{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:41:10Z","timestamp":1761716470820},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.juro.2008.11.119","type":"journal-article","created":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T14:31:17Z","timestamp":1235485877000},"page":"1550-1557","source":"Crossref","is-referenced-by-count":30,"title":["Genetics and Phenotyping of Urological Chronic Pelvic Pain Syndrome"],"prefix":"10.1097","volume":"181","author":[{"given":"Jordan","family":"Dimitrakov","sequence":"first","affiliation":[{"name":"George O'Brien Center for Urological Diseases Research, Harvard Medical School and Children's Hospital Boston, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Guthrie","sequence":"additional","affiliation":[{"name":"George O'Brien Center for Urological Diseases Research, Harvard Medical School and Children's Hospital Boston, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2008.11.119_bib1","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1056\/NEJMcp060423","article-title":"Clinical practice","volume":"355","author":"Schaeffer","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.juro.2008.11.119_bib3","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1001\/jama.282.3.236","article-title":"NIH consensus definition and classification of prostatitis","volume":"282","author":"Krieger","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.juro.2008.11.119_bib4","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1097\/01.ju.0000137953.49304.6c","article-title":"Comorbidity of interstitial cystitis with other unexplained clinical conditions","volume":"172","author":"Buffington","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.11.119_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ucl.2007.09.005","article-title":"Chronic prostatitis\/chronic pelvic pain syndrome","volume":"35","author":"Pontari","year":"2008","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.juro.2008.11.119_bib6","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.juro.2008.01.028","article-title":"Monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha as possible biomarkers for the chronic pelvic pain syndrome","volume":"179","author":"Desireddi","year":"2008","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.11.119_bib7","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1097\/01.ju.0000083020.06212.3d","article-title":"A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis","volume":"170","author":"Sant","year":"2003","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.11.119_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0090-4295(01)01127-X","article-title":"Sensitivity and specificity of antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor as urine markers for interstitial cystitis","volume":"57","author":"Keay","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.juro.2008.11.119_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ucl.2007.09.011","article-title":"Re-imagining interstitial cystitis","volume":"35","author":"Hanno","year":"2008","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.juro.2008.11.119_bib10","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1097\/01.ju.0000154891.40110.08","article-title":"Long-term followup of augmentation enterocystoplasty and continent diversion in patients with benign disease","volume":"173","author":"Blaivas","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.11.119_bib11","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1464-410X.1971.tb12092.x","article-title":"Chronic interstitial cystitis","volume":"43","author":"Badenoch","year":"1971","journal-title":"Br J Urol"},{"key":"10.1016\/j.juro.2008.11.119_bib12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/nau.1930140402","article-title":"Long-term results and complications using augmentation cystoplasty in reconstructive urology","volume":"14","author":"Flood","year":"1995","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.juro.2008.11.119_bib13","series-title":"Campbell-Walsh Urology","article-title":"Inflammatory conditions of the male genitourinary tract: prostatitis and related conditions, orchitis, and epididymitis","author":"Nickel","year":"2006"},{"key":"10.1016\/j.juro.2008.11.119_bib14","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1001\/archinte.167.18.1922","article-title":"Pharmacologic management of painful bladder syndrome\/interstitial cystitis: a systematic review","volume":"167","author":"Dimitrakov","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.juro.2008.11.119_bib15","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.urology.2005.12.015","article-title":"Management of chronic prostatitis\/chronic pelvic pain syndrome: an evidence-based approach","volume":"67","author":"Dimitrakov","year":"2006","journal-title":"Urology"},{"key":"10.1016\/j.juro.2008.11.119_bib16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.urology.2007.09.025","article-title":"Adrenocortical hormone abnormalities in men with chronic prostatitis\/chronic pelvic pain syndrome","volume":"71","author":"Dimitrakov","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.juro.2008.11.119_bib17","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.juro.2007.10.084","article-title":"Psychometric profiles and hypothalamic-pituitary-adrenal axis function in men with chronic prostatitis\/chronic pelvic pain syndrome","volume":"179","author":"Anderson","year":"2008","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.11.119_bib18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0090-4295(01)01095-0","article-title":"Fishbein\/Interstitial Cystitis Association (ICA) survey of interstitial cystitis among family members of ICA members: preliminary analysis","volume":"57","author":"Warren","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.juro.2008.11.119_bib19","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.biopsych.2007.07.021","article-title":"Panic disorder, social anxiety disorder, and a possible medical syndrome previously linked to chromosome 13","volume":"63","author":"Talati","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.juro.2008.11.119_bib20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archpsyc.61.3.273","article-title":"Interstitial cystitis and panic disorder: a potential genetic syndrome","volume":"61","author":"Weissman","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.juro.2008.11.119_bib21","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1073\/pnas.0335669100","article-title":"Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q","volume":"100","author":"Hamilton","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.juro.2008.11.119_bib22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0090-4295(99)80334-3","article-title":"The Interstitial Cystitis Data Base Study: concepts and preliminary baseline descriptive