{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:27:10Z","timestamp":1793838430371,"version":"4.6.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J01012"],"award-info":[{"award-number":["2023J01012"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20363"],"award-info":[{"award-number":["U20A20363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271054"],"award-info":[{"award-number":["82271054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900825"],"award-info":[{"award-number":["81900825"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jtos.2025.07.004","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T15:39:09Z","timestamp":1752853149000},"page":"155-169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Prostaglandin F2\u03b1 exacerbated dry eye by promoting lacrimal gland fibrosis progression through the activation of the RhoA\/ROCKs signaling pathway"],"prefix":"10.1016","volume":"38","author":[{"given":"Shujia","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruochen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoyue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2025.07.004_bib1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.07.004_bib2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.07.004_bib3","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jtos.2020.07.003","article-title":"Ageing and the natural history of dry eye disease: a prospective registry-based cross-sectional study","volume":"18","author":"Wang","year":"2020","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.07.004_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.clae.2023.101837","article-title":"The epidemiology of dry eye disease in the UK: the aston dry eye study","volume":"46","author":"Vidal-Rohr","year":"2023","journal-title":"Contact Lens Anterior Eye : J Br Contact Lens Assoc"},{"key":"10.1016\/j.jtos.2025.07.004_bib5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","article-title":"TFOS DEWS II management and therapy report","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.07.004_bib6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.07.004_bib7","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1136\/bjo.57.11.852","article-title":"Histology of the lacrimal gland in keratoconjunctivitis sicca","volume":"57","author":"Williamson","year":"1973","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jtos.2025.07.004_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/biom11060789","article-title":"The roles of various prostaglandins in fibrosis: a review","volume":"11","author":"Li","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jtos.2025.07.004_bib9","doi-asserted-by":"crossref","first-page":"296","DOI":"10.2183\/pjab.83.296","article-title":"Physiology and pathophysiology of prostanoid receptors","volume":"83","author":"Narumiya","year":"2007","journal-title":"Proc Jpn Acad B Phys Biol Sci"},{"key":"10.1016\/j.jtos.2025.07.004_bib10","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/nm.2066","article-title":"Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta","volume":"15","author":"Oga","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.jtos.2025.07.004_bib11","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.ophtha.2012.05.038","article-title":"Change in prostaglandin expression levels and synthesizing activities in dry eye disease","volume":"119","author":"Shim","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2025.07.004_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2023.109823","article-title":"Prostaglandin E2 promotes Th17 differentiation induces corneal epithelial cell apoptosis and participates in the progression of dry eye","volume":"751","author":"Zhang","year":"2024","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jtos.2025.07.004_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-29568-3","article-title":"Tear eicosanoids in healthy people and ocular surface disease","volume":"8","author":"Ambaw","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtos.2025.07.004_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260115","article-title":"Prostaglandins in biofluids in pregnancy and labour: a systematic review","volume":"16","author":"Wood","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.jtos.2025.07.004_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106315","article-title":"Trends in development and quality assessment of pharmaceutical formulations - F2\u03b1 analogues in the glaucoma treatment","volume":"180","author":"Asendrych-Wicik","year":"2023","journal-title":"Eur J Pharmaceut Sci : Official J European Federation fPharm Sci"},{"key":"10.1016\/j.jtos.2025.07.004_bib16","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/med.20098","article-title":"Novel cyclooxygenase-catalyzed bioactive prostaglandin F2alpha from physiology to new principles in inflammation","volume":"27","author":"Basu","year":"2007","journal-title":"Med Res Rev"},{"key":"10.1016\/j.jtos.2025.07.004_bib17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1136\/ard.60.6.627","article-title":"Raised levels of F(2)-isoprostanes and prostaglandin F(2alpha) in different rheumatic diseases","volume":"60","author":"Basu","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jtos.2025.07.004_bib18","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s10059-010-0157-1","article-title":"Bioactive eicosanoids: role of prostaglandin F(2\u03b1) and F2-isoprostanes in inflammation and oxidative stress related