{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:14:08Z","timestamp":1792196048069,"version":"4.4.0"},"reference-count":300,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["F251030"],"award-info":[{"award-number":["F251030"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371026"],"award-info":[{"award-number":["82371026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560202"],"award-info":[{"award-number":["82560202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["BYSYZHKC2023110"],"award-info":[{"award-number":["BYSYZHKC2023110"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009399","name":"Peking University Third Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jtos.2026.06.003","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:33:47Z","timestamp":1781076827000},"page":"185-202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Dysregulated lipid metabolism in dry eye disease: Pathophysiological mechanisms and emerging treatments"],"prefix":"10.1016","volume":"41","author":[{"given":"Hongyu","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peien","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baikai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Chul","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3066-8020","authenticated-orcid":false,"given":"Hong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2026.06.003_bib1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ajo.2025.05.033","article-title":"Tfos DEWS III: diagnostic methodology","volume":"279","author":"Wolffsohn","year":"2025","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00003226-200303000-00002","article-title":"Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component","volume":"22","author":"Barabino","year":"2003","journal-title":"Cornea"},{"issue":"Suppl","key":"10.1016\/j.jtos.2026.06.003_bib3","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1194\/jlr.R800095-JLR200","article-title":"Update of the LIPID MAPS comprehensive classification system for lipids","volume":"50","author":"Fahy","year":"2009","journal-title":"J Lipid Res"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aopr.2024.08.003","article-title":"The alterations of ocular surface metabolism and the related immunity inflammation in dry eye","volume":"5","author":"Wan","year":"2025","journal-title":"Adv Ophthalmol Pract Res"},{"issue":"5","key":"10.1016\/j.jtos.2026.06.003_bib5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/02713680802018419","article-title":"Understanding and analyzing meibomian lipids--a review","volume":"33","author":"Butovich","year":"2008","journal-title":"Curr Eye Res"},{"issue":"5","key":"10.1016\/j.jtos.2026.06.003_bib6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/cxo.12597","article-title":"Tear film evaluation and management in soft contact lens wear: a systematic approach","volume":"100","author":"Downie","year":"2017","journal-title":"Clin Exp Optom"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1542-0124(12)70138-6","article-title":"Meibomian gland function and the tear lipid layer","volume":"1","author":"McCulley","year":"2003","journal-title":"Ocul Surf"},{"issue":"9","key":"10.1016\/j.jtos.2026.06.003_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25094782","article-title":"Meibum lipidomic analysis in evaporative dry eye subjects","volume":"25","author":"Garcia-Queiruga","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1167\/iovs.11-8551","article-title":"Differences in human meibum lipid composition with meibomian gland dysfunction using NMR and principal component analysis","volume":"53","author":"Borchman","year":"2012","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"8","key":"10.1016\/j.jtos.2026.06.003_bib10","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.1167\/iovs.12-10317","article-title":"Quantitative profiling of major neutral lipid classes in human meibum by direct infusion electrospray ionization mass spectrometry","volume":"54","author":"Chen","year":"2013","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bpj.2021.12.033","article-title":"Biophysical properties of tear film lipid layer I. Surface tension and surface rheology","volume":"121","author":"Xu","year":"2022","journal-title":"Biophys J"},{"key":"10.1016\/j.jtos.2026.06.003_bib12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.chroma.2014.04.082","article-title":"Rapid identification of fatty acids and (O-acyl)-\u03c9-hydroxy fatty acids in human meibum by liquid chromatography\/high-resolution mass spectrometry","volume":"1347","author":"Mori","year":"2014","journal-title":"J Chromatogr, A"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1194\/jlr.M044826","article-title":"Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles","volume":"55","author":"Lam","year":"2014","journal-title":"J Lipid Res"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2022.184102","article-title":"A biophysical study of tear film lipid layer model membranes","volume":"1865","author":"Keramatnejad","year":"2023","journal-title":"Biochim Biophys Acta Biomembr"},{"issue":"10","key":"10.1016\/j.jtos.2026.06.003_bib15","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/j.bbamem.2016.02.020","article-title":"Tear film lipid layer: a molecular level view","volume":"1858","author":"Cwiklik","year":"2016","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"10.1016\/j.jtos.2026.06.003_bib16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jtos.2025.08.006","article-title":"Two models of the structures of the lamellae in human meibum and the tear film lipid layer, TFLL","volume":"38","author":"King-Smith","year":"2025","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2026.06.003_bib17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jtos.2021.12.011","article-title":"Characterization of the thickness of the tear film lipid layer in meibomian gland dysfunction using high resolution optical microscopy","volume":"24","author":"Bai","year":"2022","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2026.06.003_bib18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.exer.2017.03.013","article-title":"Structure-function relationship of tear film lipid layer: a contemporary perspective","volume":"163","author":"Georgiev","year":"2017","journal-title":"Exp Eye Res"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib19","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s40123-023-00669-1","article-title":"Dry eye disease associated with meibomian gland dysfunction: focus on tear film characteristics and the therapeutic landscape","volume":"12","author":"Sheppard","year":"2023","journal-title":"Ophthalmol Ther"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.exer.2003.09.019","article-title":"Functional aspects of the tear film lipid layer","volume":"78","author":"Bron","year":"2004","journal-title":"Exp Eye Res"},{"issue":"12","key":"10.1016\/j.jtos.2026.06.003_bib21","doi-asserted-by":"crossref","first-page":"5319","DOI":"10.1167\/iovs.07-1407","article-title":"Rheology of tear film lipid layer spread in normal and aqueous tear-deficient dry eyes","volume":"49","author":"Yokoi","year":"2008","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.06.003_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jtos.2025.02.003","article-title":"Effects of blinking exercises on palpebral fissure height and tear film parameters","volume":"36","author":"Arita","year":"2025","journal-title":"Ocul Surf"},{"issue":"17","key":"10.1016\/j.jtos.2026.06.003_bib23","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1038\/s41433-023-02557-1","article-title":"Tear film lipid layer and corneal oxygenation: a new function?","volume":"37","author":"Yazdani","year":"2023","journal-title":"Eye (lond Engl)"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib24","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1167\/iovs.10-6997b","article-title":"The international workshop on meibomian gland dysfunction: report of the definition and classification subcommittee","volume":"52","author":"Nelson","year":"2011","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.jtos.2026.06.003_bib25","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/ICO.0b013e318225415a","article-title":"Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study","volume":"31","author":"Lemp","year":"2012","journal-title":"Cornea"},{"issue":"2 Suppl","key":"10.1016\/j.jtos.2026.06.003_bib26","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jtos.2014.02.002","article-title":"Rethinking dry eye disease: a perspective on clinical implications","volume":"12","author":"Bron","year":"2014","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2026.06.003_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/542549","article-title":"Differential effects of dry eye disorders on metabolomic profile by 1H nuclear magnetic resonance spectroscopy","volume":"2014","author":"Galbis-Estrada","year":"2014","journal-title":"Biomed Res Int"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib28","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/bjophthalmol-2018-313379","article-title":"Dynamic assessment of the tear film muco-aqueous and lipid layers using a novel tear film imager (TFI)","volume":"104","author":"Segev","year":"2020","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib29","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/ICO.0000000000001101","article-title":"Automated measurement of tear film dynamics and lipid layer thickness for assessment of non-sj\u00f6gren dry eye syndrome with meibomian gland dysfunction","volume":"36","author":"Ji","year":"2017","journal-title":"Cornea"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib30","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jcjo.2019.03.005","article-title":"Value of lipid layer thickness and blinking pattern in approaching patients with dry eye symptoms","volume":"54","author":"Chou","year":"2019","journal-title":"Can J Ophthalmol, J Can ophtalmol"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jtos.2019.02.008","article-title":"Ellipsometry of human tears","volume":"17","author":"Glasgow","year":"2019","journal-title":"Ocul Surf"},{"issue":"12","key":"10.1016\/j.jtos.2026.06.003_bib32","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1167\/iovs.18-24690","article-title":"Spontaneous eye blink patterns in dry eye: clinical correlations","volume":"59","author":"Su","year":"2018","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib33","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/ICO.0000000000003659","article-title":"Aqueous-deficient dry eye increases lipid layer thickness measured by dynamic tear interferometry","volume":"44","author":"Ahn","year":"2024","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2026.06.003_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108189","article-title":"Delineating a novel metabolic high triglycerides-low waxes syndrome that affects lipid homeostasis in meibomian and sebaceous glands","volume":"199","author":"Butovich","year":"2020","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2026.06.003_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108713","article-title":"A spectroscopic approach to measuring meibum lipid composition and conformation in donors with sj\u04e7gren\u2019s syndrome","volume":"210","author":"Ewurum","year":"2021","journal-title":"Exp Eye Res"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib36","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.clae.2019.09.005","article-title":"Effect of the bruder moist heat eye compress on contact lens discomfort in contact lens wearers: an open-label randomized clinical trial","volume":"42","author":"Tichenor","year":"2019","journal-title":"Contact Lens Anterior Eye : J Br Contact Lens Assoc"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib37","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jtos.2018.12.005","article-title":"Human