States among adults aged 18 years and older","volume":"220","author":"Farrand","year":"2020","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib3","first-page":"102","article-title":"The TFOS DEWS II diagnostic methodology report: advances in the diagnosis of dry eye disease","volume":"19","author":"Wolffsohn","year":"2021","journal-title":"Ocul Surf"},{"issue":"2","key":"10.1016\/j.jtos.2024.12.010_bib4","first-page":"191","article-title":"Management of dry eye disease: a focus on tear film instability and inflammation","volume":"18","author":"Stapleton","year":"2020","journal-title":"Ocul Surf"},{"issue":"6","key":"10.1016\/j.jtos.2024.12.010_bib5","first-page":"721","article-title":"Towards a dynamic customized therapy for ocular surface dysfunctions","volume":"104","author":"Aragona","year":"2020","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib6","first-page":"402","article-title":"Inflammation and dry eye disease: report of the TFOS DEWS II inflammation workshop","volume":"18","author":"Pflugfelder","year":"2020","journal-title":"Ocul Surf"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jtos.2013.07.003","article-title":"Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting","volume":"11","author":"Baudouin","year":"2021","journal-title":"Ocul Surf"},{"issue":"2","key":"10.1016\/j.jtos.2024.12.010_bib8","first-page":"39","article-title":"Application of omics technologies in ocular diseases: a review","volume":"13","author":"Malhotra","year":"2021","journal-title":"Journal of Genetic Medicine"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib9","first-page":"64","article-title":"TFOS DEWS II pathophysiology report: advances in understanding the causes of dry eye disease","volume":"21","author":"Bron","year":"2022","journal-title":"Ocul Surf"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib10","first-page":"107","article-title":"The role of tear film instability and inflammation in dry eye disease","volume":"20","author":"Nichols","year":"2022","journal-title":"Ocul Surf"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib11","first-page":"1","article-title":"Integrative multi-omics approaches in the field of ophthalmology","volume":"21","author":"Ahn","year":"2023","journal-title":"J Transl Med"},{"issue":"5","key":"10.1016\/j.jtos.2024.12.010_bib12","first-page":"71","article-title":"The pathophysiology, diagnosis, and treatment of dry eye disease","volume":"112","author":"Messmer","year":"2015","journal-title":"Deutsches \u00c4rzteblatt International"},{"issue":"10","key":"10.1016\/j.jtos.2024.12.010_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/iovs.63.10.3","article-title":"AKR1C1 protects corneal epithelial cells against oxidative stress-mediated ferroptosis in dry eye","volume":"63","author":"Zuo","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"10.1016\/j.jtos.2024.12.010_bib14","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.3390\/ijms18071398","article-title":"Dry eye management: targeting the ocular surface microenvironment","volume":"18","author":"Zhang","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/jop.2019.0060","article-title":"The immunological basis of dry eye disease and current topical treatment options","volume":"36","author":"Periman","year":"2020","journal-title":"J Ocul Pharmacol Therapeut"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib16","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","article-title":"TFOS DEWS II management and therapy report","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2024.12.010_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106206","article-title":"Current trends in pharmaceutical treatment of dry eye disease: a review","volume":"175","author":"Mohamed","year":"2022","journal-title":"Eur J Pharmaceut Sci"},{"issue":"9","key":"10.1016\/j.jtos.2024.12.010_bib18","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.3390\/pharmaceutics15092301","article-title":"Combining MSC exosomes and cerium oxide nanocrystals for enhanced dry eye syndrome therapy","volume":"15","author":"Tian","year":"2023","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s40820-024-01322-7","article-title":"Dual-atom nanozyme eye drops attenuate inflammation and break the vicious cycle in dry eye disease","volume":"16","author":"Chu","year":"2024","journal-title":"Nano-Micro Lett"},{"key":"10.1016\/j.jtos.2024.12.010_bib20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jtos.2023.03.002","article-title":"MicroRNAs of extracellular vesicles derived from mesenchymal stromal cells alleviate inflammation in dry eye disease by targeting the IRAK1\/TAB2\/NF-\u03baB pathway","volume":"28","author":"Wang","year":"2023","journal-title":"Ocul Surf"},{"issue":"7418","key":"10.1016\/j.jtos.2024.12.010_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nature11412","article-title":"Comprehensive molecular portraits of human breast tumours","volume":"490","year":"2012","journal-title":"Nature"},{"issue":"6217","key":"10.1016\/j.jtos.2024.12.010_bib22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.1260825","article-title":"Variation in cancer risk among tissues can be explained by the number of stem cell divisions","volume":"347","author":"Tomasetti","year":"2015","journal-title":"Science"},{"issue":"22","key":"10.1016\/j.jtos.2024.12.010_bib23","first-page":"2186","article-title":"RNA identification of PRIME cells predicting RA flares","volume":"383","author":"Orange","year":"2020","journal-title":"N Engl J Med"},{"issue":"10055","key":"10.1016\/j.jtos.2024.12.010_bib24","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cmet.2016.09.018","article-title":"Metabolomics and metabolic diseases: where do we stand?","volume":"25","author":"Newgard","year":"2017","journal-title":"Cell Metabol"},{"issue":"8","key":"10.1016\/j.jtos.2024.12.010_bib26","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1001\/jamainternmed.2018.2933","article-title":"The carbohydrate-insulin model of obesity: beyond \"calories in, calories out.