{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:08:58Z","timestamp":1775624938754,"version":"3.50.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.juro.2011.02.018","type":"journal-article","created":{"date-parts":[[2011,4,22]],"date-time":"2011-04-22T17:54:56Z","timestamp":1303494896000},"page":"2398-2404","source":"Crossref","is-referenced-by-count":22,"title":["Regulation of Connexin 43 by Basic Fibroblast Growth Factor in the Bladder: Transcriptional and Behavioral Implications"],"prefix":"10.1097","volume":"185","author":[{"given":"Hiromitsu","family":"Negoro","sequence":"first","affiliation":[{"name":"Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Kanematsu","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Research Group1, Pharmacology Discovery Research Laboratory, Nippon Shinyaku Co., Ltd., Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsushi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Research Group1, Pharmacology Discovery Research Laboratory, Nippon Shinyaku Co., Ltd., Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Tabata","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2011.02.018_bib1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1056\/NEJMra032662","article-title":"Management of overactive bladder","volume":"350","author":"Ouslander","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.juro.2011.02.018_bib2","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0022-5347(17)35683-5","article-title":"Effects of partial outlet obstruction of the rat urinary bladder on micturition characteristics, DNA synthesis and the contractile response to field stimulation and pharmacological agents","volume":"150","author":"Saito","year":"1993","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2011.02.018_bib3","doi-asserted-by":"crossref","first-page":"R1241","DOI":"10.1152\/ajpregu.00030.2002","article-title":"Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo","volume":"284","author":"Christ","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.juro.2011.02.018_bib4","doi-asserted-by":"crossref","first-page":"C1627","DOI":"10.1152\/ajpcell.00122.2007","article-title":"Changes of gap junctional cell-cell communication in overactive detrusor in rats","volume":"293","author":"Li","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.juro.2011.02.018_bib5","doi-asserted-by":"crossref","first-page":"F46","DOI":"10.1152\/ajprenal.90207.2008","article-title":"Basic fibroblast growth factor causes urinary bladder overactivity through gap junction generation in the smooth muscle","volume":"297","author":"Imamura","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.juro.2011.02.018_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2220\/biomedres.27.203","article-title":"A gap junction blocker inhibits isolated whole bladder activity in normal rats and rats with partial bladder outlet obstruction","volume":"27","author":"Miyazato","year":"2006","journal-title":"Biomed Res"},{"key":"10.1016\/j.juro.2011.02.018_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1464-410X.1995.tb07706.x","article-title":"Urinary basic fibroblast growth factor in patients with bladder cancer and benign prostatic hypertrophy","volume":"76","author":"O'Brien","year":"1995","journal-title":"Br J Urol"},{"key":"10.1016\/j.juro.2011.02.018_bib8","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S0022-5347(01)64402-1","article-title":"Basic fibroblast growth factor in the urine of children with voiding pathology","volume":"158","author":"Bagli","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2011.02.018_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bbamem.2005.11.002","article-title":"Regulation of connexin expression","volume":"1719","author":"Oyamada","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.juro.2011.02.018_bib10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbrc.2007.03.009","article-title":"c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression","volume":"356","author":"Gao","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.juro.2011.02.018_bib11","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/molehr\/5.8.757","article-title":"Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene","volume":"5","author":"Echetebu","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.juro.2011.02.018_bib12","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1242\/jcs.111.12.1741","article-title":"Identification of connexin43 as a functional target for Wnt signalling","volume":"111","author":"van derHeyden","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1016\/j.juro.2011.02.018_bib13","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/mol.63.4.821","article-title":"Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence","volume":"63","author":"Carystinos","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.juro.2011.02.018_bib14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1152\/physiolgenomics.00181.2004","article-title":"Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells","volume":"20","author":"Adam","year":"2004","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.juro.2011.02.018_bib15","first-page":"F343","article-title":"Bradykinin stimulates the ERK\u2192Elk\u21921\u2192Fos\/AP-1 pathway in mesangial cells","volume":"275","author":"El