meibum chain branching variability with age, gender and meibomian gland dysfunction","volume":"17","author":"Borchman","year":"2019","journal-title":"Ocul Surf"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib38","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/ICO.0000000000002095","article-title":"Differences in meibum and tear lipid composition and conformation","volume":"39","author":"Borchman","year":"2020","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2026.06.003_bib39","article-title":"Meibum lipid hydrocarbon chain branching and rheology after hematopoietic stem cell transplantation","volume":"23","author":"Mudgil","year":"2020","journal-title":"Biochem Biophys Rep"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib40","article-title":"Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals","volume":"1866","author":"Tanno","year":"2021","journal-title":"Biochim Biophys Acta, Mol Cell Biol Lipids"},{"issue":"11","key":"10.1016\/j.jtos.2026.06.003_bib41","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1167\/iovs.64.11.20","article-title":"Comparative biophysical study of meibomian lipids of wild type and Soat1-null mice: implications to meibomian gland dysfunction and dry eye disease","volume":"64","author":"Xu","year":"2023","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib42","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.3390\/ijms22041583","article-title":"Depletion of cholesteryl esters causes meibomian gland dysfunction-like symptoms in a Soat1-null mouse model","volume":"22","author":"Butovich","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2026.06.003_bib43","doi-asserted-by":"crossref","unstructured":"Butovich DIA. Lipid composition determines thermotropic properties of meibum of animals and humans with meibomian gland disorders. Published online 2025. doi:10.1101\/2025.08.25.672195.","DOI":"10.1101\/2025.08.25.672195"},{"key":"10.1016\/j.jtos.2026.06.003_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2025.110703","article-title":"Abnormal meibum is associated with SREBF1 mutation and IFAP syndrome-2","volume":"262","author":"Butovich","year":"2026","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2026.06.003_bib45","article-title":"Concentration dependent cholesteryl-ester and wax-ester structural relationships and meibomian gland dysfunction","volume":"21","author":"Za","year":"2020","journal-title":"Biochem Biophys Rep"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib46","first-page":"21","article-title":"Meibum lipid composition and conformation in parkinsonism","volume":"12","author":"Blinchevsky","year":"2021","journal-title":"EC ophthalmol"},{"issue":"9","key":"10.1016\/j.jtos.2026.06.003_bib47","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1097\/ICO.0000000000001935","article-title":"Structural differences in meibum from donors after hematopoietic stem cell transplantations","volume":"38","author":"Ramasubramanian","year":"2019","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2026.06.003_bib48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.exer.2013.08.012","article-title":"Lipid order, saturation and surface property relationships: a study of human meibum saturation","volume":"116","author":"Mudgil","year":"2013","journal-title":"Exp Eye Res"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib49","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jtos.2020.06.001","article-title":"Interactions of polar lipids with cholesteryl ester multilayers elucidate tear film lipid layer structure","volume":"18","author":"Paananen","year":"2020","journal-title":"Ocul Surf"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib50","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1167\/iovs.12-10662","article-title":"Disruption and destabilization of meibomian lipid films caused by increasing amounts of ceramides and cholesterol","volume":"54","author":"Arciniega","year":"2013","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"11","key":"10.1016\/j.jtos.2026.06.003_bib51","doi-asserted-by":"crossref","first-page":"6881","DOI":"10.1167\/iovs.12-10516","article-title":"Toward an animal model of the human tear film: biochemical comparison of the mouse, canine, rabbit, and human meibomian lipidomes","volume":"53","author":"Butovich","year":"2012","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"8","key":"10.1016\/j.jtos.2026.06.003_bib52","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1167\/iovs.14-16254","article-title":"Meibum color and free fatty acid composition in patients with meibomian gland dysfunction","volume":"56","author":"Arita","year":"2015","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.06.003_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2025.1717118","article-title":"Alterations in the composition of meibomian gland secretions in patients with meibomian gland dysfunction based on raman spectroscopy","volume":"12","author":"Ou","year":"2025","journal-title":"Front Med"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib54","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.chemphyslip.2011.05.002","article-title":"Functional lipidomics of oxidized products from polyunsaturated fatty acids","volume":"164","author":"Guichardant","year":"2011","journal-title":"Chem Phys Lipids"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib55","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/bjo.2007.126144","article-title":"Differences in meibomian fatty acid composition in patients with meibomian gland dysfunction and aqueous-deficient dry eye","volume":"92","author":"Joffre","year":"2008","journal-title":"Br J Ophthalmol"},{"issue":"10","key":"10.1016\/j.jtos.2026.06.003_bib56","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/iovs.64.10.22","article-title":"Relationship between human meibum lipid composition and the severity of meibomian gland dysfunction: a spectroscopic analysis","volume":"64","author":"Nagar","year":"2023","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib57","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jdermsci.2011.06.015","article-title":"Dermal carbonyl modification is related to the yellowish color change of photo-aged japanese facial skin","volume":"64","author":"Ogura","year":"2011","journal-title":"J Dermatol Sci"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib58","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.exer.2010.05.014","article-title":"Changes in human meibum lipid with meibomian gland dysfunction using principal component analysis","volume":"91","author":"Borchman","year":"2010","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2026.06.003_bib59","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jtos.2023.11.005","article-title":"Modeling meibum secretion: alternatives for obstructive meibomian gland dysfunction (MGD)","volume":"31","author":"Luo","year":"2024","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2026.06.003_bib60","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.exer.2013.06.016","article-title":"An investigation of the likely role of (O-acyl) \u03c9-hydroxy fatty acids in meibomian lipid films using (O-oleyl) \u03c9-hydroxy palmitic acid as a model","volume":"115","author":"Schuett","year":"2013","journal-title":"Exp Eye Res"},{"issue":"5","key":"10.1016\/j.jtos.2026.06.003_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019553","article-title":"Human tear fluid lipidome: from composition to function","volume":"6","author":"Rantam\u00e4ki","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib62","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bpj.2021.12.034","article-title":"Biophysical properties of tear film lipid layer II. Polymorphism of FAHFA","volume":"121","author":"Xu","year":"2022","journal-title":"Biophys J"},{"key":"10.1016\/j.jtos.2026.06.003_bib63","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.53582","article-title":"Lipid polarity gradient formed by \u03c9-hydroxy lipids in tear film prevents dry eye disease","volume":"9","author":"Miyamoto","year":"2020","journal-title":"eLife"},{"issue":"10","key":"10.1016\/j.jtos.2026.06.003_bib64","doi-asserted-by":"crossref","first-page":"13792","DOI":"10.1096\/fj.202001191R","article-title":"Deficiency in acyl-CoA:wax alcohol acyltransferase 2 causes evaporative dry eye disease by abolishing biosynthesis of wax esters","volume":"34","author":"Widjaja-Adhi","year":"2020","journal-title":"FASEB J: off publ Fed Am Soc Exp Biol"},{"key":"10.1016\/j.jtos.2026.06.003_bib65","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jtos.2024.10.003","article-title":"Meibomian gland lipid alterations and ocular surface sequela in Awat2 knockout murine model of meibomian gland dysfunction and evaporative dry eye disease","volume":"34","author":"Hisey","year":"2024","journal-title":"Ocul Surf"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib66","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101733R","article-title":"Formation of fatty alcohols-components of meibum lipids-by the fatty acyl-CoA reductase FAR2 is essential for dry eye prevention","volume":"36","author":"Otsuka","year":"2022","journal-title":"FASEB J : Off Publ Fed Am Soc Exp Biol"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib67","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1001\/archopht.121.2.173","article-title":"Differentiation of lipid tear deficiency dry eye by kinetic analysis of tear interference images","volume":"121","author":"Goto","year":"2003","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib68","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1167\/iovs.04-0913","article-title":"Tear film dynamics in floppy eyelid syndrome","volume":"46","author":"Liu","year":"2005","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092461","article-title":"Organization of lipids in the tear film: a molecular-level view","volume":"9","author":"Wizert","year":"2014","journal-title":"PLoS One"},{"issue":"30","key":"10.1016\/j.jtos.2026.06.003_bib70","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1039\/C4SM00758A","article-title":"Surface relaxations as a tool to distinguish the dynamic interfacial properties of films formed by normal and diseased meibomian lipids","volume":"10","author":"Georgiev","year":"2014","journal-title":"Soft Matter"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib71","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1167\/iovs.10-6514","article-title":"Human meibum lipid conformation and thermodynamic changes with meibomian-gland dysfunction","volume":"52","author":"Borchman","year":"2011","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"20","key":"10.1016\/j.jtos.2026.06.003_bib72","doi-asserted-by":"crossref","first-page":"11728","DOI":"10.1021\/la8016485","article-title":"Effect of lysozyme adsorption on the interfacial rheology of DPPC and cholesteryl myristate films","volume":"24","author":"Nishimura","year":"2008","journal-title":"Langmuir: ACS j surf colloids"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib73","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jtos.2014.12.004","article-title":"Spontaneous blinking from a tribological viewpoint","volume":"13","author":"Pult","year":"2015","journal-title":"Ocul Surf"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib74","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3390\/life13040859","article-title":"Dynamic aspects of pre-soft contact lens tear film and their relation to dry eye: basic science and clinical relevance","volume":"13","author":"Yokoi","year":"2023","journal-title":"Life"},{"issue":"7","key":"10.1016\/j.jtos.2026.06.003_bib75","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/eye.2008.78","article-title":"Alterations of the tear film and ocular surface health in chronic