{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:54:39Z","timestamp":1792029279345,"version":"4.4.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ90130"],"award-info":[{"award-number":["2025JJ90130"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ6403"],"award-info":[{"award-number":["2024JJ6403"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["BX20240154"],"award-info":[{"award-number":["BX20240154"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M741610"],"award-info":[{"award-number":["2023M741610"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M751351"],"award-info":[{"award-number":["2024M751351"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970773"],"award-info":[{"award-number":["81970773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471047"],"award-info":[{"award-number":["82471047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401223"],"award-info":[{"award-number":["82401223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jtos.2026.07.008","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:41:59Z","timestamp":1784590919000},"page":"144-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The Hippo signaling pathway regulates corneal endothelial regeneration"],"prefix":"10.1016","volume":"42","author":[{"given":"Jingbin","family":"Zhuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuli","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houjian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shundong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengchao","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Quantock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9815-9623","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2026.07.008_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.07.001","article-title":"Corneal structure and transparency","volume":"49","author":"Meek","year":"2015","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2026.07.008_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2024.101275","article-title":"Cell therapy in the cornea: the emerging role of microenvironment","volume":"102","author":"Suanno","year":"2024","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2026.07.008_bib3","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/sj.eye.6700559","article-title":"Biology of the corneal endothelium in health and disease","volume":"17","author":"Bourne","year":"2003","journal-title":"Eye"},{"key":"10.1016\/j.jtos.2026.07.008_bib4","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1055\/a-1128-4445","article-title":"Corneal endothelial decompensation","volume":"237","author":"Gupta","year":"2020","journal-title":"Klin Monatsbl Augenh"},{"key":"10.1016\/j.jtos.2026.07.008_bib5","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1002\/stem.1212","article-title":"Revisited microanatomy of the corneal endothelial periphery: new evidence for continuous centripetal migration of endothelial cells in humans","volume":"30","author":"He","year":"2012","journal-title":"Stem Cell"},{"key":"10.1016\/j.jtos.2026.07.008_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116641","article-title":"Verteporfin combined with ROCK inhibitor promotes the restoration of corneal endothelial cell dysfunction in rats","volume":"231","author":"Zhang","year":"2025","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jtos.2026.07.008_bib7","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.ophtha.2023.07.024","article-title":"Descemet stripping automated endothelial keratoplasty versus descemet membrane endothelial keratoplasty for fuchs endothelial corneal dystrophy","volume":"130","author":"Viberg","year":"2023","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2026.07.008_bib8","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.ophtha.2016.03.011","article-title":"Descemet stripping endothelial keratoplasty","volume":"123","author":"Price","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2026.07.008_bib9","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1056\/NEJMoa1712770","article-title":"Injection of cultured cells with a ROCK inhibitor for bullous keratopathy","volume":"378","author":"Kinoshita","year":"2018","journal-title":"New Engl J Med"},{"key":"10.1016\/j.jtos.2026.07.008_bib10","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ophtha.2020.09.002","article-title":"Five-year Follow-up of first 11 patients undergoing injection of cultured corneal endothelial cells for corneal endothelial failure","volume":"128","author":"Numa","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jtos.2026.07.008_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/JCI146658","article-title":"Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide","volume":"132","author":"Li","year":"2022","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jtos.2026.07.008_bib12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1167\/iovs.13-12225","article-title":"Involvement of cyclin D and p27 in cell proliferation mediated by ROCK inhibitors Y-27632 and Y-39983 during corneal endothelium wound healing","volume":"55","author":"Okumura","year":"2014","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.07.008_bib13","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1167\/iovs.16-20414","article-title":"Corneal endothelial cell migration and proliferation enhanced by rho kinase (ROCK) inhibitors in in vitro and in vivo models","volume":"57","author":"Meekins","year":"2016","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.07.008_bib14","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1167\/iovs.15-18586","article-title":"Effect of the rho-associated kinase inhibitor eye drop (Ripasudil) on corneal endothelial wound