{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:42:20Z","timestamp":1792791740217,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012576","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012576","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018634","name":"Sun Yat-Sen University Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Ocular Surface"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jtos.2026.10.002","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:22:42Z","timestamp":1792106562000},"page":"359-375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The mtROS-Stat1 axis defines an acinar dysfunctional state linking metabolic stress to immune activation in cigarette smoking-associated dry eye disease"],"prefix":"10.1016","volume":"42","author":[{"given":"Zedu","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengzefang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtos.2026.10.002_bib1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ajo.2025.05.033","article-title":"Tfos DEWS III: diagnostic methodology","volume":"279","author":"Wolffsohn","year":"2025","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jtos.2026.10.002_bib2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2026.10.002_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clae.2020.02.009","article-title":"Ocular conditions and dry eye due to traditional and new forms of smoking: a review","volume":"43","author":"Makrynioti","year":"2020","journal-title":"Contact Lens Anterior Eye"},{"key":"10.1016\/j.jtos.2026.10.002_bib4","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.3390\/jcm13092619","article-title":"The impact of vaping on the ocular surface: a systematic review of the literature","volume":"13","author":"Bandara","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.jtos.2026.10.002_bib5","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.4103\/ijo.IJO_2193_21","article-title":"Association of dry eye disease with smoking: a systematic review and meta-analysis","volume":"70","author":"Tariq","year":"2022","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.jtos.2026.10.002_bib6","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jtos.2023.04.008","article-title":"TFOS Lifestyle: impact of lifestyle challenges on the ocular surface","volume":"28","author":"Galor","year":"2023","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2026.10.002_bib7","doi-asserted-by":"crossref","first-page":"DES169","DOI":"10.1167\/iovs.17-23576","article-title":"Regeneration of lacrimal Gland function to maintain the health of the ocular surface","volume":"59","author":"Kawakita","year":"2018","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.10.002_bib8","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.freeradbiomed.2011.09.025","article-title":"Corneal damage and lacrimal gland dysfunction in a smoking rat model","volume":"51","author":"Higuchi","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jtos.2026.10.002_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrrev.2021.108365","article-title":"Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer","volume":"787","author":"Caliri","year":"2021","journal-title":"Mutat Res Rev Mutat Res"},{"key":"10.1016\/j.jtos.2026.10.002_bib10","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1093\/toxsci\/kfv143","article-title":"Glutathione depletion accelerates cigarette smoke-induced inflammation and airspace enlargement","volume":"147","author":"Gould","year":"2015","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jtos.2026.10.002_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1733","article-title":"Heavy metals in cigarette smoke strongly inhibit pancreatic ductal function and promote development of chronic pancreatitis","volume":"14","author":"Pallagi","year":"2024","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.jtos.2026.10.002_bib12","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1053\/j.gastro.2013.01.068","article-title":"The epidemiology of pancreatitis and pancreatic cancer","volume":"144","author":"Yadav","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtos.2026.10.002_bib13","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.stem.2021.02.024","article-title":"Exploring the human lacrimal gland using organoids and single-cell sequencing","volume":"28","author":"Bannier-H\u00e9laou\u00ebt","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jtos.2026.10.002_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116517","article-title":"Environmental exposure augments the abundance and transferability of antibiotic resistance genes in the respiratory tract","volume":"44","author":"Yi","year":"2025","journal-title":"Cell Rep"},{"key":"10.1016\/j.jtos.2026.10.002_bib15","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/s41564-022-01196-8","article-title":"Multi-omics analyses of airway host\u2013microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions","volume":"7","author":"Yan","year":"2022","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jtos.2026.10.002_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102828","article-title":"Epigenetic modulation of Drp1-mediated mitochondrial fission by inhibition of S-adenosylhomocysteine hydrolase promotes vascular senescence and atherosclerosis","volume":"65","author":"You","year":"2023","journal-title":"Redox Biol"},{"key":"10.1016\/j.jtos.2026.10.002_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133719","article-title":"Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells","volume":"467","author":"Liu","year":"2024","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jtos.2026.10.002_bib18","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1038\/s41467-023-37727-y","article-title":"Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast cancer","volume":"14","author":"Palakurthi","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jtos.2026.10.002_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106615","article-title":"Targeting Type I IFN\/STAT1 signaling inhibited and reversed corneal squamous metaplasia in Aire-deficient mouse","volume":"187","author":"Yu","year":"2023","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jtos.2026.10.002_bib20","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jtos.2024.08.007","article-title":"Development and validation of a method to generate phenol red thread tests","volume":"34","author":"Puentes","year":"2024","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jtos.2026.10.002_bib21","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1167\/iovs.18-26457","article-title":"Evaluation of corneal damage after lacrimal gland excision in Male and female mice","volume":"60","author":"Mecum","year":"2019","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.10.002_bib22","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.3390\/cells10092177","article-title":"A universal approach to analyzing transmission electron microscopy with ImageJ","volume":"10","author":"Lam","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jtos.2026.10.002_bib23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2337\/db13-0340","article-title":"Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NF\u03baB-Opa-1 signaling