\"","volume":"178","author":"Ludwig","year":"2018","journal-title":"JAMA Intern Med"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/08830185.2012.748052","article-title":"Dry eye as a mucosal autoimmune disease","volume":"32","author":"Stern","year":"2013","journal-title":"Int Rev Immunol"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib28","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1080\/09273948.2021.1905856","article-title":"Pathophysiology of meibomian glands - an overview","volume":"29","author":"Dietrich","year":"2021","journal-title":"Ocul Immunol Inflamm"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib29","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.survophthal.2022.01.010","article-title":"Metabolomics and lipidomics approaches in human tears: a systematic review","volume":"67","author":"Khanna","year":"2022","journal-title":"Surv Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-89514-8","article-title":"Diagnostic biomarkers in tear fluid: from sampling to preanalytical processing","volume":"11","author":"Bachhuber","year":"2021","journal-title":"Sci Rep"},{"issue":"5617","key":"10.1016\/j.jtos.2024.12.010_bib31","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1126\/science.1084564","article-title":"The Human Genome Project: lessons from large-scale biology","volume":"300","author":"Collins","year":"2003","journal-title":"Science (New York, NY)"},{"issue":"5507","key":"10.1016\/j.jtos.2024.12.010_bib32","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1126\/science.1058040","article-title":"The sequence of the human genome","volume":"291","author":"Venter","year":"2001","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrm.2015.32","article-title":"The biogenesis and emerging roles of circular RNAs","volume":"17","author":"Chen","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jtos.2024.12.010_bib34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-1-60327-216-2_6","article-title":"Introduction to genomics","volume":"823","author":"Del Giacco","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"8000","key":"10.1016\/j.jtos.2024.12.010_bib35","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/d41586-024-00483-0","article-title":"Super-speedy sequencing puts genomic diagnosis in the fast lane","volume":"626","author":"Eisenstein","year":"2024","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jtos.2024.12.010_bib36","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41576-019-0127-1","article-title":"Benefits and limitations of genome-wide association studies","volume":"20","author":"Tam","year":"2019","journal-title":"Nat Rev Genet"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.preteyeres.2005.05.003","article-title":"The NEIBank project for ocular genomics: data-mining gene expression in human and rodent eye tissues","volume":"25","author":"Wistow","year":"2006","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2024.12.010_bib38","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.1167\/iovs.14-15200","article-title":"The heritability of dry eye disease in a female twin cohort","volume":"55","author":"Vehof","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"10.1016\/j.jtos.2024.12.010_bib39","first-page":"1962","article-title":"A GWAS investigation of dry eye disease in two European populations","volume":"59","author":"Vehof","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2024.12.010_bib40","series-title":"Changes in clinical indicators and tear cytokines in diabetic dry eye patients","author":"Zeng","year":"2018"},{"issue":"5","key":"10.1016\/j.jtos.2024.12.010_bib41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/tvst.13.5.13","article-title":"Predicting risks of dry eye disease development using a genome-wide polygenic risk score model","volume":"13","author":"Hsu","year":"2024","journal-title":"Translational Vision Science & Technology"},{"issue":"6","key":"10.1016\/j.jtos.2024.12.010_bib42","first-page":"1702","article-title":"Changes in conjunctival clusterin expression in severe ocular surface disease","volume":"43","author":"Nakamura","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.jtos.2024.12.010_bib43","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3390\/biom13020262","article-title":"Impact of tumor necrosis factor receptor 1 (TNFR1) polymorphism on dry eye disease","volume":"13","author":"Acuna","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jtos.2024.12.010_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.702755","article-title":"Differentially expressed gene pathways in the conjunctiva of Sj\u00f6gren syndrome keratoconjunctivitis sicca","volume":"12","author":"de Paiva","year":"2021","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib45","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3390\/ijms20030767","article-title":"MIST1, an inductive signal for salivary amylase in mesenchymal stem cells","volume":"20","author":"Mona","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2024.12.010_bib46","first-page":"2818","article-title":"Proinflammatory gene polymorphisms are potentially associated with Korean non-Sj\u00f6gren dry eye patients","volume":"17","author":"Na","year":"2011","journal-title":"Mol Vis"},{"issue":"7766","key":"10.1016\/j.jtos.2024.12.010_bib47","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41586-019-1411-0","article-title":"Advances in epigenetics link genetics to the environment and disease","volume":"571","author":"Cavalli","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jtos.2024.12.010_bib48","article-title":"Mapping epigenetic modifications by sequencing technologies","author":"Chen","year":"2023"},{"key":"10.1016\/j.jtos.2024.12.010_bib49","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.2147\/JIR.S440263","article-title":"Integrated DNA methylation and transcriptomics analyses of lacrimal glands identify the potential genes implicated in the development of Sj\u00f6gren's syndrome-related dry eye","volume":"16","author":"Sun","year":"2023","journal-title":"J Inflamm Res"},{"issue":"5","key":"10.1016\/j.jtos.2024.12.010_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1718","article-title":"The Central Dogma revisited: insights from protein synthesis, CRISPR, and beyond","volume":"13","author":"Ille","year":"2022","journal-title":"Wiley interdisciplinary reviews. RNA"},{"issue":"26","key":"10.1016\/j.jtos.2024.12.010_bib51","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1016\/j.cell.2023.11.003","article-title":"Mapping the transcriptome: realizing the full potential of spatial data analysis","volume":"186","author":"Zormpas","year":"2023","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jtos.2024.12.010_bib52","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/bfgp\/elad019","article-title":"Quantifying transcriptome diversity: a review","volume":"23","author":"Jones","year":"2024","journal-title":"Briefings in Functional Genomics"},{"issue":"7","key":"10.1016\/j.jtos.2024.12.010_bib53","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1161\/01.RES.0000036018.76903.18","article-title":"Serial analysis of gene expression: technical considerations and applications to cardiovascular biology","volume":"91","author":"Patino","year":"2002","journal-title":"Circ Res"},{"issue":"10","key":"10.1016\/j.jtos.2024.12.010_bib54","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1007\/s10792-022-02320-7","article-title":"Dry eye syndrome: comprehensive etiologies and recent clinical