Dahr","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.juro.2011.02.018_bib16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.regpep.2009.07.007","article-title":"Basic fibroblast growth factor upregulates adrenomedullin expression in ovarian epithelial carcinoma cells via JNK-AP-1 pathway","volume":"157","author":"Zhang","year":"2009","journal-title":"Regul Pept"},{"key":"10.1016\/j.juro.2011.02.018_bib17","doi-asserted-by":"crossref","first-page":"F1007","DOI":"10.1152\/ajprenal.00107.2007","article-title":"Basic fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle cells","volume":"293","author":"Imamura","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.juro.2011.02.018_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0168-3659(94)00035-2","article-title":"Enhanced vascularization and tissue granulation by basic fibroblast growth factor impregnated in gelatin hydrogels","volume":"31","author":"Tabata","year":"1994","journal-title":"J Control Release"},{"key":"10.1016\/j.juro.2011.02.018_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1163\/156856209X410193","article-title":"Controlled release of stromal-cell-derived factor-1 from gelatin hydrogels enhances angiogenesis","volume":"21","author":"Kimura","year":"2010","journal-title":"J Biomater Sci Polym Ed"},{"key":"10.1016\/j.juro.2011.02.018_bib20","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1089\/ten.tea.2009.0532","article-title":"A tissue engineering approach for prenatal closure of myelomeningocele with gelatin sponges incorporating basic fibroblast growth factor","volume":"16","author":"Watanabe","year":"2010","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.juro.2011.02.018_bib21","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0002-9440(10)62278-X","article-title":"Induction of smooth muscle cell-like phenotype in marrow-derived cells among regenerating urinary bladder smooth muscle cells","volume":"166","author":"Kanematsu","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.juro.2011.02.018_bib22","first-page":"299","article-title":"Anti-reactive oxygen species activity and anti-inflammatory activity of Eviprostat, a phytotherapeutic agent for benign prostatic hyperplasia-Relevance to its protective effect on the lower urinary tract dysfunction induced by ischemia\/reperfusion injury","volume":"18","author":"Oka","year":"2007","journal-title":"Nippon Hainyo Kino Gakkai Shi"},{"key":"10.1016\/j.juro.2011.02.018_bib23","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1074\/jbc.270.8.3863","article-title":"Identification of two regulatory elements within the promoter region of the mouse connexin 43 gene","volume":"270","author":"Chen","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.juro.2011.02.018_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000176024","article-title":"Alterations of urine TGF-beta1 and bFGF following bladder outlet obstruction: a predictor for detrusor contractibility?","volume":"82","author":"Shi","year":"2009","journal-title":"Urol Int"},{"issue":"suppl.","key":"10.1016\/j.juro.2011.02.018_bib25","first-page":"32","article-title":"Animal models of bladder outlet obstruction and molecular insights into the basis for the development of bladder dysfunction","volume":"32","author":"Buttyan","year":"1997","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2011.02.018_bib26","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/nau.20355","article-title":"Normative bladder diary measurements: night versus day","volume":"26","author":"Parsons","year":"2007","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.juro.2011.02.018_bib27","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0090-4295(02)02444-5","article-title":"Nocturia and benign prostatic hyperplasia","volume":"61","author":"Yoshimura","year":"2003","journal-title":"Urology"},{"key":"10.1016\/j.juro.2011.02.018_bib28","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.urology.2005.01.043","article-title":"Decreased cellular membrane expression of gap junctional protein, connexin 43, in rat detrusor muscle with chronic partial bladder outlet obstruction","volume":"65","author":"Mori","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.juro.2011.02.018_bib29","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s11255-008-9516-7","article-title":"Changes of bladder activity and connexin 43-derived gap junctions after partial bladder-outlet obstruction in rats","volume":"41","author":"Miyazato","year":"2009","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.juro.2011.02.018_bib30","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.eururo.2004.08.020","article-title":"Increased expression of connexin 43 in the overactive neurogenic detrusor","volume":"46","author":"Haferkamp","year":"2004","journal-title":"Eur Urol"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534711002539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534711002539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2011.02.018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T22:19:35Z","timestamp":1651184375000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2011.02.018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1016\/j.juro.2011.02.018"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2011.02.018","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}