smokers","volume":"22","author":"Matsumoto","year":"2008","journal-title":"Eye"},{"issue":"14","key":"10.1016\/j.jtos.2026.06.003_bib76","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1021\/acs.jpclett.9b01187","article-title":"Crystalline wax esters regulate the evaporation resistance of tear film lipid layers associated with dry eye syndrome","volume":"10","author":"Paananen","year":"2019","journal-title":"J Phys Chem Lett"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib77","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1080\/02713683.2022.2039205","article-title":"Management strategies for evaporative dry eye disease and future perspective","volume":"47","author":"Rolando","year":"2022","journal-title":"Curr Eye Res"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib78","first-page":"643","article-title":"[the lipid layer of the lacrimal tear film: physiology and pathology]","volume":"24","author":"Lozato","year":"2001","journal-title":"J Fr Ophtalmol"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib79","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1556\/650.2021.31958","article-title":"[meibomian gland dysfunction and dry eye: diagnosis and treatment]","volume":"162","author":"Kov\u00e1cs","year":"2021","journal-title":"Orv Hetil"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib80","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11306-025-02273-9","article-title":"Metabolomics of ocular immune diseases","volume":"21","author":"Li","year":"2025","journal-title":"Metabolomics : Off J Metabolomic Soc"},{"issue":"15","key":"10.1016\/j.jtos.2026.06.003_bib81","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20153755","article-title":"Tear metabolomics in dry eye disease: a review","volume":"20","author":"Yazdani","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2026.06.003_bib82","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-1-0716-1410-5_11","article-title":"Mass spectrometric analysis of meibomian gland lipids","volume":"2306","author":"Chen","year":"2021","journal-title":"Methods Mol Biol"},{"issue":"23","key":"10.1016\/j.jtos.2026.06.003_bib83","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262311434","article-title":"Lipid composition and thermotropic properties of meibum of animal models and humans with meibomian gland dysfunction","volume":"26","author":"Butovich","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112121","article-title":"Region-resolved multi-omics of the mouse eye","volume":"42","author":"Xiang","year":"2023","journal-title":"Cell Rep"},{"issue":"10","key":"10.1016\/j.jtos.2026.06.003_bib85","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.steroids.2010.04.011","article-title":"Fatty acid composition of cholesteryl esters of human meibomian gland secretions","volume":"75","author":"Butovich","year":"2010","journal-title":"Steroids"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib86","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1194\/jlr.M800426-JLR200","article-title":"Cholesteryl esters as a depot for very long chain fatty acids in human meibum","volume":"50","author":"Butovich","year":"2009","journal-title":"J Lipid Res"},{"issue":"10","key":"10.1016\/j.jtos.2026.06.003_bib87","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1194\/jlr.M700237-JLR200","article-title":"Lipids of human meibum: mass-spectrometric analysis and structural elucidation1","volume":"48","author":"Butovich","year":"2007","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jtos.2026.06.003_bib88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plefa.2015.02.004","article-title":"Association between very long chain fatty acids in the meibomian gland and dry eye resulting from n-3 fatty acid deficiency","volume":"97","author":"Tanaka","year":"2015","journal-title":"Prostagl Leukot Essent Fat Acids"},{"issue":"11","key":"10.1016\/j.jtos.2026.06.003_bib89","doi-asserted-by":"crossref","first-page":"5508","DOI":"10.1167\/iovs.10-5419","article-title":"Meibomian lipid films and the impact of temperature","volume":"51","author":"Butovich","year":"2010","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"12","key":"10.1016\/j.jtos.2026.06.003_bib90","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1194\/jlr.M900252-JLR200","article-title":"Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum","volume":"50","author":"Butovich","year":"2009","journal-title":"J Lipid Res"},{"issue":"9","key":"10.1016\/j.jtos.2026.06.003_bib91","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1194\/jlr.P051185","article-title":"Longitudinal changes in tear fluid lipidome brought about by eyelid-warming treatment in a cohort of meibomian gland dysfunction","volume":"55","author":"Lam","year":"2014","journal-title":"J Lipid Res"},{"issue":"9","key":"10.1016\/j.jtos.2026.06.003_bib92","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/iovs.62.9.13","article-title":"Human meibum and tear film derived (O-acyl)-omega-hydroxy fatty acids as biomarkers of tear film dynamics in meibomian gland dysfunction and dry eye disease","volume":"62","author":"Khanal","year":"2021","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.06.003_bib93","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.exer.2017.02.008","article-title":"Meibocyte differentiation and renewal: insights into novel mechanisms of meibomian gland dysfunction (MGD)","volume":"163","author":"Hwang","year":"2017","journal-title":"Exp Eye Res"},{"issue":"11","key":"10.1016\/j.jtos.2026.06.003_bib94","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.3390\/ijms23116233","article-title":"Signaling pathways used by the specialized pro-resolving mediator maresin 2 regulate goblet cell function: comparison with maresin 1","volume":"23","author":"Olsen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2026.06.003_bib95","doi-asserted-by":"crossref","DOI":"10.1038\/srep36124","article-title":"Lipoxin A4 counter-regulates histamine-stimulated glycoconjugate secretion in conjunctival goblet cells","volume":"6","author":"Hodges","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib96","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/mi.2016.33","article-title":"Lipoxin a(4) activates ALX\/FPR2 receptor to regulate conjunctival goblet cell secretion","volume":"10","author":"Hodges","year":"2017","journal-title":"Mucosal Immunol"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib97","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jtos.2020.04.011","article-title":"RvE1 uses the LTB4 receptor BLT1 to increase [Ca2+]i and stimulate mucin secretion in cultured rat and human conjunctival goblet cells","volume":"18","author":"Yang","year":"2020","journal-title":"Ocul Surf"},{"issue":"7","key":"10.1016\/j.jtos.2026.06.003_bib98","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.4049\/jimmunol.1000833","article-title":"Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation","volume":"186","author":"Dartt","year":"2011","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib99","doi-asserted-by":"crossref","first-page":"7733","DOI":"10.1096\/fj.201902196R","article-title":"Sex\u2010mediated elevation of the specialized pro\u2010resolving lipid mediator levels in a sj\u00f6gren\u2019s syndrome mouse model","volume":"34","author":"Parashar","year":"2020","journal-title":"FASEB J"},{"issue":"11","key":"10.1016\/j.jtos.2026.06.003_bib100","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1097\/ICO.0b013e31823f789e","article-title":"Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye","volume":"31","author":"De Paiva","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2026.06.003_bib101","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1098467","article-title":"Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development","volume":"14","author":"Alba","year":"2023","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib102","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/MOL.0000000000000801","article-title":"Lipids and brain inflammation in APOE4-associated dementia","volume":"33","author":"Duro","year":"2022","journal-title":"Curr Opin Lipidol"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib103","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13195-022-01084-7","article-title":"Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and alzheimer's dementia","volume":"14","author":"Ebright","year":"2022","journal-title":"Alzheimers Res Ther"},{"issue":"15","key":"10.1016\/j.jtos.2026.06.003_bib104","doi-asserted-by":"crossref","first-page":"15267","DOI":"10.1074\/jbc.M410638200","article-title":"A role for the mouse 12\/15-lipoxygenase pathway in promoting epithelial wound healing and host defense","volume":"280","author":"Gronert","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtos.2026.06.003_bib105","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.plefa.2017.01.004","article-title":"Identification and profiling of specialized pro-resolving mediators in human tears by lipid mediator metabolomics","volume":"117","author":"English","year":"2017","journal-title":"Prostagl Leukot Essent Fat Acids"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib106","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1096\/fj.201700947R","article-title":"Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice","volume":"32","author":"Sassa","year":"2018","journal-title":"FASEB J: Off Publ Fed Am Soc Exp Biol"},{"issue":"9","key":"10.1016\/j.jtos.2026.06.003_bib107","doi-asserted-by":"crossref","first-page":"10034","DOI":"10.1096\/fj.201900725R","article-title":"On the pivotal role of Elovl3\/ELOVL3 in meibogenesis and ocular physiology of mice","volume":"33","author":"Butovich","year":"2019","journal-title":"FASEB J : Off Publ Fed Am Soc Exp Biol"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2026.111160","article-title":"Time-dependent changes in meibum lipid composition and progression of dry eye following disruption of the fatty acid elongase Elovl1","volume":"302","author":"Tada","year":"2026","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtos.2026.06.003_bib109","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jtos.2021.08.016","article-title":"Inhibition of ceramide de novo synthesis ameliorates meibomian gland dysfunction induced by SCD1 deficiency","volume":"22","author":"Ji","year":"2021","journal-title":"Ocul Surf"},{"issue":"5","key":"10.1016\/j.jtos.2026.06.003_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102478","article-title":"Diverse meibum lipids produced by Awat1 and Awat2 are important for stabilizing tear film and protecting the ocular surface","volume":"24","author":"Sawai","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.jtos.2026.06.003_bib111","first-page":"679","article-title":"Lacrimal gland homeostasis is maintained by the AQP5 pathway by attenuating endoplasmic reticulum stress inflammation in the lacrimal gland of AQP5 knockout mice","volume":"27","author":"Hu","year":"2021","journal-title":"Mol Vis"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib112","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1167\/iovs.64.1.4","article-title":"Aquaporin5 deficiency aggravates ROS\/NLRP3 inflammasome-mediated pyroptosis in the lacrimal glands","volume":"64","author":"Cao","year":"2023","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"14","key":"10.1016\/j.jtos.2026.06.003_bib113","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/iovs.65.14.12","article-title":"Atg5-mediated lipophagy induces ferroptosis in corneal epithelial cells in dry eye disease","volume":"65","author":"Zuo","year":"2024","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.jtos.2026.06.003_bib114","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1167\/iovs.66.5.23","article-title":"Autophagy impairment-derived SQSTM1 accumulation promotes ferroptosis in corneal epithelial cells through ACSL4 in dry