{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:52:34Z","timestamp":1783367554786,"version":"3.54.6"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018634","name":"State Key Laboratory of Ophthalmology","doi-asserted-by":"publisher","award":["2025QNJS27"],"award-info":[{"award-number":["2025QNJS27"]}],"id":[{"id":"10.13039\/501100018634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024A1515012562"],"award-info":[{"award-number":["2024A1515012562"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Provincial Medical Research Foundation","doi-asserted-by":"publisher","award":["A2025184"],"award-info":[{"award-number":["A2025184"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472143"],"award-info":[{"award-number":["82472143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372131"],"award-info":[{"award-number":["82372131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["201803010091"],"award-info":[{"award-number":["201803010091"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jtos.2025.08.009","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T03:22:31Z","timestamp":1756437751000},"page":"290-301","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Downregulation of the core circadian gene Nr1d2 in the lacrimal gland contributes to postoperative dry eye disease by impairing lipid metabolism"],"prefix":"10.1016","volume":"38","author":[{"given":"Shiji","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuke","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejie","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1943-5736","authenticated-orcid":false,"given":"Keming","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2025.08.009_bib1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jcrs.2007.08.028","article-title":"Referrals to the wills eye institute cornea service after laser in situ keratomileusis: reasons for patient dissatisfaction","volume":"34","author":"Levinson","year":"2008","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.jtos.2025.08.009_bib2","article-title":"Dry eye after LASIK","volume":"59","author":"Toda","year":"2018","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2025.08.009_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1542-0124(12)70043-5","article-title":"Utility assessment to measure the impact of dry eye disease","volume":"4","author":"Buchholz","year":"2006","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.08.009_bib4","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0886-3350(00)00571-X","article-title":"Results of flap repositioning after laser in situ keratomileusis","volume":"26","author":"Lyle","year":"2000","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.jtos.2025.08.009_bib5","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jcrs.2003.07.003","article-title":"Chronic dry eye and regression after laser in situ keratomileusis for myopia","volume":"30","author":"Albietz","year":"2004","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.jtos.2025.08.009_bib6","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ophtha.2014.10.004","article-title":"Dry eye disease after refractive surgery: comparative outcomes of small incision lenticule extraction versus LASIK","volume":"122","author":"Denoyer","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2025.08.009_bib7","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1016\/j.jcrs.2015.06.037","article-title":"Chronic dry eye in photorefractive keratectomy and laser in situ keratomileusis: manifestations, incidence, and predictive factors","volume":"41","author":"Bower","year":"2015","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.jtos.2025.08.009_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12886-015-0129-5","article-title":"Central corneal sensitivity after small incision lenticule extraction versus femtosecond laser-assisted LASIK for myopia: a meta-analysis of comparative studies","volume":"15","author":"He","year":"2015","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.jtos.2025.08.009_bib9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0002-9394(98)00444-9","article-title":"Corneal sensitivity after photorefractive keratectomy and laser in situ keratomileusis for low myopia","volume":"127","author":"P\u00e9rez-Santonja","year":"1999","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2025.08.009_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1167\/iovs.64.7.27","article-title":"Ferroptosis in the lacrimal gland is involved in dry eye syndrome induced by corneal nerve severing","volume":"64","author":"Liu","year":"2023","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2025.08.009_bib11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3109\/02713683.2013.865757","article-title":"Basal values, intra-day and inter-day variations in tear film osmolarity and tear fluorescein clearance","volume":"39","author":"Garc\u00eda","year":"2014","journal-title":"Curr Eye Res"},{"issue":"Pt 5","key":"10.1016\/j.jtos.2025.08.009_bib12","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/eye.1987.95","article-title":"Fluorophotometric measurements of tear turnover rate in normal healthy persons: evidence for a circadian rhythm","volume":"1","author":"Webber","year":"1987","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.jtos.2025.08.009_bib13","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2020.04.013","article-title":"Type 1 diabetes mellitus impairs diurnal oscillations in murine extraorbital lacrimal glands","volume":"18","author":"Jiao","year":"2020","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.08.009_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1167\/iovs.63.6.19","article-title":"Sleep loss causes dysfunction in murine extraorbital lacrimal glands","volume":"63","author":"Huang","year":"2022","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2025.08.009_bib15","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1167\/iovs.18-26030","article-title":"Short-term high fructose intake reprograms the transcriptional clock rhythm of the murine extraorbital lacrimal gland","volume":"60","author":"Lu","year":"2019","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2025.08.009_bib16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1167\/iovs.63.5.23","article-title":"High-fat nutritional challenge reshapes circadian signatures in murine extraorbital lacrimal glands","volume":"63","author":"Zou","year":"2022","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2025.08.009_bib17","doi-asserted-by":"crossref","first-page":"R355","DOI":"10.1152\/ajpregu.00498.2007","article-title":"Sympathetic input modulates, but does not determine, phase of peripheral circadian oscillators","volume":"295","author":"Vujovic","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jtos.2025.08.009_bib18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nn1419","article-title":"Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in Mammalian clock neurons","volume":"8","author":"Aton","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jtos.2025.08.009_bib19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature11030","article-title":"Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists","volume":"485","author":"Solt","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jtos.2025.08.009_bib20","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/s41385-018-0002-y","article-title":"Alteration