trials","volume":"42","author":"Huang","year":"2022","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.jtos.2024.12.010_bib55","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.3389\/fimmu.2018.02271","article-title":"Conjunctival inflammatory gene expression profiling in dry eye disease: correlations with HLA-DRA and HLA-DRB1","volume":"9","author":"Kessal","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtos.2024.12.010_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.808940","article-title":"Long non-coding RNAs Gabarapl2 and Chrnb2 positively regulate inflammatory signaling in a mouse model of dry eye","volume":"8","author":"Yang","year":"2021","journal-title":"Front Med"},{"key":"10.1016\/j.jtos.2024.12.010_bib57","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.3389\/fimmu.2018.02271","article-title":"Conjunctival inflammatory gene expression profiling in dry eye disease: correlations with HLA-DRA and HLA-DRB1","volume":"9","author":"Kessal","year":"2018","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib58","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jtos.2019.03.005","article-title":"Correlation of clinical symptoms and signs with conjunctival gene expression in primary Sj\u00f6gren syndrome dry eye patients","volume":"17","author":"Liang","year":"2019","journal-title":"Ocul Surf"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib59","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/02713683.2013.823213","article-title":"Adaptation of impression cytology to enable conjunctival surface cell transcriptome analysis","volume":"39","author":"Bradley","year":"2014","journal-title":"Curr Eye Res"},{"issue":"5","key":"10.1016\/j.jtos.2024.12.010_bib60","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1167\/iovs.04-1380","article-title":"The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts","volume":"46","author":"Ozyildirim","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2024.12.010_bib61","first-page":"518","article-title":"Transcriptome analysis of aging mouse meibomian glands","volume":"22","author":"Parfitt","year":"2016","journal-title":"Mol Vis"},{"issue":"7","key":"10.1016\/j.jtos.2024.12.010_bib62","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/1615-9861(200207)2:7<807::AID-PROT807>3.0.CO;2-4","article-title":"Proteomics and its trends facing nature's complexity","volume":"2","author":"Hochstrasser","year":"2002","journal-title":"Proteomics"},{"issue":"8","key":"10.1016\/j.jtos.2024.12.010_bib63","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1167\/iovs.11-9022","article-title":"iTRAQ quantitative proteomics in the analysis of tears in dry eye patients","volume":"53","author":"Srinivasan","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17536-2","article-title":"Tear proteome analysis in ocular surface diseases using label-free LC-MS\/MS and multiplexed-microarray biomarker validation","volume":"7","author":"Soria","year":"2017","journal-title":"Sci Rep"},{"issue":"Pt A","key":"10.1016\/j.jtos.2024.12.010_bib65","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/978-1-4615-0717-8_84","article-title":"Mass spectrometric techniques applied to the analysis of human tears: a focus on the peptide and protein constituents","volume":"506","author":"Fung","year":"2002","journal-title":"Adv Exp Med Biol"},{"issue":"10","key":"10.1016\/j.jtos.2024.12.010_bib66","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.18240\/ijo.2019.10.15","article-title":"New approaches for diagnosis of dry eye disease","volume":"12","author":"Elhusseiny","year":"2019","journal-title":"Int J Ophthalmol"},{"issue":"5","key":"10.1016\/j.jtos.2024.12.010_bib67","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1021\/acs.jproteome.9b00149","article-title":"Integrated tear proteome and metabolome reveal panels of inflammatory-related molecules via key regulatory pathways in dry eye syndrome","volume":"18","author":"Chen","year":"2019","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jtos.2024.12.010_bib68","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jprot.2012.11.017","article-title":"Tear proteome and protein network analyses reveal a novel pentamarker panel for tear film characterization in dry eye and meibomian gland dysfunction","volume":"78","author":"Soria","year":"2013","journal-title":"J Proteonomics"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib69","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"issue":"2","key":"10.1016\/j.jtos.2024.12.010_bib70","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international dry eye WorkShop","volume":"5","year":"2007","journal-title":"Ocul Surf"},{"issue":"6","key":"10.1016\/j.jtos.2024.12.010_bib71","doi-asserted-by":"crossref","first-page":"8763","DOI":"10.3892\/mmr.2017.7754","article-title":"Evaluation of a novel dry eye model induced by oral administration of finasteride","volume":"16","author":"Li","year":"2017","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib72","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jtos.2018.10.004","article-title":"Tear film inflammatory cytokine upregulation in contact lens discomfort","volume":"17","author":"Gad","year":"2019","journal-title":"Ocul Surf"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib73","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000445622","article-title":"The effect of the aqueous extract of Bidens pilosa L. on androgen deficiency dry eye in rats","volume":"39","author":"Zhang","year":"2016","journal-title":"Cell Physiol Biochem"},{"issue":"8","key":"10.1016\/j.jtos.2024.12.010_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200702","article-title":"The use of in-strip digestion for fast proteomic analysis on tear fluid from dry eye patients","volume":"13","author":"Huang","year":"2018","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jtos.2024.12.010_bib75","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1021\/acs.jproteome.9b00149","article-title":"Integrated tear proteome and metabolome reveal panels of inflammatory-related molecules via key regulatory pathways in dry eye syndrome","volume":"18","author":"Chen","year":"2019","journal-title":"J Proteome Res"},{"issue":"12","key":"10.1016\/j.jtos.2024.12.010_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051979","article-title":"Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome","volume":"7","author":"Aluru","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib77","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1167\/iovs.04-0448","article-title":"SELDI-TOF-MS ProteinChip array profiling of tears from patients with dry eye","volume":"46","author":"Grus","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2024.12.010_bib78","doi-asserted-by":"crossref","DOI":"10.1038\/srep29629","article-title":"Proteomics analysis of human tears from aqueous-deficient and evaporative dry eye