{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:31:36Z","timestamp":1792701096062,"version":"4.5.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U24EY035067"],"award-info":[{"award-number":["U24EY035067"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1S10OD036427"],"award-info":[{"award-number":["1S10OD036427"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA125123"],"award-info":[{"award-number":["P30CA125123"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["NIH-NIDDK - 5P30DK056338"],"award-info":[{"award-number":["NIH-NIDDK - 5P30DK056338"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY026893"],"award-info":[{"award-number":["R01EY026893"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["T32 EY007001"],"award-info":[{"award-number":["T32 EY007001"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["NIEHS-5P30ES030285-03"],"award-info":[{"award-number":["NIEHS-5P30ES030285-03"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP200504"],"award-info":[{"award-number":["RP200504"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007915","name":"Baylor College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005589","name":"Center for the Study of Democratic Politics, Princeton University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017017","name":"Hamill Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017017","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001315","name":"Sid W Richardson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001315","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jtos.2026.02.001","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T01:09:07Z","timestamp":1770253747000},"page":"52-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Investigating conjunctival immune pathways in Sj\u00f6gren and non-Sj\u00f6gren disease associated dry eye"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-8950","authenticated-orcid":false,"given":"Kaitlin K.","family":"Scholand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-2893","authenticated-orcid":false,"given":"Laura","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3782-4383","authenticated-orcid":false,"given":"Jianming","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0785-9822","authenticated-orcid":false,"given":"Zhiyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9341-3482","authenticated-orcid":false,"given":"Stephen C.","family":"Pflugfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8983-9539","authenticated-orcid":false,"given":"Robert A.","family":"Britton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-5494","authenticated-orcid":false,"given":"Cintia S.","family":"de Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11S","key":"10.1016\/j.jtos.2026.02.001_bib1","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.ophtha.2017.07.010","article-title":"The pathophysiology of dry eye disease: what we know and future directions for research","volume":"124","author":"Pflugfelder","year":"2017","journal-title":"Ophthalmology"},{"issue":"23","key":"10.1016\/j.jtos.2026.02.001_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21239271","article-title":"Defining dry eye from a clinical perspective","volume":"21","author":"Tsubota","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jtos.2026.02.001_bib3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul Surf"},{"issue":"3","key":"10.1016\/j.jtos.2026.02.001_bib4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jtos.2017.05.002","article-title":"TFOS DEWS II pain and sensation report","volume":"15","author":"Belmonte","year":"2017","journal-title":"Ocul Surf"},{"issue":"12","key":"10.1016\/j.jtos.2026.02.001_bib5","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/eye.2016.186","article-title":"Depression and anxiety in dry eye disease: a systematic review and meta-analysis","volume":"30","author":"Wan","year":"2016","journal-title":"Eye (Lond)"},{"issue":"3","key":"10.1016\/j.jtos.2026.02.001_bib6","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"issue":"5","key":"10.1016\/j.jtos.2026.02.001_bib7","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/art.1780290501","article-title":"Sjogren's syndrome. Proposed criteria for classification","volume":"29","author":"Fox","year":"1986","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.47","article-title":"Sj\u00f6gren syndrome","volume":"2","author":"Brito-Zer\u00f3n","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"10.1016\/j.jtos.2026.02.001_bib9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1080\/03009740802001426","article-title":"Primary Sjogren's syndrome in men","volume":"37","author":"Gondran","year":"2008","journal-title":"Scand J Rheumatol"},{"issue":"2","key":"10.1016\/j.jtos.2026.02.001_bib10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1542-0124(12)70085-X","article-title":"Management and therapy of dry eye disease: report of the management and therapy subcommittee of the international dry eye WorkShop (2007)","volume":"5","author":"Pflugfelder","year":"2007","journal-title":"Ocul