statistics","volume":"49","author":"Simon","year":"1997","journal-title":"Urology"},{"key":"10.1016\/j.juro.2008.11.119_bib23","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1046\/j.1442-2042.10.s1.10.x","article-title":"Systemic aspects of interstitial cystitis, immunology and linkage with autoimmune disorders","volume":"10","author":"van deMerwe","year":"2003","journal-title":"Int J Urol, suppl"},{"key":"10.1016\/j.juro.2008.11.119_bib24","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1016\/S0022-5347(05)64241-3","article-title":"Molecular analysis of adrenergic receptor genes and interleukin-4\/interleukin-4 receptor genes in patients with interstitial cystitis","volume":"168","author":"Sugaya","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.11.119_bib25","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0022-5347(05)64916-6","article-title":"Cytokine polymorphisms in men with chronic prostatitis\/chronic pelvic pain syndrome: association with diagnosis and treatment response","volume":"168","author":"Shoskes","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.11.119_bib26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2220\/biomedres.27.163","article-title":"Efficacy of tricyclic antidepressant is associated with beta2-adrenoceptor genotype in patients with interstitial cystitis","volume":"27","author":"Nishijima","year":"2006","journal-title":"Biomed Res"},{"key":"10.1016\/j.juro.2008.11.119_bib27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1109557","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"308","author":"Klein","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.juro.2008.11.119_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0090-4295(01)01138-4","article-title":"A case of familial clustering of interstitial cystitis and chronic pelvic pain syndrome","volume":"58","author":"Dimitrakov","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.juro.2008.11.119_bib29","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0022-5347(17)36120-7","article-title":"The natural history of interstitial cystitis: a survey of 374 patients","volume":"149","author":"Koziol","year":"1993","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.11.119_bib30","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0022-5347(01)61947-5","article-title":"Epidemiology of interstitial cystitis: a population based study","volume":"161","author":"Curhan","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2008.11.119_bib31","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0090-4295(01)01120-7","article-title":"Concordance of interstitial cystitis in monozygotic and dizygotic twin pairs","volume":"57","author":"Warren","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.juro.2008.11.119_bib32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0022-5347(18)34568-3","article-title":"Single nucleotide polymorphism (SNP) analysis of autosomal dominant interstitial cystitis: a family-based study","volume":"173","author":"Dimitrakov","year":"2005","journal-title":"J Urol, suppl"},{"key":"10.1016\/j.juro.2008.11.119_bib33","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1126\/science.274.5290.1197","article-title":"Mapping of a gene for Parkinson's disease to chromosome 4q21-q23","volume":"274","author":"Polymeropoulos","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.juro.2008.11.119_bib34","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson's disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.juro.2008.11.119_bib35","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1212\/01.WNL.0000042088.22694.E3","article-title":"Early onset familial Alzheimer's disease: mutation frequency in 31 families","volume":"60","author":"Janssen","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.juro.2008.11.119_bib36","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3121\/cmr.1.4.291","article-title":"Mendelian forms of human hypertension and mechanisms of disease","volume":"1","author":"Luft","year":"2003","journal-title":"Clin Med Res"},{"key":"10.1016\/j.juro.2008.11.119_bib37","doi-asserted-by":"crossref","first-page":"R709","DOI":"10.1152\/ajpregu.00174.2003","article-title":"Mendelian hypertension with brachydactyly as a molecular genetic lesson in regulatory physiology","volume":"285","author":"Luft","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.juro.2008.11.119_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0025-7125(03)00118-4","article-title":"Present status of genetic mechanisms in hypertension","volume":"88","author":"Luft","year":"2004","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.juro.2008.11.119_bib39","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","article-title":"The endophenotype concept in psychiatry: etymology and strategic intentions","volume":"160","author":"Gottesman","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.juro.2008.11.119_bib40","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/nrn1993","article-title":"Intermediate phenotypes and genetic mechanisms of psychiatric disorders","volume":"7","author":"Meyer-Lindenberg","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.juro.2008.11.119_bib41","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1100\/tsw.2007.210","article-title":"Deconstruction of vulnerability to complex diseases: enhanced effect sizes and power of intermediate phenotypes","volume":"7","author":"Goldman","year":"2007","journal-title":"Sci World J"},{"key":"10.1016\/j.juro.2008.11.119_bib42","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/jmg.2007.056416","article-title":"Identifying pathogenic genetic background of simplex or multiplex retinitis pigmentosa patients: a large scale mutation screening study","volume":"45","author":"Jin","year":"2008","journal-title":"J Med Genet"},{"key":"10.1016\/j.juro.2008.11.119_bib43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/ng0593-54","article-title":"Localization of an autosomal dominant retinitis pigmentosa gene to chromosome 7q","volume":"4","author":"Jordan","year":"1993","journal-title":"Nat Genet"},{"key":"10.1016\/j.juro.2008.11.119_bib44","doi-asserted-by":"crossref","first-page":"875.","DOI":"10.1093\/hmg\/2.7.875","article-title":"Exclusion of the involvement of all known retinitis pigmentosa loci in the disease present in a family of Irish origin provides evidence for a sixth autosomal dominant locus (RP8)","volume":"2","author":"Kumar-Singh","year":"1993","journal-title":"Hum Mol Genet"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534708032825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534708032825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2008.11.119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T01:31:44Z","timestamp":1651195904000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2008.11.119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1016\/j.juro.2008.11.119"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2008.11.119","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}