eye","volume":"66","author":"Zhang","year":"2025","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"9","key":"10.1016\/j.jtos.2026.06.003_bib115","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1021\/acs.jproteome.5b00443","article-title":"Global metabonomic and proteomic analysis of human conjunctival epithelial cells (IOBA-NHC) in response to hyperosmotic stress","volume":"14","author":"Chen","year":"2015","journal-title":"J Proteome Res"},{"issue":"5","key":"10.1016\/j.jtos.2026.06.003_bib116","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.exer.2008.11.035","article-title":"sPLA2-IIa is an inflammatory mediator when the ocular surface is compromised","volume":"88","author":"Chen","year":"2009","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2026.06.003_bib117","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jtos.2024.04.008","article-title":"Effects of age on lacrimal gland bioactive lipids","volume":"33","author":"Ebright","year":"2024","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2026.06.003_bib118","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-018-0545-5","article-title":"FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression","volume":"10","author":"He","year":"2018","journal-title":"Clin Epigenet"},{"issue":"7503","key":"10.1016\/j.jtos.2026.06.003_bib119","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving lipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.jtos.2026.06.003_bib120","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/iovs.66.15.22","article-title":"Sphingomyelin synthase 2 deletion mitigates oxidative stress-induced NF-\u03baB activation via lipid metabolic reprogramming in dry eye disease","volume":"66","author":"Lu","year":"2025","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"12","key":"10.1016\/j.jtos.2026.06.003_bib121","first-page":"4874","article-title":"Effect of androgen deficiency on the human meibomian gland and ocular surface","volume":"85","author":"Krenzer","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jtos.2026.06.003_bib122","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1749-6632.2002.tb04217.x","article-title":"Androgen deficiency, meibomian gland dysfunction, and evaporative dry eye","volume":"966","author":"Sullivan","year":"2002","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib123","doi-asserted-by":"crossref","first-page":"915","DOI":"10.18240\/ijo.2021.06.18","article-title":"Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications","volume":"14","author":"Wang","year":"2021","journal-title":"Int J Ophthalmol"},{"key":"10.1016\/j.jtos.2026.06.003_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.117937","article-title":"Alpha- and beta-melanocyte stimulating hormone positively impact lipogenesis of meibomian gland cells in vitro and ex vivo","volume":"185","author":"Zahn","year":"2025","journal-title":"Biomed Pharmacother"},{"issue":"13","key":"10.1016\/j.jtos.2026.06.003_bib125","doi-asserted-by":"crossref","first-page":"7814","DOI":"10.1167\/iovs.15-18049","article-title":"Effects of insulin and high glucose on human meibomian gland epithelial cells","volume":"56","author":"Ding","year":"2015","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.06.003_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149526","article-title":"ER-1 deficiency induces inflammation and lipid deposition in meibomian gland and lacrimal gland","volume":"696","author":"Qi","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib127","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jtos.2020.04.012","article-title":"Eicosapentaenoic acid (EPA) activates PPAR\u03b3 signaling leading to cell cycle exit, lipid accumulation, and autophagy in human meibomian gland epithelial cells (hMGEC)","volume":"18","author":"Kim","year":"2020","journal-title":"Ocul Surf"},{"issue":"13","key":"10.1016\/j.jtos.2026.06.003_bib128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/iovs.66.13.1","article-title":"Aging affects lipid homeostasis in lacrimal glands by upregulating lipogenesis and changing its specificity","volume":"66","author":"Yuksel","year":"2025","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.jtos.2026.06.003_bib129","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054309","article-title":"Lacrimal gland epithelial cells shape immune responses through the modulation of inflammasomes and lipid metabolism","volume":"24","author":"Delcroix","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10792-025-03431-7","article-title":"Diurnal rhythm-modulated transcriptome analysis of meibomian gland in hyperlipidemic mice using RNA sequencing","volume":"45","author":"Zhang","year":"2025","journal-title":"Int Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib131","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1186\/s12951-025-03630-5","article-title":"Circadian disruption and ROS-NLRP3 signaling mediate sleep deprivation-enhanced silica nanoparticle toxicity in lacrimal glands","volume":"23","author":"Zhang","year":"2025","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.jtos.2026.06.003_bib132","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jtos.2025.08.009","article-title":"Downregulation of the core circadian gene Nr1d2 in the lacrimal gland contributes to postoperative dry eye disease by impairing lipid metabolism","volume":"38","author":"Liu","year":"2025","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2026.06.003_bib133","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jtos.2020.09.008","article-title":"Profile of tear lipid mediator as a biomarker of inflammation for meibomian gland dysfunction and ocular surface diseases: standard operating procedures","volume":"26","author":"Ambaw","year":"2020","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2026.06.003_bib134","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.exer.2016.02.005","article-title":"Linoleic acid content of human meibum is associated with telangiectasia and plugging of gland orifices in meibomian gland dysfunction","volume":"145","author":"Arita","year":"2016","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2026.06.003_bib135","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.preteyeres.2017.05.003","article-title":"The role of systemic and topical fatty acids for dry eye treatment","volume":"61","author":"Barabino","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2026.06.003_bib136","doi-asserted-by":"crossref","unstructured":"Lai HT, Otto MC de O, Lemaitre RN, et al. Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the cardiovascular health study: prospective cohort study. Published online October 17, 2018. doi:10.1136\/bmj.k4067.","DOI":"10.1136\/bmj.k4067"},{"key":"10.1016\/j.jtos.2026.06.003_bib137","doi-asserted-by":"crossref","unstructured":"Zhu Y, Ferrara A, Forman MR. Omega 3 polyunsaturated fatty acids and healthy ageing. BMJ. Published online October 17, 2018:k4263. doi:10.1136\/bmj.k4263.","DOI":"10.1136\/bmj.k4263"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib138","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1167\/iovs.16-19131","article-title":"\u03c9-3 tear film lipids correlate with clinical measures of dry eye","volume":"57","author":"Walter","year":"2016","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib139","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ophtha.2016.12.011","article-title":"A metabolome-wide study of dry eye disease reveals serum androgens as biomarkers","volume":"124","author":"Vehof","year":"2017","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib140","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1038\/s41598-022-08442-3","article-title":"Gut-derived butyrate suppresses ocular surface inflammation","volume":"12","author":"Schaefer","year":"2022","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib141","article-title":"Restoration of tear secretion in a murine dry eye model by oral administration of palmitoleic acid","volume":"9","author":"Kimura","year":"2017","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib142","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2008.07.048","article-title":"Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism","volume":"134","author":"Cao","year":"2008","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib143","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jtos.2013.10.001","article-title":"S100A proteins as molecular targets in the ocular surface inflammatory diseases","volume":"12","author":"Tong","year":"2014","journal-title":"Ocul Surf"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib144","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/jemt.10299","article-title":"S100A9\/S100A8: myeloid representatives of the S100 protein family as prominent players in innate immunity","volume":"60","author":"Nacken","year":"2003","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.jtos.2026.06.003_bib145","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.exer.2013.05.010","article-title":"Tear film lipids","volume":"117","author":"Butovich","year":"2013","journal-title":"Exp Eye Res"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib146","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1167\/iovs.19-26812","article-title":"Human meibum cholesteryl and wax ester variability with age, sex, and meibomian gland dysfunction","volume":"60","author":"Borchman","year":"2019","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib147","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1167\/iovs.16-20902","article-title":"Expression profiling of nonpolar lipids in meibum from patients with dry eye: a pilot study","volume":"58","author":"Chen","year":"2017","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.06.003_bib148","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108522","article-title":"Meibum lipid composition in type 2 diabetics with dry eye","volume":"206","author":"Yang","year":"2021","journal-title":"Exp Eye Res"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib149","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1194\/jlr.P041780","article-title":"Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome","volume":"55","author":"Lam","year":"2014","journal-title":"J Lipid Res"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.optom.2014.12.003","article-title":"Atomic force microscopy and langmuir-blodgett monolayer technique to assess contact lens deposits and human meibum extracts","volume":"8","author":"Hagedorn","year":"2015","journal-title":"J Optom"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib151","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jtos.2018.12.006","article-title":"Clinical signs of meibomian gland dysfunction (MGD) are associated with changes in meibum sphingolipid composition","volume":"17","author":"Paranjpe","year":"2019","journal-title":"Ocul Surf"},{"issue":"12","key":"10.1016\/j.jtos.2026.06.003_bib152","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/j.ajpath.2020.09.002","article-title":"High-fat diet-induced functional and pathologic changes in lacrimal gland","volume":"190","author":"He","year":"2020","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib153","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.exer.2009.03.020","article-title":"Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland","volume":"89","author":"Wu","year":"2009","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2026.06.003_bib154","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2024.110008","article-title":"Long-term high fructose intake reprograms the circadian transcriptome and disrupts homeostasis in mouse extra-orbital lacrimal glands","volume":"246","author":"Qi","year":"2024","journal-title":"Exp Eye Res"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/iovs.65.6.1","article-title":"The aging lacrimal gland of female C57BL\/6J mice exhibits multinucleate macrophage infiltration associated with lipid