{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:08:41Z","timestamp":1784923721050,"version":"3.55.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.juro.2007.10.031","type":"journal-article","created":{"date-parts":[[2008,2,8]],"date-time":"2008-02-08T09:41:33Z","timestamp":1202463693000},"page":"1160-1166","source":"Crossref","is-referenced-by-count":15,"title":["Protective Effects of Bilirubin Against Cyclophosphamide Induced Hemorrhagic Cystitis in Rats"],"prefix":"10.1097","volume":"179","author":[{"given":"Yoh","family":"Matsuoka","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minato","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Kihara","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2007.10.031_bib1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1023\/A:1015957026924","article-title":"Heme oxygenase\/carbon monoxide signaling pathways: regulation and functional significance","volume":"234\u2013235","author":"Ryter","year":"2002","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.juro.2007.10.031_bib2","doi-asserted-by":"crossref","first-page":"F425","DOI":"10.1152\/ajprenal.00297.2003","article-title":"The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury","volume":"286","author":"Sikorski","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.juro.2007.10.031_bib3","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/10715769900301031","article-title":"The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis","volume":"31","author":"Foresti","year":"1999","journal-title":"Free Radic Res"},{"key":"10.1016\/j.juro.2007.10.031_bib4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1164\/ajrccm.163.3.2004202","article-title":"Protective role of heme oxygenases against endotoxin-induced diaphragmatic dysfunction in rats","volume":"163","author":"Taille","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.juro.2007.10.031_bib5","doi-asserted-by":"crossref","first-page":"F563","DOI":"10.1152\/ajprenal.00220.2005","article-title":"Products of heme oxygenase and their potential therapeutic applications","volume":"290","author":"Kirkby","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.juro.2007.10.031_bib6","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1073\/pnas.96.5.2445","article-title":"Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury","volume":"96","author":"Dore","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.juro.2007.10.031_bib7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1161\/01.ATV.16.2.250","article-title":"Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease","volume":"16","author":"Hopkins","year":"1996","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.juro.2007.10.031_bib8","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1023\/A:1013794407325","article-title":"Serum bilirubin and 10-year mortality risk in a Belgian population","volume":"12","author":"Temme","year":"2001","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.juro.2007.10.031_bib9","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1046\/j.1523-1755.2001.0600031047.x","article-title":"Acute cholestatic liver disease protects against glycerol-induced acute renal failure in the rat","volume":"60","author":"Leung","year":"2001","journal-title":"Kidney Int"},{"key":"10.1016\/j.juro.2007.10.031_bib10","first-page":"247","article-title":"Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis","volume":"150","author":"Souza-Fiho","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1016\/j.juro.2007.10.031_bib11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.urology.2005.08.052","article-title":"15-deoxy-Delta12,14-prostaglandin J2 attenuates development of cyclophosphamide-induced cystitis in rats","volume":"67","author":"Masuda","year":"2006","journal-title":"Urology"},{"key":"10.1016\/j.juro.2007.10.031_bib12","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/j.1464-410X.2007.07111.x","article-title":"Protective effects of heme oxygenase-1 against cyclophosphamide-induced haemorrhagic cystitis in rats","volume":"100","author":"Matsuoka","year":"2007","journal-title":"BJU Int"},{"key":"10.1016\/j.juro.2007.10.031_bib13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0022-5347(17)44929-9","article-title":"Evaluation of misoprostol cytoprotection of the bladder with cyclophosphamide (Cytoxan) therapy","volume":"136","author":"Gray","year":"1986","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2007.10.031_bib14","first-page":"2220","article-title":"Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer","volume":"62","author":"Luo","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.juro.2007.10.031_bib15","doi-asserted-by":"crossref","first-page":"H643","DOI":"10.1152\/ajpheart.2000.278.2.H643","article-title":"Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction","volume":"278","author":"Clark","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.juro.2007.10.031_bib16","doi-asserted-by":"crossref","first-page":"16093","DOI":"10.1073\/pnas.252626999","article-title":"Biliverdin reductase: a major physiologic cytoprotectant","volume":"99","author":"Baranano","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.juro.2007.10.031_bib17","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1053\/jhep.2003.50300","article-title":"Bilirubin rinse: a simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning","volume":"38","author":"Kato","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.juro.2007.10.031_bib18","doi-asserted-by":"crossref","first-page":"F778","DOI":"10.1152\/ajprenal.00215.2004","article-title":"Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated, perfused rat kidney","volume":"288","author":"Adin","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.juro.2007.10.031_bib19","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/hep.20334","article-title":"Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats","volume":"40","author":"Wang","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.juro.2007.10.031_bib20","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s00467-005-2094-3","article-title":"In vitro analysis of the effect of hyperbilirubinemia on rabbit ureter and bladder","volume":"21","author":"Murat","year":"2006","journal-title":"Pediatr Nephrol"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534707027619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534707027619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2007.10.031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:15:45Z","timestamp":1784920545000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1016\/j.juro.2007.10.031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1016\/j.juro.2007.10.031"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2007.10.031","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}