{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:04:15Z","timestamp":1791345855050,"version":"4.3.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.juro.2009.01.015","type":"journal-article","created":{"date-parts":[[2009,3,20]],"date-time":"2009-03-20T08:34:08Z","timestamp":1237538048000},"page":"2339-2348","source":"Crossref","is-referenced-by-count":44,"title":["Sesquiterpene Lactone Parthenolide Ameliorates Bladder Inflammation and Bladder Overactivity in Cyclophosphamide Induced Rat Cystitis Model by Inhibiting Nuclear Factor-\u03baB Phosphorylation"],"prefix":"10.1097","volume":"181","author":[{"given":"Hiroshi","family":"Kiuchi","sequence":"first","affiliation":[{"name":"Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Takao","sequence":"additional","affiliation":[{"name":"Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Tsujimura","sequence":"additional","affiliation":[{"name":"Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Nonomura","sequence":"additional","affiliation":[{"name":"Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2009.01.015_bib1","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0022-5347(17)41173-6","article-title":"Urological complications of cyclophosphamide","volume":"141","author":"Levine","year":"1989","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2009.01.015_bib2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/1097-0142(19880201)61:3<451::AID-CNCR2820610308>3.0.CO;2-G","article-title":"Cyclophosphamide-induced hemorrhagic cystitis: a review of 100 patients","volume":"61","author":"Stillwell","year":"1988","journal-title":"Cancer"},{"key":"10.1016\/j.juro.2009.01.015_bib3","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/S0022-5347(01)68238-7","article-title":"Comparison of the uroprotective efficacy of mesna and HBO treatments in cyclophosphamide-induced hemorrhagic cystitis","volume":"158","author":"Etlik","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2009.01.015_bib4","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/S0022-5347(05)65134-8","article-title":"Tumor necrosis factor-\u03b1 and interleukin-1\u03b2 mediate the production of nitric oxide involved in the pathogenesis of ifosphamide induced hemorrhagic cystitis in mice","volume":"167","author":"Ribeiro","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2009.01.015_bib5","first-page":"R574","article-title":"COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat","volume":"284","author":"Hu","year":"2003","journal-title":"Am J Physiol"},{"key":"10.1016\/j.juro.2009.01.015_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.iy.12.040194.001041","article-title":"Function and activation of NF-\u03baB in the immune system","volume":"12","author":"Baeuerle","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.juro.2009.01.015_bib7","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1165\/rcmb.2006-0323OC","article-title":"Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice","volume":"36","author":"Saadane","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.juro.2009.01.015_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-\u03baB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.juro.2009.01.015_bib9","doi-asserted-by":"crossref","first-page":"7991","DOI":"10.1038\/sj.onc.1208943","article-title":"Loss of TNF-alpha-regulated COX-2 expression in ovarian cancer cells","volume":"24","author":"Yang","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.juro.2009.01.015_bib10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1146\/annurev.pharmtox.38.1.539","article-title":"Ethnopharmacology of Mexican Asteraceae (Compositae)","volume":"38","author":"Heinrich","year":"1998","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.juro.2009.01.015_bib11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tox.2006.10.025","article-title":"Parthenolide reduces cisplatin-induced renal damage","volume":"230","author":"Francescato","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.juro.2009.01.015_bib12","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1002\/ijc.22570","article-title":"Sesquiterpene lactone parthenolide suppresses tumor growth in a xenograft model of renal cell carcinoma by inhibiting the activation of NF-kappaB","volume":"120","author":"Oka","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1016\/j.juro.2009.01.015_bib13","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/S0022-5347(05)65728-X","article-title":"Effects of the nuclear factor-kappaB inhibitors 2-hydroxy-4-trifluoromethylbenzoic acid and aspirin on micturition in rats with normal and inflamed bladder","volume":"166","author":"Velasco","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2009.01.015_bib14","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/S0022-5347(01)62224-9","article-title":"Potential role of rel\/nuclear factor-kappaB in the pathogenesis of interstitial cystitis","volume":"160","author":"Abdel-Mageed","year":"1998","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2009.01.015_bib15","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0022-5347(05)67870-6","article-title":"Nuclear factor kappa B mediates lipopolysaccharide-induced inflammation in the urinary bladder","volume":"163","author":"Wang","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2009.01.015_bib16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s002100000371","article-title":"Nitric oxide synthases and cyclophosphamide-induced cystitis in rats","volume":"363","author":"Alfieri","year":"2001","journal-title":"Naunyn Schmiede Arch Pharmacol"},{"key":"10.1016\/j.juro.2009.01.015_bib17","doi-asserted-by":"crossref","first-page":"34538","DOI":"10.1074\/jbc.M504943200","article-title":"Phosphorylation of RelA\/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway","volume":"280","author":"Sasaki","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.juro.2009.01.015_bib18","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.1442-2042.2003.00709.x","article-title":"Use of dexamethasone with mesna for the prevention of ifosfamide-induced hemorrhagic cystitis","volume":"10","author":"Vieira","year":"2003","journal-title":"Int J Urol"},{"key":"10.1016\/j.juro.2009.01.015_bib19","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1158\/1535-7163.MCT-05-0030","article-title":"The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer","volume":"4","author":"Sweeney","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.juro.2009.01.015_bib20","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1182\/blood-2007-11-125278","article-title":"The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target","volume":"111","author":"Hewamana","year":"2008","journal-title":"Blood"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534709000378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534709000378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2009.01.015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T01:47:11Z","timestamp":1651196831000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2009.01.015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1016\/j.juro.2009.01.015"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2009.01.015","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}