dysregulation","volume":"65","author":"Choi","year":"2024","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib156","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/iovs.63.3.3","article-title":"Obstructive sleep apnea affects lacrimal gland function","volume":"63","author":"Wang","year":"2022","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.06.003_bib157","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jtos.2025.07.004","article-title":"Prostaglandin F2\u03b1 exacerbated dry eye by promoting lacrimal gland fibrosis progression through the activation of the RhoA\/ROCKs signaling pathway","volume":"38","author":"Guo","year":"2025","journal-title":"Ocul Surf"},{"issue":"5","key":"10.1016\/j.jtos.2026.06.003_bib158","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1021\/acs.jproteome.9b00149","article-title":"Integrated tear proteome and metabolome reveal panels of inflammatory-related molecules via key regulatory pathways in dry eye syndrome","volume":"18","author":"Chen","year":"2019","journal-title":"J Proteome Res"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib159","doi-asserted-by":"crossref","first-page":"E132","DOI":"10.1097\/OPX.0b013e318194e767","article-title":"L-carnitine and short chain ester in tears from patients with dry eye","volume":"86","author":"Pescosolido","year":"2009","journal-title":"Optom Vis Sci: Off Publ Am Acad Optom"},{"issue":"13","key":"10.1016\/j.jtos.2026.06.003_bib160","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/iovs.65.13.12","article-title":"PINK1\/parkin-mediated mitophagy ameliorates mitochondrial dysfunction in lacrimal gland acinar cells during aging","volume":"65","author":"Zhao","year":"2024","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"7","key":"10.1016\/j.jtos.2026.06.003_bib161","article-title":"Dry eye disease: oxidative stress on ocular surface and cutting-edge antioxidants","volume":"9","author":"Hu","year":"2025","journal-title":"Glob Chall"},{"key":"10.1016\/j.jtos.2026.06.003_bib162","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2025.110457","article-title":"Multi-omics analysis reveals lipid metabolism profiles and regulatory networks in meibomian glands aging","volume":"258","author":"Pengjie","year":"2025","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2026.06.003_bib163","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.3389\/fphar.2019.01622","article-title":"N-palmitoylethanolamine maintains local lipid homeostasis to relieve sleep deprivation-induced dry eye syndrome","volume":"10","author":"Chen","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jtos.2026.06.003_bib164","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.exer.2017.09.005","article-title":"Investigation of antioxidant systems in human meibomian gland and conjunctival tissues","volume":"165","author":"Nezzar","year":"2017","journal-title":"Exp Eye Res"},{"issue":"9","key":"10.1016\/j.jtos.2026.06.003_bib165","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3109\/02713683.2015.1098707","article-title":"Expression of lipid peroxidation markers in the tear film and ocular surface of patients with non-sjogren syndrome: potential biomarkers for dry eye disease","volume":"41","author":"Choi","year":"2016","journal-title":"Curr Eye Res"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib166","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/aos.14892","article-title":"Oxidative and antioxidative stress markers in dry eye disease: a systematic review and meta-analysis","volume":"100","author":"Navel","year":"2022","journal-title":"Acta Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib167","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1167\/iovs.12-10325","article-title":"Evaluation of lipid oxidative stress status in sj\u00f6gren syndrome patients","volume":"54","author":"Wakamatsu","year":"2013","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"9","key":"10.1016\/j.jtos.2026.06.003_bib168","first-page":"997","article-title":"The role of conjunctival epithelial cell xanthine oxidoreductase\/xanthine oxidase in oxidative reactions on the ocular surface of dry eye patients with sj\u00f6gren\u2019s syndrome","volume":"22","author":"Cejkov\u00e1","year":"2007","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.jtos.2026.06.003_bib169","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2023.109823","article-title":"Prostaglandin E2 promotes Th17 differentiation induces corneal epithelial cell apoptosis and participates in the progression of dry eye","volume":"751","author":"Zhang","year":"2024","journal-title":"Arch Biochem Biophys"},{"issue":"5 Pt B","key":"10.1016\/j.jtos.2026.06.003_bib170","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1016\/j.bbadis.2017.07.019","article-title":"Lipid droplet proteins and metabolic diseases","volume":"1864","author":"Xu","year":"2018","journal-title":"Biochim Biophys Acta, Mol Basis Dis"},{"issue":"11","key":"10.1016\/j.jtos.2026.06.003_bib171","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.ophtha.2012.05.038","article-title":"Change in prostaglandin expression levels and synthesizing activities in dry eye disease","volume":"119","author":"Shim","year":"2012","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib172","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1038\/s41598-018-21542-3","article-title":"Compensatory increases in tear volume and mucin levels associated with meibomian gland dysfunction caused by stearoyl-CoA desaturase-1 deficiency","volume":"8","author":"Inaba","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtos.2026.06.003_bib173","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-030-21735-8_3","article-title":"Immunoresolvent resolvin D1 maintains the health of the ocular surface","volume":"1161","author":"Dartt","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jtos.2026.06.003_bib174","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jtos.2021.12.013","article-title":"In situ metabolic profile and spatial distribution of ocular tissues: new insights into dry eye disease","volume":"24","author":"Chen","year":"2022","journal-title":"Ocul Surf"},{"issue":"24","key":"10.1016\/j.jtos.2026.06.003_bib175","doi-asserted-by":"crossref","first-page":"9975","DOI":"10.1021\/acs.analchem.4c01366","article-title":"Polarity-driven fluorescence monitoring of lipid droplet dynamics in dry eye disease","volume":"96","author":"Hou","year":"2024","journal-title":"Anal Chem"},{"issue":"9","key":"10.1016\/j.jtos.2026.06.003_bib176","article-title":"Lipidomic analysis of epithelial corneal cells following hyperosmolarity and benzalkonium chloride exposure: new insights in dry eye disease","volume":"1865","author":"Magny","year":"2020","journal-title":"Biochim Biophys Acta, Mol Cell Biol Lipids"},{"issue":"13","key":"10.1016\/j.jtos.2026.06.003_bib177","doi-asserted-by":"crossref","first-page":"5494","DOI":"10.1167\/iovs.18-24504","article-title":"Sleep deprivation induces dry eye through inhibition of PPAR\u03b1 expression in corneal epithelium","volume":"59","author":"Tang","year":"2018","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib178","article-title":"Corneal mucin-targeting liposome nanoplatforms enable effective treatment of dry eye diseases by integrated regulation of ferroptosis and inflammation","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv Sci (weinh Baden-wurtt Ger)"},{"issue":"10","key":"10.1016\/j.jtos.2026.06.003_bib179","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/iovs.63.10.3","article-title":"AKR1C1 protects corneal epithelial cells against oxidative stress-mediated ferroptosis in dry eye","volume":"63","author":"Zuo","year":"2022","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.06.003_bib180","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1407659","article-title":"Astaxanthin activated the SLC7A11\/GPX4 pathway to inhibit ferroptosis and enhance autophagy, ameliorating dry eye disease","volume":"15","author":"Hou","year":"2024","journal-title":"Front Pharmacol"},{"issue":"8","key":"10.1016\/j.jtos.2026.06.003_bib181","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s00417-020-04647-2","article-title":"Inflammation and oxidative stress induced by lipid peroxidation metabolite 4-hydroxynonenal in human corneal epithelial cells","volume":"258","author":"Liu","year":"2020","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol = Albr Von Graefes Arch Fur Klin Exp Ophthalmol"},{"key":"10.1016\/j.jtos.2026.06.003_bib182","doi-asserted-by":"crossref","unstructured":"Lian L, Le Z, Ye X, et al. SIRT1 prevents ferroptosis in corneal epithelial cells by enhancing HIF1\u03b1 protein stability in dry eye disease. Adv Sci. Published online February 25, 2026:e22806. doi:10.1002\/advs.202522806.","DOI":"10.1002\/advs.202522806"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib183","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1167\/iovs.13-13355","article-title":"Biophysical and morphological evaluation of human normal and dry eye meibum using hot stage polarized light microscopy","volume":"55","author":"Butovich","year":"2014","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"11","key":"10.1016\/j.jtos.2026.06.003_bib184","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1194\/jlr.M026732","article-title":"Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2","volume":"53","author":"Robciuc","year":"2012","journal-title":"J Lipid Res"},{"issue":"14","key":"10.1016\/j.jtos.2026.06.003_bib185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411815","article-title":"L-carnitine suppresses transient receptor potential vanilloid type 1 activation in human corneal epithelial cells","volume":"24","author":"Lucius","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib186","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1167\/iovs.67.2.39","article-title":"Altered carnitine homeostasis modulates hyperosmolarity-induced mitochondrial dysfunction and lipotoxicity in human corneal epithelial cells","volume":"67","author":"Kontoh-Twumasi","year":"2026","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.06.003_bib187","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.140995","article-title":"Polystyrene and polyvinyl chloride microplastics exposure induces ocular surface inflammation by causing mitochondrial damage and lipid metabolic disruption","volume":"502","author":"Wen","year":"2026","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jtos.2026.06.003_bib188","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.freeradbiomed.2020.04.007","article-title":"Dry eye induced by exposure to cigarette smoke pollution: an in vivo and in vitro study","volume":"153","author":"Li","year":"2020","journal-title":"Free Radical Biol Med"},{"issue":"8","key":"10.1016\/j.jtos.2026.06.003_bib189","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1080\/17435390.2024.2426548","article-title":"In vivo assessment of topically applied silver nanoparticles on entire cornea: comprehensive FTIR study","volume":"18","author":"Mahmoud","year":"2024","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.jtos.2026.06.003_bib190","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.2147\/OPTH.S322461","article-title":"The association between risk factors for metabolic syndrome and meibomian gland disease in a dry eye cohort","volume":"15","author":"Mussi","year":"2021","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.jtos.2026.06.003_bib191","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2025.110496","article-title":"Characterization of corneal and retinal changes in a metabolic syndrome model in young and adult mice","volume":"258","author":"Vivanco-Rojas","year":"2025","journal-title":"Exp Eye Res"},{"issue":"7","key":"10.1016\/j.jtos.2026.06.003_bib192","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3346\/jkms.2016.31.7.1121","article-title":"The association between symptoms of