patients","volume":"6","author":"Perumal","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtos.2024.12.010_bib79","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jprot.2012.11.017","article-title":"Tear proteome and protein network analyses reveal a novel pentamarker panel for tear film characterization in dry eye and meibomian gland dysfunction","volume":"78","author":"Soria","year":"2013","journal-title":"J Proteonomics"},{"issue":"6","key":"10.1016\/j.jtos.2024.12.010_bib80","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1136\/bjo.2010.185256","article-title":"Association of tear proteins with Meibomian gland disease and dry eye symptoms","volume":"95","author":"Tong","year":"2011","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib81","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17536-2","article-title":"Tear proteome analysis in ocular surface diseases using label-free LC-MS\/MS and multiplexed-microarray biomarker validation","volume":"7","author":"Soria","year":"2017","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.jtos.2024.12.010_bib82","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1021\/acs.jproteome.4c00163","article-title":"Discovery and verification of Sj\u00f6gren's syndrome protein biomarkers in tears by targeted LC-MRM","volume":"23","author":"L\u00e9pine","year":"2024","journal-title":"J Proteome Res"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib83","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1167\/iovs.13-12080","article-title":"Tear proteomic analysis of patients with type 2 diabetes and dry eye syndrome by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry","volume":"55","author":"Li","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib84","article-title":"Quantitative proteomics and weighted correlation network analysis of tear samples in type 2 diabetes patients complicated with dry eye","volume":"14","author":"Zou","year":"2020","journal-title":"Proteonomics Clin Appl"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib85","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0161-6420(00)00599-6","article-title":"Tear function and ocular surface changes in noninsulin-dependent diabetes mellitus","volume":"108","author":"Dogru","year":"2001","journal-title":"Ophthalmology"},{"issue":"10","key":"10.1016\/j.jtos.2024.12.010_bib86","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1167\/iovs.02-1319","article-title":"Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca","volume":"44","author":"Song","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"13","key":"10.1016\/j.jtos.2024.12.010_bib87","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/tvst.9.13.8","article-title":"Quantitative proteomics and weighted correlation network analysis of tear samples in adults and children with diabetes and dry eye","volume":"9","author":"Zou","year":"2020","journal-title":"Translational Vision Science & Technology"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib88","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1167\/iovs.15-16699","article-title":"Proteomics differentiate between thyroid-associated orbitopathy and dry eye syndrome","volume":"56","author":"Matheis","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"15","key":"10.1016\/j.jtos.2024.12.010_bib89","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1167\/iovs.19-27872","article-title":"Changes in human tear proteome following topical treatment of dry eye disease: cyclosporine A versus diquafosol tetrasodium","volume":"60","author":"Ji","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2024.12.010_bib90","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2147\/IJN.S126968","article-title":"Proteomic analysis of tears following acupuncture treatment for menopausal dry eye disease by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry","volume":"12","author":"Liu","year":"2017","journal-title":"Int J Nanomed"},{"issue":"6","key":"10.1016\/j.jtos.2024.12.010_bib91","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1021\/acs.jproteome.4c00134","article-title":"Effect of acupuncture on tear proteomics in patients with video display terminal-related dry eye","volume":"23","author":"Tang","year":"2024","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jtos.2024.12.010_bib92","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.exer.2017.03.006","article-title":"The analysis of human conjunctival epithelium proteome in ocular surface diseases using impression cytology and 2D-DIGE","volume":"167","author":"Soria","year":"2018","journal-title":"Exp Eye Res"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib93","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13817-y","article-title":"Proteomic analysis of human lacrimal and tear fluid in dry eye disease","volume":"7","author":"Jung","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib94","doi-asserted-by":"crossref","first-page":"435","DOI":"10.18240\/ijo.2024.03.04","article-title":"Dry environment on the expression of lacrimal gland S100A9, Anxa1, and Clu in rats via proteomics","volume":"17","author":"Sun","year":"2024","journal-title":"Int J Ophthalmol"},{"issue":"9","key":"10.1016\/j.jtos.2024.12.010_bib95","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1021\/acs.jproteome.5b00443","article-title":"Global metabonomic and proteomic analysis of human conjunctival epithelial cells (IOBA-NHC) in response to hyperosmotic stress","volume":"14","author":"Chen","year":"2015","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jtos.2024.12.010_bib96","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jtos.2023.12.006","article-title":"Ocular surface changes in mice with streptozotocin-induced diabetes and diabetic polyneuropathy","volume":"31","author":"Schicht","year":"2024","journal-title":"Ocul Surf"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib97","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3390\/metabo13030380","article-title":"Metabolomics in corneal diseases: a narrative review from clinical aspects","volume":"13","author":"Teo","year":"2023","journal-title":"Metabolites"},{"issue":"12","key":"10.1016\/j.jtos.2024.12.010_bib98","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s13361-016-1469-y","article-title":"Untargeted metabolomics strategies\u2014challenges and emerging directions","volume":"27","author":"Schrimpe-Rutledge","year":"2016","journal-title":"J Am Soc Mass Spectrom"},{"issue":"6","key":"10.1016\/j.jtos.2024.12.010_bib99","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbae498","article-title":"Current approaches and outstanding challenges of functional annotation of metabolites: a comprehensive review","volume":"25","author":"Nguyen","year":"2024","journal-title":"Briefings