Surf"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib11","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.1038\/s41598-021-83550-0","article-title":"Association between EBV serological patterns and lymphocytic profile of SjS patients support a virally triggered autoimmune epithelitis","volume":"11","author":"Barcelos","year":"2021","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.jtos.2026.02.001_bib12","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1136\/annrheumdis-2013-203305","article-title":"Primary sjogren's syndrome and malignancy risk: a systematic review and meta-analysis","volume":"73","author":"Liang","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jtos.2026.02.001_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.702755","article-title":"Differentially expressed gene pathways in the conjunctiva of Sjogren Syndrome Keratoconjunctivitis sicca","volume":"12","author":"de Paiva","year":"2021","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.jtos.2026.02.001_bib14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1074-7613(00)80615-9","article-title":"A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment","volume":"9","author":"de Saint-Vis","year":"1998","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.jtos.2026.02.001_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092760","article-title":"Severity of Sjogren's Syndrome Keratoconjunctivitis sicca increases with increased percentage of conjunctival antigen-presenting cells","volume":"19","author":"Pflugfelder","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.jtos.2026.02.001_bib16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/tvst.12.6.8","article-title":"Differentially expressed tear proteins in Sjogren's Syndrome Keratoconjunctivitis sicca","volume":"12","author":"Yoon","year":"2023","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.jtos.2026.02.001_bib17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jaut.2015.07.002","article-title":"Type I and II interferon signatures in Sjogren's syndrome pathogenesis: contributions in distinct clinical phenotypes and Sjogren's related lymphomagenesis","volume":"63","author":"Nezos","year":"2015","journal-title":"J Autoimmun"},{"issue":"7","key":"10.1016\/j.jtos.2026.02.001_bib18","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1002\/eji.200738008","article-title":"Systemic increase in type I interferon activity in Sjogren's syndrome: a putative role for plasmacytoid dendritic cells","volume":"38","author":"Wildenberg","year":"2008","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1016\/j.jtos.2026.02.001_bib19","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/art.20998","article-title":"Activation of the type I interferon system in primary Sjogren's syndrome: a possible etiopathogenic mechanism","volume":"52","author":"Bave","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib20","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1016\/j.tripleo.2008.09.015","article-title":"Association between IFN-alpha and primary Sjogren's syndrome","volume":"107","author":"Zheng","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"10","key":"10.1016\/j.jtos.2026.02.001_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103259","article-title":"Type I interferon signaling is required for dacryoadenitis in the Nonobese diabetic mouse model of Sjogren Syndrome","volume":"19","author":"Chaly","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.jtos.2026.02.001_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073767","article-title":"Characterization of type I interferon-associated chemokines and cytokines in lacrimal glands of Nonobese diabetic mice","volume":"22","author":"Allred","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib23","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1038\/s41598-022-08442-3","article-title":"Gut-derived butyrate suppresses ocular surface inflammation","volume":"12","author":"Schaefer","year":"2022","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.jtos.2026.02.001_bib24","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1177\/0022034513483315","article-title":"Type I interferon receptor deficiency prevents murine Sjogren's syndrome","volume":"92","author":"Szczerba","year":"2013","journal-title":"J Dent Res"},{"issue":"4","key":"10.1016\/j.jtos.2026.02.001_bib25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1167\/iovs.66.4.80","article-title":"Conjunctival MicroRNA expression signature in primary Sjogren's Syndrome dry eye: a NanoString-Based bioinformatic analysis","volume":"66","author":"Giovannetti","year":"2025","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"18","key":"10.1016\/j.jtos.2026.02.001_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11185405","article-title":"Interferon gamma targeted therapy: is it justified in primary Sjogren's Syndrome?","volume":"11","author":"Sebastian","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtos.2026.02.001_bib27","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.12659\/MSM.912010","article-title":"Tear luminex analysis in dry eye