dry eye syndrome and metabolic outcome in a general population in Korea","volume":"31","author":"Park","year":"2016","journal-title":"J Kor Med Sci"},{"issue":"11","key":"10.1016\/j.jtos.2026.06.003_bib193","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-069283","article-title":"Association between dyslipidaemia and dry eye disease: a systematic review and meta-analysis","volume":"13","author":"Li","year":"2023","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib194","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/OPX.0000000000001994","article-title":"Association between dyslipidemia and meibomian gland dysfunction: a systematic review and meta-analysis","volume":"100","author":"Akowuah","year":"2023","journal-title":"Optom Vis Sci: Off Publ Am Acad Optom"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib195","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.3390\/jcm12062131","article-title":"Dyslipidemia exacerbates meibomian gland dysfunction: a systematic review and meta-analysis","volume":"12","author":"Tomioka","year":"2023","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib196","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/ceo.13388","article-title":"Association of dyslipidaemia and oral statin use, and dry eye disease symptoms in the blue mountains eye study","volume":"47","author":"Ooi","year":"2019","journal-title":"Clin Exp Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib197","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/ICO.0000000000002133","article-title":"Association between dyslipidemia and dry eye syndrome among the korean middle-aged population","volume":"39","author":"Choi","year":"2020","journal-title":"Cornea"},{"issue":"14","key":"10.1016\/j.jtos.2026.06.003_bib198","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11144010","article-title":"Association of serum lipid level with meibum biosynthesis and meibomian gland dysfunction: a review","volume":"11","author":"Yoo","year":"2022","journal-title":"J Clin Med"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib199","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfo.2025.104467","article-title":"Evaluation of vitamin D and serum lipid profile levels in obstructive meibomian gland dysfunction","volume":"48","author":"Selimo\u011flu","year":"2025","journal-title":"J Fr Ophtalmol"},{"issue":"9","key":"10.1016\/j.jtos.2026.06.003_bib200","doi-asserted-by":"crossref","DOI":"10.3390\/nu13092986","article-title":"The protective effect of oral application of corni fructus on the disorders of the cornea, conjunctiva, lacrimal gland and retina by topical particulate matter 2.5","volume":"13","author":"Lee","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jtos.2026.06.003_bib201","doi-asserted-by":"crossref","unstructured":"Butovich IA, Wilkerson A, Yuksel S. Differential effects of dietary cholesterol and triglycerides on the lipid homeostasis in meibomian glands. J Steroid Biochem Mol Biol Published online 2021. doi:10.1016\/j.jsbmb.2021.105894.","DOI":"10.1016\/j.jsbmb.2021.105894"},{"key":"10.1016\/j.jtos.2026.06.003_bib202","doi-asserted-by":"crossref","unstructured":"Khera AV, Rodrigues A, French BC, Wilensky RL, Rader DJ. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N Engl J Med. Published online 2011:1-9. doi:10.1056\/NEJMoa1001689.","DOI":"10.1056\/NEJMoa1001689"},{"issue":"22","key":"10.1016\/j.jtos.2026.06.003_bib203","doi-asserted-by":"crossref","first-page":"8772","DOI":"10.3390\/ijms21228772","article-title":"Obese mice with dyslipidemia exhibit meibomian gland hypertrophy and alterations in meibum composition and aqueous tear production","volume":"21","author":"Osae","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.jtos.2026.06.003_bib204","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3390\/metabo13070811","article-title":"Rosacea meibomian gland dysfunction posterior blepharitis may be a marker for earlier associated dyslipidaemia and inflammation detection and treatment with statins","volume":"13","author":"Ooi","year":"2023","journal-title":"Metabolites"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib205","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jtos.2019.06.002","article-title":"Hyperlipidemia induces meibomian gland dysfunction","volume":"17","author":"Bu","year":"2019","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2026.06.003_bib206","doi-asserted-by":"crossref","unstructured":"Liu WQ, Zhang YZ, Wu Y, Zhang JJ, Et A. Myeloperoxidase-derived hypochlorous acid promotes ox-LDL-induced senescence of endothelial cells through a mechanism involving \u03b2-catenin signaling in hyperlipidemia. Biochem Biophys Res Commun. Published online 2015. doi:10.1016\/j.bbrc.2015.10.053.","DOI":"10.1016\/j.bbrc.2015.10.053"},{"key":"10.1016\/j.jtos.2026.06.003_bib207","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/7345270","article-title":"Impact of dyslipidemia on tear film and meibomian gland dysfunction: a cross-sectional study of the interplay between serum lipid profile and ocular surface health","volume":"2024","author":"Serrano-Morales","year":"2024","journal-title":"J Ophthalmol"},{"issue":"20","key":"10.1016\/j.jtos.2026.06.003_bib208","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.3390\/diagnostics15202581","article-title":"HDL may improve ocular tear film stability in patients with gastric bypass: a pilot study","volume":"15","author":"Sanchez-Sanchez","year":"2025","journal-title":"Diagnostics"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib209","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12944-024-02176-z","article-title":"Assessment of leukocyte and systemic inflammation index ratios in dyslipidemia patients with dry eye disease: a retrospective case\u2012control study","volume":"23","author":"Alhalwani","year":"2024","journal-title":"Lipids Health Dis"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib210","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.285","article-title":"Sleep deprivation disrupts the lacrimal system and induces dry eye disease","volume":"50","author":"Li","year":"2018","journal-title":"Exp Mol Med"},{"issue":"21","key":"10.1016\/j.jtos.2026.06.003_bib211","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.3390\/cells14211730","article-title":"Aging and corneal nerve health: mechanisms of degeneration and emerging therapies for the cornea","volume":"14","author":"Niktinat","year":"2025","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.jtos.2026.06.003_bib212","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.3390\/ijms26052174","article-title":"Link between metabolic syndrome, inflammation, and eye diseases","volume":"26","author":"Pie\u0144czykowska","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib213","article-title":"Hypertriglyceridemia is associated with development of metabolic glucose disorders, irrespective of glucose and insulin levels: a 15-year follow-up study","volume":"25","author":"F","year":"2014","journal-title":"Eur J Intern Med"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib214","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10067-015-3072-1","article-title":"Metabolic syndrome in sj\u00f6gren\u2019s syndrome patients: a relevant concern for clinical monitoring","volume":"35","author":"Augusto","year":"2016","journal-title":"Clin Rheumatol"},{"issue":"12","key":"10.1016\/j.jtos.2026.06.003_bib215","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.15537\/smj.2016.12.15623","article-title":"Dry eye disease in patients with metabolic syndrome","volume":"37","author":"Serefoglu Cabuk","year":"2016","journal-title":"Saudi Med J"},{"key":"10.1016\/j.jtos.2026.06.003_bib216","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1079541","article-title":"Mechanistic investigations of diabetic ocular surface diseases","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jtos.2026.06.003_bib217","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1011125","article-title":"Spatial transcriptomics of the lacrimal gland features macrophage activity and epithelium metabolism as key alterations during chronic inflammation","volume":"13","author":"Mauduit","year":"2022","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib218","article-title":"Quantitative proteomics and weighted correlation network analysis of tear samples in type 2 diabetes patients complicated with dry eye","volume":"14","author":"Zou","year":"2020","journal-title":"Proteonomics Clin Appl"},{"issue":"13","key":"10.1016\/j.jtos.2026.06.003_bib219","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/tvst.9.13.8","article-title":"Quantitative proteomics and weighted correlation network analysis of tear samples in adults and children with diabetes and dry eye","volume":"9","author":"Zou","year":"2020","journal-title":"Transl Vis Sci Technol"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib220","article-title":"Improved adipose tissue metabolism after 5-year growth hormone replacement therapy in growth hormone deficient adults: the role of zinc-\u03b12-glycoprotein","volume":"4","author":"M","year":"2014","journal-title":"Adipocyte"},{"key":"10.1016\/j.jtos.2026.06.003_bib221","article-title":"Tear dynamics testing and quantitative proteomics analysis in patients with chronic renal failure","volume":"248","author":"Zong","year":"2021","journal-title":"J Proteonomics"},{"issue":"15","key":"10.1016\/j.jtos.2026.06.003_bib222","doi-asserted-by":"crossref","DOI":"10.3390\/nu14153236","article-title":"An oral polyphenol formulation to modulate the ocular surface inflammatory process and to improve the symptomatology associated with dry eye disease","volume":"14","author":"Ng","year":"2022","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.jtos.2026.06.003_bib223","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/15287394.2020.1867274","article-title":"Metabolomics approach to biomarkers of dry eye disease using (1)H-NMR in rats","volume":"84","author":"Lee","year":"2021","journal-title":"J Toxicol Environ Health A Curr Issues"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib224","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/15287394.2024.2393770","article-title":"Mass spectrometry (MS)-based metabolomics of plasma and urine in dry eye disease (DED)-induced rat model","volume":"88","author":"Kim","year":"2025","journal-title":"J Toxicol Environ Health A Curr Issues"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib225","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00417-019-04247-9","article-title":"HMG-CoA reductase expression in human eyelid tissue and in a human meibomian gland epithelial cell line","volume":"257","author":"Ooi","year":"2019","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol = Albr Von Graefes Arch Fur Klin Exp Ophthalmol"},{"issue":"7","key":"10.1016\/j.jtos.2026.06.003_bib226","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/aos.15656","article-title":"Association of lipid-lowering agent use and dry eye disease: a nationwide matched case-control study in Taiwan, 2002-2016","volume":"101","author":"Chien","year":"2023","journal-title":"Acta Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib227","article-title":"Explanatory model of dry eye disease using health and nutrition examinations: machine learning and network-based factor analysis from a national survey","volume":"8","author":"Nam","year":"2020","journal-title":"JMIR Med Inf"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib228","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-01844-9","article-title":"Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer","volume":"11","author":"Chen","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtos.2026.06.003_bib229","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ajo.2019.02.024","article-title":"Meibomian gland dysfunction and dry eye are similar but different based on a population-based