healing","volume":"57","author":"Okumura","year":"2016","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.07.008_bib15","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/ICO.0000000000001823","article-title":"Topical rho-associated kinase inhibitor, Y27632, accelerates corneal endothelial regeneration in a canine cryoinjury model","volume":"38","author":"Miyagi","year":"2019","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2026.07.008_bib16","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1097\/ICO.0b013e318285475d","article-title":"Rho-associated kinase inhibitor eye drop treatment as a possible medical treatment for fuchs corneal dystrophy","volume":"32","author":"Koizumi","year":"2013","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2026.07.008_bib17","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1097\/ICO.0000000000001209","article-title":"Descemetorhexis without grafting for fuchs endothelial dystrophy-supplementation with topical ripasudil","volume":"36","author":"Moloney","year":"2017","journal-title":"Cornea"},{"key":"10.1016\/j.jtos.2026.07.008_bib18","article-title":"Application of Rho kinase inhibitors for the treatment of corneal endothelial diseases","volume":"2017","author":"Okumura","year":"2017","journal-title":"J Ophthalmol"},{"key":"10.1016\/j.jtos.2026.07.008_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108629","article-title":"Comparison of the rabbit and human corneal endothelial proteomes regarding proliferative capacity","volume":"209","author":"Pei","year":"2021","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jtos.2026.07.008_bib20","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1167\/iovs.03-1238","article-title":"Involvement of p27 in the proliferation of the developing corneal endothelium","volume":"45","author":"Yoshida","year":"2004","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.07.008_bib21","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1001\/archopht.1989.01070020886032","article-title":"Cell division in the healing of the corneal endothelium of cats","volume":"107","author":"Landshman","year":"1989","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jtos.2026.07.008_bib22","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.devcel.2017.11.010","article-title":"Zebrafish regulatory T cells mediate organ-specific regenerative programs","volume":"43","author":"Hui","year":"2017","journal-title":"Dev Cell"},{"key":"10.1016\/j.jtos.2026.07.008_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-44142-w","article-title":"Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina","volume":"14","author":"Lyu","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jtos.2026.07.008_bib24","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.86507","article-title":"Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration","volume":"12","author":"Celotto","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.jtos.2026.07.008_bib25","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1242\/jcs.103267","article-title":"Nuclear p120 catenin unlocks mitotic block of contact-inhibited human corneal endothelial monolayers without disrupting adherent junctions","volume":"125","author":"Zhu","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jtos.2026.07.008_bib26","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1089\/ten.tea.2020.0047","article-title":"Laminin 511 precoating promotes the functional recovery of transplanted corneal endothelial cells","volume":"26","author":"Zhao","year":"2020","journal-title":"Tissue Eng Pt A"},{"key":"10.1016\/j.jtos.2026.07.008_bib27","article-title":"Lysophosphatidic acid induces YAP-promoted proliferation of human corneal endothelial cells via PI3K and ROCK pathways","volume":"2","author":"Hsueh","year":"2015","journal-title":"Mol Ther Meth Clin D"},{"key":"10.1016\/j.jtos.2026.07.008_bib28","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.reth.2025.08.014","article-title":"Ex vivo expansion of corneal endothelial cells enabled by small molecule inhibitors of LATS kinase","volume":"30","author":"Abe-Fukasawa","year":"2025","journal-title":"Regen Ther"},{"key":"10.1016\/j.jtos.2026.07.008_bib29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1167\/iovs.65.3.15","article-title":"Substrate stiffness modulates stemness and differentiation of rabbit corneal endothelium through the Paxillin-YAP pathway","volume":"65","author":"Liu","year":"2024","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.07.008_bib30","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.matbio.2024.10.001","article-title":"COL8A2 activation enhances function of corneal endothelial cells through HIPPO signaling\/mitochondria pathway","volume":"134","author":"Ryu","year":"2024","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jtos.2026.07.008_bib31","first-page":"1674","article-title":"Integrin signalling regulates YAP and TAZ to control skin homeostasis","volume":"143","author":"Elbediwy","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.jtos.2026.07.008_bib32","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.celrep.2016.07.020","article-title":"MAPK-mediated YAP activation controls mechanical-tension-induced pulmonary alveolar regeneration","volume":"16","author":"Liu","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.jtos.2026.07.008_bib33","doi-asserted-by":"crossref","first-page":"13839","DOI":"10.1073\/pnas.1313192110","article-title":"Hippo pathway effector Yap promotes cardiac regeneration","volume":"110","author":"Xin","year":"2013","journal-title":"P Natl Acad Sci USA"},{"key":"10.1016\/j.jtos.2026.07.008_bib34","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1073\/pnas.0911427107","article-title":"Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver","volume":"107","author":"Lu","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jtos.2026.07.008_bib35","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1101\/gad.210773.112","article-title":"The