patients","volume":"24","author":"Zhao","year":"2018","journal-title":"Med Sci Monit"},{"issue":"12","key":"10.1016\/j.jtos.2026.02.001_bib28","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1167\/iovs.15-17627","article-title":"Aqueous tear deficiency increases conjunctival interferon-gamma (IFN-gamma) expression and goblet cell loss","volume":"56","author":"Pflugfelder","year":"2015","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib29","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1038\/s41598-019-43714-5","article-title":"Elevated cytokine levels in tears and saliva of patients with primary Sj\u00f6gren\u2019s syndrome correlate with clinical ocular and oral manifestations","volume":"9","author":"Chen","year":"2019","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.jtos.2026.02.001_bib30","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1167\/iovs.10-7081","article-title":"Interferon-gamma exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways","volume":"52","author":"Zhang","year":"2011","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"10","key":"10.1016\/j.jtos.2026.02.001_bib31","first-page":"2199","article-title":"Interferon-gamma induces apoptosis and expression of inflammation-related proteins in Chang conjunctival cells","volume":"40","author":"De Saint Jean","year":"1999","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.jtos.2026.02.001_bib32","doi-asserted-by":"crossref","first-page":"C1191","DOI":"10.1152\/ajpcell.00144.2008","article-title":"Proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma alter tight junction structure and function in the rat parotid gland Par-C10 cell line","volume":"295","author":"Baker","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"issue":"6","key":"10.1016\/j.jtos.2026.02.001_bib33","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1167\/iovs.07-0069","article-title":"Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma","volume":"48","author":"De Paiva","year":"2007","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib34","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-015-0582-9","article-title":"Altered balance of interleukin-13\/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjogren's syndrome","volume":"17","author":"Bian","year":"2015","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"10.1016\/j.jtos.2026.02.001_bib35","doi-asserted-by":"crossref","DOI":"10.1186\/ar4077","article-title":"Deletion of interferon-gamma delays onset and severity of dacryoadenitis in CD25KO mice","volume":"14","author":"Pelegrino","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"9","key":"10.1016\/j.jtos.2026.02.001_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184781","article-title":"Interferon-gamma treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjogren's Syndrome","volume":"12","author":"Meng","year":"2017","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.jtos.2026.02.001_bib37","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1093\/rheumatology\/kez004","article-title":"T cells in primary Sjogren's syndrome: targets for early intervention","volume":"60","author":"Verstappen","year":"2019","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/glia.1096","article-title":"Upregulation of transcription factors controlling MHC expression in multiple sclerosis lesions","volume":"36","author":"Gobin","year":"2001","journal-title":"Glia"},{"issue":"39","key":"10.1016\/j.jtos.2026.02.001_bib39","doi-asserted-by":"crossref","first-page":"14465","DOI":"10.1073\/pnas.0606450103","article-title":"Aberrant MHC class II expression in mouse joints leads to arthritis with extraarticular manifestations similar to rheumatoid arthritis","volume":"103","author":"Kanazawa","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.jtos.2026.02.001_bib40","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/annrheumdis-2013-203717","article-title":"Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming","volume":"74","author":"Rupanagudi","year":"2015","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"10.1016\/j.jtos.2026.02.001_bib41","doi-asserted-by":"crossref","DOI":"10.1093\/immhor\/vlaf030","article-title":"Exploring MHC class II I-Ab blockade as a potential treatment for Sjogren's disease in the mouse model","volume":"9","author":"Voigt","year":"2025","journal-title":"Immunohorizons"},{"issue":"11","key":"10.1016\/j.jtos.2026.02.001_bib42","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.4049\/jimmunol.158.11.5527","article-title":"Up-regulation of cytokine mRNA, adhesion molecule proteins, and MHC class II proteins in salivary glands of TGF-beta1 knockout mice: MHC class II is a factor in the pathogenesis of TGF-beta1 knockout mice","volume":"158","author":"Nakabayashi","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jtos.2026.02.001_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02271","article-title":"Conjunctival inflammatory gene expression profiling in dry eye disease: correlations with HLA-DRA and