study: the hirado-takushima study in Japan","volume":"207","author":"Arita","year":"2019","journal-title":"Am J Ophthalmol"},{"issue":"11","key":"10.1016\/j.jtos.2026.06.003_bib230","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/s41371-021-00603-7","article-title":"Risk factors for hypertension in primary sj\u00f6gren\u2019s syndrome patients: a nomogram was constructed","volume":"36","author":"Xu","year":"2022","journal-title":"J Hum Hypertens"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib231","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/bjo.79.1.54","article-title":"Adverse ocular effects associated with niacin therapy","volume":"79","author":"Fraunfelder","year":"1995","journal-title":"Br J Ophthalmol"},{"issue":"16","key":"10.1016\/j.jtos.2026.06.003_bib232","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23169478","article-title":"Activation of ADRB2\/PKA signaling pathway facilitates lipid synthesis in meibocytes, and beta-blocker glaucoma drug impedes PKA-induced lipid synthesis by inhibiting ADRB2","volume":"23","author":"Jun","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib233","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/ICO.0000000000001181","article-title":"Influence of pilocarpine and timolol on human meibomian gland epithelial cells","volume":"36","author":"Zhang","year":"2017","journal-title":"Cornea"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib234","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3341\/kjo.2021.0068","article-title":"Effects of glaucoma medication on dry eye syndrome and quality of life in patients with glaucoma","volume":"35","author":"Maeng","year":"2021","journal-title":"Korean j ophthalmol: Kor J Ophthalmol"},{"issue":"7","key":"10.1016\/j.jtos.2026.06.003_bib235","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1167\/tvst.9.7.48","article-title":"Characterization of meibomian gland atrophy and the potential risk factors for middle aged to elderly patients with cataracts","volume":"9","author":"Lin","year":"2020","journal-title":"Transl Vis Sci Technol"},{"issue":"9","key":"10.1016\/j.jtos.2026.06.003_bib236","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185603","article-title":"Risk factors for severe meibomian gland atrophy in a young adult population: a cross-sectional study","volume":"12","author":"Yeh","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jtos.2026.06.003_bib237","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jtos.2024.10.002","article-title":"Cytarabine chemotherapy induces meibomian gland dysfunction","volume":"34","author":"Liu","year":"2024","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2026.06.003_bib238","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2014.02.014","article-title":"One man's poison is another man's meat: using azithromycin-induced phospholipidosis to promote ocular surface health","volume":"320","author":"Liu","year":"2014","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib239","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/ICO.0000000000000351","article-title":"Can tetracycline antibiotics duplicate the ability of azithromycin to stimulate human meibomian gland epithelial cell differentiation?","volume":"34","author":"Liu","year":"2015","journal-title":"Cornea"},{"issue":"1 Suppl","key":"10.1016\/j.jtos.2026.06.003_bib240","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1097\/00140068-200301001-00026","article-title":"Eyelid disorders: the meibomian gland, blepharitis, and contact lenses","volume":"29","author":"McCulley","year":"2003","journal-title":"Eye Contact Lens"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib241","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/bjo.2007.133900","article-title":"Changes in meibomian fatty acids and clinical signs in patients with meibomian gland dysfunction after minocycline treatment","volume":"92","author":"Souchier","year":"2008","journal-title":"Br J Ophthalmol"},{"issue":"9","key":"10.1016\/j.jtos.2026.06.003_bib242","doi-asserted-by":"crossref","first-page":"5596","DOI":"10.1167\/iovs.14-14782","article-title":"The combined effect of azithromycin and insulin-like growth factor-1 on cultured human meibomian gland epithelial cells","volume":"55","author":"Liu","year":"2014","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.jtos.2026.06.003_bib243","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/jamaophthalmol.2013.8295","article-title":"The effects of insulin-like growth factor 1 and growth hormone on human meibomian gland epithelial cells","volume":"132","author":"Ding","year":"2014","journal-title":"JAMA ophthalmol"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib244","doi-asserted-by":"crossref","DOI":"10.1111\/dth.14029","article-title":"Isotretinoin and the eye: a review for the dermatologist","volume":"33","author":"Ruiz-Lozano","year":"2020","journal-title":"Dermatol Ther"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib245","first-page":"781","article-title":"Isotretinoin-induced severe dry eye disease and meibomian gland alterations in patients with acne vulgaris: a noncontact ocular surface analysis","volume":"80","author":"Julieana","year":"2025","journal-title":"Med J Malaysia"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib246","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1007\/s40123-023-00737-6","article-title":"The effect of oral isotretinoin therapy on meibomian gland characteristics in patients with acne vulgaris","volume":"12","author":"Zakrzewska","year":"2023","journal-title":"Ophthalmol Ther"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib247","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1172\/JCI1581","article-title":"Retinoids increase human Apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids","volume":"102","author":"Vu-Dac","year":"1998","journal-title":"J Clin Investig"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib248","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4161\/gmic.19320","article-title":"The role of gut microbiota in immune homeostasis and autoimmunity","volume":"3","author":"Wu","year":"2012","journal-title":"Gut Microbes"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib249","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3390\/microorganisms10030578","article-title":"Gut microbiota dysbiosis: triggers, consequences, diagnostic and therapeutic options","volume":"10","author":"Hrncir","year":"2022","journal-title":"Microorganisms"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib250","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1194\/jlr.R088989","article-title":"Microbial impact on cholesterol and bile acid metabolism: current status and future prospects","volume":"60","author":"Kriaa","year":"2019","journal-title":"J Lipid Res"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib251","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.chom.2023.01.009","article-title":"Gut microbiome lipid metabolism and its impact on host physiology","volume":"31","author":"Brown","year":"2023","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib252","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s12886-024-03526-2","article-title":"What is the impact of microbiota on dry eye: a literature review of the gut-eye axis","volume":"24","author":"Song","year":"2024","journal-title":"BMC Ophthalmol"},{"issue":"22","key":"10.1016\/j.jtos.2026.06.003_bib253","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212384","article-title":"Lactoferrin ameliorates dry eye disease potentially through enhancement of short-chain fatty acid production by gut microbiota in mice","volume":"22","author":"Connell","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2026.06.003_bib254","article-title":"Comprehensive analysis of the relationships between the gut Microbiota and fecal metabolome in individuals with primary sjogren's syndrome by 16S rRNA sequencing and LC-MS-Based metabolomics","volume":"13","author":"Yang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtos.2026.06.003_bib255","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jtos.2021.07.006","article-title":"Tear metabolomics highlights new potential biomarkers for differentiating between sj\u00f6gren\u2019s syndrome and other causes of dry eye","volume":"22","author":"Urbanski","year":"2021","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2026.06.003_bib256","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2023.102370","article-title":"Recent advances towards mass spectrometry-based clinical lipidomics","volume":"76","author":"Salihovic","year":"2023","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.jtos.2026.06.003_bib257","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2026.111004","article-title":"Tear fluid multi-omics and biosensor integration for diagnosis and personalized therapeutics in dry eye disease","volume":"268","author":"Ghosh","year":"2026","journal-title":"Exp Eye Res"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib258","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/ICO.0000000000002869","article-title":"Development of a novel tear lipid test strip","volume":"41","author":"Li","year":"2022","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2026.06.003_bib259","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.127855","article-title":"Transformative potentials, challenges and innovative solutions of lipidomics in multiple clinical applications","volume":"291","author":"M","year":"2025","journal-title":"Talanta"},{"issue":"9","key":"10.1016\/j.jtos.2026.06.003_bib260","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1021\/acs.analchem.9b05078","article-title":"Schirmer paper noninvasive microsampling for direct mass spectrometry analysis of human tears","volume":"92","author":"Yao","year":"2020","journal-title":"Anal Chem"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib261","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1021\/acs.analchem.2c02598","article-title":"Omic-scale high-throughput quantitative LC\u2013MS\/MS approach for circulatory lipid phenotyping in clinical research","volume":"95","author":"Medina","year":"2023","journal-title":"Anal Chem"},{"key":"10.1016\/j.jtos.2026.06.003_bib262","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.114936","article-title":"Comprehensive MSI-based protocols for the spatial lipidomics characterization of microscale organisms","volume":"217","author":"Men\u00e9ndez-Pedriza","year":"2025","journal-title":"Microchem J"},{"key":"10.1016\/j.jtos.2026.06.003_bib263","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jtos.2024.12.010","article-title":"Systems biology of dry eye: unraveling molecular mechanisms through multi-omics integration","volume":"36","author":"Zhang","year":"2025","journal-title":"Ocul Surf"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib264","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12886-018-0700-y","article-title":"Short-term effect of a developed warming moist chamber goggle for video display terminal-associated dry eye","volume":"18","author":"Ren","year":"2018","journal-title":"BMC Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib265","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/01.ICL.0000060998.20142.8D","article-title":"Increase in tear film lipid layer thickness following treatment with warm compresses in patients with meibomian gland dysfunction","volume":"29","author":"Olson","year":"2003","journal-title":"Eye Contact Lens"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib266","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0316935","article-title":"Changes in the distribution of the tear film lipid layer after intensive pulsed light combined with meibomian gland expression in patients with meibomian gland