{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:39:16Z","timestamp":1793245156536,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Taibah University Medical Sciences"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jtumed.2025.06.001","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T02:08:26Z","timestamp":1750039706000},"page":"365-375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chromium restriction in the intrauterine environment and development of metabolic diseases in mice offspring"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4538-2543","authenticated-orcid":false,"given":"Samreen","family":"Memon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umbreen","family":"Bano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syna P.","family":"Singha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Y.","family":"Shahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pashmina","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia B.","family":"Shahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3043-1213","authenticated-orcid":false,"given":"Shaheer S.","family":"Memon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtumed.2025.06.001_bib1","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1136\/bmj.303.6809.1019","article-title":"Fetal and infant growth and impaired glucose tolerance at age 64","volume":"303","author":"Hales","year":"1991","journal-title":"BMJ"},{"key":"10.1016\/j.jtumed.2025.06.001_bib2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000209222","article-title":"Maternal perinatal undernutrition alters postnatal development of chromaffin cells in the male rat adrenal medulla","volume":"90","author":"Molendi-Coste","year":"2009","journal-title":"Neuroendocrinology (Basel)"},{"key":"10.1016\/j.jtumed.2025.06.001_bib3","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/s00125-012-2589-y","article-title":"The thrifty phenotype hypothesis revisited","volume":"55","author":"Vaag","year":"2012","journal-title":"Diabetologia (Berl)"},{"key":"10.1016\/j.jtumed.2025.06.001_bib4","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1001\/jama.2008.886","article-title":"Birth weight and risk of type 2 diabetes: a systematic review","volume":"300","author":"Whincup","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.jtumed.2025.06.001_bib5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/10253890601056192","article-title":"Perinatal maternal undernutrition programs the offspring hypothalamo-pituitary-adrenal (HPA) axis","volume":"9","author":"Lesage","year":"2006","journal-title":"Stress (Luxemb)"},{"key":"10.1016\/j.jtumed.2025.06.001_bib6","first-page":"73","article-title":"Undernutrition during early lactation as an alternative model to study the onset of diabetes mellitus type II","volume":"92","author":"Moura","year":"1996","journal-title":"Res Commun Mol Pathol Pharmacol"},{"key":"10.1016\/j.jtumed.2025.06.001_bib7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1365-2826.2010.02095.x","article-title":"Metabolic imprinting by maternal protein malnourishment impairs vagal activity in adult rats","volume":"23","author":"De Oliveira","year":"2011","journal-title":"J Neuroendocrinol"},{"issue":"2B","key":"10.1016\/j.jtumed.2025.06.001_bib8","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1079\/PHN2001145","article-title":"Fetal programming and adult health","volume":"4","author":"Godfrey","year":"2001","journal-title":"Public Health Nutr"},{"issue":"1","key":"10.1016\/j.jtumed.2025.06.001_bib9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra0708473","article-title":"Effect of in utero and early-life conditions on adult health and disease","volume":"359","author":"Gluckman","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtumed.2025.06.001_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/toxsci\/kfm177","article-title":"The dynamic epigenome and its implications in toxicology","volume":"100","author":"Szyf","year":"2007","journal-title":"Toxicol Sci"},{"issue":"4","key":"10.1016\/j.jtumed.2025.06.001_bib11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.tem.2009.12.007","article-title":"Epigenetic transgenerational actions of environmental factors in disease etiology","volume":"21","author":"Skinner","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jtumed.2025.06.001_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1152\/physrev.1969.49.2.163","article-title":"Chromium occurrence and function in biological systems","volume":"49","author":"Mertz","year":"1969","journal-title":"Physiol Rev"},{"issue":"1","key":"10.1016\/j.jtumed.2025.06.001_bib13","article-title":"Dietary chromium restriction