{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:41:27Z","timestamp":1791312087829,"version":"4.3.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.juro.2008.08.119","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T01:17:10Z","timestamp":1229476630000},"page":"343-353","source":"Crossref","is-referenced-by-count":79,"title":["Annexin A3 in Urine: A Highly Specific Noninvasive Marker for Prostate Cancer Early Detection"],"prefix":"10.1097","volume":"181","author":[{"given":"Martin","family":"Schostak","sequence":"first","affiliation":[{"name":"Department of Urology, Charit\u00e9 University Medicine in Berlin, Campus Benjamin Franklin, Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard P.","family":"Schwall","sequence":"additional","affiliation":[{"name":"ProteoSys AG, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slobodan","family":"Poznanovi\u0107","sequence":"additional","affiliation":[{"name":"ProteoSys AG, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlfried","family":"Groebe","sequence":"additional","affiliation":[{"name":"ProteoSys AG, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Urology, Klinikum Ludwigshafen gemeinn\u00fctzige GmbH, Ludwigshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diethelm","family":"Messinger","sequence":"additional","affiliation":[{"name":"IST GmbH, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Urology, Charit\u00e9 University Medicine in Berlin, Campus Benjamin Franklin, Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Urology, Charit\u00e9 University Medicine in Berlin, Campus Benjamin Franklin, Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Pelzer","sequence":"additional","affiliation":[{"name":"Department of Urology, Innsbruck Medical University, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Horninger","sequence":"additional","affiliation":[{"name":"Department of Urology, Innsbruck Medical University, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Klocker","sequence":"additional","affiliation":[{"name":"Department of Urology, Innsbruck Medical University, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Hennenlotter","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Feyerabend","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnulf","family":"Stenzl","sequence":"additional","affiliation":[{"name":"ProteoSys AG, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Schrattenholz","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2008.08.119_bib1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.eururo.2005.04.015","article-title":"Use of prostate-specific antigen (PSA) isoforms for the detection of prostate cancer in men with a PSA level of 2-10 ng\/ml: systematic review and meta-analysis","volume":"48","author":"Roddam","year":"2005","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2008.08.119_bib2","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1097\/01.ju.0000139993.51181.5d","article-title":"The prostate specific antigen era in the United States is over for prostate cancer: what happened in the last 20 years?","volume":"172","author":"Stamey","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.08.119_bib3","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nrc2351","article-title":"Prostate-specific antigen and prostate cancer: prediction, detection and monitoring","volume":"8","author":"Lilja","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.juro.2008.08.119_bib4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.canlet.2006.12.029","article-title":"Molecular markers for prostate cancer","volume":"249","author":"Reynolds","year":"2007","journal-title":"Cancer Lett"},{"key":"10.1016\/j.juro.2008.08.119_bib5","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrm1661","article-title":"Annexins: linking Ca2+ signalling to membrane dynamics","volume":"6","author":"Gerke","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.juro.2008.08.119_bib6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0002-9440(10)63816-3","article-title":"Dysregulation of the annexin family protein family is associated with prostate cancer progression","volume":"162","author":"Xin","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.juro.2008.08.119_bib7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/pmic.200600646","article-title":"Differential radioactive quantification of protein abundance ratios between benign and malignant prostate tissues: cancer association of annexin A3","volume":"7","author":"Wozny","year":"2007","journal-title":"Proteomics"},{"key":"10.1016\/j.juro.2008.08.119_bib8","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.eururo.2008.01.001","article-title":"Expression and prognostic relevance of annexin A3 in prostate cancer","volume":"54","author":"K\u00f6llermann","year":"2008","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2008.08.119_bib9","doi-asserted-by":"crossref","first-page":"13368","DOI":"10.1073\/pnas.0403453101","article-title":"Identification and proteomic profiling of exosomes in human urine","volume":"101","author":"Pisitkun","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.juro.2008.08.119_bib10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1365-2605.2004.00468.x","article-title":"Prostasome antigens as targets for sperm agglutinating antibodies demonstrated by 1-D gel electrophoresis and immunoblottings","volume":"27","author":"Carlsson","year":"2004","journal-title":"Int J Androl"},{"key":"10.1016\/j.juro.2008.08.119_bib11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0090-4295(01)01268-7","article-title":"DNA-based detection of prostate cancer in urine after prostatic massage","volume":"58","author":"Goessl","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.juro.2008.08.119_bib12","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/S0022-5347(01)68188-6","article-title":"Optimization of prostate biopsy strategy using computer based analysis","volume":"158","author":"Chen","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.08.119_bib13","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.juro.2007.11.038","article-title":"PCA3: a molecular urine assay for predicting prostate biopsy outcome","volume":"179","author":"Deras","year":"2008","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.08.119_bib14","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1158\/1078-0432.CCR-03-0170","article-title":"Evidence for prostate cancer-associated diagnostic marker-1: immunohistochemistry and in situ hybridization studies","volume":"10","author":"Ohkia","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.juro.2008.08.119_bib15","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.urology.2007.01.097","article-title":"EPCA-2: a highly specific serum marker for prostate cancer","volume":"69","author":"Leman","year":"2007","journal-title":"Urology"},{"key":"10.1016\/j.juro.2008.08.119_bib16","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/S0022-5347(05)65652-2","article-title":"Prospective evaluation of prostate cancer detected on biopsies 1, 2, 3 and 4: when should we stop?","volume":"166","author":"Djavan","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.08.119_bib17","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/S0022-5347(17)35233-3","article-title":"Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men","volume":"151","author":"Catalona","year":"1994","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.08.119_bib18","first-page":"4399","article-title":"Antiprostasome antibody titres in benign and malignant prostate disease","volume":"25","author":"Minelli","year":"2005","journal-title":"Anticancer Res"},{"key":"10.1016\/j.juro.2008.08.119_bib19","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.bbrc.2005.10.004","article-title":"Annexin A3 is a potential angiogenic mediator","volume":"337","author":"Park","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.juro.2008.08.119_bib20","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1074\/mcp.M600048-MCP200","article-title":"Proteomics-based validation of genomic data: applications in colorectal cancer diagnosis","volume":"5","author":"Madoz-Gurpide","year":"2006","journal-title":"Mol Cell Proteomics"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534708024117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534708024117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2008.08.119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T21:17:05Z","timestamp":1651180625000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2008.08.119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1016\/j.juro.2008.08.119"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2008.08.119","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}