{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:57:12Z","timestamp":1793444232371,"version":"4.5.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.juro.2007.08.170","type":"journal-article","created":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T01:32:56Z","timestamp":1196472776000},"page":"177-185","source":"Crossref","is-referenced-by-count":94,"title":["Safety and Efficacy of the Use of Intravesical and Oral Pentosan Polysulfate Sodium for Interstitial Cystitis: A Randomized Double-Blind Clinical Trial"],"prefix":"10.1097","volume":"179","author":[{"given":"Edward L.","family":"Davis","sequence":"first","affiliation":[{"name":"Citrus Valley Medical Research, Inc., Glendora, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar R.","family":"El Khoudary","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn O.","family":"Talbott","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Davis","sequence":"additional","affiliation":[{"name":"Citrus Valley Medical Research, Inc., Glendora, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Regan","sequence":"additional","affiliation":[{"name":"Citrus Valley Medical Research, Inc., Glendora, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2007.08.170_bib1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/00042307-200411000-00005","article-title":"Interstitial cystitis: how should we diagnose it and treat it in 2004?","volume":"14","author":"Nordling","year":"2004","journal-title":"Curr Opin Urol"},{"key":"10.1016\/j.juro.2007.08.170_bib2","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/S0022-5347(05)65195-6","article-title":"Depressive symptoms and quality of life in patients with interstitial cystitis","volume":"167","author":"Rothrock","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2007.08.170_bib3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0022-5347(01)61947-5","article-title":"Epidemiology of interstitial cystitis: a population based study","volume":"161","author":"Curhan","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2007.08.170_bib4","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1097\/01.ju.0000181203.82693.95","article-title":"Prevalence of interstitial cystitis symptoms in women: a population based study in the primary care office","volume":"174","author":"Rosenberg","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2007.08.170_bib5","doi-asserted-by":"crossref","first-page":"821","DOI":"10.2165\/00003495-200666060-00006","article-title":"Pentosan polysulfate: a review of its use in the relief of bladder pain or discomfort in interstitial cystitis","volume":"66","author":"Anderson","year":"2006","journal-title":"Drugs"},{"key":"10.1016\/j.juro.2007.08.170_bib6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0022-5347(17)43243-5","article-title":"Successful therapy of interstitial cystitis with pentosanpolysulfate","volume":"138","author":"Parsons","year":"1987","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2007.08.170_bib7","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/0090-4295(90)80116-5","article-title":"Pentosan polysulfate sodium for therapy of interstitial cystitis","volume":"35","author":"Mulholland","year":"1990","journal-title":"Urology"},{"key":"10.1016\/j.juro.2007.08.170_bib8","unstructured":"Ortho-McNeil Pharmaceutical Inc.: Elmiron\u00ae 100 mg (pentosan polysulfate sodium) capsules. Available at http:\/\/www.orthoelmiron.com. Accessed March 5, 2007."},{"key":"10.1016\/j.juro.2007.08.170_bib9","series-title":"Interstitial Cystitis","article-title":"Intravesical therapies for interstitial cystitis","author":"La Rock","year":"1997"},{"key":"10.1016\/j.juro.2007.08.170_bib10","first-page":"17","article-title":"Intravesical 50% dimethyl sulfoxide (Rimso-50) in treatment of interstitial cystitis","volume":"29","author":"Sant","year":"1987","journal-title":"Urology"},{"key":"10.1016\/j.juro.2007.08.170_bib11","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1046\/j.1464-410X.1997.03384.x","article-title":"A placebo-controlled study of intravesical pentosanpolysulphate for the treatment of interstitial cystitis","volume":"79","author":"Bade","year":"1997","journal-title":"Br J Urol"},{"key":"10.1016\/j.juro.2007.08.170_bib12","series-title":"Practice Building Today, A Supplement to Physician\u2019s Money Digest","first-page":"18","article-title":"Pentosan polysulfate sodium intravesical instillation\u2014end-organ therapy","author":"Parsons","year":"2003"},{"key":"10.1016\/j.juro.2007.08.170_bib13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0090-4295(99)80333-1","article-title":"The interstitial cystitis symptom index and problem index","volume":"49","author":"O\u2019Leary","year":"1997","journal-title":"Urology"},{"key":"10.1016\/j.juro.2007.08.170_bib14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0090-4295(02)01829-0","article-title":"Increased prevalence of interstitial cystitis: previously unrecognized urologic and gynecologic cases using a new symptom questionnaire and intravesical potassium sensitivity","volume":"60","author":"Parsons","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.juro.2007.08.170_bib15","series-title":"SF-36\u00ae Health Survey Manual and Interpretation Guide","author":"Ware","year":"1993"},{"key":"10.1016\/j.juro.2007.08.170_bib16","unstructured":"Bioniche Life Sciences Inc.: Human Health News Release: Preliminary Results of North American Cystistat\u00ae Trial Announced. Available at http:\/\/www.bioniche.com\/news_item.cfm?id=2010. Accessed June 21, 2007."},{"key":"10.1016\/j.juro.2007.08.170_bib17","series-title":"The association of clinical outcomes and symptom triad research insights into interstitial cystitis: a basic and clinical science symposium","article-title":"A prospective evaluation of intravesical instillation of pentosan polysulfate sodium (PPS; Elmiron\u00ae [Ortho-McNeil]) in patients with interstitial cystitis","author":"Davis","year":"2003"},{"key":"10.1016\/j.juro.2007.08.170_bib18","unstructured":"U.S. Food and Drug Administration: Drug Approvals for September 1996. Available at http:\/\/www.fda.gov\/cder\/da\/da996.htm. Accessed September 10, 2006."},{"key":"10.1016\/j.juro.2007.08.170_bib19","unstructured":"Declaration of Helsinki IV, World Medical Association, 41st World Medical Assembly, Hong Kong, September 1989. In: The Nazi Doctors and the Nuremberg Code: Human Rights in Human Experimentation. Edited by GJ Annas and MA Grodin. New York: Oxford University Press 1992."}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534707023506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534707023506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2007.08.170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:43:29Z","timestamp":1784911409000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.juro.2007.08.170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1016\/j.juro.2007.08.170"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2007.08.170","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1120911.577178","asserted-by":"object"}]},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}