{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T16:23:45Z","timestamp":1766247825517,"version":"3.48.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Taibah University Medical Sciences"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jtumed.2025.11.007","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T21:01:32Z","timestamp":1765918892000},"page":"846-854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of remineralizing dentifrices against caries lesions: A systematic approach"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7160-2661","authenticated-orcid":false,"given":"Fatima T.","family":"Zahra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-4449","authenticated-orcid":false,"given":"Mehmood","family":"Asghar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5157-7067","authenticated-orcid":false,"given":"Muhammad S.","family":"Zafar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9624-1842","authenticated-orcid":false,"given":"Asma T.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9934-9744","authenticated-orcid":false,"given":"Muhammad","family":"Kaleem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2015","series-title":"Dental caries: the disease and its clinical management","author":"Fejerskov","key":"10.1016\/j.jtumed.2025.11.007_bib1"},{"issue":"7","key":"10.1016\/j.jtumed.2025.11.007_bib2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.sdentj.2021.04.004","article-title":"Bioactive toothpastes in dentin hypersensitivity treatment: a systematic review","volume":"33","author":"Freitas","year":"2021","journal-title":"Saudi Dent J"},{"issue":"3","key":"10.1016\/j.jtumed.2025.11.007_bib3","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3233\/THC-230722","article-title":"Long term remineralizing effect of casein phosphopeptide amorphous calcium phosphate in white spot lesions: a systematic review and meta-analysis","volume":"32","author":"AlBuraiki","year":"2024","journal-title":"Technol Health Care"},{"issue":"s1","key":"10.1016\/j.jtumed.2025.11.007_bib4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/adj.12048","article-title":"Diagnosis of the early carious lesion","volume":"58","author":"Manton","year":"2013","journal-title":"Aust Dent J"},{"issue":"10","key":"10.1016\/j.jtumed.2025.11.007_bib5","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1177\/154405910808701019","article-title":"Elevated fluoride products enhance remineralization of advanced enamel lesions","volume":"87","author":"ten Cate","year":"2008","journal-title":"J Dent Res"},{"issue":"7","key":"10.1016\/j.jtumed.2025.11.007_bib6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.archoralbio.2010.05.002","article-title":"Comparison of the remineralization potential of CPP-ACP and CPP-ACP with 900 ppm fluoride on eroded human enamel: an in situ study","volume":"55","author":"Srinivasan","year":"2010","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.jtumed.2025.11.007_bib7","doi-asserted-by":"crossref","first-page":"17030","DOI":"10.1038\/nrdp.2017.30","article-title":"Dental caries","volume":"3","author":"Pitts","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"10.1016\/j.jtumed.2025.11.007_bib8","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3233\/THC-161221","article-title":"Remineralization of early enamel caries lesions using different bioactive elements containing toothpastes: an in vitro study","volume":"24","author":"Wang","year":"2016","journal-title":"Technol Health Care"},{"issue":"1","key":"10.1016\/j.jtumed.2025.11.007_bib9","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1186\/s12903-022-02549-9","article-title":"Synthesis and characterization of nano bioactive glass for improving enamel remineralization ability of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP)","volume":"22","author":"Akbarzade","year":"2022","journal-title":"BMC Oral Health"},{"issue":"3","key":"10.1016\/j.jtumed.2025.11.007_bib10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4103\/JCD.JCD_62_20","article-title":"Comparative evaluation of remineralization potential of nanohydroxyapatite crystals, bioactive glass, casein phosphopeptide-amorphous calcium phosphate, and fluoride on initial enamel lesion (scanning electron microscope analysis) - an in vitro study","volume":"23","author":"Geeta","year":"2020","journal-title":"J Conserv Dent"},{"issue":"9","key":"10.1016\/j.jtumed.2025.11.007_bib11","article-title":"A novel fluoride containing bioactive glass paste is capable of re-mineralizing early caries lesions","volume":"11","author":"Bakry","year":"2018"},{"issue":"1","key":"10.1016\/j.jtumed.2025.11.007_bib12","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12903-022-02321-z","article-title":"Effect of strontium-doped bioactive glass-ceramic containing toothpaste on prevention of artificial dentine caries formation: an in vitro study","volume":"22","author":"Dai","year":"2022","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.jtumed.2025.11.007_bib13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.17135\/jdhs.2024.24.4.343","article-title":"Enamel remineralization of mesoporous bioactive glass - in vitro study","volume":"24","author":"Jeon","year":"2024","journal-title":"Journal of Dental Hygiene Science"},{"issue":"5","key":"10.1016\/j.jtumed.2025.11.007_bib14","first-page":"670","article-title":"Evaluation of the remineralisation potential of bioactive glass, nanohydroxyapatite and casein phosphopeptide-amorphous calcium phosphate fluoride-based toothpastes on enamel erosion lesion -An Ex vivo study","volume":"31","author":"Suryani","year":"2020"},{"issue":"3","key":"10.1016\/j.jtumed.2025.11.007_bib15","first-page":"92","article-title":"The effect of different percentages of nano-bioactive glass in the synthesized CPP\/ACP paste on the remineralization of demineralized enamel","volume":"15","author":"Khamverdi","year":"2023"},{"issue":"2","key":"10.1016\/j.jtumed.2025.11.007_bib16","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000453622","article-title":"Anticaries potential of a sodium monofluorophosphate dentifrice containing calcium sodium phosphosilicate: exploratory in situ randomized trial","volume":"51","author":"Parkinson","year":"2017","journal-title":"Caries