{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:02:55Z","timestamp":1784905375241,"version":"3.55.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.juro.2006.11.072","type":"journal-article","created":{"date-parts":[[2007,3,24]],"date-time":"2007-03-24T07:05:45Z","timestamp":1174719945000},"page":"1531-1536","source":"Crossref","is-referenced-by-count":25,"title":["Cyclophosphamide Induced Cystitis: Role of Nitric Oxide Synthase, Cyclooxygenase-1 and 2, and NK\n                    <sub>1<\/sub>\n                    Receptors"],"prefix":"10.1097","volume":"177","author":[{"given":"Beatriz E.","family":"Linares-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine \u201cDr. Luis Razetti\u201d, Central University of Venezuela, Caracas, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna B.","family":"Alfieri","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Central University of Venezuela, Caracas, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2006.11.072_bib1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0022-5347(05)65932-0","article-title":"Prevention of further induced hemorrhagic cystitis by hyperbaric oxygen and mesna in guinea pigs","volume":"166","author":"Korkmaz","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2006.11.072_bib2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/j.1476-5381.1994.tb14845.x","article-title":"Characterizacion of the capsaicin-sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder","volume":"111","author":"Ahluwalia","year":"1994","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.juro.2006.11.072_bib3","first-page":"824","article-title":"Nitric oxide and NK1-tachykinin receptors in cyclophosphamide-induced cystitis, in rats","volume":"295","author":"Alfieri","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.juro.2006.11.072_bib4","first-page":"247","article-title":"Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis","volume":"150:","author":"Ponte Souza-Filho","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1016\/j.juro.2006.11.072_bib5","first-page":"353","article-title":"Nitric oxide synthases and cyclophosphamide-induced cystitis in rats","volume":"363","author":"Alfieri","year":"2001","journal-title":"Naunyn Mar"},{"key":"10.1016\/j.juro.2006.11.072_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0014-2999(01)00911-6","article-title":"Cyclo-oxygenase-2 protein and prostaglandin E2 production are up-regulated in a rat bladder inflammation model","volume":"417","author":"Wheeler","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.juro.2006.11.072_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0165-0270(83)90050-X","article-title":"Evans blue fluorescence quantitative and morphological evaluation of vascular permeability in animal tissue","volume":"8","author":"Saria","year":"1983","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.juro.2006.11.072_bib8","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0006-291X(89)80219-0","article-title":"A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells","volume":"158","author":"Palmer","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.juro.2006.11.072_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.juro.2006.11.072_bib10","first-page":"G1298","article-title":"NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats","volume":"279:","author":"Stucchi","year":"2000","journal-title":"Am J Physiol"},{"key":"10.1016\/j.juro.2006.11.072_bib11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1515\/bchm2.1933.219.3-4.148","article-title":"Eine mikromethode zur bestimmung des prolins und des oxyprolins","volume":"219","author":"Lang","year":"1933","journal-title":"Z Physiol Chem"},{"key":"10.1016\/j.juro.2006.11.072_bib12","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0006-2952(98)00221-4","article-title":"Biochemical and connective tissue changes in cyclophosphamide induced lung fibrosis in rats","volume":"156","author":"Venkatesan","year":"1998","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.juro.2006.11.072_bib13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jneuroim.2005.09.006","article-title":"Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNF\u03b1 in the cutaneous microvasculature","volume":"171","author":"Costa","year":"2006","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.juro.2006.11.072_bib14","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1074\/jbc.275.8.5425","article-title":"Nitric oxide modulates the catalytic activity of myeloperoxidase","volume":"275","author":"Abu-Soud","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.juro.2006.11.072_bib15","doi-asserted-by":"crossref","first-page":"R574","DOI":"10.1152\/ajpregu.00465.2002","article-title":"COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat","volume":"284","author":"Hu","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.juro.2006.11.072_bib16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.7326\/0003-4819-132-2-200001180-00008","article-title":"Do cyclooxygenase-2 inhibitors provide benefits similar to those of traditional nonsteroidal anti-inflammatory drugs, with less gastrointestinal toxicity?","volume":"132","author":"Feldman","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.juro.2006.11.072_bib17","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/sj.bjp.0702420","article-title":"Limited anti-inflammatory efficacy of cyclo-oxygenase-2 inhibition in carrageenan-airpouch inflammation","volume":"126","author":"Wallace","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.juro.2006.11.072_bib18","doi-asserted-by":"crossref","first-page":"13371","DOI":"10.1073\/pnas.222543099","article-title":"Cyclooxygenase-3 (COX-3): filling in the gaps towards a COX continuum?","volume":"99","author":"Warner","year":"2002","journal-title":"PNAS"},{"key":"10.1016\/j.juro.2006.11.072_bib19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000076768","article-title":"Effects of aminoguanidine and cyclooxygenase inhibitors on nitric oxide and prostaglandin production, and nitric oxide synthase and cyclooxygenase expression induced by lipopolysaccharide in the estrogenized rat uterus","volume":"11","author":"Ribeiro","year":"2004","journal-title":"Neuroimmunomodulation"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534706031077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534706031077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2006.11.072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:09:21Z","timestamp":1784902161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.juro.2006.11.072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1016\/j.juro.2006.11.072"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2006.11.072","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}