pathology","volume":"30","author":"Basu","year":"2010","journal-title":"Mol Cells"},{"key":"10.1016\/j.jtos.2025.07.004_bib19","first-page":"1408","article-title":"Prostaglandins E2 and E2 alpha are elevated in saliva of cystic fibrosis patients","volume":"84","author":"Rigas","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jtos.2025.07.004_bib20","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.biocel.2012.03.013","article-title":"Prostaglandin F2\u03b1 facilitates collagen synthesis in cardiac fibroblasts via an F-prostanoid receptor\/protein kinase C\/Rho kinase pathway independent of transforming growth factor \u03b21","volume":"44","author":"Ding","year":"2012","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jtos.2025.07.004_bib21","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s00109-013-1119-9","article-title":"FP-receptor gene silencing ameliorates myocardial fibrosis and protects from diabetic cardiomyopathy","volume":"92","author":"Ding","year":"2014","journal-title":"Journal of molecular medicine (Berlin, Germany)"},{"key":"10.1016\/j.jtos.2025.07.004_bib22","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1167\/iovs.18-24013","article-title":"0.005% preservative-free latanoprost induces dry eye-like ocular surface damage via promotion of inflammation in mice","volume":"59","author":"Yang","year":"2018","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2025.07.004_bib23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.jtos.2025.07.004_bib24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1210\/me.2007-0272","article-title":"Prostaglandin F2alpha stimulates the expression and secretion of transforming growth factor B1 via induction of the early growth response 1 gene (EGR1) in the bovine corpus luteum","volume":"22","author":"Hou","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jtos.2025.07.004_bib25","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/art.37767","article-title":"Alpha2-antiplasmin regulates the development of dermal fibrosis in mice by prostaglandin F(2\u03b1) synthesis through adipose triglyceride lipase\/calcium-independent phospholipase A(2)","volume":"65","author":"Kanno","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jtos.2025.07.004_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155081","article-title":"Berberine ameliorate inflammation and apoptosis via modulating PI3K\/AKT\/NF\u03baB and MAPK pathway on dry eye","volume":"121","author":"Han","year":"2023","journal-title":"Phytomedicine : Int J phytother phytopharmacol"},{"key":"10.1016\/j.jtos.2025.07.004_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1535370215597194","article-title":"Epithelial-mesenchymal transition: an emerging target in tissue fibrosis","volume":"241","author":"Li","year":"2016","journal-title":"Experimental biology and medicine (Maywood, NJ)"},{"key":"10.1016\/j.jtos.2025.07.004_bib28","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1167\/iovs.19-27469","article-title":"The effect of chloroquine on the development of dry eye in Sj\u00f6gren Syndrome animal model","volume":"60","author":"Lee","year":"2019","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2025.07.004_bib29","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.2353\/ajpath.2007.070388","article-title":"Autoimmune dacryoadenitis of NOD\/LtJ mice and its subsequent effects on tear protein composition","volume":"171","author":"Doyle","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2025.07.004_bib30","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jtos.2017.03.006","article-title":"TFOS DEWS II tear film report","volume":"15","author":"Willcox","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.07.004_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11010065","article-title":"Gut Microbiota-Derived PGF2\u03b1 fights against radiation-induced lung toxicity through the MAPK\/NF-\u03baB pathway","volume":"11","author":"Chen","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.jtos.2025.07.004_bib32","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1021\/acs.biomac.0c01468","article-title":"Intralacrimal sustained delivery of Rapamycin shows therapeutic effects without systemic toxicity in a mouse model of Autoimmune dacryoadenitis characteristic of Sj\u00f6gren's Syndrome","volume":"22","author":"Ju","year":"2021","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jtos.2025.07.004_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11123551","article-title":"Sj\u00f6gren's syndrome-related organs fibrosis: hypotheses and realities","volume":"11","author":"Sisto","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtos.2025.07.004_bib34","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ajo.2016.03.020","article-title":"Ocular manifestations of Stevens-Johnson Syndrome and toxic epidermal necrolysis in children","volume":"166","author":"Catt","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2025.07.004_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1133381","article-title":"Challenges and concepts in the diagnosis and management of ocular graft-versus-host disease","volume":"10","author":"Tappeiner","year":"2023","journal-title":"Front Med"},{"key":"10.1016\/j.jtos.2025.07.004_bib36","series-title":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","first-page":"491","article-title":"Clinical features of IgG4-related dacryoadenitis","volume":"252","author":"Koizumi","year":"2014"},{"key":"10.1016\/j.jtos.2025.07.004_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21145082","article-title":"The