Res"},{"key":"10.1016\/j.jtumed.2025.11.007_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/4788668","article-title":"The effect of formulated dentin remineralizing gel containing hydroxyapatite, fluoride, and bioactive glass on dentin microhardness: an in vitro study","volume":"2024","author":"Asadi","year":"2024","journal-title":"International Journal of Dentistry"},{"key":"10.1016\/j.jtumed.2025.11.007_bib18","doi-asserted-by":"crossref","first-page":"959","DOI":"10.4103\/jpbs.jpbs_117_22","article-title":"Comparative evaluation of efficacy of bioactive glass, tricalcium phosphate, and ozone remineralizing agents on artificial carious lesion","volume":"14","author":"Jena","year":"2022","journal-title":"J Pharm BioAllied Sci"},{"key":"10.1016\/j.jtumed.2025.11.007_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000510180","article-title":"Effects of additional use of bioactive glasses or a hydroxyapatite toothpaste on remineralization of artificial lesions in vitro","volume":"54","author":"K\u00f6rner","year":"2020","journal-title":"Caries Res"},{"key":"10.1016\/j.jtumed.2025.11.007_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/biomimetics8010017","article-title":"Comparative efficacy of novel biomimetic remineralising technologies","volume":"8","author":"Shen","year":"2023","journal-title":"Biomimetics"},{"issue":"5\u20136","key":"10.1016\/j.jtumed.2025.11.007_bib21","first-page":"487","article-title":"An in-vitro evaluation of fluoride content and enamel remineralization potential of two toothpastes containing different bioactive glasses","volume":"30","author":"Ali","year":"2020","journal-title":"Bio Med Mater Eng"},{"issue":"4","key":"10.1016\/j.jtumed.2025.11.007_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering10040472","article-title":"Analysis of dental enamel remineralization: a systematic review of technique comparisons","volume":"10","author":"Malcangi","year":"2023","journal-title":"Bioengineering"},{"issue":"1","key":"10.1016\/j.jtumed.2025.11.007_bib23","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0022-0248(84)90137-4","article-title":"A simple model for the effect of flouride ions on remineralization of partly demineralized tooth enamel","volume":"67","author":"Christoffersen","year":"1984","journal-title":"J Cryst Growth"},{"issue":"5\u20136","key":"10.1016\/j.jtumed.2025.11.007_bib24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0300-5712(98)00017-7","article-title":"Fluoride release and cariostatic ability of a compomer and a resin-modified glass ionomer cement used for orthodontic bonding","volume":"26","author":"Chung","year":"1998","journal-title":"J Dent"},{"issue":"2","key":"10.1016\/j.jtumed.2025.11.007_bib25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0939-6411(98)00060-5","article-title":"In vitro investigation of the liberation of fluoride ions from toothpaste compounds in a permeation model","volume":"47","author":"Eggert","year":"1999","journal-title":"Eur J Pharm Biopharm"},{"issue":"1","key":"10.1016\/j.jtumed.2025.11.007_bib26","first-page":"23","article-title":"In vivo evaluation of fluoride dentifrice and diet control on the demineralization\/remineralization process using laser readouts at the margin of the orthodontic bracket\/enamel interface","volume":"28","author":"De Queiroz","year":"2015","journal-title":"Am J Dent"},{"issue":"2","key":"10.1016\/j.jtumed.2025.11.007_bib27","first-page":"158","article-title":"Enamel white spot lesions can remineralise using bio-active glass and polyacrylic acid-modified bio-active glass powders","volume":"42","author":"Milly","year":"2014"},{"issue":"5","key":"10.1016\/j.jtumed.2025.11.007_bib28","first-page":"2027","article-title":"Enhanced effect of a novel bioactive glass\u2013ceramic for dental application","volume":"27","author":"Qiu","year":"2023"},{"issue":"1","key":"10.1016\/j.jtumed.2025.11.007_bib29","first-page":"593","article-title":"Composite materials of amorphous calcium phosphate and bioactive glass nanoparticles for preventive dentistry","volume":"50","author":"Degli","year":"2024"},{"issue":"4","key":"10.1016\/j.jtumed.2025.11.007_bib30","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jebdp.2012.10.001","article-title":"Guidelines for reporting pre-clinical in vitro studies on dental materials","volume":"12","author":"Faggion","year":"2012","journal-title":"J Evid Base Dent Pract"},{"key":"10.1016\/j.jtumed.2025.11.007_bib31","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.jtumed.2025.11.007_bib32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12874-021-01295-w","article-title":"Quality assessment tools used in systematic reviews of in vitro studies: a systematic review","volume":"21","author":"Tran","year":"2021","journal-title":"BMC Med Res Methodol"},{"issue":"11","key":"10.1016\/j.jtumed.2025.11.007_bib33","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.4103\/njcp.njcp_188_19","article-title":"Comparative evaluation of combined remineralization agents on demineralized tooth surface","volume":"22","author":"Aras","year":"2019","journal-title":"Niger J Clin Pract"},{"issue":"3","key":"10.1016\/j.jtumed.2025.11.007_bib34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ajodo.2004.12.026","article-title":"In-vivo effects of fluoridated antiplaque dentifrice and bonding material on enamel demineralization adjacent to orthodontic appliances","volume":"130","author":"de Moura","year":"2006","journal-title":"Am J Orthod Dentofacial Orthop"}],"container-title":["Journal of Taibah University Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658361225001362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658361225001362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T16:21:12Z","timestamp":1766247672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1658361225001362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1658361225001362"],"URL":"https:\/\/doi.org\/10.1016\/j.jtumed.2025.11.007","relation":{},"ISSN":["1658-3612"],"issn-type":[{"type":"print","value":"1658-3612"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of remineralizing dentifrices against caries lesions: A systematic approach","name":"articletitle","label":"Article Title"},{"value":"Journal of Taibah University Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtumed.2025.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}