HLA-DRB1","volume":"9","author":"Kessal","year":"2018","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1084\/jem.20050198","article-title":"Restricted MHC-peptide repertoire predisposes to autoimmunity","volume":"202","author":"Logunova","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jtos.2026.02.001_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120182","article-title":"Blocking IAg(7) class II major histocompatibility complex by drug-like small molecules alleviated Sjogren's syndrome in NOD mice","volume":"288","author":"Gupta","year":"2022","journal-title":"Life Sci"},{"issue":"9","key":"10.1016\/j.jtos.2026.02.001_bib46","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.tim.2010.06.010","article-title":"BST-2\/tetherin: a new component of the innate immune response to enveloped viruses","volume":"18","author":"Evans","year":"2010","journal-title":"Trends Microbiol"},{"issue":"11","key":"10.1016\/j.jtos.2026.02.001_bib47","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/j.jcms.2018.08.008","article-title":"Aberrant expression of the innate restriction factor bone marrow stromal antigen-2 in primary Sjogren's syndrome","volume":"46","author":"Chen","year":"2018","journal-title":"J Craniomaxillofac Surg"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112399","article-title":"BST-2\/Tetherin is involved in BAFF-enhanced proliferation and survival via canonical NF-kappaB signaling in neoplastic B-lymphoid cells","volume":"398","author":"Fu","year":"2021","journal-title":"Exp Cell Res"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib49","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41467-024-54686-0","article-title":"Molecular and spatial analysis of tertiary lymphoid structures in Sjogren's syndrome","volume":"16","author":"Nayar","year":"2025","journal-title":"Nat Commun"},{"issue":"14","key":"10.1016\/j.jtos.2026.02.001_bib50","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70713","article-title":"Featured immune characteristics of periodontitis and primary Sjogren's Syndrome revealed by single-cell transcriptome analyses","volume":"29","author":"Li","year":"2025","journal-title":"J Cell Mol Med"},{"issue":"6","key":"10.1016\/j.jtos.2026.02.001_bib51","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/(SICI)1097-0215(19960315)65:6<740::AID-IJC5>3.0.CO;2-Z","article-title":"Biliary glycoprotein (BGP) expression on T cells and on a natural-killer-cell sub-population","volume":"65","author":"M\u00f6ller","year":"1996","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.jtos.2026.02.001_bib52","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/rheumatology\/kep357","article-title":"Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice","volume":"49","author":"De Paiva","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jtos.2026.02.001_bib53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jtos.2023.07.008","article-title":"Conditional deletion of CD25 in the corneal epithelium reveals sex differences in barrier disruption","volume":"30","author":"Abu-Romman","year":"2023","journal-title":"Ocul Surf"},{"issue":"142","key":"10.1016\/j.jtos.2026.02.001_bib54","article-title":"The interferon-signature of Sj\u00f6gren\u2019s syndrome: how unique biomarkers can identify underlying inflammatory and immunopathological mechanisms of specific diseases","volume":"4","author":"Nguyen","year":"2013","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.jtos.2026.02.001_bib55","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1365-2249.2004.02562.x","article-title":"Relationship between serum levels of IL-18 and IgG1 in patients with primary Sjogren's syndrome, rheumatoid arthritis and healthy controls","volume":"137","author":"Eriksson","year":"2004","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"10.1016\/j.jtos.2026.02.001_bib56","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.4049\/jimmunol.181.4.2898","article-title":"Identification of IL-18 and Th17 cells in salivary glands of patients with Sjogren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18","volume":"181","author":"Sakai","year":"2008","journal-title":"J Immunol"},{"issue":"12","key":"10.1016\/j.jtos.2026.02.001_bib57","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1002\/art.23073","volume":"56","author":"Manoussakis","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.jtos.2026.02.001_bib58","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1136\/annrheumdis-2015-208659","article-title":"Genome-wide DNA methylation analysis in multiple tissues in primary Sjogren's syndrome reveals regulatory effects at interferon-induced genes","volume":"75","author":"Imgenberg-Kreuz","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib59","doi-asserted-by":"crossref","first-page":"8299","DOI":"10.1038\/s41467-025-63935-9","article-title":"Comparative single-cell and spatial profiling of anti-SSA-positive and anti-centromere-positive Sjogren's disease reveals common and distinct immune activation and fibroblast-mediated inflammation","volume":"16","author":"Inamo","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.jtos.2026.02.001_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109251","article-title":"Ectopic