{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T20:14:06Z","timestamp":1784837646627,"version":"3.55.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.juro.2006.10.036","type":"journal-article","created":{"date-parts":[[2007,2,11]],"date-time":"2007-02-11T06:58:30Z","timestamp":1171177110000},"page":"1186-1190","source":"Crossref","is-referenced-by-count":11,"title":["Intravesical Suplatast Tosilate (IPD-1151T) Inhibits Experimental Bladder Inflammation"],"prefix":"10.1097","volume":"177","author":[{"given":"W.","family":"Boucher","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and Experimental Therapeutics, Biochemistry and Internal Medicine, Tufts University School of Medicine and Tufts-New England Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kempuraj","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Experimental Therapeutics, Biochemistry and Internal Medicine, Tufts University School of Medicine and Tufts-New England Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cao","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Experimental Therapeutics, Biochemistry and Internal Medicine, Tufts University School of Medicine and Tufts-New England Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Papaliodis","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Experimental Therapeutics, Biochemistry and Internal Medicine, Tufts University School of Medicine and Tufts-New England Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.C.","family":"Theoharides","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Experimental Therapeutics, Biochemistry and Internal Medicine, Tufts University School of Medicine and Tufts-New England Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2006.10.036_bib1","series-title":"Campbell\u2019s Urology","first-page":"631","article-title":"Interstitial cystitis and related disorders","author":"Hanno","year":"2002"},{"key":"10.1016\/j.juro.2006.10.036_bib2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0094-0143(02)00055-1","article-title":"Current management of interstitial cystitis","volume":"29","author":"Lukban","year":"2002","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.juro.2006.10.036_bib3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.urology.2004.08.052","article-title":"Immunomodulators for the treatment of interstitial cystitis","volume":"65","author":"Theoharides","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.juro.2006.10.036_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0090-4295(01)01129-3","article-title":"Mast cell involvement in interstitial cystitis: a review of human and experimental evidence","volume":"57","author":"Theoharides","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.juro.2006.10.036_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0090-4295(01)01166-9","article-title":"Biopsy features are associated with primary symptoms in interstitial cystitis: results from the interstitial cystitis database study","volume":"57","author":"Tomaszewski","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.juro.2006.10.036_bib6","first-page":"369","article-title":"IPD-1151T: a prototype drug for IgE antibody synthesis modulation","volume":"34","author":"Koda","year":"1991","journal-title":"Agents Actions, suppl"},{"key":"10.1016\/j.juro.2006.10.036_bib7","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1254\/jjp.79.501","article-title":"IPD-1151T (suplatast tosilate) inhibits interleukin (IL)-13 release but not IL-4 release from basophils","volume":"79","author":"Shichijo","year":"1999","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.juro.2006.10.036_bib8","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/S0022-5347(05)66917-0","article-title":"Improvement of interstitial cystitis symptoms and problems that developed during treatment with oral IPD-1151T","volume":"164","author":"Ueda","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2006.10.036_bib9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000024306","article-title":"Effect of suplatast tosilate (IPD-1151T) on a mouse model of asthma: inhibition of eosinophilic inflammation and bronchial hyperresponsiveness","volume":"121","author":"Zhao","year":"2000","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.juro.2006.10.036_bib10","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/01.ju.0000143192.68223.f7","article-title":"Modulating bladder neuro-inflammation: RDP58, a novel anti-inflammatory peptide, decreases inflammation and nerve growth factor production in experimental cystitis","volume":"173","author":"Gonzalez","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2006.10.036_bib11","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000069516","article-title":"Acute stress results in skin corticotropin-releasing hormone secretion, mast cell activation and vascular permeability, an effect mimicked by intradermal corticotropin-releasing hormone and inhibited by histamine-1 receptor antagonists","volume":"130","author":"Lytinas","year":"2003","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.juro.2006.10.036_bib12","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1182\/blood.V93.10.3338.410k05_3338_3346","article-title":"Characterization of mast cell-committed progenitors present in human umbilical cord blood","volume":"93","author":"Kempuraj","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.juro.2006.10.036_bib13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1152\/physiolgenomics.00117.2001","article-title":"Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis","volume":"9","author":"Malley","year":"2002","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.juro.2006.10.036_bib14","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0022-5347(05)00171-0","article-title":"Tumor necrosis factor promotes differential trafficking of bladder mast cells in neurogenic cystitis","volume":"175","author":"Chen","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2006.10.036_bib15","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.1073\/pnas.0602210103","article-title":"Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process","volume":"103","author":"Donelan","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.juro.2006.10.036_bib16","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0090-4295(98)00627-X","article-title":"Neurotensin mediates rat bladder mast cell degranulation triggered by acute psychological stress","volume":"53","author":"Alexacos","year":"1999","journal-title":"Urology"},{"key":"10.1016\/j.juro.2006.10.036_bib17","first-page":"345","article-title":"Neuroimmune connections and regulation of function in the urinary bladder","volume":"vol 15","author":"Theoharides","year":"2003"},{"key":"10.1016\/j.juro.2006.10.036_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0090-4295(01)01639-9","article-title":"Targeting afferent hyperexcitability for therapy of the painful bladder syndrome","volume":"59","author":"Yoshimura","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.juro.2006.10.036_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2003.10.041","article-title":"Critical role of mast cells in inflammatory diseases and the effect of acute stress","volume":"146","author":"Theoharides","year":"2004","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.juro.2006.10.036_bib20","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0022-5347(05)64750-7","article-title":"Mast cell activation triggers a urothelial inflammatory response mediated by tumor necrosis factor-alpha","volume":"168","author":"Batler","year":"2002","journal-title":"J Urol"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534706027649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534706027649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2006.10.036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:45:14Z","timestamp":1784835914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.juro.2006.10.036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1016\/j.juro.2006.10.036"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2006.10.036","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}