Bioinf"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib100","doi-asserted-by":"crossref","first-page":"236","DOI":"10.5507\/bp.2020.028","article-title":"Metabolomic analysis in ophthalmology","volume":"164","author":"Nazifova-Tasinova","year":"2020","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib101","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.4103\/IJO.IJO_2981_22","article-title":"Tear biomarkers in dry eye disease: progress in the last decade","volume":"71","author":"Kumar","year":"2023","journal-title":"Indian J Ophthalmol"},{"issue":"7","key":"10.1016\/j.jtos.2024.12.010_bib102","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1080\/02713683.2024.2335271","article-title":"Method development for omics analyses using Schirmer strips","volume":"49","author":"Gundersen","year":"2024","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2024.12.010_bib103","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3389\/fcell.2020.00344","article-title":"A set of global metabolomic biomarker candidates to predict the risk of dry eye disease","volume":"8","author":"Jiang","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"10","key":"10.1016\/j.jtos.2024.12.010_bib104","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1089\/photob.2022.0058","article-title":"Intense pulsed light therapy to inhibit meibomian gland inflammation: untargeted metabolomics analysis of meibomian gland secretions","volume":"40","author":"Li","year":"2022","journal-title":"Photobiomodulation, Photomedicine, and Laser Surgery"},{"issue":"9","key":"10.1016\/j.jtos.2024.12.010_bib105","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1021\/acs.jproteome.5b00443","article-title":"Global metabonomic and proteomic analysis of human conjunctival epithelial cells (IOBA-NHC) in response to hyperosmotic stress","volume":"14","author":"Chen","year":"2015","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jtos.2024.12.010_bib106","first-page":"555","article-title":"A metabolomic approach to dry eye disorders: the role of oral supplements with antioxidants and omega 3 fatty acids","volume":"21","author":"Galbis-Estrada","year":"2015","journal-title":"Mol Vis"},{"issue":"5","key":"10.1016\/j.jtos.2024.12.010_bib107","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1021\/acs.jproteome.9b00149","article-title":"Integrated tear proteome and metabolome reveal panels of inflammatory-related molecules via key regulatory pathways in dry eye syndrome","volume":"18","author":"Chen","year":"2019","journal-title":"J Proteome Res"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib108","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ophtha.2016.12.011","article-title":"A metabolome-wide study of dry eye disease reveals serum androgens as biomarkers","volume":"124","author":"Vehof","year":"2017","journal-title":"Ophthalmology"},{"issue":"11","key":"10.1016\/j.jtos.2024.12.010_bib109","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3390\/metabo13111125","article-title":"Tear and saliva metabolomics in evaporative dry eye disease in females","volume":"13","author":"Fineide","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.jtos.2024.12.010_bib110","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jtos.2021.07.006","article-title":"Tear metabolomics highlights new potential biomarkers for differentiating between Sj\u00f6gren's syndrome and other causes of dry eye","volume":"22","author":"Urbanski","year":"2021","journal-title":"Ocul Surf"},{"issue":"8","key":"10.1016\/j.jtos.2024.12.010_bib111","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/15287394.2020.1867274","article-title":"Metabolomics approach to biomarkers of dry eye disease using 1H-NMR in rats","volume":"84","author":"Lee","year":"2021","journal-title":"J Toxicol Environ Health"},{"key":"10.1016\/j.jtos.2024.12.010_bib112","first-page":"1","article-title":"Mass spectrometry (MS)-based metabolomics of plasma and urine in dry eye disease (DED)-induced rat model","volume":"33","author":"Kim","year":"2024","journal-title":"J Toxicol Environ Health"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib113","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.survophthal.2022.01.010","article-title":"Metabolomics and lipidomics approaches in human tears: a systematic review","volume":"67","author":"Khanna","year":"2022","journal-title":"Surv Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib114","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13167-016-0065-3","article-title":"Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine","volume":"7","author":"Hagan","year":"2016","journal-title":"EPMA J"},{"key":"10.1016\/j.jtos.2024.12.010_bib115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024339","article-title":"Meibum lipid composition in Asians with dry eye disease","volume":"6","author":"Lam","year":"2011","journal-title":"PLoS One"},{"issue":"14","key":"10.1016\/j.jtos.2024.12.010_bib116","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.3390\/ijms20143505","article-title":"Dyslipidemia and meibomian gland dysfunction: utility of lipidomics and experimental prospects with a diet-induced obesity mouse model","volume":"20","author":"Osae","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.jtos.2024.12.010_bib117","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1167\/iovs.16-19131","article-title":"\u03c9-3 tear film lipids correlate with clinical measures of dry eye","volume":"57","author":"Walter","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"10.1016\/j.jtos.2024.12.010_bib118","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1194\/jlr.P051185","article-title":"Longitudinal changes in tear fluid lipidome brought about by eyelid-warming treatment in a cohort of meibomian gland dysfunction","volume":"55","author":"Lam","year":"2014","journal-title":"JLR (J Lipid Res)"},{"issue":"2","key":"10.1016\/j.jtos.2024.12.010_bib119","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1194\/jlr.P041780","article-title":"Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome","volume":"55","author":"Lam","year":"2014","journal-title":"JLR (J Lipid Res)"},{"issue":"9","key":"10.1016\/j.jtos.2024.12.010_bib120","article-title":"Lipidomic analysis of epithelial corneal cells following hyperosmolarity and benzalkonium chloride exposure: new insights in dry eye disease","volume":"1865","author":"Magny","year":"2020","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.1016\/j.jtos.2024.12.010_bib121","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jtos.2024.04.008","article-title":"Effects of age on lacrimal gland bioactive lipids","volume":"33","author":"Ebright","year":"2024","journal-title":"Ocul Surf"},{"issue":"9","key":"10.1016\/j.jtos.2024.12.010_bib122","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/iovs.62.9.13","article-title":"Human