lymphoid structures in the aged lacrimal glands","author":"Galletti","year":"2023","journal-title":"Clin Immunol"},{"issue":"8","key":"10.1016\/j.jtos.2026.02.001_bib61","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1136\/annrheumdis-2020-219649","article-title":"Lysosome-associated membrane protein 3 misexpression in salivary glands induces a Sjogren's syndrome-like phenotype in mice","volume":"80","author":"Nakamura","year":"2021","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-71669-5","article-title":"LAMP3 induces apoptosis and autoantigen release in Sjogren's syndrome patients","volume":"10","author":"Tanaka","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib63","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000027387","article-title":"Conjunctival epithelium expression of HLA-DR in dry eye patients","volume":"213","author":"Tsubota","year":"1999","journal-title":"Ophthalmologica"},{"issue":"4","key":"10.1016\/j.jtos.2026.02.001_bib64","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1167\/tvst.8.4.31","article-title":"Conjunctival HLA-DR expression and its Association with symptoms and signs in the DREAM Study","volume":"8","author":"Roy","year":"2019","journal-title":"Transl Vis Sci Technol"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib65","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/art.39859","article-title":"2016 American college of rheumatology\/european league against rheumatism classification criteria for primary Sjogren's Syndrome: a consensus and data-driven methodology involving three international patient cohorts","volume":"69","author":"Shiboski","year":"2017","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"10.1016\/j.jtos.2026.02.001_bib66","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1167\/iovs.09-3875","article-title":"Association between high tear epidermal growth factor levels and corneal subepithelial fibrosis in dry eye conditions","volume":"51","author":"Rao","year":"2010","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.jtos.2026.02.001_bib67","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ajo.2013.09.024","article-title":"Tear meniscus dimensions in tear dysfunction and their correlation with clinical parameters","volume":"157","author":"Tung","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2026.02.001_bib68","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/1471-2164-13-296","article-title":"ReadqPCR and NormqPCR: r packages for the reading, quality checking and normalisation of RT-qPCR quantification cycle (Cq) data","volume":"13","author":"Perkins","year":"2012","journal-title":"BMC Genom"},{"key":"10.1016\/j.jtos.2026.02.001_bib69","series-title":"Fpc: flexible procedures for clustering","author":"Hennig","year":"2024"},{"key":"10.1016\/j.jtos.2026.02.001_bib70","series-title":"Enrichment analysis for gene ontology","author":"Alexa","year":"2024"},{"issue":"D1","key":"10.1016\/j.jtos.2026.02.001_bib71","doi-asserted-by":"crossref","first-page":"D351","DOI":"10.1093\/nar\/gky1100","article-title":"InterPro in 2019: improving coverage, classification and access to protein sequence annotations","volume":"47","author":"Mitchell","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"10.1016\/j.jtos.2026.02.001_bib72","doi-asserted-by":"crossref","first-page":"D492","DOI":"10.1093\/nar\/gkp858","article-title":"The NCBI BioSystems database","volume":"38","author":"Geer","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"43","key":"10.1016\/j.jtos.2026.02.001_bib73","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.jtos.2026.02.001_bib74","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"issue":"D1","key":"10.1016\/j.jtos.2026.02.001_bib75","doi-asserted-by":"crossref","first-page":"D649","DOI":"10.1093\/nar\/gkx1132","article-title":"The reactome pathway knowledgebase","volume":"46","author":"Fabregat","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"10.1016\/j.jtos.2026.02.001_bib76","doi-asserted-by":"crossref","first-page":"D661","DOI":"10.1093\/nar\/gkx1064","article-title":"WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research","volume":"46","author":"Slenter","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.jtos.2026.02.001_bib77","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jtos.2026.02.001_bib78","author":"Oliveros"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012426000182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012426000182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:44:44Z","timestamp":1782189884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012426000182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":78,"alternative-id":["S1542012426000182"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2026.02.001","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating conjunctival immune pathways in Sj\u00f6gren and non-Sj\u00f6gren disease associated dry eye","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2026.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}