of pregnant mice changes the methylation status of hepatic genes involved with insulin signaling in adult male offspring","volume":"12","author":"Zhang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jtumed.2025.06.001_bib14","first-page":"286","article-title":"Minerals","volume":"17","author":"Candilish","year":"2000","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.jtumed.2025.06.001_bib15","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/jdi.12350","article-title":"Effects of chromium malate on glycometabolism, glycometabolism-related enzyme levels and lipid metabolism in type 2 diabetic rats: a dose-response and curative effects study","volume":"6","author":"Feng","year":"2015","journal-title":"J. Diabetes Investig"},{"key":"10.1016\/j.jtumed.2025.06.001_bib16","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jinorgbio.2010.03.015","article-title":"Urinary chromium loss associated with diabetes is offset by increases in absorption","volume":"104","author":"Rhodes","year":"2010","journal-title":"J Inorg Biochem"},{"issue":"4","key":"10.1016\/j.jtumed.2025.06.001_bib17","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1210\/endo-103-4-1440","article-title":"The effect of zinc on insulin metabolism","volume":"103","author":"Arquilla","year":"1978","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.jtumed.2025.06.001_bib18","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/0006-291X(66)90785-6","article-title":"The reduced secretion of, and sensitivity to insulin in zinc-deficient rats","volume":"25","author":"Quarterman","year":"1966","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.jtumed.2025.06.001_bib19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3181\/00379727-150-39077","article-title":"Glucose tolerance, plasma and pancreatic insulin levels in zinc deficient rats","volume":"150","author":"Brown","year":"1975","journal-title":"Proc Soc Exp Biol Med"},{"issue":"3","key":"10.1016\/j.jtumed.2025.06.001_bib20","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/ajcn\/37.3.382","article-title":"Tissue zinc status of genetically diabetic and streptozotocin-induced diabetic mice","volume":"37","author":"Levine","year":"1983","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"10.1016\/j.jtumed.2025.06.001_bib21","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/jcpt.12147","article-title":"Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes","volume":"39","author":"Suksomboon","year":"2014","journal-title":"J Clin Pharm Therapeut"},{"issue":"2","key":"10.1016\/j.jtumed.2025.06.001_bib22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1123\/ijsn.2.2.111","article-title":"Efficacy of chromium supplementation in athletes: emphasis on anabolism","volume":"2","author":"Lefavi","year":"1992","journal-title":"Int J Sport Nutr"},{"issue":"6","key":"10.1016\/j.jtumed.2025.06.001_bib23","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.clnu.2022.02.015","article-title":"ESPEN micronutrient guideline","volume":"41","author":"Berger","year":"2022","journal-title":"Clin Nutr"},{"issue":"10","key":"10.1016\/j.jtumed.2025.06.001_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17101767","article-title":"Maternal chromium restriction leads to glucose metabolism imbalance in mice offspring through insulin signaling and wnt signaling pathways","volume":"17","author":"Zhang","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jtumed.2025.06.001_bib25","article-title":"Dietary chromium restriction of pregnant mice changes the methylation status of hepatic genes involved with insulin signaling in adult male offspring","volume":"12","author":"Zhang","year":"2017","journal-title":"PLoS One"},{"issue":"14","key":"10.1016\/j.jtumed.2025.06.001_bib26","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1177\/1535370217719059","article-title":"Maternal chromium restriction modulates miRNA profiles related to lipid metabolism disorder in mice offspring","volume":"242","author":"Zhang","year":"2017","journal-title":"Exp Biol Med"},{"issue":"5 Suppl","key":"10.1016\/j.jtumed.2025.06.001_bib27","doi-asserted-by":"crossref","first-page":"838s","DOI":"10.1093\/jn\/127.5.838S","article-title":"Components of the AIN-93 diets as improvements in the AIN-76A diet","volume":"127","author":"Reeves","year":"1997","journal-title":"J Nutr"},{"issue":"3","key":"10.1016\/j.jtumed.2025.06.001_bib28","first-page":"1547","article-title":"Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA","volume":"41","author":"Zhang","year":"2018","journal-title":"Int J Mol Med"},{"issue":"5","key":"10.1016\/j.jtumed.2025.06.001_bib29","first-page":"521","article-title":"Epigenetic effects