meibum and tear film derived (O-acyl)-omega-hydroxy fatty acids as biomarkers of tear film dynamics in meibomian gland dysfunction and dry eye disease","volume":"62","author":"Khanal","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2024.12.010_bib123","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jtos.2021.10.003","article-title":"Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction","volume":"26","author":"Suzuki","year":"2022","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2024.12.010_bib124","article-title":"Changes of tear lipid mediators after eyelid warming or thermopulsation treatment for meibomian gland dysfunction","volume":"151","author":"Ambaw","year":"2020","journal-title":"Prostag Other Lipid Mediat"},{"key":"10.1016\/j.jtos.2024.12.010_bib125","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3109\/02713683.2015.1098707","article-title":"Expression of lipid peroxidation markers in the tear film and ocular surface of patients with non-Sj\u00f6gren syndrome: potential biomarkers for dry eye disease","volume":"41","author":"Choi","year":"2016","journal-title":"Curr Eye Res"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib126","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s40168-020-00875-0","article-title":"Microbiome definition re-visited: old concepts and new challenges","volume":"8","author":"Berg","year":"2020","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib127","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40779-024-00534-7","article-title":"Advances in the isolation, cultivation, and identification of gut microbes","volume":"11","author":"Xu","year":"2024","journal-title":"Military Medical Research"},{"issue":"2","key":"10.1016\/j.jtos.2024.12.010_bib128","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41579-023-00969-0","article-title":"The gut microbiota and its biogeography","volume":"22","author":"McCallum","year":"2024","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib129","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.chom.2017.03.010","article-title":"The gut microbiome: connecting spatial organization to function","volume":"21","author":"Tropini","year":"2017","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib130","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrmicro3552","article-title":"Gut biogeography of the bacterial microbiota","volume":"14","author":"Donaldson","year":"2016","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jtos.2024.12.010_bib131","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3389\/fimmu.2019.00426","article-title":"Microbiome dependent regulation of Tregs and Th17 cells in mucosa","volume":"10","author":"Pandiyan","year":"2019","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib132","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ajo.2014.06.014","article-title":"Considerations in understanding the ocular surface microbiome","volume":"158","author":"Zegans","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2024.12.010_bib133","doi-asserted-by":"crossref","DOI":"10.1038\/srep23561","article-title":"Altered mucosal microbiome diversity and disease severity in Sj\u00f6gren syndrome","volume":"6","author":"de Paiva","year":"2016","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.jtos.2024.12.010_bib134","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1167\/iovs.15-18396","article-title":"Inflammatory response to lipopolysaccharide on the ocular surface in a murine dry eye model","volume":"57","author":"Simmons","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"10.1016\/j.jtos.2024.12.010_bib135","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3390\/jcm8091439","article-title":"Dry eye disease: emerging approaches to disease analysis and therapy","volume":"8","author":"Heidari","year":"2019","journal-title":"J Clin Med"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib136","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/apm.13285","article-title":"An insight on the eye bacterial microbiota and its role on dry eye disease","volume":"131","author":"Hern\u00e1ndez-Zulueta","year":"2023","journal-title":"APMIS"},{"issue":"6","key":"10.1016\/j.jtos.2024.12.010_bib137","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.survophthal.2021.03.010","article-title":"The ocular microbiome and microbiota and their effects on ocular surface pathophysiology and disorders","volume":"66","author":"Aragona","year":"2021","journal-title":"Surv Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib138","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s12886-024-03526-2","article-title":"What is the impact of microbiota on dry eye: a literature review of the gut-eye axis","volume":"24","author":"Song","year":"2024","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.jtos.2024.12.010_bib139","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.716867","article-title":"Comparison of the ocular microbiomes of dry eye patients with and without autoimmune disease","volume":"11","author":"Qi","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jtos.2024.12.010_bib140","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jtos.2024.02.002","article-title":"Culture- and non-culture-based approaches reveal unique features of the ocular microbiome in dry eye patients","volume":"32","author":"Naqvi","year":"2024","journal-title":"Ocul Surf"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib141","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jtos.2020.07.007","article-title":"Assessing the ocular surface microbiome in severe ocular surface diseases","volume":"18","author":"Zilliox","year":"2020","journal-title":"Ocul Surf"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib142","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12866-023-03176-2","article-title":"Unique composition of ocular surface microbiome in the old patients with dry eye and diabetes mellitus in a community from Shanghai, China","volume":"24","author":"Chen","year":"2024","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jtos.2024.12.010_bib143","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.1034131","article-title":"Shotgun metagenomic sequencing analysis of ocular surface microbiome in Singapore residents with mild dry eye","volume":"9","author":"Tong","year":"2022","journal-title":"Front Med"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib144","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.4103\/ijo.IJO_1756_22","article-title":"Ocular conjunctival microbiome profiling in dry eye disease: a case control pilot study","volume":"71","author":"Gupta","year":"2023","journal-title":"Indian J Ophthalmol"},{"issue":"12","key":"10.1016\/j.jtos.2024.12.010_bib145","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.18240\/ijo.2023.12.10","article-title":"Ocular