cellular and molecular bases of allergy, inflammation and tissue fibrosis in patients with IgG4-related disease","volume":"21","author":"Hsieh","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2025.07.004_bib38","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jtos.2023.06.008","article-title":"Epithelial-mesenchymal transition in the lacrimal gland morphogenesis, damage and repair","volume":"29","author":"Singh","year":"2023","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.07.004_bib39","article-title":"Dynamic ocular surface and lacrimal gland changes induced in experimental murine dry eye","volume":"10","author":"Xiao","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jtos.2025.07.004_bib40","first-page":"131","article-title":"The role of TGF-\u03b2 and epithelial-to mesenchymal transition in diabetic nephropathy","volume":"22","author":"Hills","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jtos.2025.07.004_bib41","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1165\/rcmb.2017-0075OC","article-title":"The rho kinase isoforms ROCK1 and ROCK2 each contribute to the development of experimental pulmonary fibrosis","volume":"58","author":"Knipe","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jtos.2025.07.004_bib42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1124\/pr.114.009381","article-title":"The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis","volume":"67","author":"Knipe","year":"2015","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jtos.2025.07.004_bib43","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/039463201402700106","article-title":"ROCK activation in lung of idiopathic pulmonary fibrosis with oxidative stress","volume":"27","author":"Shimizu","year":"2014","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.jtos.2025.07.004_bib44","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/bjp.2008.142","article-title":"Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes","volume":"154","author":"Liang","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jtos.2025.07.004_bib45","doi-asserted-by":"crossref","first-page":"8136","DOI":"10.1038\/s41467-023-43922-8","article-title":"Structures of human prostaglandin F(2\u03b1) receptor reveal the mechanism of ligand and G protein selectivity","volume":"14","author":"Lv","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jtos.2025.07.004_bib46","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1124\/pr.112.007088","article-title":"Recent progress in prostaglandin F2\u03b1 ethanolamide (prostamide F2\u03b1) research and therapeutics","volume":"65","author":"Woodward","year":"2013","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jtos.2025.07.004_bib47","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/bph.14335","article-title":"Prostaglandin FP receptor antagonists: discovery, pharmacological characterization and therapeutic utility","volume":"176","author":"Sharif","year":"2019","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jtos.2025.07.004_bib48","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1002\/jcb.25448","article-title":"DMSO enhances TGF-\u03b2 activity by recruiting the type II TGF-\u03b2 receptor from intracellular vesicles to the plasma membrane","volume":"117","author":"Huang","year":"2016","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jtos.2025.07.004_bib49","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1167\/iovs.09-4212","article-title":"Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland","volume":"52","author":"Pitcher","year":"2011","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2025.07.004_bib50","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","article-title":"TFOS DEWS II Diagnostic Methodology report","volume":"15","author":"Wolffsohn","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.07.004_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0275624","article-title":"Evaluation of dry eye symptoms and risk factors among medical students in Serbia","volume":"17","author":"A\u0107imovi\u0107","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.jtos.2025.07.004_bib52","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/ICL.0000000000001105","article-title":"Prevalence of computer vision syndrome and its risk factors in a Spanish university population","volume":"50","author":"Ortiz-Toquero","year":"2024","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.jtos.2025.07.004_bib53","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12886-018-0825-z","article-title":"Ocular surface health in Shanghai University students: a cross-sectional study","volume":"18","author":"Li","year":"2018","journal-title":"BMC Ophthalmol"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012425000928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012425000928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:28:50Z","timestamp":1778617730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012425000928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":53,"alternative-id":["S1542012425000928"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2025.07.004","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prostaglandin F2\u03b1 exacerbated dry eye by promoting lacrimal gland fibrosis progression through the activation of the RhoA\/ROCKs signaling pathway","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2025.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}