hippo pathway: regulators and regulations","volume":"27","author":"Yu","year":"2013","journal-title":"Gene Dev"},{"key":"10.1016\/j.jtos.2026.07.008_bib36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2005.06.007","article-title":"The hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the homolog of YAP","volume":"122","author":"Huang","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jtos.2026.07.008_bib37","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.ajpath.2019.11.008","article-title":"Hyperlipidemia affects tight junctions and pump function in the corneal endothelium","volume":"190","author":"Bu","year":"2020","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtos.2026.07.008_bib38","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1167\/iovs.12-11320","article-title":"The ROCK inhibitor eye drop accelerates corneal endothelium wound healing","volume":"54","author":"Okumura","year":"2013","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.07.008_bib39","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1073\/pnas.1912546116","article-title":"Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected","volume":"117","author":"Liu","year":"2020","journal-title":"P Natl Acad Sci USA"},{"key":"10.1016\/j.jtos.2026.07.008_bib40","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1182\/blood.V86.5.1828.bloodjournal8651828","article-title":"Endothelial-specific gene expression directed by the tie gene promoter in vivo","volume":"86","author":"Korhonen","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.jtos.2026.07.008_bib41","doi-asserted-by":"crossref","first-page":"C796","DOI":"10.1152\/ajpcell.00445.2019","article-title":"NAD(+) precursors protect corneal endothelial cells from UVB-induced apoptosis","volume":"318","author":"Zhao","year":"2020","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jtos.2026.07.008_bib42","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1167\/iovs.06-1126","article-title":"A novel method of isolation, preservation, and expansion of human corneal endothelial cells","volume":"48","author":"Li","year":"2007","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.07.008_bib43","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.stemcr.2022.03.017","article-title":"Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film","volume":"17","author":"Li","year":"2022","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.jtos.2026.07.008_bib44","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.jhep.2014.06.033","article-title":"YAP activation is an early event and a potential therapeutic target in liver cancer development","volume":"61","author":"Perra","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jtos.2026.07.008_bib45","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ upstream signals and downstream responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jtos.2026.07.008_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf2304","article-title":"Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration","volume":"8","author":"Fan","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jtos.2026.07.008_bib48","doi-asserted-by":"crossref","first-page":"6983","DOI":"10.1038\/s41598-017-07557-2","article-title":"Descemet's membrane supports corneal endothelial cell regeneration in rabbits","volume":"7","author":"Chen","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtos.2026.07.008_bib49","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41580-018-0086-y","article-title":"Hippo-YAP\/TAZ signalling in organ regeneration and regenerative medicine","volume":"20","author":"Moya","year":"2019","journal-title":"Nat Rev Mol Cell Bio"},{"key":"10.1016\/j.jtos.2026.07.008_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-23395-3","article-title":"Small-molecule inhibition of lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues","volume":"12","author":"Kastan","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jtos.2026.07.008_bib51","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.stem.2019.01.013","article-title":"MAP4K4 inhibition promotes survival of human stem cell-derived cardiomyocytes and reduces infarct size","volume":"24","author":"Fiedler","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jtos.2026.07.008_bib52","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.cell.2016.11.052","article-title":"In vivo amelioration of age-associated hallmarks by partial reprogramming","volume":"167","author":"Ocampo","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jtos.2026.07.008_bib53","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.cell.2014.03.060","article-title":"Hippo pathway activity influences liver cell fate","volume":"157","author":"Yimlamai","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jtos.2026.07.008_bib54","doi-asserted-by":"crossref","first-page":"13839","DOI":"10.1073\/pnas.1313192110","article-title":"Hippo pathway effector Yap promotes cardiac regeneration","volume":"110","author":"Xin","year":"2013","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012426001072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012426001072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:15:55Z","timestamp":1791850555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012426001072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":53,"alternative-id":["S1542012426001072"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2026.07.008","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Hippo signaling pathway regulates corneal endothelial regeneration","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2026.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}