surface microbiota in patients with varying degrees of dry eye severity","volume":"16","author":"Zou","year":"2023","journal-title":"Int J Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib146","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-68952-w","article-title":"The closed eye harbours a unique microbiome in dry eye disease","volume":"10","author":"Willis","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib147","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s12866-023-03013-6","article-title":"Metagenomic analysis of microbiological changes on the ocular surface of diabetic children and adolescents with a dry eye","volume":"23","author":"Chen","year":"2023","journal-title":"BMC Microbiol"},{"issue":"12","key":"10.1016\/j.jtos.2024.12.010_bib148","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/iovs.62.12.13","article-title":"Ocular surface microbiota in diabetic patients with dry eye disease","volume":"62","author":"Zhang","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2024.12.010_bib149","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jtos.2020.09.003","article-title":"Ocular surface microbiota in patients with aqueous tear-deficient dry eye","volume":"19","author":"Andersson","year":"2021","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2024.12.010_bib150","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.731867","article-title":"Metagenomic analysis reveals the heterogeneity of conjunctival microbiota dysbiosis in dry eye disease","volume":"9","author":"Liang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jtos.2024.12.010_bib151","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109615","article-title":"Ocular microbiome changes in dry eye disease and meibomian gland dysfunction","volume":"235","author":"Ozkan","year":"2023","journal-title":"Exp Eye Res"},{"issue":"6","key":"10.1016\/j.jtos.2024.12.010_bib152","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1167\/iovs.65.6.28","article-title":"Lid margin microbiome in Stevens-Johnson syndrome patients with lid margin keratinization and severe dry eye disease","volume":"65","author":"Singh","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib153","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.4103\/IJO.IJO_2821_22","article-title":"Tear film microbiome in Sjogren's and non-Sjogren's aqueous deficiency dry eye","volume":"71","author":"Pal","year":"2023","journal-title":"Indian J Ophthalmol"},{"issue":"18","key":"10.1016\/j.jtos.2024.12.010_bib154","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241814091","article-title":"The human ocular surface microbiome and its associations with the tear proteome in dry eye disease","volume":"24","author":"Schlegel","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2024.12.010_bib155","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.841112","article-title":"Analysis of conjunctival sac microbiome in dry eye patients with and without Sj\u00f6gren's syndrome","volume":"9","author":"Song","year":"2022","journal-title":"Front Med"},{"issue":"5","key":"10.1016\/j.jtos.2024.12.010_bib156","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/ICL.0000000000001077","article-title":"The conjunctival microbiome and dry eye: what we know and controversies","volume":"50","author":"Shih","year":"2024","journal-title":"Eye Contact Lens"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib157","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3390\/antibiotics8030088","article-title":"The case for a more holistic approach to dry eye disease: is it time to move beyond antibiotics?","volume":"8","author":"Tavakoli","year":"2019","journal-title":"Antibiotics"},{"key":"10.1016\/j.jtos.2024.12.010_bib158","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1225859","article-title":"Gut microbiota and eye diseases: a bibliometric study and visualization analysis","volume":"13","author":"Fu","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib159","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/ICL.0000000000000953","article-title":"The gut-eye axis: correlation between the gut microbiota and autoimmune dry eye in individuals with Sj\u00f6gren syndrome","volume":"49","author":"Bai","year":"2023","journal-title":"Eye Contact Lens"},{"issue":"18","key":"10.1016\/j.jtos.2024.12.010_bib160","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.3390\/jcm13185611","article-title":"From gut to eye: exploring the role of microbiome imbalance in ocular diseases","volume":"13","author":"T\u00eerziu","year":"2024","journal-title":"J Clin Med"},{"issue":"22","key":"10.1016\/j.jtos.2024.12.010_bib161","doi-asserted-by":"crossref","first-page":"8443","DOI":"10.3390\/ijms21228443","article-title":"Can gut microbiota affect dry eye syndrome?","volume":"21","author":"Moon","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib162","doi-asserted-by":"crossref","DOI":"10.1136\/bmjophth-2021-000956","article-title":"Microbiome and immune-mediated dry eye: a review","volume":"7","author":"Watane","year":"2022","journal-title":"BMJ Open Ophthalmology"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib163","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12866-021-02173-7","article-title":"Association between aging-dependent gut microbiome dysbiosis and dry eye severity in C57BL\/6 male mouse model: a pilot study","volume":"21","author":"Yoon","year":"2021","journal-title":"BMC Microbiol"},{"issue":"2","key":"10.1016\/j.jtos.2024.12.010_bib164","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0229029","article-title":"Gut dysbiosis is prevailing in Sj\u00f6gren's syndrome and is related to dry eye severity","volume":"15","author":"Moon","year":"2020","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jtos.2024.12.010_bib165","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2174\/1574884712666170704145046","article-title":"Aging eye microbiota in dry eye syndrome in patients treated with Enterococcus faecium and Saccharomyces boulardii","volume":"12","author":"Chisari","year":"2017","journal-title":"Curr Clin Pharmacol"},{"issue":"6","key":"10.1016\/j.jtos.2024.12.010_bib166","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.3390\/ijms25063528","article-title":"Consumption of Limosilactobacillus fermentum inhibits corneal damage and inflammation in dry eye disease mouse model through regulating the gut microbiome","volume":"25","author":"Lee","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"16","key":"10.1016\/j.jtos.2024.12.010_bib167","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.3390\/nu15163499","article-title":"A randomized, double-blind, placebo-controlled study of an anthocyanin-rich functional ingredient on cognitive function and eye dryness in late