dysfunction","volume":"20","author":"Lee","year":"2025","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jtos.2026.06.003_bib267","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.ophtha.2023.07.009","article-title":"Thermal pulsation in the management of meibomian gland dysfunction and dry eye: a report by the american academy of ophthalmology","volume":"130","author":"Tao","year":"2023","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib268","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00417-018-3932-x","article-title":"The effects of 3% diquafosol sodium eye drop application on meibomian gland and ocular surface alterations in the Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice","volume":"256","author":"Ikeda","year":"2018","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol = Albr Von Graefes Arch Fur Klin Exp Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib269","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0014-4835(03)00068-X","article-title":"Localization of ocular P2Y2 receptor gene expression by in situ hybridization","volume":"77","author":"Cowlen","year":"2003","journal-title":"Exp Eye Res"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib270","doi-asserted-by":"crossref","first-page":"9091","DOI":"10.1038\/s41598-019-45475-7","article-title":"Tear film lipid layer increase after diquafosol instillation in dry eye patients with meibomian gland dysfunction: a randomized clinical study","volume":"9","author":"Fukuoka","year":"2019","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.jtos.2026.06.003_bib271","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.xphs.2020.03.026","article-title":"Interactions of perfluorohexyloctane with polyethylene and polypropylene pharmaceutical packaging materials","volume":"109","author":"Falk","year":"2020","journal-title":"J Pharmacol Sci"},{"issue":"1\u20132","key":"10.1016\/j.jtos.2026.06.003_bib272","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijpharm.2018.01.019","article-title":"Semifluorinated alkane based systems for enhanced corneal penetration of poorly soluble drugs","volume":"538","author":"Agarwal","year":"2018","journal-title":"Int J Pharm"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib273","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1001\/jamaophthalmol.2023.0270","article-title":"Perfluorohexyloctane eye drops for dry eye disease associated with meibomian gland dysfunction in chinese patients: a randomized clinical trial","volume":"141","author":"Tian","year":"2023","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.jtos.2026.06.003_bib274","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2147\/OPTH.S13773","article-title":"Systane lubricant eye drops in the management of ocular dryness","volume":"5","author":"Benelli","year":"2011","journal-title":"Clin Ophthalmol"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib275","doi-asserted-by":"crossref","first-page":"122","DOI":"10.5301\/ejo.5000883","article-title":"Clinical evaluation of an oil-based lubricant eyedrop in dry eye patients with lipid deficiency","volume":"27","author":"Baudouin","year":"2017","journal-title":"Eur J Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib276","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000367851","article-title":"Efficacy and safety of topical atorvastatin for the treatment of dry eye associated with blepharitis: a pilot study","volume":"54","author":"Ooi","year":"2015","journal-title":"Ophthalmic Res"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib277","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s13258-024-01598-4","article-title":"miR-214-3p inhibits LPS-induced macrophage inflammation and attenuates the progression of dry eye syndrome by regulating ferroptosis in cells","volume":"47","author":"Zhao","year":"2025","journal-title":"Genes Genomics"},{"key":"10.1016\/j.jtos.2026.06.003_bib278","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119368","article-title":"Total saponin extracts of pseudostellaria heterophylla ameliorates meibomian gland dysfunction through SCD1\/SPT1\/ceramide axis","volume":"342","author":"Du","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jtos.2026.06.003_bib279","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177311","article-title":"Exploring the effect of chlorogenic acid on oxidative stress and autophagy in dry eye mice via the AMPK\/ULK1 pathway","volume":"991","author":"Chen","year":"2025","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib280","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ophtha.2019.07.009","article-title":"Effects of omega-3 supplementation on exploratory outcomes in the dry eye assessment and management study","volume":"127","author":"Oydanich","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2026.06.003_bib281","first-page":"336","article-title":"The role of omega-3 dietary supplementation in blepharitis and meibomian gland dysfunction (an AOS thesis)","volume":"106","author":"Macsai","year":"2008","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.jtos.2026.06.003_bib282","first-page":"555","article-title":"A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids","volume":"21","author":"Galbis-Estrada","year":"2015","journal-title":"Mol Vis"},{"issue":"4","key":"10.1016\/j.jtos.2026.06.003_bib283","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/ajcn\/82.4.887","article-title":"Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women","volume":"82","author":"Miljanovi\u0107","year":"2005","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib284","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.plefa.2014.02.005","article-title":"Potential for daily supplementation of n-3 fatty acids to reverse symptoms of dry eye in mice","volume":"90","author":"Harauma","year":"2014","journal-title":"Prostagl Leukot Essent Fat Acids"},{"issue":"8","key":"10.1016\/j.jtos.2026.06.003_bib285","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3945\/jn.109.118901","article-title":"Oral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eye","volume":"140","author":"Larmo","year":"2010","journal-title":"J Nutr"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib286","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1097\/ICL.0000000000001155","article-title":"Treatment of meibomian gland dysfunction by classical eyelid hygiene measures with and without additional lipid substitution for tear film stabilization","volume":"51","author":"Weinstein","year":"2025","journal-title":"Eye Contact Lens"},{"issue":"6","key":"10.1016\/j.jtos.2026.06.003_bib287","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1038\/s41385-018-0070-z","article-title":"Dietary DHA amplifies LXA(4) circuits in tissues and lymph node PMN and is protective in immune-driven dry eye disease","volume":"11","author":"Gao","year":"2018","journal-title":"Mucosal Immunol"},{"issue":"7","key":"10.1016\/j.jtos.2026.06.003_bib288","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.4049\/jimmunol.1500610","article-title":"Female-specific downregulation of tissue polymorphonuclear neutrophils drives impaired regulatory T cell and amplified effector T cell responses in autoimmune dry eye disease","volume":"195","author":"Gao","year":"2015","journal-title":"J Immunol"},{"issue":"7","key":"10.1016\/j.jtos.2026.06.003_bib289","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/jamaophthalmol.2024.1482","article-title":"Re-esterified triglyceride \u03c9-3 fatty acids in dry eye disease with meibomian gland dysfunction: a randomized clinical trial","volume":"142","author":"Eom","year":"2024","journal-title":"JAMA Ophthalmol"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib290","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2025.100730","article-title":"Magnitude and predictors of the placebo effects in the dry eye assessment and management study","volume":"5","author":"Han","year":"2025","journal-title":"Ophthalmol Sci"},{"key":"10.1016\/j.jtos.2026.06.003_bib291","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-3-319-07320-0_7","article-title":"Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease","volume":"824","author":"Tosi","year":"2014","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"10.1016\/j.jtos.2026.06.003_bib292","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.jacl.2017.06.011","article-title":"Relationship between the omega-3 index and specialized pro-resolving lipid mediators in patients with peripheral arterial disease taking fish oil supplements","volume":"11","author":"Schaller","year":"2017","journal-title":"J Clin Lipidol"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib293","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/antiox15010009","article-title":"Specialized pro-resolving lipid mediators and dietary omega-3\/6 fatty acids in selected inflammatory skin diseases: a systematic review","volume":"15","author":"Bie\u0142ach-Bazyluk","year":"2025","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.jtos.2026.06.003_bib294","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1001\/archophthalmol.2007.61","article-title":"Topical omega-3 and omega-6 fatty acids for treatment of dry eye","volume":"126","author":"Rashid","year":"2008","journal-title":"Arch Ophthalmol"},{"issue":"Suppl 1","key":"10.1016\/j.jtos.2026.06.003_bib295","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2165\/0126839-200809001-00002","article-title":"The aging eye and the role of L-carnitine and its derivatives","volume":"9","author":"Pescosolido","year":"2008","journal-title":"Drugs R&D"},{"issue":"3","key":"10.1016\/j.jtos.2026.06.003_bib296","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.survophthal.2025.01.003","article-title":"Extracellular vesicles in dry eye disease and sj\u00f6gren\u2019s syndrome: a systematic review on their diagnostic and therapeutic role","volume":"70","author":"Chopra","year":"2025","journal-title":"Surv Ophthalmol"},{"issue":"1","key":"10.1016\/j.jtos.2026.06.003_bib297","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/iovs.13-12577","article-title":"Lipid-modifying enzymes in human tear fluid and corneal epithelial stress response","volume":"55","author":"Robciuc","year":"2014","journal-title":"Investig Opthalmology Vis Sci"},{"issue":"10","key":"10.1016\/j.jtos.2026.06.003_bib298","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1002\/1873-3468.70004","article-title":"The enigmatic world of tear extracellular vesicles (EVs)\u2013exploring their role in ocular health and beyond","volume":"599","author":"Fatima","year":"2025","journal-title":"FEBS Lett"},{"issue":"12","key":"10.1016\/j.jtos.2026.06.003_bib299","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1080\/02713683.2025.2503214","article-title":"Extracellular vesicles of tears and ocular surface: an enigma","volume":"50","author":"Fatima","year":"2025","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jtos.2026.06.003_bib300","doi-asserted-by":"crossref","unstructured":"Lecolier N, Mortemousque G, Dupuy C, et al. Validation of a standardized metabo-lipidomic workflow for human conjunctival impression cytology specimens. Am J Ophthalmol. Published online November 2025:S0002939425006312. doi:10.1016\/j.ajo.2025.11.032.","DOI":"10.1016\/j.ajo.2025.11.032"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012426000698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012426000698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:06:00Z","timestamp":1790283960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012426000698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":300,"alternative-id":["S1542012426000698"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2026.06.003","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulated lipid metabolism in dry eye disease: Pathophysiological mechanisms and emerging treatments","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2026.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}