pathway","volume":"63","author":"Parra","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jtos.2026.10.002_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2024.102921","article-title":"Protocol to examine immune subpopulations in murine conjunctiva and lacrimal gland using flow cytometry","volume":"5","author":"Ma","year":"2024","journal-title":"STAR Protoc"},{"key":"10.1016\/j.jtos.2026.10.002_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2024.103395","article-title":"Protocol for the generation of single-nuclei RNA-seq libraries and quantification of heterogeneous cell types activated during social interaction","volume":"5","author":"Walker","year":"2024","journal-title":"STAR Protoc"},{"key":"10.1016\/j.jtos.2026.10.002_bib26","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrrheum.2017.23","article-title":"The emerging safety profile of JAK inhibitors in rheumatic disease","volume":"13","author":"Winthrop","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jtos.2026.10.002_bib27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1167\/iovs.66.4.4","article-title":"Comparative evaluation of cigarette smoke and a heated tobacco product on corneal oxidative stress in an Air\/Liquid interface model","volume":"66","author":"Giallongo","year":"2025","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.10.002_bib28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.freeradbiomed.2020.04.007","article-title":"Dry eye induced by exposure to cigarette smoke pollution: an in vivo and in vitro study","volume":"153","author":"Li","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jtos.2026.10.002_bib29","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.3390\/ijms24033015","article-title":"The EPH\/Ephrin System in pancreatic ductal adenocarcinoma (PDAC): from pathogenesis to treatment","volume":"24","author":"Papadakos","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2026.10.002_bib30","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.biocel.2008.07.019","article-title":"Eph\/ephrin signaling in epithelial development and homeostasis","volume":"41","author":"Miao","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jtos.2026.10.002_bib31","article-title":"NRG4 suppresses breast cancer metastasis via ERBB4-YAP1-mediated down-regulation of MMPs","volume":"13","author":"Wang","year":"2026","journal-title":"Genes Dis"},{"key":"10.1016\/j.jtos.2026.10.002_bib32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.preteyeres.2009.04.003","article-title":"Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases","volume":"28","author":"Dartt","year":"2009","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jtos.2026.10.002_bib33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.freeradbiomed.2021.02.036","article-title":"Hyperglycemia-induced severe mitochondrial bioenergetic deficit of lacrimal gland contributes to the early onset of dry eye in diabetic mice","volume":"166","author":"Qu","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jtos.2026.10.002_bib34","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41420-024-02159-0","article-title":"Multifaceted mitochondrial as a novel therapeutic target in dry eye: insights and interventions","volume":"10","author":"Ouyang","year":"2024","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.jtos.2026.10.002_bib35","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/iovs.65.13.12","article-title":"PINK1\/Parkin-Mediated mitophagy ameliorates mitochondrial dysfunction in lacrimal gland Acinar cells during aging","volume":"65","author":"Zhao","year":"2024","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtos.2026.10.002_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1503087","article-title":"Mitochondrial dysfunction in pancreatic acinar cells: mechanisms and therapeutic strategies in acute pancreatitis","volume":"15","author":"Chen","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtos.2026.10.002_bib37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ceca.2007.11.013","article-title":"Mitochondrial injury in pancreatitis","volume":"44","author":"Mukherjee","year":"2008","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jtos.2026.10.002_bib38","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jtos.2026.10.002_bib39","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1136\/ard-2023-224842","article-title":"Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sj\u00f6gren\u2019s disease","volume":"83","author":"Gupta","year":"2024","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jtos.2026.10.002_bib40","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2022-002694","article-title":"Phosphorylated signal transducer and activator of transcription proteins 1 in salivary glandular tissue: an important histological marker for diagnosis of primary Sj\u00f6gren\u2019s syndrome","volume":"9","author":"Zheng","year":"2023","journal-title":"RMD Open"},{"key":"10.1016\/j.jtos.2026.10.002_bib41","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3390\/antiox14121395","article-title":"ROS-driven STAT1 S-Glutathionylation sustains IFN\u03b3 signaling and pro-inflammatory microglial polarization","volume":"14","author":"Brattini","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.jtos.2026.10.002_bib42","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1038\/s42255-025-01390-y","article-title":"Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology","volume":"7","author":"Barnett","year":"2025","journal-title":"Nat Metab"},{"key":"10.1016\/j.jtos.2026.10.002_bib43","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/bjophthalmol-2015-307415","article-title":"Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction","volume":"100","author":"Baudouin","year":"2016","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jtos.2026.10.002_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262110583","article-title":"The immunobiology of dry eye disease: a review of the pathogenesis, regulation and therapeutic implications","volume":"26","author":"Saram","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtos.2026.10.002_bib45","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41584-021-00605-2","article-title":"Epithelial-immune cell interplay in primary Sj\u00f6gren syndrome salivary gland pathogenesis","volume":"17","author":"Verstappen","year":"2021","journal-title":"Nat Rev Rheumatol"}],"container-title":["The Ocular Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012426001266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542012426001266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:29:50Z","timestamp":1792790990000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542012426001266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":45,"alternative-id":["S1542012426001266"],"URL":"https:\/\/doi.org\/10.1016\/j.jtos.2026.10.002","relation":{},"ISSN":["1542-0124"],"issn-type":[{"value":"1542-0124","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mtROS-Stat1 axis defines an acinar dysfunctional state linking metabolic stress to immune activation in cigarette smoking-associated dry eye disease","name":"articletitle","label":"Article Title"},{"value":"The Ocular Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtos.2026.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}