in nerves and neurotransmitter stimulation of lacrimal gland secretion in the TSP-1(-\/-) mouse model of aqueous deficiency dry eye","volume":"11","author":"Bhattacharya","year":"2018","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jtos.2025.08.009_bib21","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jtos.2021.02.001","article-title":"Light cycle phase advance as a model for jet lag reprograms the circadian rhythms of murine extraorbital lacrimal glands","volume":"20","author":"Huang","year":"2021","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.08.009_bib22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","article-title":"TFOS DEWS II diagnostic methodology report","volume":"15","author":"Wolffsohn","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.08.009_bib23","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1126\/science.1150179","article-title":"Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways","volume":"318","author":"Yin","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jtos.2025.08.009_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196787","article-title":"Distinct roles for REV-ERB\u03b1 and REV-ERB\u03b2 in oxidative capacity and mitochondrial biogenesis in skeletal muscle","volume":"13","author":"Amador","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jtos.2025.08.009_bib25","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1172\/JCI93910","article-title":"Circadian clock component REV-ERB\u03b1 controls homeostatic regulation of pulmonary inflammation","volume":"128","author":"Pariollaud","year":"2018","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jtos.2025.08.009_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nature25170","article-title":"Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence","volume":"553","author":"Sulli","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jtos.2025.08.009_bib27","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/j.ajpath.2020.09.002","article-title":"High-fat diet\u2013induced functional and pathologic changes in lacrimal gland","volume":"190","author":"He","year":"2020","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2025.08.009_bib28","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/01.ico.0000183664.80004.44","article-title":"Identification of steroidogenic enzyme mRNAs in the human lacrimal gland, meibomian gland, cornea, and conjunctiva","volume":"25","author":"Schirra","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2025.08.009_bib29","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-neuro-060909-153128","article-title":"Central and peripheral circadian clocks in mammals","volume":"35","author":"Mohawk","year":"2012","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.jtos.2025.08.009_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41580-019-0179-2","article-title":"Molecular mechanisms and physiological importance of circadian rhythms","volume":"21","author":"Patke","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jtos.2025.08.009_bib31","doi-asserted-by":"crossref","first-page":"e451","DOI":"10.1038\/emm.2017.285","article-title":"Sleep deprivation disrupts the lacrimal system and induces dry eye disease","volume":"50","author":"Li","year":"2018","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jtos.2025.08.009_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpath.2021.08.006","article-title":"Microbial reconstitution improves aging-driven lacrimal gland circadian dysfunction","author":"Jiao","year":"2021","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2025.08.009_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108524","article-title":"Circadian clock regulates tear secretion in the lacrimal gland","volume":"206","author":"Vu","year":"2021","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2025.08.009_bib34","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jtos.2024.09.008","article-title":"BMAL1 deficiency provokes dry mouth and eyes by down-regulating ITPR2\/3","volume":"34","author":"Zhang","year":"2024","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.08.009_bib35","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.exer.2014.02.007","article-title":"Wounding the cornea to learn how it heals","volume":"121","author":"Stepp","year":"2014","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2025.08.009_bib36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41420-018-0066-1","article-title":"BRD4 inhibitor JQ1 inhibits and reverses mechanical injury-induced corneal scarring","volume":"4","author":"Qu","year":"2018","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.jtos.2025.08.009_bib37","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-1-4939-7113-8_8","article-title":"Mouse models of corneal scarring","volume":"1627","author":"Ritti\u00e9","year":"2017","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jtos.2025.08.009_bib38","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/ICU.0b013e3283009ef8","article-title":"Postrefractive surgery dry eye","volume":"19","author":"Quinto","year":"2008","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.jtos.2025.08.009_bib39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jtos.2013.09.001","article-title":"The role of corneal innervation in LASIK-Induced neuropathic dry eye","volume":"12","author":"Chao","year":"2014","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2025.08.009_bib40","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/ICU.0000000000000077","article-title":"Ocular surface diseases and corneal refractive surgery","volume":"25","author":"Garcia-Zalisnak","year":"2014","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.jtos.2025.08.009_bib41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jcjo.2019.07.005","article-title":"Dry eye after refractive surgery: a meta-analysis","volume":"55","author":"Sambhi","year":"2020","journal-title":"Can J Ophthalmol"},{"key":"10.1016\/j.jtos.2025.08.009_bib42","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/ICO.0b013e3181c11e45","article-title":"Diurnal variation of visual function and the signs and symptoms of dry eye","volume":"29","author":"Walker","year":"2010","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2025.08.009_bib43","article-title":"Diurnal variation on tear stability and correlation with tear cytokine concentration","volume":"45","author":"Arroyo-del Arroyo","year":"2022","journal-title":"Contact Lens Anterior Eye"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012425001090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012425001090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:36:54Z","timestamp":1772890614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012425001090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":43,"alternative-id":["S1542012425001090"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2025.08.009","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Downregulation of the core circadian gene Nr1d2 in the lacrimal gland contributes to postoperative dry eye disease by impairing lipid metabolism","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2025.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}