adulthood volunteers: roles of epigenetic and gut microbiome modulations","volume":"15","author":"Wattanathorn","year":"2023","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.jtos.2024.12.010_bib168","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1089\/jop.2021.0029","article-title":"Aquaporin5-targeted treatment for dry eye through bioactive compounds and gut microbiota","volume":"37","author":"Rastmanesh","year":"2021","journal-title":"J Ocul Pharmacol Therapeut"},{"issue":"2","key":"10.1016\/j.jtos.2024.12.010_bib169","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/bib\/bbw114","article-title":"Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences","volume":"19","author":"Manzoni","year":"2018","journal-title":"Briefings Bioinf"},{"issue":"8","key":"10.1016\/j.jtos.2024.12.010_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110486","article-title":"Applications of single-cell technologies in drug discovery for tumor treatment","volume":"27","author":"Liu","year":"2024","journal-title":"iScience"},{"issue":"10","key":"10.1016\/j.jtos.2024.12.010_bib171","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.tcb.2024.01.006","article-title":"Functional analysis of cell plasticity using single-cell technologies","volume":"34","author":"Qin","year":"2024","journal-title":"Trends Cell Biol"},{"issue":"9","key":"10.1016\/j.jtos.2024.12.010_bib172","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/s12276-020-0420-2","article-title":"Single-cell multiomics: technologies and data analysis methods","volume":"52","author":"Lee","year":"2020","journal-title":"Exp Mol Med"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib173","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41385-022-00507-w","article-title":"Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes","volume":"15","author":"Alam","year":"2022","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jtos.2024.12.010_bib174","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jtos.2020.12.004","article-title":"Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea","volume":"20","author":"Li","year":"2021","journal-title":"Ocul Surf"},{"issue":"10","key":"10.1016\/j.jtos.2024.12.010_bib175","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1167\/iovs.19-27656","article-title":"Single-cell RNA transcriptome helps define the limbal\/corneal epithelial stem\/early transit amplifying cells and how autophagy affects this population","volume":"60","author":"Kaplan","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib176","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/jnr.24757","article-title":"Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers","volume":"99","author":"Bargagna-Mohan","year":"2021","journal-title":"J Neurosci Res"},{"issue":"6","key":"10.1016\/j.jtos.2024.12.010_bib177","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105123","article-title":"Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling","volume":"40","author":"Wieghofer","year":"2021","journal-title":"EMBO J"},{"issue":"7","key":"10.1016\/j.jtos.2024.12.010_bib178","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/archophthalmol.2009.125","article-title":"Amelioration of murine dry eye disease by topical antagonist to chemokine receptor 2","volume":"127","author":"Goyal","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2024.12.010_bib179","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1362336","article-title":"Single cell analysis of short-term dry eye induced changes in cornea immune cell populations","volume":"11","author":"Alam","year":"2024","journal-title":"Front Med"},{"issue":"7","key":"10.1016\/j.jtos.2024.12.010_bib180","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.stem.2021.02.024","article-title":"Exploring the human lacrimal gland using organoids and single-cell sequencing","volume":"28","author":"Bannier-H\u00e9laou\u00ebt","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib181","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1167\/iovs.65.4.46","article-title":"Single-nuclei characterization of lacrimal gland in scopolamine-induced dry eye disease","volume":"65","author":"Tang","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.jtos.2024.12.010_bib182","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.mucimm.2023.11.008","article-title":"Single-cell landscape reveals the epithelial cell-centric pro-inflammatory immune microenvironment in dry eye development","volume":"17","author":"Liu","year":"2024","journal-title":"Mucosal Immunol"},{"issue":"10","key":"10.1016\/j.jtos.2024.12.010_bib183","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/s41581-024-00841-1","article-title":"Spatial transcriptomics in health and disease","volume":"20","author":"Jain","year":"2024","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.jtos.2024.12.010_bib184","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jtos.2021.12.013","article-title":"In situ metabolic profile and spatial distribution of ocular tissues: new insights into dry eye disease","volume":"24","author":"Chen","year":"2022","journal-title":"Ocul Surf"},{"issue":"Suppl 2","key":"10.1016\/j.jtos.2024.12.010_bib185","doi-asserted-by":"crossref","first-page":"S141","DOI":"10.1097\/ICL.0000000000000650","article-title":"Imaging biomarkers for dry eye disease","volume":"46","author":"Villani","year":"2020","journal-title":"Eye Contact Lens"},{"issue":"1","key":"10.1016\/j.jtos.2024.12.010_bib186","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12938-017-0426-8","article-title":"Image-based quantitative analysis of tear film lipid layer thickness for meibomian gland evaluation","volume":"16","author":"Hwang","year":"2017","journal-title":"Biomed Eng Online"},{"issue":"4","key":"10.1016\/j.jtos.2024.12.010_bib187","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/ICO.0000000000003172","article-title":"Classification of tear film lipid layer en face maps obtained using optical coherence tomography and their correlation with clinical parameters","volume":"42","author":"Stegmann","year":"2023","journal-title":"Cornea"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012424001459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012424001459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:13:30Z","timestamp":1762550010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012424001459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":187,"alternative-id":["S1542012424001459"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2024.12.010","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systems biology of dry eye: Unraveling molecular mechanisms through multi-omics integration","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2024.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}