{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:07:31Z","timestamp":1789913251298,"version":"4.0.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.juro.2008.03.184","type":"journal-article","created":{"date-parts":[[2008,6,13]],"date-time":"2008-06-13T15:20:18Z","timestamp":1213370418000},"page":"737-741","source":"Crossref","is-referenced-by-count":43,"title":["Localization and Expression of Inducible Nitric Oxide Synthase in Biopsies From Patients With Interstitial Cystitis"],"prefix":"10.1097","volume":"180","author":[{"given":"L. Renstr\u00f6m","family":"Koskela","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Thiel","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ehr\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"De Verdier","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.P.","family":"Wiklund","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2008.03.184_bib1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s001920050006","article-title":"Treatment guidelines for classic and non-ulcer interstitial cystitis","volume":"11","author":"Peeker","year":"2000","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"key":"10.1016\/j.juro.2008.03.184_bib2","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1097\/01.ju.0000110501.96416.40","article-title":"Intravesical nitric oxide production discriminates between classic and nonulcer interstitial cystitis","volume":"171","author":"Logadottir","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.03.184_bib3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1749-6632.1997.tb51989.x","article-title":"Nitric oxide in the vasculature: physiology and pathophysiology","volume":"811","author":"Moncada","year":"1997","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.juro.2008.03.184_bib4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/00001703-199610000-00009","article-title":"Neurotransmitters and neuroreceptors in the lower urinary tract","volume":"8","author":"Andersson","year":"1996","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.juro.2008.03.184_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/0264-6021:3570593","article-title":"Nitric oxide synthases: structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem J"},{"key":"10.1016\/j.juro.2008.03.184_bib6","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1183\/09031936.93.06091368","article-title":"Increased amount of nitric oxide in exhaled air of asthmatics","volume":"6","author":"Alving","year":"1993","journal-title":"Eur Respir J"},{"key":"10.1016\/j.juro.2008.03.184_bib7","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0140-6736(94)90460-X","article-title":"Greatly increased luminal nitric oxide in ulcerative colitis","volume":"344","author":"Lundberg","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.juro.2008.03.184_bib8","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0090-4295(96)00423-2","article-title":"Elevated nitric oxide in the urinary bladder in infectious and noninfectious cystitis","volume":"48","author":"Lundberg","year":"1996","journal-title":"Urology"},{"key":"10.1016\/j.juro.2008.03.184_bib9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0022-5347(05)68551-5","article-title":"Nitric oxide: a useful gas in the detection of lower urinary tract inflammation","volume":"162","author":"Ehren","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.03.184_bib10","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0090-4295(99)00120-X","article-title":"Measurement of luminal nitric oxide in bladder inflammation using a silicon balloon catheter: a novel minimally invasive method","volume":"54","author":"Ehren","year":"1999","journal-title":"Urology"},{"key":"10.1016\/j.juro.2008.03.184_bib11","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/bjc.1998.545","article-title":"The role of nitric oxide in Bacillus Calmette-Guerin mediated anti-tumor effects in human bladder cancer","volume":"78","author":"Jansson","year":"1998","journal-title":"Br J Cancer"},{"key":"10.1016\/j.juro.2008.03.184_bib12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1046\/j.1464-410x.2000.00459.x","article-title":"Nitric oxide in the lower urinary tract: physiological and pathological implications","volume":"85","author":"Mumtaz","year":"2000","journal-title":"BJU Int"},{"key":"10.1016\/j.juro.2008.03.184_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.juro.2008.03.184_bib14","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1021\/tx00030a017","article-title":"Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide","volume":"5","author":"Koppenol","year":"1998","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.juro.2008.03.184_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/01.shk.0000112346.38599.10","article-title":"Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice","volume":"21","author":"Han","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.juro.2008.03.184_bib16","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0022-5347(17)38437-9","article-title":"Epithelial dysfunction in nonbacterial cystitis (interstitial cystitis)","volume":"145","author":"Parson","year":"1991","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.03.184_bib17","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1097\/01.ju.0000118938.09119.a5","article-title":"Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis","volume":"171","author":"Slobodov","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.03.184_bib18","doi-asserted-by":"crossref","first-page":"F305","DOI":"10.1152\/ajprenal.00341.2003","article-title":"Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8 and -12 in bladder epithelium","volume":"287","author":"Acharya","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.juro.2008.03.184_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00024382-200303000-00006","article-title":"Proinflammatory cytokines cause NO- dependent and independent changes in expression and localization of tight junction proteins in intestinal epithelial cells","volume":"19","author":"Han","year":"2003","journal-title":"Shock"},{"key":"10.1016\/j.juro.2008.03.184_bib20","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/S0022-5347(05)66402-6","article-title":"Localization of constitutive nitric oxide synthase isoforms and the nitric oxide target enzyme soluble guanylyl cyclase in the human bladder","volume":"165","author":"Fathian-Sabet","year":"2001","journal-title":"J Urol"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534708009257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534708009257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2008.03.184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T18:04:16Z","timestamp":1738260256000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2008.03.184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1016\/j.juro.2008.03.184"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2008.03.184","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}