{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:02:55Z","timestamp":1784905375218,"version":"3.55.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.juro.2006.11.071","type":"journal-article","created":{"date-parts":[[2007,3,24]],"date-time":"2007-03-24T07:05:45Z","timestamp":1174719945000},"page":"1558-1561","source":"Crossref","is-referenced-by-count":32,"title":["Effect of Melatonin on Age Associated Changes in Guinea Pig Bladder Function"],"prefix":"10.1097","volume":"177","author":[{"given":"Pedro J.","family":"Gomez-Pinilla","sequence":"first","affiliation":[{"name":"Department of Physiology, Nursing School, University of Extremadura, Caceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petter","family":"Hedlund","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Sw\u00e4rd","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hellstrand","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro J.","family":"Camello","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nursing School, University of Extremadura, Caceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"Pozo","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nursing School, University of Extremadura, Caceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Erik","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Lund University, Lund, Sweden"},{"name":"Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2006.11.071_bib1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1124\/pr.56.4.4","article-title":"Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence","volume":"56","author":"Andersson","year":"2004","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.juro.2006.11.071_bib2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0047-6374(84)90043-5","article-title":"Age-related changes in sensitivity of rat urinary bladder to autonomic agents","volume":"27","author":"Kolta","year":"1984","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.juro.2006.11.071_bib3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0022-5347(17)42543-2","article-title":"Regional noradrenergic and cholinergic neurochemistry in the rat urinary bladder\u2014effects of age","volume":"139","author":"Johnson","year":"1988","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2006.11.071_bib4","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/S0022-5347(17)36981-1","article-title":"Comparison of urinary-bladder function in 6 and 24 month male and female rats","volume":"148","author":"Longhurst","year":"1992","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2006.11.071_bib5","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-5347(17)35541-6","article-title":"Contractile and metabolic properties of longitudinal smooth muscle from rat urinary bladder and the effects of aging","volume":"150","author":"Munro","year":"1993","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2006.11.071_bib6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0531-5565(00)00175-3","article-title":"Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth muscles","volume":"36","author":"Yoshida","year":"2001","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.juro.2006.11.071_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00210-005-1084-0","article-title":"Effects of ageing on muscarinic receptor subtypes and function in rat urinary bladder","volume":"372","author":"Schneider","year":"2005","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.juro.2006.11.071_bib8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0022-5347(17)42546-8","article-title":"Effect of age on in vivo urinary bladder function in the rat","volume":"139","author":"Chun","year":"1988","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2006.11.071_bib9","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s002400000135","article-title":"Altered neural control of micturition in the aged F344 rat","volume":"28","author":"Chai","year":"2000","journal-title":"Urol Res"},{"key":"10.1016\/j.juro.2006.11.071_bib10","doi-asserted-by":"crossref","first-page":"R964","DOI":"10.1152\/ajpregu.2000.278.4.R964","article-title":"Functional and morphological modifications of the urinary bladder in aging female rats","volume":"278","author":"Lluel","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.juro.2006.11.071_bib11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0921-8734(92)90030-S","article-title":"Free-radical theory of aging","volume":"275","author":"Harman","year":"1992","journal-title":"Mutat Res"},{"key":"10.1016\/j.juro.2006.11.071_bib12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000014635","article-title":"Significance of melatonin in antioxidative defense system: reactions and products","volume":"9","author":"Tan","year":"2000","journal-title":"Biol Signals Recept"},{"key":"10.1016\/j.juro.2006.11.071_bib13","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/BF02253360","article-title":"Actions of melatonin in the reduction of oxidative stress\u2014a review","volume":"7","author":"Reiter","year":"2000","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.juro.2006.11.071_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/bies.950140307","article-title":"The aging pineal gland and its physiological consequences","volume":"14","author":"Reiter","year":"1992","journal-title":"Bioessays"},{"key":"10.1016\/j.juro.2006.11.071_bib15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1385\/ENDO:27:2:201","article-title":"Melatonin, aging, and age-related diseases: perspectives for prevention, intervention, and therapy","volume":"27","author":"Poeggeler","year":"2005","journal-title":"Endocrine"},{"key":"10.1016\/j.juro.2006.11.071_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.1464-410X.1998.0820s1059.x","article-title":"The human urinary bladder in ageing","volume":"82","author":"Hald","year":"1998","journal-title":"Br J Urol, suppl."},{"key":"10.1016\/j.juro.2006.11.071_bib17","doi-asserted-by":"crossref","first-page":"R1287","DOI":"10.1152\/ajpregu.00499.2001","article-title":"Age-related changes in urethrovesical coordination in male rats: relationship with bladder instability?","volume":"284","author":"Lluel","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.juro.2006.11.071_bib18","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1136\/bmj.282.6270.1103","article-title":"Clinical and urodynamic studies in 100 elderly incontinent patients","volume":"282","author":"Castleden","year":"1981","journal-title":"Br Med J"},{"key":"10.1016\/j.juro.2006.11.071_bib19","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1097\/01.ju.0000110442.47593.ea","article-title":"Melatonin pharmacotherapy for nocturia in men with benign prostatic enlargement","volume":"171","author":"Drake","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2006.11.071_bib20","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.lfs.2003.07.038","article-title":"Melatonin treatment protects against sepsis-induced functional and biochemical changes in rat ileum and urinary bladder","volume":"74","author":"Paskaloglu","year":"2004","journal-title":"Life Sci"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534706031089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534706031089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2006.11.071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:09:21Z","timestamp":1784902161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.juro.2006.11.071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1016\/j.juro.2006.11.071"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2006.11.071","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}