of in utero bisphenol A administration: diabetogenic and atherogenic changes in mice offspring","volume":"22","author":"Bano","year":"2019","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.jtumed.2025.06.001_bib30","first-page":"15.11.11","article-title":"Experimental autoimmune encephalomyelitis in the mouse","volume":"88","author":"Miller","year":"2010","journal-title":"Curr Protoc Im"},{"issue":"26","key":"10.1016\/j.jtumed.2025.06.001_bib31","first-page":"10","article-title":"A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments","volume":"10","author":"Robert","year":"2014","journal-title":"Mol Pain"},{"key":"10.1016\/j.jtumed.2025.06.001_bib32","volume":"vol. 8","author":"Kim","year":"2012"},{"issue":"3","key":"10.1016\/j.jtumed.2025.06.001_bib33","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1186\/1751-0147-42-311","article-title":"Experimental copper deficiency, chromium deficiency and additional molybdenum supplementation in goats--pathological findings","volume":"42","author":"Aupperle","year":"2001","journal-title":"Acta Vet Scand"},{"issue":"3","key":"10.1016\/j.jtumed.2025.06.001_bib34","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1179\/147683010X12611460764084","article-title":"Improved cognitive-cerebral function in older adults with chromium supplementation","volume":"13","author":"Krikorian","year":"2010","journal-title":"Nutr Neurosci"},{"issue":"11","key":"10.1016\/j.jtumed.2025.06.001_bib35","article-title":"Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment","volume":"11","author":"McCleery","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"10.1016\/j.jtumed.2025.06.001_bib36","doi-asserted-by":"crossref","first-page":"820","DOI":"10.2337\/diab.26.9.820","article-title":"Metabolic effects of the glucose tolerance factor (GTF) in normal and genetically diabetic mice","volume":"26","author":"Tuman","year":"1977","journal-title":"Diabetes"},{"key":"10.1016\/j.jtumed.2025.06.001_bib37","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.3390\/ijms17101767","article-title":"Maternal chromium restriction leads to glucose metabolism imbalance in mice offspring through insulin signaling and wnt signaling pathways","volume":"17","author":"Zhang","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jtumed.2025.06.001_bib38","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2337\/db09-0779","article-title":"Chronic maternal dietary chromium restriction modulates visceral adiposity: probable underlying mechanisms","volume":"59","author":"Padmavathi","year":"2010","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.jtumed.2025.06.001_bib39","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0026-0495(68)90066-8","article-title":"Failure of trivalent chromium to improve hyperglycemia in diabetes mellitus","volume":"17","author":"Sherman","year":"1968","journal-title":"Metab, Clin Exp"},{"key":"10.1016\/j.jtumed.2025.06.001_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2021.126879","article-title":"The effect of chromium intake on oxidative stress parameters: a systematic review and meta-analysis","volume":"69","author":"Morvaridzadeh","year":"2022","journal-title":"J Trace Elem Med Biol"},{"issue":"1\u20132","key":"10.1016\/j.jtumed.2025.06.001_bib41","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mce.2008.06.020","article-title":"Fetal programming of glucose-insulin metabolism","volume":"297","author":"Jones","year":"2009","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"10.1016\/j.jtumed.2025.06.001_bib42","article-title":"Dietary chromium restriction of pregnant mice changes the methylation status of hepatic genes involved with insulin signaling in adult male offspring","volume":"12","author":"Zhang","year":"2017","journal-title":"PLoS One"}],"container-title":["Journal of Taibah University Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658361225000538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658361225000538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:37:13Z","timestamp":1762555033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1658361225000538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1658361225000538"],"URL":"https:\/\/doi.org\/10.1016\/j.jtumed.2025.06.001","relation":{},"ISSN":["1658-3612"],"issn-type":[{"value":"1658-3612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chromium restriction in the intrauterine environment and development of metabolic diseases in mice offspring","name":"articletitle","label":"Article Title"},{"value":"Journal of Taibah University Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtumed.2025.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}